메뉴 건너뛰기




Volumn 5, Issue 4, 2013, Pages 112-115

Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis

Author keywords

ATP synthase inhibitor; Bedaquiline; MDR TB; Tuberculosis; XDR TB

Indexed keywords


EID: 84895109493     PISSN: 09751483     EISSN: 09751505     Source Type: Journal    
DOI: 10.1016/j.jyp.2013.12.002     Document Type: Review
Times cited : (68)

References (30)
  • 1
    • 71549144519 scopus 로고    scopus 로고
    • WHO [Internet]. [cited 2013 Nov 27]. Available from
    • WHO Global Tuberculosis Report 2013 WHO [Internet]. [cited 2013 Nov 27]. Available from: http://www.who.int/tb/publications/global-report/en/
    • (2013) WHO Global Tuberculosis Report
  • 2
    • 60349100584 scopus 로고    scopus 로고
    • WHO Treatment of Tuberculosis WHO. [cited 2013 Nov 27]
    • WHO Treatment of Tuberculosis: Guidelines for National Programmes [Internet]. WHO. [cited 2013 Nov 27]. Available from: http://www.who.int/tb/ publications/tb-treatmentguidelines/en/.
    • Guidelines for National Programmes [Internet]
  • 3
    • 77952357833 scopus 로고    scopus 로고
    • New initiative speeds tuberculosis drug development: Novel drug regimens become possible in years, not decades
    • M. Spigelman, R. Woosley, and J. Gheuens New initiative speeds tuberculosis drug development: novel drug regimens become possible in years, not decades Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis 14 2010 663 664
    • (2010) Int J Tuberc Lung Dis off J Int Union Tuberc Lung Dis , vol.14 , pp. 663-664
    • Spigelman, M.1    Woosley, R.2    Gheuens, J.3
  • 4
    • 77649141318 scopus 로고    scopus 로고
    • Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia
    • M. Berney, and G.M. Cook Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia PLoS One 5 2010 e8614
    • (2010) PLoS One , vol.5 , pp. 8614
    • Berney, M.1    Cook, G.M.2
  • 5
    • 21844435978 scopus 로고    scopus 로고
    • The F1Fo-ATP synthase of Mycobacterium smegmatis is essential for growth
    • S.L. Tran, and G.M. Cook The F1Fo-ATP synthase of Mycobacterium smegmatis is essential for growth J Bacteriol 187 2005 5023 5028
    • (2005) J Bacteriol , vol.187 , pp. 5023-5028
    • Tran, S.L.1    Cook, G.M.2
  • 6
    • 0035923515 scopus 로고    scopus 로고
    • Pause and rotation of F(1)-ATPase during catalysis
    • Y. Hirono-Hara, H. Noji, and M. Nishiura et al. Pause and rotation of F(1)-ATPase during catalysis Proc Natl Acad Sci U S A 98 2001 13649 13654
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 13649-13654
    • Hirono-Hara, Y.1    Noji, H.2    Nishiura, M.3
  • 7
    • 0041923728 scopus 로고    scopus 로고
    • The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer
    • R. Yasuda, T. Masaike, K. Adachi, H. Noji, H. Itoh, and K. Kinosita Jr. The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer Proc Natl Acad Sci U S A 100 2003 9314 9318
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9314-9318
    • Yasuda, R.1    Masaike, T.2    Adachi, K.3    Noji, H.4    Itoh, H.5    Kinosita, Jr.K.6
  • 8
    • 0024473396 scopus 로고
    • Vacuolar ATPases, like F1,F0-ATPases, show a strong dependence of the reaction velocity on the binding of more than one ATP per enzyme
    • V.N. Kasho, and P.D. Boyer Vacuolar ATPases, like F1,F0-ATPases, show a strong dependence of the reaction velocity on the binding of more than one ATP per enzyme Proc Natl Acad Sci U S A 86 1989 8708 8711
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 8708-8711
    • Kasho, V.N.1    Boyer, P.D.2
  • 9
    • 80051850771 scopus 로고    scopus 로고
    • Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase
    • A.C. Haagsma, I. Podasca, and A. Koul et al. Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase PLoS One 6 2011 e23575
    • (2011) PLoS One , vol.6 , pp. 23575
    • Haagsma, A.C.1    Podasca, I.2    Koul, A.3
  • 10
    • 62949223223 scopus 로고    scopus 로고
    • Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue
    • A.C. Haagsma, R. Abdillahi-Ibrahim, and M.J. Wagner et al. Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue Antimicrob Agents Chemother 53 2009 1290 1292
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1290-1292
    • Haagsma, A.C.1    Abdillahi-Ibrahim, R.2    Wagner, M.J.3
  • 11
    • 84895156953 scopus 로고    scopus 로고
    • Drugs@FDA: FDA Approved Drug Products [Internet]. [cited 2013 Nov 27]
    • Drugs@FDA: FDA Approved Drug Products [Internet]. [cited 2013 Nov 27]. Available from: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm? fuseaction=Search.DrugDetails.
  • 12
    • 84859753546 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267
    • K.E. Dooley, J.-G. Park, and S. Swindells et al. Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267 J Acquir Immune Defic Syndr 59 2012 455 462
    • (2012) J Acquir Immune Defic Syndr , vol.59 , pp. 455-462
    • Dooley, K.E.1    Park, J.-G.2    Swindells, S.3
  • 13
    • 19944429772 scopus 로고    scopus 로고
    • A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    • K. Andries, P. Verhasselt, and J. Guillemont et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis Science 307 2005 223 227
    • (2005) Science , vol.307 , pp. 223-227
    • Andries, K.1    Verhasselt, P.2    Guillemont, J.3
  • 14
    • 84857157134 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis
    • M.-C. Rouan, N. Lounis, and T. Gevers et al. Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis Antimicrob Agents Chemother 56 2012 1444 1451
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1444-1451
    • Rouan, M.-C.1    Lounis, N.2    Gevers, T.3
  • 15
    • 54049095245 scopus 로고    scopus 로고
    • Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model
    • N. Lounis, T. Gevers, J. Van Den Berg, and K. Andries Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model Antimicrob Agents Chemother 52 2008 3568 3572
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3568-3572
    • Lounis, N.1    Gevers, T.2    Van Den Berg, J.3    Andries, K.4
  • 16
    • 33847647151 scopus 로고    scopus 로고
    • Synergistic activity of R207910 combined with pyrazinamide against murine tuberculosis
    • M. Ibrahim, K. Andries, and N. Lounis et al. Synergistic activity of R207910 combined with pyrazinamide against murine tuberculosis Antimicrob Agents Chemother 51 2007 1011 1015
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1011-1015
    • Ibrahim, M.1    Andries, K.2    Lounis, N.3
  • 17
    • 78049264832 scopus 로고    scopus 로고
    • Bactericidal potencies of new regimens are not predictive of their sterilizing potencies in a murine model of tuberculosis
    • K. Andries, T. Gevers, and N. Lounis Bactericidal potencies of new regimens are not predictive of their sterilizing potencies in a murine model of tuberculosis Antimicrob Agents Chemother 54 2010 4540 4544
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 4540-4544
    • Andries, K.1    Gevers, T.2    Lounis, N.3
  • 19
    • 33746906651 scopus 로고    scopus 로고
    • Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis
    • R.J. Basaraba, D.D. Dailey, and C.T. McFarland et al. Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis Tuberc Edinb Scotl 86 2006 386 394
    • (2006) Tuberc Edinb Scotl , vol.86 , pp. 386-394
    • Basaraba, R.J.1    Dailey, D.D.2    McFarland, C.T.3
  • 20
    • 78650653480 scopus 로고    scopus 로고
    • Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs
    • S. Shang, C.A. Shanley, and M.L. Caraway et al. Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs Antimicrob Agents Chemother 55 2011 124 131
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 124-131
    • Shang, S.1    Shanley, C.A.2    Caraway, M.L.3
  • 21
    • 35948964746 scopus 로고    scopus 로고
    • Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910
    • A.J. Lenaerts, D. Hoff, and S. Aly et al. Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910 Antimicrob Agents Chemother 51 2007 3338 3345
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3338-3345
    • Lenaerts, A.J.1    Hoff, D.2    Aly, S.3
  • 22
    • 48749120676 scopus 로고    scopus 로고
    • Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis
    • R. Rustomjee, A.H. Diacon, and J. Allen et al. Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis Antimicrob Agents Chemother 52 2008 2831 2835
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2831-2835
    • Rustomjee, R.1    Diacon, A.H.2    Allen, J.3
  • 23
    • 66649090346 scopus 로고    scopus 로고
    • The diarylquinoline TMC207 for multidrug-resistant tuberculosis
    • A.H. Diacon, A. Pym, and M. Grobusch et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis N Engl J Med 360 2009 2397 2405
    • (2009) N Engl J Med , vol.360 , pp. 2397-2405
    • Diacon, A.H.1    Pym, A.2    Grobusch, M.3
  • 24
    • 84861140844 scopus 로고    scopus 로고
    • Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: Long-term outcome, tolerability, and effect on emergence of drug resistance
    • A.H. Diacon, P.R. Donald, and A. Pym et al. Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance Antimicrob Agents Chemother 56 2012 3271 3276
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3271-3276
    • Diacon, A.H.1    Donald, P.R.2    Pym, A.3
  • 25
    • 84895162239 scopus 로고    scopus 로고
    • Use of Bedaquiline (TMC-207) for treatment of MDR-TB
    • [Internet] [cited 2013 Nov 27]. Available from
    • Use of Bedaquiline (TMC-207) for treatment of MDR-TB [Internet] Int Union Against Tuberc Lung Dis 2012 [cited 2013 Nov 27]. Available from: http://uwclh.conference2web.com/content/2168
    • (2012) Int Union Against Tuberc Lung Dis
  • 27
    • 35848948213 scopus 로고    scopus 로고
    • In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor
    • E. Huitric, P. Verhasselt, K. Andries, and S.E. Hoffner In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor Antimicrob Agents Chemother 51 2007 4202 4204
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 4202-4204
    • Huitric, E.1    Verhasselt, P.2    Andries, K.3    Hoffner, S.E.4
  • 28
    • 34248998479 scopus 로고    scopus 로고
    • Diarylquinolines target subunit c of mycobacterial ATP synthase
    • A. Koul, N. Dendouga, and K. Vergauwen et al. Diarylquinolines target subunit c of mycobacterial ATP synthase Nat Chem Biol 3 2007 323 324
    • (2007) Nat Chem Biol , vol.3 , pp. 323-324
    • Koul, A.1    Dendouga, N.2    Vergauwen, K.3
  • 29
    • 34248545958 scopus 로고    scopus 로고
    • A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910
    • M.R. De Jonge, L.H.M. Koymans, J.E.G. Guillemont, A. Koul, and K. Andries A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910 Proteins 67 2007 971 980
    • (2007) Proteins , vol.67 , pp. 971-980
    • De Jonge, M.R.1    Koymans, L.H.M.2    Guillemont, J.E.G.3    Koul, A.4    Andries, K.5
  • 30
    • 84860157680 scopus 로고    scopus 로고
    • New mutations in the mycobacterial ATP synthase: New insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure
    • E. Segala, W. Sougakoff, A. Nevejans-Chauffour, V. Jarlier, and S. Petrella New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure Antimicrob Agents Chemother 56 2012 2326 2334
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 2326-2334
    • Segala, E.1    Sougakoff, W.2    Nevejans-Chauffour, A.3    Jarlier, V.4    Petrella, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.