메뉴 건너뛰기




Volumn 53, Issue 10, 2009, Pages 573-581

Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium

Author keywords

Adrenomedullin; Colitis; Epithelial barrier

Indexed keywords

ADRENOMEDULLIN; CYTOKINE; DEXTRAN SULFATE; GAMMA INTERFERON; STAT1 PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; CELL ADHESION MOLECULE; STAT1 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; VASODILATOR AGENT;

EID: 73349093417     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2009.00159.x     Document Type: Article
Times cited : (44)

References (51)
  • 2
    • 0031696393 scopus 로고    scopus 로고
    • Distribution and expression of adrenomedullin in human gastrointestinal tissue
    • Kitani M., Sakata J., Asada Y., Kitamura K., Eto T. (1998) Distribution and expression of adrenomedullin in human gastrointestinal tissue. Ann Clin Biochem35(Pt 5): 643-8.
    • (1998) Ann Clin Biochem , vol.35 , Issue.PART 5 , pp. 643-648
    • Kitani, M.1    Sakata, J.2    Asada, Y.3    Kitamura, K.4    Eto, T.5
  • 5
    • 0031763330 scopus 로고    scopus 로고
    • Novel sites of adrenomedullin gene expression in mouse and rat tissues
    • Cameron V.A., Fleming A.M. (1998) Novel sites of adrenomedullin gene expression in mouse and rat tissues. Endocrinology 139: 2253-64.
    • (1998) Endocrinology , vol.139 , pp. 2253-2264
    • Cameron, V.A.1    Fleming, A.M.2
  • 6
    • 0037090768 scopus 로고    scopus 로고
    • Adrenomedullin has multiple roles in disease stress: Development and remission of the inflammatory response
    • Elsasser T.H., Kahl S. (2002) Adrenomedullin has multiple roles in disease stress: development and remission of the inflammatory response. Microsc Res Tech 57: 120-9.
    • (2002) Microsc Res Tech , vol.57 , pp. 120-129
    • Elsasser, T.H.1    Kahl, S.2
  • 7
    • 0034802638 scopus 로고    scopus 로고
    • Adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect
    • Marutsuka K., Nawa Y., Asada Y., Hara S., Kitamura K., Eto T., Sumiyoshi A. (2001) Adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect. Exp Physiol 86: 543-5.
    • (2001) Exp Physiol , vol.86 , pp. 543-545
    • Marutsuka, K.1    Nawa, Y.2    Asada, Y.3    Hara, S.4    Kitamura, K.5    Eto, T.6    Sumiyoshi, A.7
  • 9
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C. (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205.
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 10
    • 0032707898 scopus 로고    scopus 로고
    • Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
    • StroberW
    • Blumberg R.S., Saubermann L.J., StroberW. (1999) Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol 11: 648-56.
    • (1999) Curr Opin Immunol , vol.11 , pp. 648-656
    • Blumberg, R.S.1    Saubermann, L.J.2
  • 12
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • StroberW
    • Bouma G., StroberW. (2003) The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3: 521-33.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1
  • 15
    • 0032030636 scopus 로고    scopus 로고
    • A mucosal intranet: Intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes
    • Yamamoto M., Fujihashi K., Kawabata K., McGhee J.R., Kiyono H. (1998) A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol 160: 2188-96.
    • (1998) J Immunol , vol.160 , pp. 2188-2196
    • Yamamoto, M.1    Fujihashi, K.2    Kawabata, K.3    McGhee, J.R.4    Kiyono, H.5
  • 17
    • 23344451487 scopus 로고    scopus 로고
    • IELs: Enforcing law and order in the court of the intestinal epithelium
    • Cheroutre H. (2005) IELs: enforcing law and order in the court of the intestinal epithelium. Immunol Rev 206: 114-31.
    • (2005) Immunol Rev , vol.206 , pp. 114-131
    • Cheroutre, H.1
  • 18
    • 33748182763 scopus 로고    scopus 로고
    • Komori H.K., Meehan T.F., HavranW.L. (2006) Epithelial and mucosal gamma delta T cells. Curr Opin Immunol 18: 534-8.
    • Komori H.K., Meehan T.F., HavranW.L. (2006) Epithelial and mucosal gamma delta T cells. Curr Opin Immunol 18: 534-8.
  • 20
  • 21
    • 33646779859 scopus 로고    scopus 로고
    • Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease
    • Gonzalez-Rey E., Fernandez-Martin A., Chorny A., Delgado M. (2006) Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease. Gut 55: 824-32.
    • (2006) Gut , vol.55 , pp. 824-832
    • Gonzalez-Rey, E.1    Fernandez-Martin, A.2    Chorny, A.3    Delgado, M.4
  • 25
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • StroberW
    • Fuss I.J., Neurath M., Boirivant M., Klein J.S., de la Motte C., Strong S.A., Fiocchi C., StroberW. (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157: 1261-70.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    de la Motte, C.5    Strong, S.A.6    Fiocchi, C.7
  • 26
    • 0026432216 scopus 로고
    • Inflammatory bowel disease (1)
    • Podolsky D.K. (1991) Inflammatory bowel disease (1).N Engl J Med 325: 928-37.
    • (1991) N Engl J Med , vol.325 , pp. 928-937
    • Podolsky, D.K.1
  • 27
    • 0031914778 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • Rogler G., Andus T. (1998) Cytokines in inflammatory bowel disease. World J Surg 22: 382-9.
    • (1998) World J Surg , vol.22 , pp. 382-389
    • Rogler, G.1    Andus, T.2
  • 28
    • 0031919849 scopus 로고    scopus 로고
    • LeonardW.J., O'Shea J.J. (1998) Jaks and STATs: biological implications. Annu Rev Immunol 16: 293-322.
    • LeonardW.J., O'Shea J.J. (1998) Jaks and STATs: biological implications. Annu Rev Immunol 16: 293-322.
  • 29
    • 44949130806 scopus 로고    scopus 로고
    • Signaling molecules: The pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
    • Atreya R., Neurath M.F. (2008) Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr Drug Targets 9: 369-74.
    • (2008) Curr Drug Targets , vol.9 , pp. 369-374
    • Atreya, R.1    Neurath, M.F.2
  • 31
    • 0041302153 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling and inflammatory diseases
    • Inagaki-Ohara K., Hanada T., Yoshimura A. (2003) Negative regulation of cytokine signaling and inflammatory diseases. Curr Opin Pharmacol 3: 435-42.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 435-442
    • Inagaki-Ohara, K.1    Hanada, T.2    Yoshimura, A.3
  • 32
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • Mombaerts P., Mizoguchi E., Grusby M.J., Glimcher L.H., Bhan A.K., Tonegawa S. (1993) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75: 274-82.
    • (1993) Cell , vol.75 , pp. 274-282
    • Mombaerts, P.1    Mizoguchi, E.2    Grusby, M.J.3    Glimcher, L.H.4    Bhan, A.K.5    Tonegawa, S.6
  • 33
    • 0037195101 scopus 로고    scopus 로고
    • Chen Y., Chou K., Fuchs E., HavranW.L., Boismenu R. (2002) Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99: 14338-43.
    • Chen Y., Chou K., Fuchs E., HavranW.L., Boismenu R. (2002) Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99: 14338-43.
  • 34
    • 0037369552 scopus 로고    scopus 로고
    • Intestinal epithelial responses to enteric pathogens: Effects on the tight junction barrier, ion transport, and inflammation
    • Berkes J., Viswanathan V.K., Savkovic S.D., Hecht G. (2003) Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 52: 439-51.
    • (2003) Gut , vol.52 , pp. 439-451
    • Berkes, J.1    Viswanathan, V.K.2    Savkovic, S.D.3    Hecht, G.4
  • 36
    • 0029918501 scopus 로고    scopus 로고
    • Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: Effects in CD4(+) -cell depleted, athymic and NK-cell depleted SCID mice
    • Axelsson L.G., Landstrom E., Goldschmidt T.J., Gronberg A., Bylund-Fellenius A.C. (1996) Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4(+) -cell depleted, athymic and NK-cell depleted SCID mice. Inflamm Res 45: 181-91.
    • (1996) Inflamm Res , vol.45 , pp. 181-191
    • Axelsson, L.G.1    Landstrom, E.2    Goldschmidt, T.J.3    Gronberg, A.4    Bylund-Fellenius, A.C.5
  • 38
    • 0033768784 scopus 로고    scopus 로고
    • Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency
    • Egger B., Bajaj-Elliott M., MacDonald T.T., Inglin R., Eysselein V.E., Buchler M.W. (2000) Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion 62: 240-8.
    • (2000) Digestion , vol.62 , pp. 240-248
    • Egger, B.1    Bajaj-Elliott, M.2    MacDonald, T.T.3    Inglin, R.4    Eysselein, V.E.5    Buchler, M.W.6
  • 39
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
    • Powrie F., Carlino J., Leach M.W., Mauze S., Coffman R.L. (1996) A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J ExpMed 183: 2669-74.
    • (1996) J ExpMed , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3    Mauze, S.4    Coffman, R.L.5
  • 40
    • 0029995799 scopus 로고    scopus 로고
    • Neurath M.F., Fuss I., Kelsall B.L., Presky D.H.,WaegellW., Strober W. (1996) Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J ExpMed 183: 2605-16.
    • Neurath M.F., Fuss I., Kelsall B.L., Presky D.H.,WaegellW., Strober W. (1996) Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J ExpMed 183: 2605-16.
  • 41
    • 0034600789 scopus 로고    scopus 로고
    • Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation
    • Kitani A., Fuss I.J., Nakamura K., Schwartz O.M., Usui T., Strober W. (2000) Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation. J ExpMed 192: 41-52.
    • (2000) J ExpMed , vol.192 , pp. 41-52
    • Kitani, A.1    Fuss, I.J.2    Nakamura, K.3    Schwartz, O.M.4    Usui, T.5    Strober, W.6
  • 42
    • 0026695311 scopus 로고
    • Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation
    • Ehrhardt R.O., StroberW., Harriman G.R. (1992) Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation. J Immunol 148: 3830-6.
    • (1992) J Immunol , vol.148 , pp. 3830-3836
    • Ehrhardt, R.O.1    StroberW2    Harriman, G.R.3
  • 43
    • 75749129030 scopus 로고    scopus 로고
    • Fujihashi K., Kawabata S., Hiroi T., Yamamoto M., McGhee J.R., Nishikawa S., Kiyono H. (1996) Interleukin 2 (IL-2) and interleukin
    • Fujihashi K., Kawabata S., Hiroi T., Yamamoto M., McGhee J.R., Nishikawa S., Kiyono H. (1996) Interleukin 2 (IL-2) and interleukin
  • 44
    • 75749145480 scopus 로고    scopus 로고
    • IL-7 reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes
    • (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proc Natl Acad Sci U S A 93: 3613-8.
    • Proc Natl Acad Sci U S A , vol.93 , pp. 3613-3618
  • 45
    • 0030714613 scopus 로고    scopus 로고
    • Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice
    • Inagaki-Ohara K., Nishimura H., Mitani A., Yoshikai Y. (1997) Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice. Eur J Immunol 27: 2885-91.
    • (1997) Eur J Immunol , vol.27 , pp. 2885-2891
    • Inagaki-Ohara, K.1    Nishimura, H.2    Mitani, A.3    Yoshikai, Y.4
  • 47
    • 0033405176 scopus 로고    scopus 로고
    • The intestinal epithelial cell: Processing and presentation of antigen to the mucosal immune system
    • Campbell N., Yio X.Y., So L.P., Li Y., Mayer L. (1999) The intestinal epithelial cell: processing and presentation of antigen to the mucosal immune system. Immunol Rev 172: 315-24.
    • (1999) Immunol Rev , vol.172 , pp. 315-324
    • Campbell, N.1    Yio, X.Y.2    So, L.P.3    Li, Y.4    Mayer, L.5
  • 48
    • 0032734313 scopus 로고    scopus 로고
    • Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium
    • O'Neil D.A., Porter E.M., Elewaut D., Anderson G.M., Eckmann L., Ganz T., Kagnoff M.F. (1999) Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 163: 6718-24.
    • (1999) J Immunol , vol.163 , pp. 6718-6724
    • O'Neil, D.A.1    Porter, E.M.2    Elewaut, D.3    Anderson, G.M.4    Eckmann, L.5    Ganz, T.6    Kagnoff, M.F.7
  • 49
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma
    • Mankertz J., Tavalali S., Schmitz H., Mankertz A., Riecken E.O., Fromm M., Schulzke J.D. (2000) Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 113(Pt 11): 2085-90.
    • (2000) J Cell Sci , vol.113 , Issue.PART 11 , pp. 2085-2090
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3    Mankertz, A.4    Riecken, E.O.5    Fromm, M.6    Schulzke, J.D.7
  • 50
    • 0026573173 scopus 로고
    • Intestinal permeability in patients with Crohn's disease and their first degree relatives
    • Teahon K., Smethurst P., Levi A.J., Menzies I.S., Bjarnason I. (1992) Intestinal permeability in patients with Crohn's disease and their first degree relatives. Gut 33: 320-3.
    • (1992) Gut , vol.33 , pp. 320-323
    • Teahon, K.1    Smethurst, P.2    Levi, A.J.3    Menzies, I.S.4    Bjarnason, I.5
  • 51
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
    • Irvine E.J., Marshall J.K. (2000) Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 119: 1740-4.
    • (2000) Gastroenterology , vol.119 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.