L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 6, 2012, Pages 3121-3132

  Zhong, Maohua ^a   He, Benxia ^a   Yang, Jingyi ^a   Bao, Rong ^a,c   Zhang, Yan ^a   Zhou, Dihan ^a   Chen, Yaoqing ^a   Li, Angzhu ^b   Han, Chen ^a   Yang, Yi ^a   Sun, Ying ^a   Cao, Yuan ^a   Li, Yaoming ^a   Shi, Wei ^a   Jiang, Shibo ^b   Zhang, Xiaoyan ^b   Yan, Huimin ^a  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

^b FUDAN UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; CARBOXYMETHYLCELLULOSE; DODECYL SULFATE SODIUM; INTERLEUKIN 6; L SELECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NONOXINOL 9; PADGEM PROTEIN; TENOFOVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG SAFETY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION PREVENTION; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; UTERINE CERVICITIS; VAGINITIS;

ADENINE; ANIMALS; ANTI-INFECTIVE AGENTS; BENZALKONIUM COMPOUNDS; BIOLOGICAL MARKERS; CARBOXYMETHYLCELLULOSE SODIUM; CERVIX UTERI; CHEMOKINE CCL2; FEMALE; HIV INFECTIONS; INFLAMMATION; INTERLEUKIN-6; L-SELECTIN; MICE; MICE, INBRED C57BL; MUCOUS MEMBRANE; NONOXYNOL; ORGANOPHOSPHONATES; P-SELECTIN; SODIUM DODECYL SULFATE;

EID: 84861172621     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05950-11     Document Type: Article

References (45)

1. Abdool Karim Q, et al. 2010. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 329:1168-1174.
2. Alt C, et al. 2009. Increased CCL2 expression and macrophage/monocyte migration during microbicide-induced vaginal irritation. Curr. HIV Res. 7:639-649.
3. Atashili J, Poole C, Ndumbe PM, Adimora AA, Smith JS. 2008. Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS 22:1493-1501.
4. Barkhausen T, Krettek C, van Griensven M. 2005. L-selectin: adhesion, signalling and its importance in pathologic posttraumatic endotoxemia and non-septic inflammation. Exp. Toxicol. Pathol. 57:39-52. (Pubitemid 40922622)
5. Barthel SR, Gavino JD, Descheny L, Dimitroff CJ. 2007. Targeting selectins and selectin ligands in inflammation and cancer. Expert Opin. Ther. Targets 11:1473-1491. (Pubitemid 350200482)
6. Calza L, et al. 2009. Plasma levels of VCAM-1, ICAM-1, E-selectin, and P-selectin in 99 HIV-positive patients versus 51 HIV-negative healthy controls. J. Acquir. Immune Defic. Syndr. 50:430-432.
7. Catalone BJ, et al. 2004. Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides. Antimicrob. Agents Chemother. 48:1837-1847. (Pubitemid 38544396)
8. Catalone BJ, et al. 2005. Comparative safety evaluation of the candidate vaginal microbicide C31G. Antimicrob. Agents Chemother. 49:1509-1520. (Pubitemid 40463383)
9. Cone RA, et al. 2006. Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect. Dis. 6:90.
10. Cummins JE, Jr, Doncel GF. 2009. Biomarkers of cervicovaginal inflammation for the assessment of microbicide safety. Sex. Transm. Dis. 36: S84-S91.
11. Eckstein P, Jackson MC, Millman N, Sobrero AJ. 1969. Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys. J. Reprod. Fertil. 20:85-93.
12. Fichorova RN. 2004. Guiding the vaginal microbicide trials with biomarkers of inflammation. J. Acquir. Immune Defic. Syndr 37(Suppl 3): S184-S193. (Pubitemid 39435045)
13. Fichorova RN, et al. 2004. Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol. Reprod. 71: 761-769. (Pubitemid 39108635)
14. Fichorova RN, et al. 2011. Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trials. Cytokine 55: 134-140.
15. Fichorova RN, Tucker LD, Anderson DJ. 2001. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J. Infect. Dis. 184: 418-428. (Pubitemid 32718505)
16. Galen BT, et al. 2007. A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety. J. Infect. Dis. 195:1332-1339. (Pubitemid 46649620)
17. Goke M, Hoffmann JC, Evers J, Kruger H, Manns MP. 1997. Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease. J. Gastroenterol. 32:480-486. (Pubitemid 27367977)
18. Hillier SL, et al. 2005. In vitro and in vivo: the story of nonoxynol 9. J. Acquir. Immune Defic. Syndr. 39:1-8. (Pubitemid 40617012)
19. Jamieson DJ, et al. 2001. Longitudinal analysis of bacterial vaginosis: findings from the HIV epidemiology research study. Obstet. Gynecol. 98: 656-663. (Pubitemid 32907463)
20. Kelly M, Hwang JM, Kubes P. 2007. Modulating leukocyte recruitment in inflammation. J. Allergy Clin. Immunol. 120:3-10. (Pubitemid 46990511)
21. Kourtis AP, et al. 2000. Correlation of virus load and soluble L-selectin, a marker of immune activation, in pediatric HIV-1 infection. AIDS 14: 2429-2436.
22. Laga M, et al. 1993. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 7:95-102. (Pubitemid 23069039)
23. Langer HF, Chavakis T. 2009. Leukocyte-endothelial interactions in inflammation. J. Cell. Mol. Med. 13:1211-1220.
24. Ley K. 2003. The role of selectins in inflammation and disease. Trends Mol. Med. 9:263-268. (Pubitemid 36841686)
25. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. 2007. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7:678-689. (Pubitemid 47327397)
26. Li G, Sanders JM, Phan ET, Ley K, Sarembock IJ. 2005. Arterial macrophages and regenerating endothelial cells express P-selectin in atherosclerosis-prone apolipoprotein E-deficient mice. Am. J. Pathol. 167:1511-1518. (Pubitemid 41713306)
27. Li LZ, et al. 2010. Establishing a Th17 based mouse model for preclinical assessment of the toxicity of candidate microbicides. Chin. Med. J. (Engl.). 123:3381-3388.
28. Mania-Pramanik J, Kerkar SC, Salvi VS. 2009. Bacterial vaginosis: a cause of infertility? Int. J. STD AIDS 20:778-781.
29. Mauck CK. 2009. Biomarkers for evaluating vaginal microbicides and contraceptives: discovery and early validation. Sex. Transm. Dis. 36: S73-S75.
30. Mauck CK, Baker JM, Barr SP, Johanson WM, Archer DF. 1997. A phase I comparative study of three contraceptive vaginal films containing nonoxynol-9. Postcoital testing and colposcopy. Contraception 56: 97-102. (Pubitemid 27400974)
31. Miller TL, et al. 2010. Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1. J. Acquir. Immune Defic. Syndr. 55:182-188.
32. Milligan GN, Dudley KL, Bourne N, Reece A, Stanberry LR. 2002. Entry of inflammatory cells into the mouse vagina following application of candidate microbicides: comparison of detergent-based and sulfated polymer-based agents. Sex. Transm. Dis. 29:597-605.
33. Mohan JS, Lip GY, Wright J, Bareford D, Blann AD. 2005. Plasma levels of tissue factor and soluble E-selectin in sickle cell disease: relationship to genotype and to inflammation. Blood Coagul. Fibrinolysis 16:209-214. (Pubitemid 40547277)
34. Naruse T, et al. 2002. P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. Kidney Int. 62: 94-105. (Pubitemid 34754052)
35. Ramjee G. 2010. Microbicide research: current and future directions. Curr. Opin. HIV AIDS 5:316-321.
36. Ridker PM, Buring JE, Rifai N. 2001. Soluble P-selectin and the risk of future cardiovascular events. Circulation 103:491-495. (Pubitemid 32116231)
37. Sonoda Y, et al. 1998. Physiologic regulation of postovulatory neutrophil migration into vagina in mice by a C-X-C chemokine(s). J. Immunol. 160:6159-6165. (Pubitemid 28298081)
38. Tchernychev B, Furie B, Furie BC. 2003. Peritoneal macrophages express both P-selectin and PSGL-1. J. Cell Biol. 163:1145-1155. (Pubitemid 37541889)
39. Trifonova RT, et al. 2007. Biomarkers of leukocyte traffic and activation in the vaginal mucosa. Biomarkers 12:608-622. (Pubitemid 350048076)
40. Van Damme L, et al. 2000. Safety of multiple daily applications of COL-1492, a nonoxynol-9 vaginal gel, among female sex workers. COL-1492 Phase II Study Group. AIDS 14:85-88. (Pubitemid 30072081)
41. Van Damme L, et al. 1998. Safety evaluation of nonoxynol-9 gel in women at low risk of HIV infection. AIDS 12:433-437. (Pubitemid 28077541)
42. Van Damme L, et al. 2002. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 360:971-977. (Pubitemid 35284107)
43. Yan MX, Mao HT, Liu Q, Wang WQ, Li YQ. 2006. Elevated levels of serum soluble E-selectin in patients with chronic hepatitis B: correlation with T lymphocyte subsets, NK cells and liver inflammation. Hepatol. Res. 35:111-117.
44. Zarbock A, et al. 2008. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J. Exp. Med. 205:2339-2347.
45. Zegels G, Van Raemdonck GA, Tjalma WA, Van Ostade XW. 2010. Use of cervicovaginal fluid for the identification of biomarkers for pathologies of the female genital tract. Proteome Sci. 8:63.