메뉴 건너뛰기




Volumn 764, Issue , 2015, Pages 140-148

Bench-to-bedside pharmacology of adrenomedullin

Author keywords

Adrenomedullin; Angiogenesis; Anti inflammation; Cardiovascularprotection; Cerebralprotection; Tumor growth

Indexed keywords

ADRENOMEDULLIN; AMYLIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN RECEPTOR LIKE RECEPTOR; CYCLIC AMP; CYCLOOXYGENASE 2; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; RECEPTOR ACTIVITY MODIFYING PROTEIN; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA;

EID: 84936802765     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.06.061     Document Type: Review
Times cited : (63)

References (113)
  • 2
    • 73349093417 scopus 로고    scopus 로고
    • Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium
    • S. Ashizuka, K. Inagaki-Ohara, K. Kuwasako, J. Kato, H. Inatsu, and K. Kitamura Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium Microbiol. Immunol. 53 2009 573 581
    • (2009) Microbiol. Immunol. , vol.53 , pp. 573-581
    • Ashizuka, S.1    Inagaki-Ohara, K.2    Kuwasako, K.3    Kato, J.4    Inatsu, H.5    Kitamura, K.6
  • 4
    • 27944503407 scopus 로고    scopus 로고
    • Effect of adrenomedullin administration on acetic acid-induced colitis in rats
    • S. Ashizuka, N. Ishikawa, J. Kato, J. Yamaga, H. Inatsu, T. Eto, and K. Kitamura Effect of adrenomedullin administration on acetic acid-induced colitis in rats Peptides 26 2005 2610 2615
    • (2005) Peptides , vol.26 , pp. 2610-2615
    • Ashizuka, S.1    Ishikawa, N.2    Kato, J.3    Yamaga, J.4    Inatsu, H.5    Eto, T.6    Kitamura, K.7
  • 5
    • 84876406616 scopus 로고    scopus 로고
    • Adrenomedullin: A novel therapy for intractable ulcerative colitis
    • S. Ashizuka, T. Kita, H. Inatsu, and K. Kitamura Adrenomedullin: a novel therapy for intractable ulcerative colitis Inflamm. Bowel Dis. 19 2013 E26 E27
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. E26-E27
    • Ashizuka, S.1    Kita, T.2    Inatsu, H.3    Kitamura, K.4
  • 7
    • 0035895276 scopus 로고    scopus 로고
    • Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
    • K.M. Caron, and O. Smithies Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene Proc. Natl. Acad. Sci. USA 98 2001 615 619
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 615-619
    • Caron, K.M.1    Smithies, O.2
  • 9
    • 0023579739 scopus 로고
    • Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
    • G.J. Cooper, A.C. Willis, A. Clark, R.C. Turner, R.B. Sim, and K.B. Reid Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients Proc. Natl. Acad. Sci. USA 84 1987 8628 8632
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8628-8632
    • Cooper, G.J.1    Willis, A.C.2    Clark, A.3    Turner, R.C.4    Sim, R.B.5    Reid, K.B.6
  • 10
    • 33645230587 scopus 로고    scopus 로고
    • Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene
    • R.T. Dackor, K. Fritz-Six, W.P. Dunworth, C.L. Gibbons, O. Smithies, and K.M. Caron Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene Mol. Cell. Biol. 26 2006 2511 2518
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 2511-2518
    • Dackor, R.T.1    Fritz-Six, K.2    Dunworth, W.P.3    Gibbons, C.L.4    Smithies, O.5    Caron, K.M.6
  • 11
    • 34547107623 scopus 로고    scopus 로고
    • Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age
    • R. Dackor, K. Fritz-Six, O. Smithies, and K. Caron Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age J. Biol. Chem. 282 2007 18094 18099
    • (2007) J. Biol. Chem. , vol.282 , pp. 18094-18099
    • Dackor, R.1    Fritz-Six, K.2    Smithies, O.3    Caron, K.4
  • 12
    • 18544369738 scopus 로고    scopus 로고
    • The cardiovascular continuum and renin-angiotensin-aldosterone system blockade
    • V. Dzau The cardiovascular continuum and renin-angiotensin-aldosterone system blockade J. Hypertens. Suppl. 23 2005 S9 S17
    • (2005) J. Hypertens. Suppl. , vol.23 , pp. S9-S17
    • Dzau, V.1
  • 13
    • 0028116160 scopus 로고
    • Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells
    • S. Eguchi, Y. Hirata, H. Iwasaki, K. Sato, T.X. Watanabe, T. Inui, K. Nakajima, S. Sakakibara, and F. Marumo Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells Endocrinology 135 1994 2454 2458
    • (1994) Endocrinology , vol.135 , pp. 2454-2458
    • Eguchi, S.1    Hirata, Y.2    Iwasaki, H.3    Sato, K.4    Watanabe, T.X.5    Inui, T.6    Nakajima, K.7    Sakakibara, S.8    Marumo, F.9
  • 14
    • 38449115088 scopus 로고    scopus 로고
    • Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia
    • C. Ertmer, A. Morelli, S. Rehberg, M. Lange, C. Hucklenbruch, H. Van Aken, M. Booke, and M. Westphal Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia Br. J. Anaesth. 99 2007 830 836
    • (2007) Br. J. Anaesth. , vol.99 , pp. 830-836
    • Ertmer, C.1    Morelli, A.2    Rehberg, S.3    Lange, M.4    Hucklenbruch, C.5    Van Aken, H.6    Booke, M.7    Westphal, M.8
  • 15
    • 0028088778 scopus 로고
    • L-NAME modulates responses to adrenomedullin in the hindquarters vascular bed of the rat
    • C.J. Feng, B. Kang, A.D. Kaye, P.J. Kadowitz, and B.D. Nossaman L-NAME modulates responses to adrenomedullin in the hindquarters vascular bed of the rat Life Sci. 55 1994 PL433 PL438
    • (1994) Life Sci. , vol.55 , pp. PL433-PL438
    • Feng, C.J.1    Kang, B.2    Kaye, A.D.3    Kadowitz, P.J.4    Nossaman, B.D.5
  • 16
    • 33646779859 scopus 로고    scopus 로고
    • Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease
    • E. Gonzalez-Rey, A. Fernandez-Martin, A. Chorny, and M. Delgado Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease Gut 55 2006 824 832
    • (2006) Gut , vol.55 , pp. 824-832
    • Gonzalez-Rey, E.1    Fernandez-Martin, A.2    Chorny, A.3    Delgado, M.4
  • 17
  • 18
    • 33746048039 scopus 로고    scopus 로고
    • A critical cytoprotective role of endogenous adrenomedullin in acute myocardial infarction
    • S.A. Hamid, and G.F. Baxter A critical cytoprotective role of endogenous adrenomedullin in acute myocardial infarction J. Mol. Cell Cardiol. 41 2006 360 363
    • (2006) J. Mol. Cell Cardiol. , vol.41 , pp. 360-363
    • Hamid, S.A.1    Baxter, G.F.2
  • 25
    • 78349305772 scopus 로고    scopus 로고
    • Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model
    • O. Hurtado, J. Serrano, M. Sobrado, A.P. Fernández, I. Lizasoain, R. Martínez-Murillo, M.A. Moro, and A. Martínez Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model Neuroscience 171 2010 885 892
    • (2010) Neuroscience , vol.171 , pp. 885-892
    • Hurtado, O.1    Serrano, J.2    Sobrado, M.3    Fernández, A.P.4    Lizasoain, I.5    Martínez-Murillo, R.6    Moro, M.A.7    Martínez, A.8
  • 26
    • 12244298914 scopus 로고    scopus 로고
    • Adrenomedullin: A cardiac depressant factor in septic shock
    • J.M. Hyvelin, Q. Shan, and J.P. Bourreau Adrenomedullin: a cardiac depressant factor in septic shock J. Card. Surg. 17 2002 328 335
    • (2002) J. Card. Surg. , vol.17 , pp. 328-335
    • Hyvelin, J.M.1    Shan, Q.2    Bourreau, J.P.3
  • 32
    • 0033431877 scopus 로고    scopus 로고
    • Adrenomedullin suppresses interleukin-1β-induced tumor necrosis factor-α production in Swiss 3T3 cells
    • Y. Isumi, A. Kubo, T. Katafuchi, K. Kangawa, and N. Minamino Adrenomedullin suppresses interleukin-1β-induced tumor necrosis factor-α production in Swiss 3T3 cells FEBS Lett. 463 1999 110 114
    • (1999) FEBS Lett. , vol.463 , pp. 110-114
    • Isumi, Y.1    Kubo, A.2    Katafuchi, T.3    Kangawa, K.4    Minamino, N.5
  • 34
    • 56549093824 scopus 로고    scopus 로고
    • Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
    • D. Jin, K. Harada, S. Ohnishi, K. Yamahara, K. Kangawa, and N. Nagaya Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema Cardiovasc. Res. 80 2008 339 345
    • (2008) Cardiovasc. Res. , vol.80 , pp. 339-345
    • Jin, D.1    Harada, K.2    Ohnishi, S.3    Yamahara, K.4    Kangawa, K.5    Nagaya, N.6
  • 36
    • 84859790113 scopus 로고    scopus 로고
    • Understanding RAMPs through genetically engineered mouse models
    • M. Kadmiel, K.L. Fritz-Six, and K.M. Caron Understanding RAMPs through genetically engineered mouse models Adv. Exp. Med. Biol. 744 2012 49 60
    • (2012) Adv. Exp. Med. Biol. , vol.744 , pp. 49-60
    • Kadmiel, M.1    Fritz-Six, K.L.2    Caron, K.M.3
  • 38
    • 0029025737 scopus 로고
    • Adrenomedullin inhibits the secretion of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages
    • H. Kamoi, H. Kanazawa, K. Hirata, N. Kurihara, Y. Yano, and S. Otani Adrenomedullin inhibits the secretion of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages Biochem. Biophys. Res. Commun. 211 1995 1031 1035
    • (1995) Biochem. Biophys. Res. Commun. , vol.211 , pp. 1031-1035
    • Kamoi, H.1    Kanazawa, H.2    Hirata, K.3    Kurihara, N.4    Yano, Y.5    Otani, S.6
  • 41
  • 44
    • 0037300425 scopus 로고    scopus 로고
    • Adrenomedullin: A possible autocrine or paracrine hormone in the cardiac ventricles
    • J. Kato, T. Tsuruda, K. Kitamura, and T. Eto Adrenomedullin: a possible autocrine or paracrine hormone in the cardiac ventricles Hypertens. Res. 26 2003 S113 S119
    • (2003) Hypertens. Res. , vol.26 , pp. S113-S119
    • Kato, J.1    Tsuruda, T.2    Kitamura, K.3    Eto, T.4
  • 45
    • 0141788738 scopus 로고    scopus 로고
    • Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion
    • K. Kato, H. Yin, J. Agata, H. Yoshida, L. Chao, and J. Chao Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion Am. J. Physiol. Heart Circ. Physiol. 285 2003 H1506 H1514
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285 , pp. H1506-H1514
    • Kato, K.1    Yin, H.2    Agata, J.3    Yoshida, H.4    Chao, L.5    Chao, J.6
  • 47
    • 2642529116 scopus 로고    scopus 로고
    • Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells
    • W. Kim, S.O. Moon, M.J. Sung, S.H. Kim, S. Lee, J.N. So, and S.K. Park Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells FASEB J. 17 2003 1937 1939
    • (2003) FASEB J. , vol.17 , pp. 1937-1939
    • Kim, W.1    Moon, S.O.2    Sung, M.J.3    Kim, S.H.4    Lee, S.5    So, J.N.6    Park, S.K.7
  • 48
    • 77950492890 scopus 로고    scopus 로고
    • Hemodynamic and hormonal effects of exogenous adrenomedullin administration in humans and relationship to insulin resistance
    • T. Kita, Y. Suzuki, and K. Kitamura Hemodynamic and hormonal effects of exogenous adrenomedullin administration in humans and relationship to insulin resistance Hypertens. Res. 33 2010 314 319
    • (2010) Hypertens. Res. , vol.33 , pp. 314-319
    • Kita, T.1    Suzuki, Y.2    Kitamura, K.3
  • 49
    • 0036127418 scopus 로고    scopus 로고
    • Adrenomedullin and PAMP: Discovery, structures, and cardiovascular functions
    • K. Kitamura, K. Kangawa, and T. Eto Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions Microsc. Res. Tech. 57 2002 3 13
    • (2002) Microsc. Res. Tech. , vol.57 , pp. 3-13
    • Kitamura, K.1    Kangawa, K.2    Eto, T.3
  • 52
    • 78650308844 scopus 로고    scopus 로고
    • Pre-treatment of adrenomedullin suppresses cerebral edema caused by transient focal cerebral ischemia in rats detected by magnetic resonance imaging
    • T. Kondoh, Y. Ueta, and K. Torii Pre-treatment of adrenomedullin suppresses cerebral edema caused by transient focal cerebral ischemia in rats detected by magnetic resonance imaging Brain Res. Bull. 84 2011 69 74
    • (2011) Brain Res. Bull. , vol.84 , pp. 69-74
    • Kondoh, T.1    Ueta, Y.2    Torii, K.3
  • 55
    • 84899574159 scopus 로고    scopus 로고
    • Roles of receptor activity-modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice
    • C. Kurashige, K. Hosono, H. Matsuda, K. Tsujikawa, H. Okamoto, and M. Majima Roles of receptor activity-modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice FASEB J. 28 2014 1237 1247
    • (2014) FASEB J. , vol.28 , pp. 1237-1247
    • Kurashige, C.1    Hosono, K.2    Matsuda, H.3    Tsujikawa, K.4    Okamoto, H.5    Majima, M.6
  • 56
    • 79960291828 scopus 로고    scopus 로고
    • Shared and separate functions of the RAMP-based adrenomedullin receptors
    • K. Kuwasako, K. Kitamura, S. Nagata, T. Hikosaka, Y. Takei, and J. Kato Shared and separate functions of the RAMP-based adrenomedullin receptors Peptides 32 2011 1540 1550
    • (2011) Peptides , vol.32 , pp. 1540-1550
    • Kuwasako, K.1    Kitamura, K.2    Nagata, S.3    Hikosaka, T.4    Takei, Y.5    Kato, J.6
  • 57
    • 0034703047 scopus 로고    scopus 로고
    • Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling
    • K. Kuwasako, Y. Shimekake, M. Masuda, K. Nakahara, T. Yoshida, M. Kitaura, K. Kitamura, T. Eto, and T. Sakata Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling J. Biol. Chem. 275 2000 29602 29629
    • (2000) J. Biol. Chem. , vol.275 , pp. 29602-29629
    • Kuwasako, K.1    Shimekake, Y.2    Masuda, M.3    Nakahara, K.4    Yoshida, T.5    Kitaura, M.6    Kitamura, K.7    Eto, T.8    Sakata, T.9
  • 58
    • 0031028561 scopus 로고    scopus 로고
    • Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles
    • M.G. Lang, R. Paternò, F.M. Faraci, and D.D. Heistad Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles Stroke 28 1997 181 185
    • (1997) Stroke , vol.28 , pp. 181-185
    • Lang, M.G.1    Paternò, R.2    Faraci, F.M.3    Heistad, D.D.4
  • 60
    • 0031689073 scopus 로고    scopus 로고
    • Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin
    • O. Lisy, M. Jougasaki, J.A. Schirger, H.H. Chen, P.T. Barclay, and J.C. Burnett Jr. Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin Am. J. Physiol. 275 3Pt 2 1998 F410 F414
    • (1998) Am. J. Physiol. , vol.275 , Issue.3 PART 2 , pp. F410-F414
    • Lisy, O.1    Jougasaki, M.2    Schirger, J.A.3    Chen, H.H.4    Barclay, P.T.5    Burnett, Jr.J.C.6
  • 61
    • 84878161187 scopus 로고    scopus 로고
    • RNA interference targeting adrenomedullin induces apoptosis and reduces the growth of human bladder urothelial cell carcinoma
    • A.G. Liu, X.Z. Zhang, F.B. Li, Y.L. Zhao, Y.C. Guo, and R.M. Yang RNA interference targeting adrenomedullin induces apoptosis and reduces the growth of human bladder urothelial cell carcinoma Med. Oncol 30 2013 616
    • (2013) Med. Oncol , vol.30 , pp. 616
    • Liu, A.G.1    Zhang, X.Z.2    Li, F.B.3    Zhao, Y.L.4    Guo, Y.C.5    Yang, R.M.6
  • 63
    • 84861313006 scopus 로고    scopus 로고
    • A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo
    • P.I. Mapp, D.F. McWilliams, M.J. Turley, E. Hargin, and D.A. Walsh A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo Br. J. Pharmacol. 166 2012 1261 1271
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 1261-1271
    • Mapp, P.I.1    McWilliams, D.F.2    Turley, M.J.3    Hargin, E.4    Walsh, D.A.5
  • 64
    • 33646514892 scopus 로고    scopus 로고
    • A new family of angiogenic factors
    • A. Martínez A new family of angiogenic factors Cancer Lett. 236 2006 157 163
    • (2006) Cancer Lett. , vol.236 , pp. 157-163
    • Martínez, A.1
  • 66
    • 0035163227 scopus 로고    scopus 로고
    • Biosynthesis and secretion of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a rat model of endotoxin shock
    • E. Matsui, K. Kitamura, M. Yoshida, J. Kato, Y. Asada, A. Sumiyoshi, and T. Eto Biosynthesis and secretion of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a rat model of endotoxin shock Hypertens. Res. 24 2001 543 549
    • (2001) Hypertens. Res. , vol.24 , pp. 543-549
    • Matsui, E.1    Kitamura, K.2    Yoshida, M.3    Kato, J.4    Asada, Y.5    Sumiyoshi, A.6    Eto, T.7
  • 67
    • 2442619096 scopus 로고    scopus 로고
    • Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia
    • H. Matsui, T. Shimosawa, K. Itakura, X. Guanqun, K. Ando, and T. Fujita Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia Circulation 109 2004 2246 2251
    • (2004) Circulation , vol.109 , pp. 2246-2251
    • Matsui, H.1    Shimosawa, T.2    Itakura, K.3    Guanqun, X.4    Ando, K.5    Fujita, T.6
  • 71
    • 71949115323 scopus 로고    scopus 로고
    • Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice
    • N. Miyamoto, R. Tanaka, T. Shimosawa, Y. Yatomi, T. Fujita, N. Hattori, and T. Urabe Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice J. Cereb. Blood Flow Metab. 29 2009 1769 1779
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1769-1779
    • Miyamoto, N.1    Tanaka, R.2    Shimosawa, T.3    Yatomi, Y.4    Fujita, T.5    Hattori, N.6    Urabe, T.7
  • 75
    • 9144264798 scopus 로고    scopus 로고
    • Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension
    • N. Nagaya, S. Kyotani, M. Uematsu, K. Ueno, H. Oya, N. Nakanishi, M. Shirai, H. Mori, K. Miyatake, and K. Kangawa Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension Circulation 109 2004 351 356
    • (2004) Circulation , vol.109 , pp. 351-356
    • Nagaya, N.1    Kyotani, S.2    Uematsu, M.3    Ueno, K.4    Oya, H.5    Nakanishi, N.6    Shirai, M.7    Mori, H.8    Miyatake, K.9    Kangawa, K.10
  • 81
    • 0033841052 scopus 로고    scopus 로고
    • Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium
    • L.L. Nikitenko, I.Z. MacKenzie, M.C. Rees, and R. Bicknell Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium Mol. Hum. Reprod. 6 2000 811 819
    • (2000) Mol. Hum. Reprod. , vol.6 , pp. 811-819
    • Nikitenko, L.L.1    Mackenzie, I.Z.2    Rees, M.C.3    Bicknell, R.4
  • 84
    • 0034728767 scopus 로고    scopus 로고
    • Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis
    • Y. Ono, I. Okano, M. Kojima, K. Okada, and K. Kangawa Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis Biochem. Biophys. Res. Commun. 271 2000 197 202
    • (2000) Biochem. Biophys. Res. Commun. , vol.271 , pp. 197-202
    • Ono, Y.1    Okano, I.2    Kojima, M.3    Okada, K.4    Kangawa, K.5
  • 86
    • 84893903308 scopus 로고    scopus 로고
    • Adrenomedullin alleviates pulmonary artery collagen accumulation in rats with pulmonary hypertension induced by high blood flow
    • L. Pang, J. Qi, Y. Gao, H. Jin, and J. Du Adrenomedullin alleviates pulmonary artery collagen accumulation in rats with pulmonary hypertension induced by high blood flow Peptides 54 2014 101 107
    • (2014) Peptides , vol.54 , pp. 101-107
    • Pang, L.1    Qi, J.2    Gao, Y.3    Jin, H.4    Du, J.5
  • 88
    • 33847390312 scopus 로고    scopus 로고
    • Chronic administration of adrenomedullin attenuates hypoxic pulmonary vascular structural remodeling and inhibits proadrenomedullin N-terminal 20-peptide production in rats
    • J.G. Qi, Y.G. Ding, C.S. Tang, and J.B. Du Chronic administration of adrenomedullin attenuates hypoxic pulmonary vascular structural remodeling and inhibits proadrenomedullin N-terminal 20-peptide production in rats Peptides 28 2007 910 919
    • (2007) Peptides , vol.28 , pp. 910-919
    • Qi, J.G.1    Ding, Y.G.2    Tang, C.S.3    Du, J.B.4
  • 89
    • 1342346545 scopus 로고    scopus 로고
    • Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    • J. Roh, C.L. Chang, A. Bhalla, C. Klein, and S.Y. Hsu Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes J. Biol. Chem. 279 2004 7264 7274
    • (2004) J. Biol. Chem. , vol.279 , pp. 7264-7274
    • Roh, J.1    Chang, C.L.2    Bhalla, A.3    Klein, C.4    Hsu, S.Y.5
  • 91
    • 0028922340 scopus 로고
    • Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells
    • Y. Shimekake, K. Nagata, S. Ohta, Y. Kambayashi, H. Teraoka, K. Kitamura, T. Eto, K. Kangawa, and H. Matsuo Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells J. Biol. Chem. 270 1995 4412 4417
    • (1995) J. Biol. Chem. , vol.270 , pp. 4412-4417
    • Shimekake, Y.1    Nagata, K.2    Ohta, S.3    Kambayashi, Y.4    Teraoka, H.5    Kitamura, K.6    Eto, T.7    Kangawa, K.8    Matsuo, H.9
  • 92
    • 0029790011 scopus 로고    scopus 로고
    • Adrenomedullin: Changes in circulating and cardiac tissue concentration in Dahl salt-sensitive rats on a high-salt diet
    • T. Shimokubo, J. Sakata, K. Kitamura, K. Kangawa, H. Matsuo, and T. Eto Adrenomedullin: changes in circulating and cardiac tissue concentration in Dahl salt-sensitive rats on a high-salt diet Clin. Exp. Hypertens. 18 1996 949 961
    • (1996) Clin. Exp. Hypertens. , vol.18 , pp. 949-961
    • Shimokubo, T.1    Sakata, J.2    Kitamura, K.3    Kangawa, K.4    Matsuo, H.5    Eto, T.6
  • 93
    • 0037658913 scopus 로고    scopus 로고
    • Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress
    • T. Shimosawa, T. Ogihara, H. Matsui, T. Asano, K. Ando, and T. Fujita Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress Hypertension 41 2003 1080 1085
    • (2003) Hypertension , vol.41 , pp. 1080-1085
    • Shimosawa, T.1    Ogihara, T.2    Matsui, H.3    Asano, T.4    Ando, K.5    Fujita, T.6
  • 96
    • 0842324727 scopus 로고    scopus 로고
    • Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation
    • Y. Suzuki, T. Horio, T. Hayashi, H. Nonogi, K. Kitamura, T. Eto, K. Kangawa, and Y. Kawano Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation Regul. Pept. 118 2004 99 104
    • (2004) Regul. Pept. , vol.118 , pp. 99-104
    • Suzuki, Y.1    Horio, T.2    Hayashi, T.3    Nonogi, H.4    Kitamura, K.5    Eto, T.6    Kangawa, K.7    Kawano, Y.8
  • 97
    • 0346094400 scopus 로고    scopus 로고
    • Identification of novel adrenomedullin in mammals: A potent cardiovascular and renal regulator
    • Y. Takei, K. Inoue, M. Ogoshi, T. Kawahara, H. Bannai, and S. Miyano Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator FEBS Lett. 556 2004 53 58
    • (2004) FEBS Lett. , vol.556 , pp. 53-58
    • Takei, Y.1    Inoue, K.2    Ogoshi, M.3    Kawahara, T.4    Bannai, H.5    Miyano, S.6
  • 98
    • 80755186517 scopus 로고    scopus 로고
    • Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis
    • E. Talero, M. Alvarez de Sotomayor, S. Sánchez-Fidalgo, and V. Motilva Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis Eur. J. Pharmacol. 670 2011 601 607
    • (2011) Eur. J. Pharmacol. , vol.670 , pp. 601-607
    • Talero, E.1    Alvarez De Sotomayor, M.2    Sánchez-Fidalgo, S.3    Motilva, V.4
  • 103
  • 105
    • 0032439411 scopus 로고    scopus 로고
    • The pivotal role of adrenomedullin in producing hyperdynamic circulation during the early stage of sepsis
    • P. Wang, Z.F. Ba, W.G. Cioffi, K.I. Bland, and I.H. Chaudry The pivotal role of adrenomedullin in producing hyperdynamic circulation during the early stage of sepsis Arch. Surg. 133 1998 1298 1304
    • (1998) Arch. Surg. , vol.133 , pp. 1298-1304
    • Wang, P.1    Ba, Z.F.2    Cioffi, W.G.3    Bland, K.I.4    Chaudry, I.H.5
  • 106
    • 0033386873 scopus 로고    scopus 로고
    • Interrupting the renin-angiotensin system: The role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertension
    • M.A. Weber Interrupting the renin-angiotensin system: the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertension Am. J. Hypertens. 12 12Pt 3 1999 189S 194S
    • (1999) Am. J. Hypertens. , vol.12 , Issue.12 PART 3 , pp. 189S-194S
    • Weber, M.A.1
  • 107
    • 0034826945 scopus 로고    scopus 로고
    • Adrenomedullin (ADM) in the human forearm vascular bed: Effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP)
    • I.B. Wilkinson, C.M. McEniery, K.H. Bongaerts, H. MacCallum, D.J. Webb, and J.R. Cockcroft Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP) Br. J. Clin. Pharmacol. 52 2001 159 164
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 159-164
    • Wilkinson, I.B.1    McEniery, C.M.2    Bongaerts, K.H.3    Maccallum, H.4    Webb, D.J.5    Cockcroft, J.R.6
  • 108
    • 30444438526 scopus 로고    scopus 로고
    • Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis
    • C.F. Xia, H. Yin, C.V. Borlongan, J. Chao, and L. Chao Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis Exp. Neurol. 197 2006 521 530
    • (2006) Exp. Neurol. , vol.197 , pp. 521-530
    • Xia, C.F.1    Yin, H.2    Borlongan, C.V.3    Chao, J.4    Chao, L.5
  • 110
    • 0036830201 scopus 로고    scopus 로고
    • Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: Role of adrenomedullin and adrenomedullin binding protein-1
    • S. Yang, M. Zhou, I.H. Chaudry, and P. Wang Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1 Ann. Surg. 236 2002 625 633
    • (2002) Ann. Surg. , vol.236 , pp. 625-633
    • Yang, S.1    Zhou, M.2    Chaudry, I.H.3    Wang, P.4
  • 111
    • 0031693759 scopus 로고    scopus 로고
    • Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline
    • F. Yoshihara, T. Nishikimi, T. Horio, C. Yutani, S. Takishita, H. Matsuo, T. Ohe, and K. Kangawa Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline Eur. J. Pharmacol. 355 1998 33 39
    • (1998) Eur. J. Pharmacol. , vol.355 , pp. 33-39
    • Yoshihara, F.1    Nishikimi, T.2    Horio, T.3    Yutani, C.4    Takishita, S.5    Matsuo, H.6    Ohe, T.7    Kangawa, K.8
  • 112
    • 79960297447 scopus 로고    scopus 로고
    • Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats
    • J. Zhang, B.H. Zhang, Y.R. Yu, C.S. Tang, and Y.F. Qi Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats Peptides 32 2011 1415 1421
    • (2011) Peptides , vol.32 , pp. 1415-1421
    • Zhang, J.1    Zhang, B.H.2    Yu, Y.R.3    Tang, C.S.4    Qi, Y.F.5
  • 113
    • 84918808257 scopus 로고    scopus 로고
    • Plasma adrenomedullin levels and nasopharyngeal carcinoma prognosis
    • Z.L. Zhang, S.X. Huang, S. Lin, and L. Chai Plasma adrenomedullin levels and nasopharyngeal carcinoma prognosis Clin. Chim. Acta 440 2015 172 176
    • (2015) Clin. Chim. Acta , vol.440 , pp. 172-176
    • Zhang, Z.L.1    Huang, S.X.2    Lin, S.3    Chai, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.