Sexual transmission of HIV

New England Journal of Medicine

Volumn 336, Issue 15, 1997, Pages 1072-1078

  Royce, Rachel A ^a   Seña, Arlene ^a,b   Cates Jr , Willard ^a,c   Cohen, Myron S ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c FAMILY HEALTH INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD TRANSFUSION; GENETIC SUSCEPTIBILITY; HOST SUSCEPTIBILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; PLACENTAL TRANSFER; PRIORITY JOURNAL; REVIEW; SEXUAL TRANSMISSION; VIRUS CELL INTERACTION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

COITUS; DISEASE SUSCEPTIBILITY; DISEASE TRANSMISSION, HORIZONTAL; FEMALE; HIV; HIV INFECTIONS; HUMANS; MALE; RISK FACTORS; SEXUAL BEHAVIOR; SOCIAL ENVIRONMENT;

EID: 1842333851     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199704103361507     Document Type: Review

References (97)

1. Joint United Nations Programme on HIV/AIDS. The HIV/AIDS situation in mid 1996: global and regional highlights. UNAIDS Fact Sheet. July 1, 1996.
2. Downs AM, de Vincenzi I. Probability of heterosexual transmission of HIV: relationship to the number of unprotected sexual contacts. J Acquir Immune Defic Syndr Hum Retrovirol 1996;11:388-95.
3. Mastro TD, Satten GA, Nopkesorn T, Sangkharomya S, Longini IM Jr. Probability of female-to-male transmission of HIV-1 in Thailand. Lancet 1994;343:204-7.
4. Nagachinta T, Duerr A, Gargiullo PM, et al. HIV infectivity by contraceptive method from a partner study in northern Thailand. In: Volume 1 of abstracts of the 11th International Conference on AIDS, Vancouver, B.C., July 7-12, 1996:42. abstract.
5. Ahlgren DJ, Gorny MK, Stein AC. Model-based optimization of infectivity parameters: a study of the early epidemic in San Francisco. J Acquir Immune Defic Syndr 1990;3:631-43.
6. Kaplan EH. Modeling HIV infectivity: must sex acts be counted? J Acquir Immune Defic Syndr 1990;3:55-61.
7. Henderson DK, Fahey BJ, Willy M, et al. Risk for occupational transmission of human immunodeficiency virus type 1 (HIV-1) associated with clinical exposures: a prospective evaluation. Ann Intern Med 1990;113: 740-6.
8. Kaplan EH, Heimer R. A model-based estimate of HIV infectivity via needle sharing. J Acquir Immune Defic Syndr 1992;5:1116-8.
9. Zidovudine for the prevention of HIV transmission from mother to infant. MMWR Morb Mortal Wkly Rep 1994;43:285-7.
10. Tovo P-A, de Martino M, Gabiano C, et al. Mode of delivery and gestational age influence perinatal HIV-1 transmission. J Acquir Immune Defic Syndr Hum Retrovirol 1996;11:88-94.
11. Donegan E, Stuart M, Niland JC, et al. Infection with human immunodeficiency virus type 1 (HIV-1) among recipients of antibody-positive blood donations. Ann Intern Med 1990;113:733-9.
12. Anderson RM, May RM. Infectious diseases of humans: dynamics and control. Oxford, England: Oxford University Press, 1991.
13. Weiss R. HIV receptors and the pathogenesis of AIDS. Science 1996; 272:1885-6.
14. Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996;381:667-73.
15. Spira AI, Marx PA, Patterson BK, et al. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 1996;183:215-25.
16. Hussain LA, Lehner T. Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia. Immunology 1995;85:475-84.
17. Nuovo G, Forde A, MacConnell P, Fahrenwald R. In situ detection of PCR-amplified HIV-1 nucleic acids and tumor necrosis factor cDNA in cervical tissues. Am J Pathol 1993;143:40-8.
18. Clemetson DB, Moss GB, Willerford DM, et al. Detection of HIV DNA in cervical and vaginal secretions: prevalence and correlates among women in Nairobi, Kenya. JAMA 1993;269:2860-4.
19. Bagasra O, Farzadegan H, Seshamma T, Oakes JW, Saah A, Pomerantz RJ. Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men. AIDS 1994;8:1669-74.
20. Stanley SK, Ostrowski MA, Justement JS, et al. Eftect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N Engl J Med 1996;334:1222-30.
21. O'Connor TJ, Kinchington D, Kangro HO, Jeffries DJ. The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro. Int J STD AIDS 1995;6:267-72.
22. Shearer GM, Clerici M. Protective immunity against HIV infection: has nature done the experiment for us? Immunol Today 1995;17:21-4.
23. Willerford DM, Bwayo JJ, Hensel M, et al. Human immunodeficiency virus infection among high-risk seronegative prostitutes in Nairobi. J Infect Dis 1993;167:1414-7.
24. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-62.
25. deVincenzi I. A longitudinal study of human immunodeficiency virus transmission by heterosexual partners. N Engl J Med 1994;331:341-6.
26. Lazzarin A, Saracco A, Musicco M, Nicolosi A. Man-to-woman sexual transmission of the human immunodeficiency virus: risk factors related to sexual behavior, man's infectiousness, and woman's susceptibility. Arch Intern Med 1991;151:2411-6.
27. European Study Group on Heterosexual Transmission of HIV. Comparison of female to male and male to female transmission of HIV in 563 stable couples. BMJ 1992;304:809-13.
28. Seidlin M, Vogler M, Lee E, Lee YS, Dubin N. Heterosexual transmission of HIV in a cohort of couples in New York City. AIDS 1993;7:1247-54. [Erratum, AIDS 1993;7:1541.]
29. Fischl MA, Dickinson GM, Scott GB, Klimas N, Fletcher MA, Parks W. Evaluation of heterosexual partners, children, and household contacts of adults with AIDS. JAMA 1987;257:640-4.
30. Caceres CF, van Griensven GJ. Male homosexual transmission of HIV-1. AIDS 1994;8:1051-61.
31. Lee T-H, Sakahara N, Fiebig E, Busch MP, O'Brien TR, Herman SA. Correlation of HIV-1 RNA levels in plasma and heterosexual transmission of HIV-1 from infected transfusion recipients. J Acquir Immune Defic Syndr Hum Retrovirol 1996;12:427-8.
32. Mellors J, Rinaldo CR Jr, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HFV-1 infection predicted by the quantity of virus in plasma. Science 1996;272:1167-70.
33. Liuzzi G, Chirianni A, Clementi M, et al. Analysis of HFV-1 load in blood, semen and saliva: evidence for different viral compartments in a cross-sectional and longitudinal study. AIDS 1996;10:F51-F56.
34. Vernazza PL, Eron JJ, Cohen MS, van der Horst CM, Troiani L, Fiscus SA. Detection and biologic characterization of infectious HIV-1 in semen of seropositive men. AIDS 1994;8:1325-9.
35. Anderson DJ, O'Brien TR, Politch JA, et al. Effects of disease stage and zidovudine therapy on the detection of human immunodeficiency virus type 1 in semen. JAMA 1992;267:2769-74.
36. Krieger JN, Coombs RW, Collier AC, et al. Recovery of human immunodeficiency virus type 1 from semen: minimal impact of stage of infection and currently antiviral chemotherapy. J Infect Dis 1991;163:386-8.
37. Krieger JN, Coombs RW, Collier AC, Ross SO, Speck C, Corey L. Seminal shedding of human immunodeficiency virus type 1 and human cytomegalovirus: evidence for different immunologic controls. J Infect Dis 1995;171:1018-22.
38. Krieger JN, Coombs RW, Collier AC, et al. Intermittent shedding of human immunodeficiency virus in semen: implications for sexual transmission. J Urol 1995;154:1035-40.
39. Borzy MS, Connell RS, Kiessling AA. Detection of human immunodeficiency virus in cell-free seminal fluid. J Acquir Immune Defic Syndr 1988;1:419-24.
40. Hamed K, Winters M, Holodniy M, Katzenstein DA, Merigan TC. Detection of human immunodeficiency virus type 1 in semen: effects of disease stage and nucleoside therapy. J Infect Dis 1993;167:798-802.
41. Rasheed S, Li Z, Xu D, Kovacs A. Presence of cell-free human immunodeficiency virus in cervicovaginal secretions is independent of viral load in the blood of human immunodeficiency virus-infected women. Am J Obstet Gynccol 1996;175:122-9.
42. Hénin Y, Mandelbrot L, Henrion R, Pradinaud R, Coulaud JP, Montagnier L. Virus excretion in the cervicovaginal secretions of pregnant and nonpregnant HIV-infected women. J Acquir Immune Defic Syndr 1993;6: 72-5.
43. Jacquez JA, Koopman SJ, Simon CP, Longini IM Jr. Role of the primary infection in epidemics of HIV infection in gay cohorts. J Acquir Immune Defic Syndr 1994;7:1169-84.
44. Koopman J. Emerging objectives and methods in epidemiology. Am J Public Health 1996;86:630-2.
45. Piatak M Jr, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993;259:1749-54.
46. Kinloch de Loës S, Hirschel BJ, Hoen B, et al. A controlled trial of zidovudine in primary human immunodeficiency virus infection. N Engl J Med 1995;333:408-13. [Erratum, N Engl J Med 1995;333:1367.]
47. Daar ES, Moudgil T, Meyer RD, Ho DD. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 1991;324:961-4.
48. McCusker J, Stoddard AM, Mayer KH, Cowan DN, Groopman JE. Behavioral risk factors for HIV infection among homosexual men at a Boston community health center. Am J Public Health 1988;78:68-71.
49. Peterman TA, Stoneburner RL, Allen JR, Jaffe HW, Curran JW. Risk of human immunodeficiency virus transmission from heterosexual adults with transfusion-associated infections. JAMA 1988;259:55-8. [Erratum, JAMA 1989;262:502.]
50. DeGruttola V, Seage GR III, Mayer KH, Horsburgh CR Jr. Infectiousness of HIV between male homosexual partners. J Clin Epidemiol 1989; 42:849-56.
51. Gilliam BL, Dyer J, Cohen MS, Fiscus S, Eron JJ Jr. Effects of reverse transcriptase inhibitor therapy on HIV-1 viral burden in semen. In: Volume 1 of abstracts of the 11th International Conference on AIDS, Vancouver, B.C., July 7-12, 1996:69. abstract.
52. Mermin JH, Holodniy M, Katzenstein DA, Merigan TC. Detection of human immunodeficiency virus DNA and RNA in semen by the polymerase chain reaction. J Infect Dis 1991;164:769-72
53. Musicco M, Lazzarin A, Nicolosi A, et al. Antiretroviral treatment of men infected with human immunodeficiency virus type 1 reduces the incidence of heterosexual transmission: Italian Study Group on HIV Heterosexual Transmission. Arch Intern Med 1994;154:1971-6.
54. Katz MH, Gerberding JL. Postexposure treatment of people exposed to the human immunodeficiency virus through sexual contact or injection-drug use. N Engl J Med 1997;336:1097-100.
55. Case-control study of HIV seroconversion in health-care workers after percutaneous exposure to HIV-infected blood - France, United Kingdom, and United States, January 1988-August 1994. MMWR Morb Mortal Wkly Rep 1995;44:929-33.
56. Wasserheit JN. Epidemiological synergy: interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Transm Dis 1992;19:61-77.
57. Kreiss J, Hopkins SG. The association between circumcision status and human immunodeficiency virus infection among homosexual men. J Infect Dis 1993;168:1404-8.
58. Plummer FA, Simonsen JN, Cameron DW, et al. Cofactors in male-female sexual transmission of human immunodeficiency virus type 1. J Infect Dis 1991;163:233-9.
59. Laga M, Manoka A, Kivuvu M, et al. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 1993;7:95-102.
60. Cohen CR, Duerr A, Pruithithada N, et al. Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai, Thailand. AIDS 1995;9:1093-7.
61. Kapiga SH, Shao JF, Lwihula GK, Hunter DJ. Risk factors for HIV infection among women in Dar-es-Salaam, Tanzania. J Acquir Immune Defic Syndr 1994;7:301-9.
62. Plourde PJ, Pepin J, Agoki E, et al. Human immunodeficiency virus type 1 seroconversion in women with genital ulcers. J Infect Dis 1994;170:313-7.
63. Moss GB, Overbaugh J, Welch M, et al. Human immunodeficiency virus DNA in urethral secretions in men: association with gonococcal urethritis and CD4 cell depletion. J Infect Dis 1995;172:1469-74.
64. Hoffman I, Maida M, Royce R, et al. Effects of urethritis therapy on the concentration of HIV-1 in seminal plasma. In: Supplement to abstracts of the 11th International Conference on AIDS, Vancouver, B.C., July 7-12, 1996:15. abstract.
65. Atkins MC, Carlin EM, Emery VC, Griffiths PD, Boag F. Fluctuations of HIV load in semen of HIV positive patients with newly acquired sexually transmitted diseases. BMJ 1996;313:341-2.
66. Kreiss J, Willerford DM, Hensel M, et al. Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA. J Infect Dis 1994;170:1597-601.
67. Cameron DW, Simonsen JN, D'Costa LJ, et al. Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men. Lancet 1989;2:403-7.
68. Nicolosi A, Correa Leite ML, Musicco M, Arici C, Gavazzeni G, Lazzarin A. The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Epidemiology 1994;5:570-5.
69. Mati JK, Hunter DJ, Maggwa BN, Tukei PM. Contraceptive use and the risk of HIV infection in Nairobi, Kenya. Int J Gynaecol Obstet 1995; 48:61-7.
70. Royce R. Does male circumcision prevent HIV infection? In: Mann JM, Tarantola DJM, Netter TW, eds. AIDS in the world. Cambridge, Mass.: Harvard University Press, 1992:645-52.
71. Hunter D. AIDS in sub-Saharan Africa: the epidemiology of heterosexual transmission and the prospects for prevention. Epidemiology 1993; 4:63-72.
72. Daly CC, Helling-Giese GE, Mati JK, Hunter DJ. Contraceptive methods and the transmission of HIV: implications for family planning. Genitourin Med 1994;70:110-7.
73. Feldblum P, Morrison C, Cates W Jr. The effectiveness of barrier methods of contraception in preventing the spread of HIV. AIDS 1995;9:S85-S93.
74. Saracco A, Musicco M, Nicolosi A, et al. Man-to-woman sexual transmission of HIV: longitudinal study of 343 steady partners of infected men. J Acquir Immune Defic Syndr 1993;6:497-502.
75. Guimaraes MD, Munoz A, Boschi-Pinto C, Castilho EA. HIV infection among female partners of seropositive men in Brazil: Rio de Janeiro Heterosexual Study Group. Am J Epidemiol 1995;142:538-47.
76. Chao A, Bulterys M, Musanganire F, et al. Risk factors associated with prevalent HIV-1 infection among pregnant women in Rwanda: National University of Rwanda-Johns Hopkins University AIDS Research Team. Int J Epidemiol 1994;23:371-80.
77. Sinei SK, Fortney JA, Kigondu CS, et al. Contraceptive use and HIV infection in Kenyan family planning clinic attenders. Int J STD AIDS 1996; 7:65-70.
78. Critchlow CW, Wölner-Hanssen P, Eschenbach DA, et al. Determinants of cervical ectopia and of cervicitis: age, oral contraception, specific cervical infection, smoking, and douching. Am J Obstet Gynecol 1995; 173:534-43.
79. Marx PA, Spira AI, Gettie A, et al. Progesterone implants enhance SIV vaginal transmission and early virus load. Nat Med 1996;2:1084-9.
80. Vogt MW, Witt DJ, Craven DE, et al. Isolation patterns of the human immunodeficiency virus from cervical secretions during the menstrual cycle of women at risk for the acquired immunodeficiency syndrome. Ann Intern Med 1987;106:380-2.
81. Aral SO, Holmes KK, Padian NS, Cates W Jr. Individual and population approaches to the epidemiology and prevention of sexually transmitted diseases and human immunodeficiency virus infection. J Infect Dis 1996;174:Suppl 2:S127-S133.
82. Mastro TD, de Vincenzi I. Probabilities of sexual HIV-1 transmission. AIDS 1996;10:Suppl A:S75-S82.
83. Watts CH, May RM. The influence of concurrent partnerships on the dynamics of HIV/AIDS. Math Biosci 1992;108:89-104.
84. Morris M, Kretzschmar M. Concurrent partnerships and transmission dynamics in networks. Soc Networks 1995;17:299-318.
85. Barnett T, Grellier R. Cultural influence on society vulnerability. In: Mann JM, Tarantola DJM, eds. AIDS in the world II: global dimensions, social roots, and responses: the Global AIDS Policy Coalition. New York: Oxford University Press, 1996:444-6.
86. Hu DJ, Dondero TJ, Rayfield MA, et al. The emerging genetic diversity of HIV: the importance of global surveillance for diagnostics, research, and prevention. JAMA 1996;275:210-6.
87. Soto-Ramirez LE, Renjifo B, McLane MF, et al. HIV-1 Langerhans cell tropism associated with heterosexual transmission of HIV. Science 1996;271:1291-3.
88. Zhu T, Wang N, Carr A, et al. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol 1996;70:3098-107.
89. Lu Y, Brosio P, Lafaile M, et al. Vaginal transmission of chimeric simian/human immunodeficiency viruses in rhesus macaques. J Virol 1996; 70:3045-50.
90. Poss M, Martin HL, Kreiss JK, et al. Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1. J Virol 1995;69: 8118-22.
91. Kroodsma KL, Kozal MJ, Hamed KA, Winters MA, Merigan TC. Detection of drug resistance mutations in the human immunodeficiency virus type 1 (HIV-1) pol gene: differences in semen and blood HIV-1 RNA and proviral DNA. J Infect Dis 1994;170:1292-5.
92. Cohen MS, Dallabetta G, Laga M, Holmes KK. A new deal in HIV prevention: lessons from the global approach. Ann Intern Med 1994;120: 340-1.
93. Hanenberg RS, Rojanapithayakorn W, Kunasol P, Sokal DC. Impact of Thailand's HIV-control programme as indicated by the decline of sexually transmitted diseases. Lancet 1994;344:243-5.
94. Grosskurth H, Mosha F, Todd J, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet 1995;346:530-6.
95. Wawer M, Sewankambo N, Gray R, et al. Community-based trial of mass STD treatment for HIV control, Rakai, Uganda: preliminary data on STD declines. In: Volume 1 of abstracts of the 11th International Conference on AIDS, Vancouver, B.C., July 7-12, 1996:39.
96. Blower S, McLean AR. Prophylactic vaccines, risk behavior change, and the probability of eradicating HIV in San Francisco. Science 1994; 265:14514.
97. Schacker T, Collier AC, Hughes J, Shea T, Corey L. Clinical and epidemiologic features of primary HIV infection. Ann Intern Med 1996;125: 257-64.