메뉴 건너뛰기




Volumn 241, Issue 2, 2015, Pages 387-399

Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota

Author keywords

Germ free mice; Host gut microbiota interactions; Mucosal immune system; Polyphenolic metabolites; Systems biology approach; Trimethylamine N oxide

Indexed keywords

APOLIPOPROTEIN E; BACTERIAL ENZYME; LIPID; METHYLAMINE; POLYPHENOL DERIVATIVE; SHORT CHAIN FATTY ACID; BIOLOGICAL MARKER;

EID: 84936805972     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.05.035     Document Type: Review
Times cited : (70)

References (138)
  • 1
    • 84861992769 scopus 로고    scopus 로고
    • Therapeutic modulation of microbiota-host metabolic interactions
    • 137rv6
    • Holmes E., et al. Therapeutic modulation of microbiota-host metabolic interactions. Sci. Transl. Med. 2012, 4(137):137rv6.
    • (2012) Sci. Transl. Med. , vol.4 , Issue.137
    • Holmes, E.1
  • 2
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper L.V., Littman D.R., Macpherson A.J. Interactions between the microbiota and the immune system. Science 2012, 336(6086):1268-1273.
    • (2012) Science , vol.336 , Issue.6086 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 3
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson J.K., et al. Host-gut microbiota metabolic interactions. Science 2012, 336(6086):1262-1267.
    • (2012) Science , vol.336 , Issue.6086 , pp. 1262-1267
    • Nicholson, J.K.1
  • 4
    • 77649086402 scopus 로고    scopus 로고
    • Immune adaptations that maintain homeostasis with the intestinal microbiota
    • Hooper L.V., Macpherson A.J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat. Rev. Immunol. 2010, 10(3):159-169.
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.3 , pp. 159-169
    • Hooper, L.V.1    Macpherson, A.J.2
  • 5
    • 84866167497 scopus 로고    scopus 로고
    • Reciprocal interactions of the intestinal microbiota and immune system
    • Maynard C.L., et al. Reciprocal interactions of the intestinal microbiota and immune system. Nature 2012, 489(7415):231-241.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 231-241
    • Maynard, C.L.1
  • 6
    • 79952750340 scopus 로고    scopus 로고
    • Vaginal microbiome of reproductive-age women
    • Ravel J., et al. Vaginal microbiome of reproductive-age women. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(Suppl. 1):4680-4687.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 4680-4687
    • Ravel, J.1
  • 7
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko T., et al. Human gut microbiome viewed across age and geography. Nature 2012, 486(7402):222-227.
    • (2012) Nature , vol.486 , Issue.7402 , pp. 222-227
    • Yatsunenko, T.1
  • 8
    • 84920909558 scopus 로고    scopus 로고
    • Diet dominates host genotype in shaping the murine gut microbiota
    • Carmody R.N., et al. Diet dominates host genotype in shaping the murine gut microbiota. Cell. Host Microbe 2015, 17(1):72-84.
    • (2015) Cell. Host Microbe , vol.17 , Issue.1 , pp. 72-84
    • Carmody, R.N.1
  • 9
    • 84905276988 scopus 로고    scopus 로고
    • Individual diet has sex-dependent effects on vertebrate gut microbiota
    • Bolnick D.I., et al. Individual diet has sex-dependent effects on vertebrate gut microbiota. Nat. Commun. 2014, 5:4500.
    • (2014) Nat. Commun. , vol.5 , pp. 4500
    • Bolnick, D.I.1
  • 10
    • 78449296237 scopus 로고    scopus 로고
    • Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
    • Benson A.K., et al. Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(44):18933-18938.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.44 , pp. 18933-18938
    • Benson, A.K.1
  • 11
    • 84872156123 scopus 로고    scopus 로고
    • Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
    • Parks B.W., et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell. Metab. 2013, 17(1):141-152.
    • (2013) Cell. Metab. , vol.17 , Issue.1 , pp. 141-152
    • Parks, B.W.1
  • 12
    • 84910096224 scopus 로고    scopus 로고
    • Human genetics shape the gut microbiome
    • Goodrich J.K., et al. Human genetics shape the gut microbiome. Cell 2014, 159(4):789-799.
    • (2014) Cell , vol.159 , Issue.4 , pp. 789-799
    • Goodrich, J.K.1
  • 13
    • 79952748287 scopus 로고    scopus 로고
    • Unravelling the effects of the environment and host genotype on the gut microbiome
    • Spor A., Koren O., Ley R. Unravelling the effects of the environment and host genotype on the gut microbiome. Nat. Rev. Microbiol. 2011, 9(4):279-290.
    • (2011) Nat. Rev. Microbiol. , vol.9 , Issue.4 , pp. 279-290
    • Spor, A.1    Koren, O.2    Ley, R.3
  • 14
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh P.J., et al. A core gut microbiome in obese and lean twins. Nature 2009, 457(7228):480-484.
    • (2009) Nature , vol.457 , Issue.7228 , pp. 480-484
    • Turnbaugh, P.J.1
  • 15
    • 84871454511 scopus 로고    scopus 로고
    • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
    • Holmes E., et al. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell. Metab. 2012, 16(5):559-564.
    • (2012) Cell. Metab. , vol.16 , Issue.5 , pp. 559-564
    • Holmes, E.1
  • 16
    • 77952243141 scopus 로고    scopus 로고
    • QIIME allows analysis of high-throughput community sequencing data
    • Caporaso J.G., et al. QIIME allows analysis of high-throughput community sequencing data. Nat. Methods 2010, 7(5):335-336.
    • (2010) Nat. Methods , vol.7 , Issue.5 , pp. 335-336
    • Caporaso, J.G.1
  • 17
    • 72949107142 scopus 로고    scopus 로고
    • Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    • Schloss P.D., et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl. Environ. Microbiol. 2009, 75(23):7537-7541.
    • (2009) Appl. Environ. Microbiol. , vol.75 , Issue.23 , pp. 7537-7541
    • Schloss, P.D.1
  • 18
    • 84893161170 scopus 로고    scopus 로고
    • VAMPS: a website for visualization and analysis of microbial population structures
    • Huse S.M., et al. VAMPS: a website for visualization and analysis of microbial population structures. BMC Bioinforma. 2014, 15:41.
    • (2014) BMC Bioinforma. , vol.15 , pp. 41
    • Huse, S.M.1
  • 19
    • 84920404296 scopus 로고    scopus 로고
    • How informative is the mouse for human gut microbiota research?
    • Nguyen T.L., et al. How informative is the mouse for human gut microbiota research?. Dis. Model Mech. 2015, 8(1):1-16.
    • (2015) Dis. Model Mech. , vol.8 , Issue.1 , pp. 1-16
    • Nguyen, T.L.1
  • 20
    • 0021322457 scopus 로고
    • Yogurt-an autodigesting source of lactose
    • Kolars J.C., et al. Yogurt-an autodigesting source of lactose. N. Engl. J. Med. 1984, 310(1):1-3.
    • (1984) N. Engl. J. Med. , vol.310 , Issue.1 , pp. 1-3
    • Kolars, J.C.1
  • 21
    • 0036399823 scopus 로고    scopus 로고
    • How host-microbial interactions shape the nutrient environment of the mammalian intestine
    • Hooper L.V., Midtvedt T., Gordon J.I. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev. Nutr. 2002, 22:283-307.
    • (2002) Annu Rev. Nutr. , vol.22 , pp. 283-307
    • Hooper, L.V.1    Midtvedt, T.2    Gordon, J.I.3
  • 22
    • 79960501919 scopus 로고    scopus 로고
    • Interaction between obesity and the gut microbiota: relevance in nutrition
    • Delzenne N.M., Cani P.D. Interaction between obesity and the gut microbiota: relevance in nutrition. Annu Rev. Nutr. 2011, 31:15-31.
    • (2011) Annu Rev. Nutr. , vol.31 , pp. 15-31
    • Delzenne, N.M.1    Cani, P.D.2
  • 23
    • 84921626523 scopus 로고    scopus 로고
    • Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
    • Everard A., et al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J. 2014, 8(10):2116-2130.
    • (2014) ISME J. , vol.8 , Issue.10 , pp. 2116-2130
    • Everard, A.1
  • 24
    • 0034678402 scopus 로고    scopus 로고
    • Infectious agents are not necessary for murine atherogenesis
    • Wright S.D., et al. Infectious agents are not necessary for murine atherogenesis. J. Exp. Med. 2000, 191(8):1437-1442.
    • (2000) J. Exp. Med. , vol.191 , Issue.8 , pp. 1437-1442
    • Wright, S.D.1
  • 25
    • 77956330642 scopus 로고    scopus 로고
    • Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet
    • Stepankova R., et al. Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet. J. Atheroscler. Thromb. 2010, 17(8):796-804.
    • (2010) J. Atheroscler. Thromb. , vol.17 , Issue.8 , pp. 796-804
    • Stepankova, R.1
  • 26
    • 84910129274 scopus 로고    scopus 로고
    • Gamma-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO
    • Koeth R.A., et al. Gamma-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell. Metab. 2014, 20(5):799-812.
    • (2014) Cell. Metab. , vol.20 , Issue.5 , pp. 799-812
    • Koeth, R.A.1
  • 27
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth R.A., et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 2013, 19(5):576-585.
    • (2013) Nat. Med. , vol.19 , Issue.5 , pp. 576-585
    • Koeth, R.A.1
  • 28
    • 84906567656 scopus 로고    scopus 로고
    • Microbiology: microbiome science needs a healthy dose of scepticism
    • Hanage W.P. Microbiology: microbiome science needs a healthy dose of scepticism. Nature 2014, 512(7514):247-248.
    • (2014) Nature , vol.512 , Issue.7514 , pp. 247-248
    • Hanage, W.P.1
  • 30
    • 0024511197 scopus 로고
    • Association between dental health and acute myocardial infarction
    • Mattila K.J., et al. Association between dental health and acute myocardial infarction. BMJ 1989, 298(6676):779-781.
    • (1989) BMJ , vol.298 , Issue.6676 , pp. 779-781
    • Mattila, K.J.1
  • 31
    • 80155193051 scopus 로고    scopus 로고
    • Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis
    • Rosenfeld M.E., Campbell L.A. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis. Thromb. Haemost. 2011, 106(5):858-867.
    • (2011) Thromb. Haemost. , vol.106 , Issue.5 , pp. 858-867
    • Rosenfeld, M.E.1    Campbell, L.A.2
  • 32
    • 0026595043 scopus 로고
    • Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study
    • Saikku P., et al. Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann. Intern Med. 1992, 116(4):273-278.
    • (1992) Ann. Intern Med. , vol.116 , Issue.4 , pp. 273-278
    • Saikku, P.1
  • 33
    • 42549095024 scopus 로고    scopus 로고
    • Infection and atherosclerosis. An alternative view on an outdated hypothesis
    • Stassen F.R., Vainas T., Bruggeman C.A. Infection and atherosclerosis. An alternative view on an outdated hypothesis. Pharmacol. Rep. 2008, 60(1):85-92.
    • (2008) Pharmacol. Rep. , vol.60 , Issue.1 , pp. 85-92
    • Stassen, F.R.1    Vainas, T.2    Bruggeman, C.A.3
  • 34
    • 0029132190 scopus 로고
    • In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae
    • Godzik K.L., et al. In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae. J. Clin. Microbiol. 1995, 33(9):2411-2414.
    • (1995) J. Clin. Microbiol. , vol.33 , Issue.9 , pp. 2411-2414
    • Godzik, K.L.1
  • 35
    • 0034903164 scopus 로고    scopus 로고
    • Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J mice
    • Blessing E., et al. Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J mice. Atherosclerosis 2001, 158(1):13-17.
    • (2001) Atherosclerosis , vol.158 , Issue.1 , pp. 13-17
    • Blessing, E.1
  • 36
    • 0033023633 scopus 로고    scopus 로고
    • Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s)
    • Coombes B.K., Mahony J.B. Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s). Infect. Immun. 1999, 67(6):2909-2915.
    • (1999) Infect. Immun. , vol.67 , Issue.6 , pp. 2909-2915
    • Coombes, B.K.1    Mahony, J.B.2
  • 37
    • 0033105576 scopus 로고    scopus 로고
    • The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae
    • Hu H., Pierce G.N., Zhong G. The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J. Clin. Invest 1999, 103(5):747-753.
    • (1999) J. Clin. Invest , vol.103 , Issue.5 , pp. 747-753
    • Hu, H.1    Pierce, G.N.2    Zhong, G.3
  • 38
    • 0031912008 scopus 로고    scopus 로고
    • Induction of macrophage foam cell formation by Chlamydia pneumoniae
    • Kalayoglu M.V., Byrne G.I. Induction of macrophage foam cell formation by Chlamydia pneumoniae. J. Infect. Dis. 1998, 177(3):725-729.
    • (1998) J. Infect. Dis. , vol.177 , Issue.3 , pp. 725-729
    • Kalayoglu, M.V.1    Byrne, G.I.2
  • 39
    • 0032562148 scopus 로고    scopus 로고
    • Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model
    • Muhlestein J.B., et al. Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 1998, 97(7):633-636.
    • (1998) Circulation , vol.97 , Issue.7 , pp. 633-636
    • Muhlestein, J.B.1
  • 40
    • 84879411235 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis: direct versus indirect mechanisms
    • Rosenfeld M.E. Inflammation and atherosclerosis: direct versus indirect mechanisms. Curr. Opin. Pharmacol. 2013, 13(2):154-160.
    • (2013) Curr. Opin. Pharmacol. , vol.13 , Issue.2 , pp. 154-160
    • Rosenfeld, M.E.1
  • 41
    • 33644795042 scopus 로고    scopus 로고
    • Chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated C-reactive protein in serum
    • Johnston S.C., et al. Chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated C-reactive protein in serum. Arterioscler. Thromb. Vasc. Biol. 2005, 25(12):2648-2653.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , Issue.12 , pp. 2648-2653
    • Johnston, S.C.1
  • 42
    • 0032575305 scopus 로고    scopus 로고
    • Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression
    • Kol A., et al. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 1998, 98(4):300-307.
    • (1998) Circulation , vol.98 , Issue.4 , pp. 300-307
    • Kol, A.1
  • 43
    • 58149185425 scopus 로고    scopus 로고
    • Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae
    • Hogdahl M., Soderlund G., Kihlstrom E. Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae. APMIS 2008, 116(12):1082-1088.
    • (2008) APMIS , vol.116 , Issue.12 , pp. 1082-1088
    • Hogdahl, M.1    Soderlund, G.2    Kihlstrom, E.3
  • 44
    • 0033557202 scopus 로고    scopus 로고
    • Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
    • Kol A., et al. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J. Clin. Invest 1999, 103(4):571-577.
    • (1999) J. Clin. Invest , vol.103 , Issue.4 , pp. 571-577
    • Kol, A.1
  • 45
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010, 464(7293):1357-1361.
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1357-1361
    • Duewell, P.1
  • 46
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
    • Rajamaki K., et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 2010, 5(7):e11765.
    • (2010) PLoS One , vol.5 , Issue.7 , pp. e11765
    • Rajamaki, K.1
  • 47
    • 84899140315 scopus 로고    scopus 로고
    • Inflammasomes and metabolic disorders: old genes in modern diseases
    • Robbins G.R., Wen H., Ting J.P. Inflammasomes and metabolic disorders: old genes in modern diseases. Mol. Cell. 2014, 54(2):297-308.
    • (2014) Mol. Cell. , vol.54 , Issue.2 , pp. 297-308
    • Robbins, G.R.1    Wen, H.2    Ting, J.P.3
  • 48
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker P.M., et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 2000, 342(12):836-843.
    • (2000) N. Engl. J. Med. , vol.342 , Issue.12 , pp. 836-843
    • Ridker, P.M.1
  • 49
    • 77954953757 scopus 로고    scopus 로고
    • The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis
    • Campbell L.A., et al. The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis. Microb. Infect. 2010, 12(8-9):598-606.
    • (2010) Microb. Infect. , vol.12 , Issue.8-9 , pp. 598-606
    • Campbell, L.A.1
  • 50
    • 84898034935 scopus 로고    scopus 로고
    • Persistent C. pneumoniae infection in atherosclerotic lesions: rethinking the clinical trials
    • Campbell L.A., Rosenfeld M.E. Persistent C. pneumoniae infection in atherosclerotic lesions: rethinking the clinical trials. Front. Cell. Infect. Microbiol. 2014, 4:34.
    • (2014) Front. Cell. Infect. Microbiol. , vol.4 , pp. 34
    • Campbell, L.A.1    Rosenfeld, M.E.2
  • 51
    • 79952758083 scopus 로고    scopus 로고
    • Human oral, gut, and plaque microbiota in patients with atherosclerosis
    • Koren O., et al. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc. Natl. Acad. Sci. U. S. A. 2010, 108(Suppl. 1):4592-4598.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 4592-4598
    • Koren, O.1
  • 52
    • 84896095903 scopus 로고    scopus 로고
    • Microbial composition of atherosclerotic plaques
    • Calandrini C.A., et al. Microbial composition of atherosclerotic plaques. Oral Dis. 2012, 20(3):e128-e134.
    • (2012) Oral Dis. , vol.20 , Issue.3 , pp. e128-e134
    • Calandrini, C.A.1
  • 53
    • 0020710588 scopus 로고
    • Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats
    • Wostmann B.S., et al. Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. Lab. Anim. Sci. 1983, 33(1):46-50.
    • (1983) Lab. Anim. Sci. , vol.33 , Issue.1 , pp. 46-50
    • Wostmann, B.S.1
  • 54
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh P.J., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444(7122):1027-1031.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 55
    • 23344442120 scopus 로고    scopus 로고
    • Obesity alters gut microbial ecology
    • Ley R.E., et al. Obesity alters gut microbial ecology. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(31):11070-11075.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.31 , pp. 11070-11075
    • Ley, R.E.1
  • 56
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura V.K., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013, 341(6150):1241214.
    • (2013) Science , vol.341 , Issue.6150 , pp. 1241214
    • Ridaura, V.K.1
  • 57
    • 84914145315 scopus 로고    scopus 로고
    • From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology
    • Natarajan N., Pluznick J.L. From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology. Am. J. Physiol. Cell. Physiol. 2014, 307(11):C979-C985.
    • (2014) Am. J. Physiol. Cell. Physiol. , vol.307 , Issue.11 , pp. C979-C985
    • Natarajan, N.1    Pluznick, J.L.2
  • 58
    • 33751074139 scopus 로고    scopus 로고
    • Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8
    • Iwanaga T., et al. Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Biomed. Res. 2006, 27(5):243-254.
    • (2006) Biomed. Res. , vol.27 , Issue.5 , pp. 243-254
    • Iwanaga, T.1
  • 59
    • 78650800467 scopus 로고    scopus 로고
    • Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
    • Bjursell M., et al. Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 2010, 300(1):E211-E220.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.300 , Issue.1 , pp. E211-E220
    • Bjursell, M.1
  • 60
    • 50449087891 scopus 로고    scopus 로고
    • Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    • Ge H., et al. Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology 2008, 149(9):4519-4526.
    • (2008) Endocrinology , vol.149 , Issue.9 , pp. 4519-4526
    • Ge, H.1
  • 61
    • 84875047650 scopus 로고    scopus 로고
    • Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    • Pluznick J.L., et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(11):4410-4415.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.11 , pp. 4410-4415
    • Pluznick, J.L.1
  • 62
    • 84878812591 scopus 로고    scopus 로고
    • Innate immune receptors: key regulators of metabolic disease progression
    • Jin C., Henao-Mejia J., Flavell R.A. Innate immune receptors: key regulators of metabolic disease progression. Cell. Metab. 2013, 17(6):873-882.
    • (2013) Cell. Metab. , vol.17 , Issue.6 , pp. 873-882
    • Jin, C.1    Henao-Mejia, J.2    Flavell, R.A.3
  • 63
    • 85027951898 scopus 로고    scopus 로고
    • Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice
    • Ding Y., et al. Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2012, 32(7):1596-1604.
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , Issue.7 , pp. 1596-1604
    • Ding, Y.1
  • 64
    • 84859986329 scopus 로고    scopus 로고
    • Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    • Jin T., et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 2012, 36(4):561-571.
    • (2012) Immunity , vol.36 , Issue.4 , pp. 561-571
    • Jin, T.1
  • 65
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482(7384):179-185.
    • (2012) Nature , vol.482 , Issue.7384 , pp. 179-185
    • Henao-Mejia, J.1
  • 66
    • 84896691062 scopus 로고    scopus 로고
    • NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion
    • Wlodarska M., et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 2014, 156(5):1045-1059.
    • (2014) Cell , vol.156 , Issue.5 , pp. 1045-1059
    • Wlodarska, M.1
  • 67
    • 79960542894 scopus 로고    scopus 로고
    • Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
    • Bauernfeind F., et al. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J. Immunol. 2011, 187(2):613-617.
    • (2011) J. Immunol. , vol.187 , Issue.2 , pp. 613-617
    • Bauernfeind, F.1
  • 68
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: mechanisms of activation and function
    • Latz E. The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 2010, 22(1):28-33.
    • (2010) Curr. Opin. Immunol. , vol.22 , Issue.1 , pp. 28-33
    • Latz, E.1
  • 69
    • 84878237993 scopus 로고    scopus 로고
    • Activation and regulation of the inflammasomes
    • Latz E., Xiao T.S., Stutz A. Activation and regulation of the inflammasomes. Nat. Rev. Immunol. 2013, 13(6):397-411.
    • (2013) Nat. Rev. Immunol. , vol.13 , Issue.6 , pp. 397-411
    • Latz, E.1    Xiao, T.S.2    Stutz, A.3
  • 70
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette A., et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat. Med. 2014, 20(2):159-166.
    • (2014) Nat. Med. , vol.20 , Issue.2 , pp. 159-166
    • Trompette, A.1
  • 72
    • 54249156545 scopus 로고    scopus 로고
    • Metabolic syndrome: from epidemiology to systems biology
    • Lusis A.J., Attie A.D., Reue K. Metabolic syndrome: from epidemiology to systems biology. Nat. Rev. Genet. 2008, 9(11):819-830.
    • (2008) Nat. Rev. Genet. , vol.9 , Issue.11 , pp. 819-830
    • Lusis, A.J.1    Attie, A.D.2    Reue, K.3
  • 73
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • David L.A., et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014, 505(7484):559-563.
    • (2014) Nature , vol.505 , Issue.7484 , pp. 559-563
    • David, L.A.1
  • 74
    • 62749167937 scopus 로고    scopus 로고
    • The gut and intestinal bacteria in chronic heart failure
    • Sandek A., Anker S.D., von Haehling S. The gut and intestinal bacteria in chronic heart failure. Curr. Drug Metab. 2009, 10(1):22-28.
    • (2009) Curr. Drug Metab. , vol.10 , Issue.1 , pp. 22-28
    • Sandek, A.1    Anker, S.D.2    von Haehling, S.3
  • 75
    • 84907587722 scopus 로고    scopus 로고
    • Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice-role of intestinal permeability and macrophage activation
    • Ghosh S.S., et al. Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice-role of intestinal permeability and macrophage activation. PLoS One 2014, 9(9):e108577.
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e108577
    • Ghosh, S.S.1
  • 76
    • 84859033154 scopus 로고    scopus 로고
    • High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects
    • Harte A.L., et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care 2012, 35(2):375-382.
    • (2012) Diabetes Care , vol.35 , Issue.2 , pp. 375-382
    • Harte, A.L.1
  • 77
    • 84855174006 scopus 로고    scopus 로고
    • Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
    • Caricilli A.M., et al. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol. 2011, 9(12):e1001212.
    • (2011) PLoS Biol. , vol.9 , Issue.12 , pp. e1001212
    • Caricilli, A.M.1
  • 78
    • 84930478579 scopus 로고    scopus 로고
    • The gut microbiota and its relationship to diet and obesity: new insights
    • Clarke S.F., et al. The gut microbiota and its relationship to diet and obesity: new insights. Gut. Microb. 2012, 3(3):186-202.
    • (2012) Gut. Microb. , vol.3 , Issue.3 , pp. 186-202
    • Clarke, S.F.1
  • 79
    • 80054862011 scopus 로고    scopus 로고
    • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats
    • Islam K.B., et al. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011, 141(5):1773-1781.
    • (2011) Gastroenterology , vol.141 , Issue.5 , pp. 1773-1781
    • Islam, K.B.1
  • 80
    • 84922758254 scopus 로고    scopus 로고
    • Bile acids as metabolic regulators
    • Li T., Chiang J.Y. Bile acids as metabolic regulators. Curr. Opin. Gastroenterol. 2015, 31(2):159-165.
    • (2015) Curr. Opin. Gastroenterol. , vol.31 , Issue.2 , pp. 159-165
    • Li, T.1    Chiang, J.Y.2
  • 81
    • 77951087292 scopus 로고    scopus 로고
    • The gut microbiota modulates host energy and lipid metabolism in mice
    • Velagapudi V.R., et al. The gut microbiota modulates host energy and lipid metabolism in mice. J. Lipid Res. 2009, 51(5):1101-1112.
    • (2009) J. Lipid Res. , vol.51 , Issue.5 , pp. 1101-1112
    • Velagapudi, V.R.1
  • 82
    • 79952749979 scopus 로고    scopus 로고
    • Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
    • Swann J.R., et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(Suppl. 1):4523-4530.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 4523-4530
    • Swann, J.R.1
  • 83
    • 0015781684 scopus 로고
    • Intestinal bile acids and cholesterol absorption in the germfree rat
    • Wostmann B.S. Intestinal bile acids and cholesterol absorption in the germfree rat. J. Nutr. 1973, 103(7):982-990.
    • (1973) J. Nutr. , vol.103 , Issue.7 , pp. 982-990
    • Wostmann, B.S.1
  • 84
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin S.I., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell. Metab. 2013, 17(2):225-235.
    • (2013) Cell. Metab. , vol.17 , Issue.2 , pp. 225-235
    • Sayin, S.I.1
  • 85
    • 84887960056 scopus 로고    scopus 로고
    • Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
    • Li F., et al. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat. Commun. 2013, 4:2384.
    • (2013) Nat. Commun. , vol.4 , pp. 2384
    • Li, F.1
  • 86
    • 84901020405 scopus 로고    scopus 로고
    • Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
    • Joyce S.A., et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(20):7421-7426.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.20 , pp. 7421-7426
    • Joyce, S.A.1
  • 87
    • 60549086580 scopus 로고    scopus 로고
    • Human gut microbiota in obesity and after gastric bypass
    • Zhang H., et al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(7):2365-2370.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , Issue.7 , pp. 2365-2370
    • Zhang, H.1
  • 88
    • 78650037263 scopus 로고    scopus 로고
    • Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    • Furet J.P., et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 2010, 59(12):3049-3057.
    • (2010) Diabetes , vol.59 , Issue.12 , pp. 3049-3057
    • Furet, J.P.1
  • 89
    • 84898051705 scopus 로고    scopus 로고
    • FXR is a molecular target for the effects of vertical sleeve gastrectomy
    • Ryan K.K., et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 2014, 509(7499):183-188.
    • (2014) Nature , vol.509 , Issue.7499 , pp. 183-188
    • Ryan, K.K.1
  • 90
    • 84866973849 scopus 로고    scopus 로고
    • Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b
    • Wang D., et al. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b. Circ. Res. 2012, 111(8):967-981.
    • (2012) Circ. Res. , vol.111 , Issue.8 , pp. 967-981
    • Wang, D.1
  • 91
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011, 472(7341):57-63.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 57-63
    • Wang, Z.1
  • 92
    • 84907486084 scopus 로고    scopus 로고
    • The contributory role of gut microbiota in cardiovascular disease
    • Tang W.H., Hazen S.L. The contributory role of gut microbiota in cardiovascular disease. J. Clin. Invest 2014, 124(10):4204-4211.
    • (2014) J. Clin. Invest , vol.124 , Issue.10 , pp. 4204-4211
    • Tang, W.H.1    Hazen, S.L.2
  • 93
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang W.H., et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 2013, 368(17):1575-1584.
    • (2013) N. Engl. J. Med. , vol.368 , Issue.17 , pp. 1575-1584
    • Tang, W.H.1
  • 94
    • 84920704729 scopus 로고    scopus 로고
    • Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
    • Shih D.M., et al. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J. Lipid Res. 2014, 56(1):22-37.
    • (2014) J. Lipid Res. , vol.56 , Issue.1 , pp. 22-37
    • Shih, D.M.1
  • 95
    • 84921636319 scopus 로고    scopus 로고
    • Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
    • Gao X., et al. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J. Biosci. Bioeng. 2014, 118(4):476-481.
    • (2014) J. Biosci. Bioeng. , vol.118 , Issue.4 , pp. 476-481
    • Gao, X.1
  • 96
    • 84925862053 scopus 로고    scopus 로고
    • Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease
    • Tang W.H., et al. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ. Res. 2015, 116(3):448-455.
    • (2015) Circ. Res. , vol.116 , Issue.3 , pp. 448-455
    • Tang, W.H.1
  • 97
    • 0027272625 scopus 로고
    • The fish odour syndrome: biochemical, familial, and clinical aspects
    • Ayesh R., et al. The fish odour syndrome: biochemical, familial, and clinical aspects. BMJ 1993, 307(6905):655-657.
    • (1993) BMJ , vol.307 , Issue.6905 , pp. 655-657
    • Ayesh, R.1
  • 98
    • 84872497868 scopus 로고    scopus 로고
    • FMO3 allelic variants in Sicilian and Sardinian populations: trimethylaminuria and absence of fish-like body odor
    • D'Angelo R., et al. FMO3 allelic variants in Sicilian and Sardinian populations: trimethylaminuria and absence of fish-like body odor. Gene 2013, 515(2):410-415.
    • (2013) Gene , vol.515 , Issue.2 , pp. 410-415
    • D'Angelo, R.1
  • 99
    • 70350397069 scopus 로고    scopus 로고
    • G protein-coupled receptor mediated trimethylamine sensing
    • Suska A., et al. G protein-coupled receptor mediated trimethylamine sensing. Biosens. Bioelectron. 2009, 25(4):715-720.
    • (2009) Biosens. Bioelectron. , vol.25 , Issue.4 , pp. 715-720
    • Suska, A.1
  • 100
    • 84873497634 scopus 로고    scopus 로고
    • Human trace amine-associated receptor TAAR5 can be activated by trimethylamine
    • Wallrabenstein I., et al. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One 2013, 8(2):e54950.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e54950
    • Wallrabenstein, I.1
  • 101
    • 84901335706 scopus 로고    scopus 로고
    • Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine
    • Hartiala J., et al. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler. Thromb. Vasc. Biol. 2014, 34(6):1307-1313.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , Issue.6 , pp. 1307-1313
    • Hartiala, J.1
  • 102
    • 84872139636 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
    • Bennett B.J., et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell. Metab. 2013, 17(1):49-60.
    • (2013) Cell. Metab. , vol.17 , Issue.1 , pp. 49-60
    • Bennett, B.J.1
  • 103
    • 84923913674 scopus 로고    scopus 로고
    • Transmission of atherosclerosis susceptibility with gut microbial transplantation
    • Gregory J.C., et al. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J. Biol. Chem. 2014, 290(9):5647-5660.
    • (2014) J. Biol. Chem. , vol.290 , Issue.9 , pp. 5647-5660
    • Gregory, J.C.1
  • 104
    • 84921417572 scopus 로고    scopus 로고
    • The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases
    • Brown J.M., Hazen S.L. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev. Med. 2015, 66:343-359.
    • (2015) Annu Rev. Med. , vol.66 , pp. 343-359
    • Brown, J.M.1    Hazen, S.L.2
  • 105
    • 84908424139 scopus 로고    scopus 로고
    • Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation
    • Kuka J., et al. Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation. Life Sci. 2014, 117(2):84-92.
    • (2014) Life Sci. , vol.117 , Issue.2 , pp. 84-92
    • Kuka, J.1
  • 106
    • 85052274144 scopus 로고    scopus 로고
    • Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease
    • Brugere J.F., et al. Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease. Gut. Microb. 2014, 5(1):5-10.
    • (2014) Gut. Microb. , vol.5 , Issue.1 , pp. 5-10
    • Brugere, J.F.1
  • 107
    • 84910057313 scopus 로고    scopus 로고
    • Host lifestyle affects human microbiota on daily timescales
    • David L.A., et al. Host lifestyle affects human microbiota on daily timescales. Genome Biol. 2014, 15(7):R89.
    • (2014) Genome Biol. , vol.15 , Issue.7 , pp. R89
    • David, L.A.1
  • 108
    • 33847233644 scopus 로고    scopus 로고
    • Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces
    • Duncan S.H., et al. Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl. Environ. Microbiol. 2007, 73(4):1073-1078.
    • (2007) Appl. Environ. Microbiol. , vol.73 , Issue.4 , pp. 1073-1078
    • Duncan, S.H.1
  • 109
    • 34247371381 scopus 로고    scopus 로고
    • Understanding the effects of diet on bacterial metabolism in the large intestine
    • Louis P., et al. Understanding the effects of diet on bacterial metabolism in the large intestine. J. Appl. Microbiol. 2007, 102(5):1197-1208.
    • (2007) J. Appl. Microbiol. , vol.102 , Issue.5 , pp. 1197-1208
    • Louis, P.1
  • 110
    • 76349111356 scopus 로고    scopus 로고
    • Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
    • Zhang C., et al. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J. 2010, 4(2):232-241.
    • (2010) ISME J. , vol.4 , Issue.2 , pp. 232-241
    • Zhang, C.1
  • 111
    • 70350110294 scopus 로고    scopus 로고
    • High-fat diet determines the composition of the murine gut microbiome independently of obesity
    • 1716-24 e1-2
    • Hildebrandt M.A., et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009, 137(5). 1716-24 e1-2.
    • (2009) Gastroenterology , vol.137 , Issue.5
    • Hildebrandt, M.A.1
  • 112
    • 69949143928 scopus 로고    scopus 로고
    • Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13
    • Joller D., et al. Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13. Anim. Genet. 2009, 40(5):749-752.
    • (2009) Anim. Genet. , vol.40 , Issue.5 , pp. 749-752
    • Joller, D.1
  • 113
    • 84862491799 scopus 로고    scopus 로고
    • Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits
    • McKnite A.M., et al. Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One 2012, 7(6):e39191.
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e39191
    • McKnite, A.M.1
  • 114
    • 0034433421 scopus 로고    scopus 로고
    • A DNA polymorphism influencing alpha(1,2)fucosyltransferase activity of the pig FUT1 enzyme determines susceptibility of small intestinal epithelium to Escherichia coli F18 adhesion
    • Meijerink E., et al. A DNA polymorphism influencing alpha(1,2)fucosyltransferase activity of the pig FUT1 enzyme determines susceptibility of small intestinal epithelium to Escherichia coli F18 adhesion. Immunogenetics 2000, 52(1-2):129-136.
    • (2000) Immunogenetics , vol.52 , Issue.1-2 , pp. 129-136
    • Meijerink, E.1
  • 115
    • 80052742085 scopus 로고    scopus 로고
    • Refined mapping of the Escherichia coli F4ab/F4ac receptor gene(s) on pig chromosome 13
    • Niu X., et al. Refined mapping of the Escherichia coli F4ab/F4ac receptor gene(s) on pig chromosome 13. Anim. Genet. 2011, 42(5):552-555.
    • (2011) Anim. Genet. , vol.42 , Issue.5 , pp. 552-555
    • Niu, X.1
  • 116
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar M., et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010, 328(5975):228-231.
    • (2010) Science , vol.328 , Issue.5975 , pp. 228-231
    • Vijay-Kumar, M.1
  • 117
    • 84904890211 scopus 로고    scopus 로고
    • From meta-omics to causality: experimental models for human microbiome research
    • Fritz J.V., et al. From meta-omics to causality: experimental models for human microbiome research. Microbiome 2013, 1(1):14.
    • (2013) Microbiome , vol.1 , Issue.1 , pp. 14
    • Fritz, J.V.1
  • 118
    • 84911972606 scopus 로고    scopus 로고
    • Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics
    • O'Connor A., et al. Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics. Mamm. Genome 2014, 25(11-12):583-599.
    • (2014) Mamm. Genome , vol.25 , Issue.11-12 , pp. 583-599
    • O'Connor, A.1
  • 119
    • 84908079780 scopus 로고    scopus 로고
    • A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics
    • Donia M.S., et al. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell 2014, 158(6):1402-1414.
    • (2014) Cell , vol.158 , Issue.6 , pp. 1402-1414
    • Donia, M.S.1
  • 120
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • Kim H.J., et al. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab. Chip 2012, 12(12):2165-2174.
    • (2012) Lab. Chip , vol.12 , Issue.12 , pp. 2165-2174
    • Kim, H.J.1
  • 121
    • 84890546613 scopus 로고    scopus 로고
    • Systems genetics approaches to understand complex traits
    • Civelek M., Lusis A.J. Systems genetics approaches to understand complex traits. Nat. Rev. Genet. 2014, 15(1):34-48.
    • (2014) Nat. Rev. Genet. , vol.15 , Issue.1 , pp. 34-48
    • Civelek, M.1    Lusis, A.J.2
  • 122
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Consortium, H.M.P. Structure, function and diversity of the healthy human microbiome. Nature 2013, 486(7402):207-214.
    • (2013) Nature , vol.486 , Issue.7402 , pp. 207-214
  • 123
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J., et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464(7285):59-65.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 59-65
    • Qin, J.1
  • 124
    • 84885789047 scopus 로고    scopus 로고
    • Systems biology approaches to epidemiological studies of complex diseases
    • Li H. Systems biology approaches to epidemiological studies of complex diseases. Wiley Interdiscip. Rev. Syst. Biol. Med. 2013, 5(6):677-686.
    • (2013) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.5 , Issue.6 , pp. 677-686
    • Li, H.1
  • 125
    • 0036591308 scopus 로고    scopus 로고
    • Chemical and biological liberation of trimethylamine from foods
    • Mitchell S.C., Zhang A.Q., Smith R.L. Chemical and biological liberation of trimethylamine from foods. J. Food Compos Anal. 2002, 15:277-282.
    • (2002) J. Food Compos Anal. , vol.15 , pp. 277-282
    • Mitchell, S.C.1    Zhang, A.Q.2    Smith, R.L.3
  • 126
    • 84874590719 scopus 로고    scopus 로고
    • Meat consumption and mortality-results from the European Prospective Investigation into Cancer and Nutrition
    • Rohrmann S., et al. Meat consumption and mortality-results from the European Prospective Investigation into Cancer and Nutrition. BMC Med. 2013, 11:63.
    • (2013) BMC Med. , vol.11 , pp. 63
    • Rohrmann, S.1
  • 127
    • 84888187402 scopus 로고    scopus 로고
    • Gut microbiota metabolism of L-carnitine and cardiovascular risk
    • Ussher J.R., Lopaschuk G.D., Arduini A. Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis 2013, 231(2):456-461.
    • (2013) Atherosclerosis , vol.231 , Issue.2 , pp. 456-461
    • Ussher, J.R.1    Lopaschuk, G.D.2    Arduini, A.3
  • 128
    • 84923818422 scopus 로고    scopus 로고
    • Why microbiome treatments could pay off soon
    • Knight R. Why microbiome treatments could pay off soon. Nature 2015, 518:55.
    • (2015) Nature , vol.518 , pp. 55
    • Knight, R.1
  • 129
    • 85017909468 scopus 로고    scopus 로고
    • Microbiome engineering: synthetic biology may lead to the creation of smart microbes that can detect and treat disease
    • Sonnenburg J.L. Microbiome engineering: synthetic biology may lead to the creation of smart microbes that can detect and treat disease. Nature 2015, 518:510.
    • (2015) Nature , vol.518 , pp. 510
    • Sonnenburg, J.L.1
  • 130
    • 77949918387 scopus 로고    scopus 로고
    • Jamming bacterial communication: new approaches for the treatment of infectious diseases
    • Njoroge J., Sperandio V. Jamming bacterial communication: new approaches for the treatment of infectious diseases. EMBO Mol. Med. 2009, 1(4):201-210.
    • (2009) EMBO Mol. Med. , vol.1 , Issue.4 , pp. 201-210
    • Njoroge, J.1    Sperandio, V.2
  • 131
    • 84983208863 scopus 로고    scopus 로고
    • Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
    • Citorik R.J., Mimee M., Lu T.K. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat. Biotechnol. 2014, 32(11):1141-1145.
    • (2014) Nat. Biotechnol. , vol.32 , Issue.11 , pp. 1141-1145
    • Citorik, R.J.1    Mimee, M.2    Lu, T.K.3
  • 132
    • 84923654518 scopus 로고    scopus 로고
    • Antibiotics in early life and obesity
    • Cox L.M., Blaser M.J. Antibiotics in early life and obesity. Nat. Rev. Endocrinol. 2015, 11(3):182-190.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , Issue.3 , pp. 182-190
    • Cox, L.M.1    Blaser, M.J.2
  • 133
    • 79955111608 scopus 로고    scopus 로고
    • Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release
    • Hofmann A.F. Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release. Hepatology 2011, 53(5):1784.
    • (2011) Hepatology , vol.53 , Issue.5 , pp. 1784
    • Hofmann, A.F.1
  • 134
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst J.J. The physiology of glucagon-like peptide 1. Physiol. Rev. 2007, 87(4):1409-1439.
    • (2007) Physiol. Rev. , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 135
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C., et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell. Metab. 2009, 10(3):167-177.
    • (2009) Cell. Metab. , vol.10 , Issue.3 , pp. 167-177
    • Thomas, C.1
  • 136
    • 84861682490 scopus 로고    scopus 로고
    • TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
    • Harach T., et al. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci. Rep. 2012, 2:430.
    • (2012) Sci. Rep. , vol.2 , pp. 430
    • Harach, T.1
  • 137
    • 84871837954 scopus 로고    scopus 로고
    • Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    • Craciun S., Balskus E.P. Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(52):21307-21312.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , Issue.52 , pp. 21307-21312
    • Craciun, S.1    Balskus, E.P.2
  • 138
    • 84896537331 scopus 로고    scopus 로고
    • Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
    • Zhu Y., et al. Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(11):4268-4273.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.11 , pp. 4268-4273
    • Zhu, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.