Gene expression profiling of human vaginal cells in vitro discriminates compounds with pro-inflammatory and mucosa-altering properties: Novel biomarkers for preclinical testing of HIV microbicide candidates

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Zalenskaya, Irina A ^a   Joseph, Theresa ^a,d   Bavarva, Jasmin ^b,e   Yousefieh, Nazita ^a   Jackson, Suzanne S ^a   Fashemi, Titilayo ^c   Yamamoto, Hidemi S ^c   Settlage, Robert ^b   Fichorova, Raina N ^c   Doncel, Gustavo F ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); LACTOBACILLUS GASSERI; PREVOTELLA BIVIA;

ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOLOGIC FACTOR;

BACTERIAL COUNT; BACTERIUM; BIOLOGICAL MODEL; CELL LINE; CLUSTER ANALYSIS; CYTOLOGY; DNA MICROARRAY; DRUG EFFECTS; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GROWTH, DEVELOPMENT AND AGING; HIV INFECTIONS; HUMAN; INFLAMMATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MUCOSA; PATHOLOGY; PRECLINICAL STUDY; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; VAGINA;

ANTI-INFECTIVE AGENTS; BACTERIA; BIOMARKERS; CELL LINE; CLUSTER ANALYSIS; COLONY COUNT, MICROBIAL; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; HIV INFECTIONS; HUMANS; IMMUNOLOGIC FACTORS; INFLAMMATION; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MUCOUS MEMBRANE; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TRANSCRIPTION, GENETIC; VAGINA;

EID: 84936869232     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128557     Document Type: Article

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