Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Wallrabenstein, Ivonne ^a   Kuklan, Jonas ^a   Weber, Lea ^a   Zborala, Sandra ^a   Werner, Markus ^a   Altmüller, Janine ^c   Becker, Christian ^c   Schmidt, Anna ^b   Hatt, Hanns ^a   Hummel, Thomas ^b   Gisselmann, Günter ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR PROTEIN; TRACE AMINE ASSOCIATED RECEPTOR 5; TRIMETHYLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANOSMIA; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; GENE LOCATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY RECEPTOR; OOCYTE; PROTEIN EXPRESSION; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TRACE AMINE ASSOCIATED RECEPTOR 5 GENE; XENOPUS LAEVIS;

CELL LINE; ETHYLAMINES; HUMANS; METHYLAMINES; OLFACTORY MUCOSA; OLFACTORY RECEPTOR NEURONS; OPEN READING FRAMES; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84873497634     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054950     Document Type: Article

References (38)

1. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, et al. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A 98: 8966-8971.
2. Liberles SD, Buck LB, (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature 442: 645-650.
3. Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, et al. (2012) Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity. ACS Chem Biol 7: 1184-1189.
4. Liberles SD, (2009) Trace amine-associated receptors are olfactory receptors in vertebrates. Ann N Y Acad Sci 1170: 168-172.
5. Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, et al. (2011) Detection and avoidance of a carnivore odor by prey. Proc Natl Acad Sci U S A 108: 11235-11240.
6. Zucchi R, Chiellini G, Scanlan TS, Grandy DK, (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol 149: 967-978.
7. Nishimura K, Utsumi K, Yuhara M, Fujitani Y, Iritani A, (1989) Identification of puberty-accelerating pheromones in male mouse urine. J Exp Zool 251: 300-305.
8. Gavaghan McKee CL, Wilson ID, Nicholson JK, (2006) Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice. J Proteome Res 5: 378-384.
9. Snoddy AM, Heckathorn D, Tessel RE, (1985) Cold-restraint stress and urinary endogenous beta-phenylethylamine excretion in rats. Pharmacol Biochem Behav 22: 497-500.
10. Paulos MA, Tessel RE, (1982) Excretion of beta-phenethylamine is elevated in humans after profound stress. Science 215: 1127-1129.
11. Staubert C, Boselt I, Bohnekamp J, Rompler H, Enard W, et al. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS One 5: e11133.
12. Carnicelli V, Santoro A, Sellari-Franceschini S, Berrettini S, Zucchi R, (2010) Expression of Trace Amine-Associated Receptors in Human Nasal Mucosa. Chemosensory Perception 3: 99-107.
13. Zhuang H, Matsunami H, (2008) Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. Nat Protoc 3: 1402-1413.
14. Zhuang H, Matsunami H, (2007) Synergism of accessory factors in functional expression of mammalian odorant receptors. J Biol Chem 282: 15284-15293.
15. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, et al. (2001) Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60: 1181-1188.
16. Wetzel CH, Oles M, Wellerdieck C, Kuczkowiak M, Gisselmann G, et al. (1999) Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. J Neurosci 19: 7426-7433.
17. Abaffy T, Matsunami H, Luetje CW, (2006) Functional analysis of a mammalian odorant receptor subfamily. J Neurochem 97: 1506-1518.
18. Amoore JE, Forrester LJ, (1976) Specific Anosmia to Trimethylamine: the Fishy Primary Odor. J Chem EeoL 2: 49-56.
19. Amoore JE, (1979) Directions for preparing aqueous solutions of primary odorants to diagnose eight types of specific anosmia. Chemical Senses and Flavour 4: 153-161.
20. Bansal V, Tewhey R, Leproust EM, Schork NJ, (2011) Efficient and cost effective population resequencing by pooling and in-solution hybridization. PLoS One 6: e18353.
21. Exome Variant Server NESPE, Seattle, WA. Available: http://evs.gs.washington.edu/EVS/). Accessed 2012 Jul 11.
22. Keydar I, Ben-Asher E, Feldmesser E, Nativ N, Oshimoto A, et al. (2012) General Olfactory Sensitivity Database (GOSdb): Candidate Genes and their Genomic Variations. Hum Mutat.
23. Mitchell SC, Smith RL, (2001) Trimethylaminuria: the fish malodor syndrome. Drug Metab Dispos 29: 517-521.
24. Shirasu M, Touhara K, (2011) The scent of disease: volatile organic compounds of the human body related to disease and disorder. J Biochem 150: 257-266.
25. Shimizu M, Cashman JR, Yamazaki H, (2007) Transient trimethylaminuria related to menstruation. BMC Med Genet 8: 2.
26. Navarrete-Palacios E, Hudson R, Reyes-Guerrero G, Guevara-Guzman R, (2003) Lower olfactory threshold during the ovulatory phase of the menstrual cycle. Biol Psychol 63: 269-279.
27. Johnson MA, Tsai L, Roy DS, Valenzuela DH, Mosley C, et al. (2012) Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem. Proc Natl Acad Sci U S A 109: 13410-13415.
28. Pacifico R, Dewan A, Cawley D, Guo C, Bozza T, (2012) An olfactory subsystem that mediates high-sensitivity detection of volatile amines. Cell Rep 2: 76-88.
29. Saito H, Kubota M, Roberts RW, Chi Q, Matsunami H, (2004) RTP family members induce functional expression of mammalian odorant receptors. Cell 119: 679-691.
30. Amoore JE, (1977) Specific Anosmia and Concept of Primary Odors. Chemical Senses & Flavour 2: 267-281.
31. Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H, (2007) Genetic variation in a human odorant receptor alters odour perception. Nature 449: 468-472.
32. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, et al. (2007) Genetic elucidation of human hyperosmia to isovaleric acid. PLoS Biol 5: e284.
33. Li Q, Korzan WJ, Ferrero DM, Chang RB, Roy DS, et al. (2012) Synchronous Evolution of an Odor Biosynthesis Pathway and Behavioral Response. Curr Biol.
34. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD, (2009) Odor coding by a Mammalian receptor repertoire. Sci Signal 2: ra9.
35. Von Dannecker LE, Mercadante AF, Malnic B, (2006) Ric-8B promotes functional expression of odorant receptors. Proc Natl Acad Sci U S A 103: 9310-9314.
36. Saras A, Gisselmann G, Vogt-Eisele AK, Erlkamp KS, Kletke O, et al. (2008) Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J Biol Chem 283: 10470-10475.
37. Langmead B, Trapnell C, Pop M, Salzberg SL, (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10: R25.
38. Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, et al. (2009) The Sequence Alignment/Map format and SAMtools. Bioinformatics 25: 2078-2079.