IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Matsumoto, Atsuhiro ^a   Kanai, Takanori ^a   Mikami, Yohei ^a   Chu, Po Sung ^a   Nakamoto, Nobuhiro ^a   Ebinuma, Hirotoshi ^a   Saito, Hidetsugu ^a   Sato, Toshiro ^a   Yagita, Hideo ^b   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; INTERLEUKIN 22; MONOCLONAL ANTIBODY; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR GAMMA T; THYROXINE; UNCLASSIFIED DRUG; ALLOANTIBODY; ANTI-THY ANTIBODY; DNA BINDING PROTEIN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ACUTE HEPATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; IMMUNE RESPONSE; LIVER CELL; LIVER PROTECTION; LYMPHOID CELL; MACROPHAGE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; ANIMAL HEPATITIS; BIOSYNTHESIS; CHEMICALLY INDUCED; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; LIVER; LYMPHOCYTE; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBPOPULATION; METABOLISM; NATURAL KILLER CELL; PATHOLOGY;

MURINAE; MUS;

ANIMALS; DNA-BINDING PROTEINS; HEPATITIS, ANIMAL; IMMUNITY, INNATE; INTERLEUKINS; ISOANTIBODIES; KILLER CELLS, NATURAL; LIVER; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MICE; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3;

EID: 84876561418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062853     Document Type: Article

References (31)

1. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133.
2. Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, et al. (2010) Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464: 1371-1375.
3. Eberl G, Littman DR, (2003) The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunol Rev 195: 81-90.
4. Bettelli E, Korn T, Oukka M, Kuchroo VK, (2008) Induction and effector functions of T(H)17 cells. Nature 453: 1051-1057.
5. Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, et al. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445: 648-651.
6. Hoegl S, Bachmann M, Scheiermann P, Goren I, Hofstetter C, et al. (2011) Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Am J Respir Cell Mol Biol 44: 369-376.
7. Radaeva S, Sun R, Pan HN, Hong F, Gao B, (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39: 1332-1342.
8. Pan H, Hong F, Radaeva S, Gao B, (2004) Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol 1: 43-49.
9. Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, et al. (2007) Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659.
10. Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, et al. (2005) Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22: 705-716.
11. Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S, (2005) Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc Natl Acad Sci U S A 102: 5114-5119.
12. Tiegs G, Hentschel J, Wendel A, (1992) A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest. 90: 196-203.
13. Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, et al. (2000) Augmentation of Valpha1 KT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 191: 105-114.
14. Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G, (1995) Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21: 190-198.
15. Kusters S, Gantner F, Kunstle G, Tiegs G, (1996) Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology. 111: 462-471.
16. Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, et al. (2000) Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 97: 5498-5503.
17. Spits H, Di Santo JP, (2011) The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol 12: 21-27.
18. Eberl G, Littman DR, (2004) Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305: 248-251.
19. Nakamoto N, Ebinuma H, Kanai T, Chu PS, Ono Y, et al. (2012) CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis. Gastroenterology 142: 366-376.
20. Raczynski AR, Muthupalani S, Schlieper K, Fox JG, Tannenbaum SR, et al. (2012) Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. PLoS One 7: e33099.
21. Berthelot P, (1973) Mechanisms and prediction of drug-induced liver disease. Gut 14: 332-339.
22. Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, et al. (2010) Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 33: 736-751.
23. Michel ML, Mendes-da-Cruz D, Keller AC, Lochner M, Schneider E, et al. (2008) Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc Natl Acad Sci U S A 105: 19845-19850.
24. Park O, Jeong WI, Wang L, Wang H, Lian ZX, et al. (2009) Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 49: 1683-1694.
25. Tupin E, Kinjo Y, Kronenberg M, (2007) The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol 5: 405-417.
26. Crispe IN, (2009) The liver as a lymphoid organ. Annu Rev Immunol 27: 147-163.
27. Dong Z, Wei H, Sun R, Tian Z, (2007) The roles of innate immune cells in liver injury and regeneration. Cell Mol Immunol 4: 241-252.
28. Miyagi T, Takehara T, Tatsumi T, Kanto T, Suzuki T, et al. (2003) CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver. Int J Cancer 106: 81-89.
29. Heneghan MA, McFarlane IG, (2002) Current and novel immunosuppressive therapy for autoimmune hepatitis. Hepatology 35: 7-13.
30. Lafdil F, Wang H, Park O, Zhang W, Moritoki Y, et al. (2009) Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology 137: 2125-2135 e2121-2122.
31. Nagata T, McKinley L, Peschon JJ, Alcorn JF, Aujla SJ, et al. (2008) Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells. J Immunol 181: 7473-7479.