A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo

British Journal of Pharmacology

Volumn 166, Issue 4, 2012, Pages 1261-1271

  Mapp, Paul I ^a   McWilliams, Daniel F ^a   Turley, Matthew J ^a,b   Hargin, Edward ^a,c   Walsh, David A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c NONE   (United Kingdom)

Author keywords

angiogenesis; calcitonin gene related peptide; capsaicin; endothelial cell proliferation

Indexed keywords

ADRENOMEDULLIN RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CAPSAICIN; MESSENGER RNA; NOLPITANTIUM; OLCEGEPANT; SODIUM CHLORIDE;

ADULT; AGED; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CELL NUCLEUS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; KNEE; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN SUBUNIT; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; RNA ANALYSIS; SPECIES COMPARISON; SYNOVITIS; SYNOVIUM;

EID: 84861313006     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01848.x     Document Type: Article

References (50)

1. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th Edition. Br J Pharmacol 164 (Suppl. 1): S1-S324.
2. Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, et al,. (1991). The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum 34: 505-514.
3. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al,. (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-324.
4. Ashraf S, Mapp PI, Walsh DA, (2010). Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis. Arthritis Rheum 62: 1890-1898.
5. Buckley TL, Brain SD, Collins PD, Williams TJ, (1991). Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide. J Immunol 146: 3424-3430.
6. Cruwys SC, Kidd BL, Mapp PI, Walsh DA, Blake DR, (1992). The effects of calcitonin gene-related peptide on formation of intra-articular oedema by inflammatory mediators. Br J Pharmacol 107: 116-119.
7. Doods H, Hallermayer G, Wu D, Entzeroth M, Rudolf K, Engel W, et al,. (2000). Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br J Pharmacol 129: 420-423.
8. Emonds-Alt X, Doutremepuich JD, Heaulme M, Neliat G, Santucci V, Steinberg R, et al,. (1993). In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur J Pharmacol 250: 403-413.
9. Haegerstrand A, Dalsgaard CJ, Jonzon B, Larsson O, Nilsson J, (1990). Calcitonin gene-related peptide stimulates proliferation of human endothelial cells. Proc Natl Acad Sci U S A 87: 3299-3303.
10. Hay DL, Conner AC, Howitt SG, Takhshid MA, Simms J, Mahmoud K, et al,. (2004). The pharmacology of CGRP-responsive receptors in cultured and transfected cells. Peptides 25: 2019-2026.
11. Hay DL, Christopoulos G, Christopoulos A, Sexton PM, (2006). Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl] carbonyl]pentyl]amino]-1- [(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4- (1,4-dihydro-2-oxo-3(2 H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors-the role of receptor activity modifying protein 1. Mol Pharmacol 70: 1984-1991.
12. Haywood L, McWilliams DF, Pearson CI, Gill SE, Ganesan A, Wilson D, et al,. (2003). Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum 48: 2173-2177.
13. Klareskog L, Catrina AI, Paget S, (2009). Rheumatoid arthritis. Lancet 373: 659-672.
14. Lam FY, Ferrell WR, (1991). Specific neurokinin receptors mediate plasma extravasation in the rat knee joint. Br J Pharmacol 103: 1263-1267.
15. Linscheid P, Seboek D, Zulewski H, Keller U, Muller B, (2005). Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. Endocrinology 146: 2699-2708.
16. Malcangio M, Bowery NG, (1994). Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord. Br J Pharmacol 113: 635-641.
17. Male D, Rahman J, Linke A, Zhao W, Hickey W, (1995). An interferon-inducible molecule on brain endothelium which controls lymphocyte adhesion mediated by integrins. Immunology 84: 453-460.
18. Mallee JJ, Salvatore CA, Lebourdelles B, Oliver KR, Longmore J, Koblan KS, et al,. (2002). Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. J Biol Chem 277: 14294-14298.
19. Mapp PI, Kidd BL, Gibson SJ, Terry JM, Revell PA, Ibrahim NB, et al,. (1990). Substance P-, calcitonin gene-related peptide- and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis. Neuroscience 37: 143-153.
20. Mapp PI, Walsh DA, Garrett NE, Kidd BL, Cruwys SC, Polak JM, et al,. (1994). Effect of three animal models of inflammation on nerve fibres in the synovium. Ann Rheum Dis 53: 240-246.
21. Mapp PI, Kerslake S, Brain SD, Blake DR, Cambridge H, (1996). The effect of intra-articular capsaicin on nerve fibres within the synovium of the rat knee joint. J Chem Neuroanat 10: 11-18.
22. Matsushita T, Matsui N, Yoshiya S, Fujioka H, Kurosaka M, (2004). Production of adrenomedullin from synovial cells in rheumatoid arthritis patients. Rheumatol Int 24: 20-24.
23. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al,. (1998). RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333-339.
24. McMurdo L, Lockhart JC, Ferrell WR, (1997). Modulation of synovial blood flow by the calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP(8-37). Br J Pharmacol 121: 1075-1080.
25. McWilliams DF, Watson SA, Crosbee DM, Michaeli D, Seth R, (1998). Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines. Gut 42: 795-798.
26. Min JK, Han KY, Kim EC, Kim YM, Lee SW, Kim OH, et al,. (2004). Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 64: 644-651.
27. Miyashita K, Itoh H, Sawada N, Fukunaga Y, Sone M, Yamahara K, et al,. (2003). Adrenomedullin promotes proliferation and migration of cultured endothelial cells. Hypertens Res 26 (Suppl.): S93-S98.
28. Pan CS, Jiang W, Zhong GZ, Zhao J, Pang YZ, Tang CS, et al,. (2005). Hypertension induced by nitric oxide synthase inhibitor increases responsiveness of ventricular myocardium and aorta of rat tissue to adrenomedullin stimulation in vitro. Life Sci 78: 398-405.
29. Pyun BJ, Choi S, Lee Y, Kim TW, Min JK, Kim Y, et al,. (2008). Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res 68: 227-235.
30. Recober A, Russo AF, (2009). Calcitonin gene-related peptide: an update on the biology. Curr Opin Neurol 22: 241-246.
31. Seegers HC, Hood VC, Kidd BL, Cruwys SC, Walsh DA, (2003). Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther 306: 8-12.
32. Seegers HC, Avery PS, McWilliams DF, Haywood L, Walsh DA, (2004). Combined effect of bradykinin B2 and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitis. FASEB J 18: 762-764.
33. Shenker NG, Haigh RC, Mapp PI, Harris N, Blake DR, (2008). Contralateral hyperalgesia and allodynia following intradermal capsaicin injection in man. Rheumatology (Oxford) 47: 1417-1421.
34. Shichiri M, Fukai N, Ozawa N, Iwasaki H, Hirata Y, (2003). Adrenomedullin is an autocrine/paracrine growth factor for rat vascular smooth muscle cells. Regul Pept 112: 167-173.
35. Stander S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, et al,. (2004). Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol 13: 129-139.
36. Szallasi A, Blumberg PM, (1999). Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51: 159-212.
37. Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, et al,. (2008). Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci U S A 105: 13550-13555.
38. Uzan B, Ea HK, Launay JM, Garel JM, Champy R, Cressent M, et al,. (2006). A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis. J Immunol 176: 5548-5558.
39. Verheggen R, Bumann K, Kaumann AJ, (2002). BIBN4096BS is a potent competitive antagonist of the relaxant effects of alpha-CGRP on human temporal artery: comparison with CGRP(8-37). Br J Pharmacol 136: 120-126.
40. Walker CS, Conner AC, Poyner DR, Hay DL, (2010). Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends Pharmacol Sci 31: 476-483.
41. Walsh DA, (1999). Angiogenesis and arthritis. Rheumatology (Oxford) 38: 103-112.
42. Walsh DA, Haywood L, (2001). Angiogenesis: a therapeutic target in arthritis. Curr Opin Investig Drugs 2: 1054-1063.
43. Walsh DA, McWilliams DF, (2006). Tachykinins and the cardiovascular system. Curr Drug Targets 7: 1031-1042.
44. Walsh DA, Mapp PI, Wharton J, Rutherford RA, Kidd BL, Revell PA, et al,. (1992). Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis. Ann Rheum Dis 51: 313-317.
45. Walsh DA, Salmon M, Mapp PI, Wharton J, Garrett N, Blake DR, et al,. (1993). Microvascular substance P binding to normal and inflamed rat and human synovium. J Pharmacol Exp Ther 267: 951-960.
46. Walsh DA, Rodway HA, Claxson A, (1998). Vascular turnover during carrageenan synovitis in the rat. Lab Invest 78: 1513-1521.
47. Waseem NH, Lane DP, (1990). Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. J Cell Sci 96 (Pt 1): 121-129.
48. Zhao Y, Hague S, Manek S, Zhang L, Bicknell R, Rees MC, (1998). PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium. Oncogene 16: 409-415.
49. Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, et al,. (2010). Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. Am J Physiol Cell Physiol 299: C1485-C1492.
50. Ziche M, Morbidelli L, Pacini M, Geppetti P, Alessandri G, Maggi CA, (1990). Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc Res 40: 264-278.