The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3

Nature Immunology

Volumn 11, Issue 8, 2010, Pages 743-750

  Kim, Hwijin ^a,b   Seed, Brian ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; TRANSCRIPTION FACTOR MAFB;

ARTICLE; CONTROLLED STUDY; ENTEROVIRUS; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INTERFERON PRODUCTION; MATHEMATICAL MODEL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; VIRUS INFECTION;

ANIMALS; CELL LINE, TUMOR; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; INTERFERON-BETA; MAFB TRANSCRIPTION FACTOR; MICE; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; VIRUS DISEASES;

EID: 77954947887     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1897     Document Type: Article

References (50)

1. Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010).
2. Yoneyama, M. & Fujita, T. RNA recognition and signal transduction by RIG-I-like receptors. Immunol. Rev. 227, 54-65 (2009).
3. Motohashi, H., O'Connor, T., Katsuoka, F., Engel, J.D. & Yamamoto, M. Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene 294, 1-12 (2002).
4. Eychene, A., Rocques, N. & Pouponnot, C. A new MAFia in cancer. Nat. Rev. Cancer 8, 683-693 (2008).
5. Wang, P.W. et al. Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Genomics 59, 275-281 (1999).
6. Kelly, L.M., Englmeier, U., Lafon, I., Sieweke, M.H. & Graf, T. MafB is an inducer of monocytic differentiation. EMBO J. 19, 1987-1997 (2000).
7. Artner, I. et al. MafB: an activator of the glucagon gene expressed in developing islet alpha-and beta-cells. Diabetes 55, 297-304 (2006).
8. Nishimura, W. et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev. Biol. 293, 526-539 (2006).
9. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737 (2004).
10. Kato, H. et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105 (2006).
11. Maniatis, T. et al. Structure and function of the interferon-β enhanceosome. Cold Spring Harb. Symp. Quant. Biol. 63, 609-620 (1998).
12. Escalante, C.R., Nistal-Villan, E., Shen, L., Garcia-Sastre, A. & Aggarwal, A.K. Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-β enhancer. Mol. Cell 26, 703-716 (2007).
13. Moriguchi, T. et al. MafB is essential for renal development and F4/80 expression in macrophages. Mol. Cell. Biol. 26, 5715-5727 (2006).
14. Fitzgerald, K.A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496 (2003).
15. Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148-1151 (2003).
16. Hiscott, J. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282, 15325-15329 (2007).
17. Tamura, T., Yanai, H., Savitsky, D. & Taniguchi, T. The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 26, 535-584 (2008).
18. Lin, R., Heylbroeck, C, Pitha, P.M. & Hiscott, J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18, 2986-2996 (1998).
19. Lin, R., Genin, P., Mamane, Y. & Hiscott, J. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of oc/p interferon genes by interferon regulatory factors 3 and 7. Mol. Cell. Biol. 20, 6342-6353 (2000).
20. Wathelet, M.G. et al. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-p enhancer in vivo. Mol. Cell 1, 507-518 (1998).
21. Yoneyama, M. et al. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 17, 1087-1095 (1998).
22. Kumar, K.P., McBride, K.M., Weaver, B.K., Dingwall, C. & Reich, N.C. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol. Cell. Biol. 20, 4159-4168 (2000).
23. Cordes, S.P. & Barsh, G.S. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell 79, 1025-1034 (1994).
24. Sieweke, M.H., Tekotte, H., Frampton, J. & Graf, T. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell 85, 49-60 (1996).
25. Mizukami, J. & Taniguchi, T. The antidiabetic agent thiazolidinedione stimulates the interaction between PPARy and CBP. Biochem. Biophys. Res. Commun. 240, 61-64 (1997).
26. Tillmanns, S. et al. SUMO modifcation regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression. Mol. Cell. Biol. 27, 5554-5564 (2007).
27. Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F. & Lanzavecchia, A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6, 769-776 (2005).
28. Stetson, D.B. & Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24, 93-103 (2006).
29. Pruett, S.B., Schwab, C, Zheng, Q. & Fan, R. Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3. J. Immunol. 173, 2715-2724 (2004).
30. Hammer, M. et al. Dual specifcity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J. Exp. Med. 203, 15-20 (2006).
31. Cao, W. et al. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat. Immunol. 9, 1157-1164 (2008).
32. Ylipaasto, P. et al. Global profling of coxsackievirus-and cytokine-induced gene expression in human pancreatic islets. Diabetologia 48, 1510-1522 (2005).
33. Gaither, L.A. et al. Multiple cyclophilins involved in different cellular pathways mediate HCV replication. Virology 397, 43-55 (2010).
34. Hyoty, H. & Taylor, K.W. The role of viruses in human diabetes. Diabetologia 45, 1353-1361 (2002).
35. Ylipaasto, P. et al. Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells. Diabetologia 47, 225-239 (2004).
36. Foulis, A.K. et al. A search for the presence of the enteroviral capsid protein VP1 in pancreases of patients with type 1 (insulin-dependent) diabetes and pancreases and hearts of infants who died of coxsackieviral myocarditis. Diabetologia 33, 290-298 (1990).
37. Maffei, A. et al. Identifcation of tissue-restricted transcripts in human islets. Endocrinology 145, 4513-4521 (2004).
38. Marselli, L. et al. Gene expression of purifed beta-cell tissue obtained from human pancreas with laser capture microdissection. J. Clin. Endocrinol. Metab. 93, 1046-1053 (2008).
39. See, D.M. & Tilles, J.G. Pathogenesis of virus-induced diabetes in mice. J. Infect. Dis. 171, 1131-1138 (1995).
40. Chehadeh, W. et al. Persistent infection of human pancreatic islets by coxsackievirus B is associated with a interferon synthesis in beta cells. J. Virol. 74, 10153-10164 (2000).
41. Serreze, D.V., Prochazka, M., Reifsnyder, P.C., Bridgett, M.M. & Leiter, E.H. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J. Exp. Med. 180, 1553-1558 (1994).
42. Drescher, K.M., Kono, K., Bopegamage, S., Carson, S.D. & Tracy, S. Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection. Virology 329, 381-394 (2004).
43. Carter, J.D., Dula, S.B., Corbin, K.L., Wu, R. & Nunemaker, C.S. A Practical guide to rodent islet isolation and assessment. Biol. Proced. Online 11, 3-31 (2009).
44. Senger, K. et al. Gene repression by coactivator repulsion. Mol. Cell 6, 931-937 (2000).
45. Saitoh, T. et al. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol. 7, 598-605 (2006).
46. Revollo, J.R. & Cidlowski, J.A. Mechanisms generating diversity in glucocorticoid receptor signaling. Ann. NY Acad. Sci. 1179, 167-178 (2009).
47. Pouponnot, C. et al. Cell context reveals a dual role for Maf in oncogenesis. Oncogene 25, 1299-1310 (2006).
48. Whelan, S.P., Ball, L.A., Barr, J.N. & Wertz, G.T. Effcient recovery of infectious vesicular stomatitis virus entirely from cDNA clones. Proc. Natl. Acad. Sci. USA 92, 8388-8392 (1995).
49. Iwamura, T. et al. Induction of IRF-3/-7 kinase and NF-κB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 6, 375-388 (2001).
50. Kim, H. & Perelson, A.S. Viral and latent reservoir persistence in HIV-1-infected patients on therapy. PLOS Comput. Biol. 2, e135 (2006).