Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: Protection by adrenomedullin

Critical Care

Volumn 18, Issue 2, 2014, Pages

  Müller Redetzky, Holger C ^a   Will, Daniel ^a   Hellwig, Katharina ^a   Kummer, Wolfgang ^b,c   Tschernig, Thomas ^d   Pfeil, Uwe ^b   Paddenberg, Renate ^b   Menger, Michael D ^d   Kershaw, Olivia ^e   Gruber, Achim D ^e   Weissmann, Norbert ^f   Hippenstiel, Stefan ^a   Suttorp, Norbert ^a   Witzenrath, Martin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c German Center for Lung Research   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

^f Excellencecluster Cardio Pulmonary System Department of Internal Medicine   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; CYTOKINE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; BRONCHODILATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL LOAD; CONTINUOUS INFUSION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HISTOPATHOLOGY; INTESTINE INJURY; KIDNEY INJURY; LEUKOPENIA; LIVER INJURY; LUNG HEMODYNAMICS; LUNG MECHANICS; LUNG PERMEABILITY; MEMBRANE PERMEABILITY; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT INTUBATION; RESPIRATORY TRACT PARAMETERS; SEPSIS; STREPTOCOCCUS PNEUMONIA; SYSTEMIC DISEASE; TISSUE OXYGENATION; VENTILATOR INDUCED LUNG INJURY; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; PATHOLOGY; PNEUMONIA, PNEUMOCOCCAL; VENTILATOR-INDUCED LUNG INJURY;

ADRENOMEDULLIN; ANIMALS; BRONCHODILATOR AGENTS; FEMALE; MICE; MICE, INBRED C57BL; PNEUMONIA, PNEUMOCOCCAL; RESPIRATION, ARTIFICIAL; SEPSIS; VENTILATOR-INDUCED LUNG INJURY;

EID: 84901405086     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13830     Document Type: Article

References (33)

1. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000, 342:1301-1308.
2. Terragni PP, Del Sorbo L, Mascia L, Urbino R, Martin EL, Birocco A, Faggiano C, Quintel M, Gattinoni L, Ranieri VM. Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal. Anesthesiology 2009, 111:826-835. 10.1097/ALN.0b013e3181b764d2, 19741487.
3. Wolthuis EK, Vlaar AP, Choi G, Roelofs JJ, Juffermans NP, Schultz MJ. Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. Crit Care 2009, 13:R1. 10.1186/cc7688, 2688111, 19152704.
4. Dhanireddy S, Altemeier WA, Matute-Bello G, O'Mahony DS, Glenny RW, Martin TR, Liles WC. Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. Lab Invest 2006, 86:790-799. 10.1038/labinvest.3700440, 16855596.
5. Brunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C, Nierhaus A, Jaschinski U, Meier-Hellmann A, Weyland A, Grundling M, Moerer O, Riessen R, Seibel A, Ragaller M, Buchler MW, John S, Bach F, Spies C, Reill L, Fritz H, Kiehntopf M, Kuhnt E, Bogatsch H, Engel C, Loeffler M, Kollef MH, Reinhart K, Welte T. Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA 2012, 307:2390-2399. 10.1001/jama.2012.5833, 22692171.
6. van Kaam AH, Lachmann RA, Herting E, De Jaegere A, van Iwaarden F, Noorduyn LA, Kok JH, Haitsma JJ, Lachmann B. Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia. Am J Respir Crit Care Med 2004, 169:1046-1053. 10.1164/rccm.200312-1779OC, 14977624.
7. van Kaam AH, Lutter R, Lachmann RA, Haitsma JJ, Herting E, Snoek M, De Jaegere A, Kok JH, Lachmann B. Effect of ventilation strategy and surfactant on inflammation in experimental pneumonia. Eur Respir J 2005, 26:112-117. 10.1183/09031936.05.00144504, 15994397.
8. Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 2003, 289:2104-2112. 10.1001/jama.289.16.2104, 12709468.
9. Ranieri VM, Giunta F, Suter PM, Slutsky AS. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA 2000, 284:43-44. 10.1001/jama.284.1.43, 10872010.
10. Temmesfeld-Wollbruck B, Hocke AC, Suttorp N, Hippenstiel S. Adrenomedullin and endothelial barrier function. Thromb Haemost 2007, 98:944-951.
11. Hippenstiel S, Witzenrath M, Schmeck B, Hocke A, Krisp M, Krull M, Seybold J, Seeger W, Rascher W, Schutte H, Suttorp N. Adrenomedullin reduces endothelial hyperpermeability. Circ Res 2002, 91:618-625. 10.1161/01.RES.0000036603.61868.F9, 12364390.
12. Hocke AC, Temmesfeld-Wollbrueck B, Schmeck B, Berger K, Frisch EM, Witzenrath M, Brell B, Suttorp N, Hippenstiel S. Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin. Histochem Cell Biol 2006, 126:305-316. 10.1007/s00418-006-0174-5, 16596365.
13. Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S. Adrenomedullin attenuates ventilator-induced lung injury in mice. Thorax 2010, 65:1077-1084. 10.1136/thx.2010.135996, 20971983.
14. Temmesfeld-Wollbruck B, Brell B, David I, Dorenberg M, Adolphs J, Schmeck B, Suttorp N, Hippenstiel S. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med 2007, 33:703-710. 10.1007/s00134-007-0561-y, 17318497.
15. Witzenrath M, Schmeck B, Doehn JM, Tschernig T, Zahlten J, Loeffler JM, Zemlin M, Müller H, Gutbier B, Schutte H, Hippenstiel S, Fischetti VA, Suttorp N, Rosseau S. Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Crit Care Med 2009, 37:642-649. 10.1097/CCM.0b013e31819586a6, 19114881.
16. Müller-Redetzky HC, Kummer W, Pfeil U, Hellwig K, Will D, Paddenberg R, Tabeling C, Hippenstiel S, Suttorp N, Witzenrath M. Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice. PLoS ONE 2012, 7:e35832. 10.1371/journal.pone.0035832, 3341380, 22563471.
17. Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M. Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care 2010, 14:R143. 10.1186/cc9209, 2945124, 20673352.
18. Paddenberg R, Konig P, Faulhammer P, Goldenberg A, Pfeil U, Kummer W. Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices. Respir Res 2006, 7:93. 10.1186/1465-9921-7-93, 1524949, 16808843.
19. Vecchi A, Garlanda C, Lampugnani MG, Resnati M, Matteucci C, Stoppacciaro A, Schnurch H, Risau W, Ruco L, Mantovani A. Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol 1994, 63:247-254.
20. Sperling J, Schafer T, Ziemann C, Benz-Weiber A, Kollmar O, Schilling MK, Menger MD. Hepatic arterial infusion of bevacizumab in combination with oxaliplatin reduces tumor growth in a rat model of colorectal liver metastases. Clin Exp Metastasis 2012, 29:91-99. 10.1007/s10585-011-9432-6, 22052392.
21. Vaporidi K, Voloudakis G, Priniannakis G, Kondili E, Koutsopoulos A, Tsatsanis C, Georgopoulos D. Effects of respiratory rate on ventilator-induced lung injury at a constant PaCO2 in a mouse model of normal lung. Crit Care Med 2008, 36:1277-1283. 10.1097/CCM.0b013e318169f30e, 18379255.
22. Gonzalez-Rey E, Chorny A, Varela N, Robledo G, Delgado M. Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response. Am J Pathol 2006, 168:1921-1930. 10.2353/ajpath.2006.051104, 1606636, 16723707.
23. Itoh T, Obata H, Murakami S, Hamada K, Kangawa K, Kimura H, Nagaya N. Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol 2007, 293:L446-L452. 10.1152/ajplung.00412.2005, 17557801.
24. Wilson MR, O'Dea KP, Zhang D, Shearman AD, van Rooijen N, Takata M. Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury. Am J Respir Crit Care Med 2009, 179:914-922. 10.1164/rccm.200806-877OC, 2684018, 19218195.
25. Brell B, Temmesfeld-Wollbruck B, Altzschner I, Frisch E, Schmeck B, Hocke AC, Suttorp N, Hippenstiel S. Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage. Crit Care Med 2005, 33:819-826. 10.1097/01.CCM.0000159194.53695.7A, 15818111.
26. Brell B, Hippenstiel S, David I, Pries AR, Habazettl H, Schmeck B, Suttorp N, Temmesfeld-Wollbruck B. Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin-an intravital microscopic study on an isolated rat ileum. Crit Care Med 2005, 33:2810-016. 10.1097/01.CCM.0000190625.14268.09, 16352964.
27. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008, 358:111-124. 10.1056/NEJMoa071366, 18184957.
28. Vincent JL, De Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care 2005, 9:S9-S12. 10.1186/cc3748, 3226162, 16168075.
29. Charles PE, Piroth L, Desbiolles N, Lequeu C, Martin L, Portier H, Chavanet P. New model of ventilator-associated pneumonia in immunocompetent rabbits. Crit Care Med 2002, 30:2278-2283. 10.1097/00003246-200210000-00016, 12394956.
30. Pugin J, Dunn-Siegrist I, Dufour J, Tissieres P, Charles PE, Comte R. Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth. Am J Respir Cell Mol Biol 2008, 38:362-370. 10.1165/rcmb.2007-0114OC, 17921360.
31. Hammerschmidt S, Wolff S, Hocke A, Rosseau S, Muller E, Rohde M. Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect Immun 2005, 73:4653-4667. 10.1128/IAI.73.8.4653-4667.2005, 1201225, 16040978.
32. Carrizo GJ, Wu R, Cui X, Dwivedi AJ, Simms HH, Wang P. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Surgery 2007, 141:245-253. 10.1016/j.surg.2006.05.017, 17263982.
33. Yin H, Chao L, Chao J. Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling. Hypertension 2004, 43:109-116. 10.1161/01.HYP.0000103696.60047.55, 14662648.