Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells

Journal of Hypertension

Volumn 14, Issue 2, 1996, Pages 209-213

  Kano, Hiroaki ^a   Kohno, Masakazu ^a   Yasunari, Kenichi ^a   Yokokawa, Koji ^a   Horio, Takeshi ^a   Ikeda, Miwako ^a   Minami, Mieko ^a   Hanehira, Takao ^a   Takeda, Tadanao ^a   Yoshikawa, Junichi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenomedullin; Cellular proliferation; Cyclic AMP; Vascular smooth muscle

Indexed keywords

8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC AMP; FORSKOLIN; THYMIDINE;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL COUNT; CELL PROLIFERATION; DNA SYNTHESIS; MUSCLE FIBER CULTURE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; VASCULAR SMOOTH MUSCLE;

EID: 0029937835     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199602000-00009     Document Type: Article

References (17)

1. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, et al.: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993, 192:553-560.
2. Ishizaka Y, Tanaka M, Kitamura K, Kangawa K, Minamino N, Matsuo H, et al.: Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells. Biochem Biophys Res Commun 1994, 200:642-646.
3. Eguchi S, Hirata Y, Kano H, Sato K, Watanabe Y, Watanabe TX, et al.: Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett 1994, 340:225-230.
4. Nuki C, Kawasaki H, Kitamura K, Takenaga M, Kangawa K, Eto T, et al.: Vasodilator effect of adrenomedullin and calcitonin gene related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun 1993, 196:245-251.
5. Kohno M, Yokokawa K, Tasunari K, Kano H, Horio T, Takeda T: Stimulation of cyclic adenosine monophosphate formation by the novel vasorelaxant peptide adrenomedullin in cultured rat mesangial cells. Metabolism 1995, 44:10-12.
6. Kohno M, Kano H, Hoario T, Yokokawa K, Tasunari K, Takeda T: Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells. Hypertension 1995, 25:1185-1190.
7. Kitamura K, Ichiki Y, Tanaka M, Kawamoto M, Emura J, Sakakibara S, et al.: Immunoreactive adrenomedullin in human plasma. FEBS Lett 1994, 341:288-290.
8. Horio T, Kohno M, Kano H, Ikeda M, Yasunari K, Yokokawa K, et al.: Adrenomedullin as a novel antimigration factor of vascular smooth muscle cells. Circ Res 1995, 77:660-664.
9. Yasunari K, Kohno M, Balmforth A, Murakawa K, Yokokawa K, Kurihara N, et al.:Glucocorticoids and dopamine-1 receptors on vascular smooth muscle cells. Hypertension 1989, 13:575-581.
10. Yasunari K, Kohno M, Murakawa K, Yokokawa K, Horio T, Takeda T; Interaction between a phorbol ester and dopamine DA1 receptors on vascular smooth muscle. Am J Physiol 1993, 264:F24-F30.
11. Eguchi S, Hirata Y, Ihara M, Yano M, Marumo F: A novel ETA antagonist (BQ-123) inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells. FEBS Lett 1992, 302:243-246.
12. Kohno M, Yasunari K, Yokokawa K, Murakawa K, Horio T, Takeda T: Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest 1991, 87:1999-2004.
13. Kohno M, Horio T, Ikeda M, Yokokawa K, Fukui T, Yasunari K, et al: Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int 1992, 42:860-866.
14. Wallenstein S, Zucker CL, Fleiss JL: Some statistical methods useful in circulation research. Circ Res 1980, 47:1-9.
15. Ishimitsu T, Nishikima T, Saito Y, Kitamura K, Eto T, Kangawa K, et al.: Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure. J Clin Invest 1994, 94:2158-2161.
16. Kohno M, Hanehira T, Kano H, Horio T, Yokokawa K, Ikeda M, et al.: Plasma adrenomedullin concentrations in essential hypertension. Hypertension 1996, 27:102-107.
17. Sugo S, Minamino N, Kangawa K, Miyamoto K, Kitamura K, Sakata J, et al.: Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 1994, 201:1160-1166.