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Volumn 19, Issue 20, 2013, Pages 5740-5748

The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; CALCITONIN RECEPTOR LIKE RECEPTOR; MESSENGER RNA;

EID: 84886427983     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1712     Document Type: Article
Times cited : (23)

References (49)
  • 2
    • 0034453838 scopus 로고    scopus 로고
    • Adrenomedullin, a multifunctional regulatory peptide
    • Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 2000;21:138-67.
    • (2000) Endocr Rev , vol.21 , pp. 138-167
    • Hinson, J.P.1    Kapas, S.2    Smith, D.M.3
  • 5
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia a key regulatory factor in tumour growth
    • Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 6
    • 0032574982 scopus 로고    scopus 로고
    • RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    • McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor- like receptor. Nature 1998;393: 333-9.
    • (1998) Nature , vol.393 , pp. 333-339
    • McLatchie, L.M.1    Fraser, N.J.2    Main, M.J.3    Wise, A.4    Brown, J.5    Thompson, N.6
  • 7
    • 0036266044 scopus 로고    scopus 로고
    • International union of pharmacology. XXXII. Themammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
    • Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, et al. International Union of Pharmacology. XXXII. Themammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002;54:233-46.
    • (2002) Pharmacol Rev , vol.54 , pp. 233-246
    • Poyner, D.R.1    Sexton, P.M.2    Marshall, I.3    Smith, D.M.4    Quirion, R.5    Born, W.6
  • 8
    • 0346882649 scopus 로고    scopus 로고
    • G-protein-coupled receptors at a glance
    • Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. J Cell Sci 2003;116:4867-9.
    • (2003) J Cell Sci , vol.116 , pp. 4867-4869
    • Kroeze, W.K.1    Sheffler, D.J.2    Roth, B.L.3
  • 10
    • 79952488185 scopus 로고    scopus 로고
    • Therapeutic potential of betaarrestin-and G protein-biased agonists
    • Whalen EJ, Rajagopal S, Lefkowitz RJ. Therapeutic potential of betaarrestin-and G protein-biased agonists. Trends Mol Med 2011;17: 126-39.
    • (2011) Trends Mol Med , vol.17 , pp. 126-139
    • Whalen, E.J.1    Rajagopal, S.2    Lefkowitz, R.J.3
  • 11
    • 78650845707 scopus 로고    scopus 로고
    • G protein-coupled receptors: Novel targets for drug discovery in cancer
    • Lappano R, Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 2011;10:47-60.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 47-60
    • Lappano, R.1    Maggiolini, M.2
  • 12
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007;7:79-94.
    • (2007) Nat Rev Cancer , vol.7 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 14
    • 1342288026 scopus 로고    scopus 로고
    • Affy-analysis of Affymetrix GeneChip data at the probe level
    • Gautier L, Cope L, Bolstad BM, Irizarry RA. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004;20:307-15.
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 16
    • 3042738138 scopus 로고    scopus 로고
    • Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    • Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Makinen T, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 2004;36:687-93.
    • (2004) Nat Genet , vol.36 , pp. 687-693
    • Wang, H.W.1    Trotter, M.W.2    Lagos, D.3    Bourboulia, D.4    Henderson, S.5    Makinen, T.6
  • 17
    • 0034945441 scopus 로고    scopus 로고
    • Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus
    • Nikitenko LL, Brown NS, Smith DM, MacKenzie IZ, Bicknell R, Rees MC. Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus. Mol Hum Reprod 2001;7:655-64.
    • (2001) Mol Hum Reprod , vol.7 , pp. 655-664
    • Nikitenko, L.L.1    Brown, N.S.2    Smith, D.M.3    Mackenzie, I.Z.4    Bicknell, R.5    Rees, M.C.6
  • 18
    • 77952815349 scopus 로고    scopus 로고
    • Automated uro-oncology data collection: The Cancer Research Uro-Oncology Database
    • Charlesworth PJ, Kilbey N, Taylor M, Leek R, Cranston D, Turner G, et al. Automated uro-oncology data collection: the Cancer Research Uro-Oncology Database. BJU Int 2010;105:1663-6.
    • (2010) BJU Int , vol.105 , pp. 1663-1666
    • Charlesworth, P.J.1    Kilbey, N.2    Taylor, M.3    Leek, R.4    Cranston, D.5    Turner, G.6
  • 20
    • 0020376310 scopus 로고
    • Prognostic significance of morphologic parameters in renal cell carcinoma
    • Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6: 655-63.
    • (1982) Am J Surg Pathol , vol.6 , pp. 655-663
    • Fuhrman, S.A.1    Lasky, L.C.2    Limas, C.3
  • 22
    • 33645223704 scopus 로고    scopus 로고
    • Adrenomedullin and CGRP interact with endogenous calcitoninreceptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms
    • Nikitenko LL, Blucher N, Fox SB, Bicknell R, Smith DM, Rees MC. Adrenomedullin and CGRP interact with endogenous calcitoninreceptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms. J Cell Sci 2006;119:910-22.
    • (2006) J Cell Sci , vol.119 , pp. 910-922
    • Nikitenko, L.L.1    Blucher, N.2    Fox, S.B.3    Bicknell, R.4    Smith, D.M.5    Rees, M.C.6
  • 23
    • 58749090733 scopus 로고    scopus 로고
    • The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy
    • Tan EY, Yan M, Campo L, Han C, Takano E, Turley H, et al. The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. Br J Cancer 2009;100:405-11.
    • (2009) Br J Cancer , vol.100 , pp. 405-411
    • Tan, E.Y.1    Yan, M.2    Campo, L.3    Han, C.4    Takano, E.5    Turley, H.6
  • 24
    • 25444506836 scopus 로고    scopus 로고
    • Upregulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL. Upregulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005;65:8690-7.
    • (2005) Cancer Res , vol.65 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 25
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in realtime RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 26
    • 77950560825 scopus 로고    scopus 로고
    • Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer
    • Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, et al. Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am J Pathol 2010;176:2019-28.
    • (2010) Am J Pathol , vol.176 , pp. 2019-2028
    • Jubb, A.M.1    Soilleux, E.J.2    Turley, H.3    Steers, G.4    Parker, A.5    Low, I.6
  • 27
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • Leek RD, Landers RJ, Harris AL, Lewis CE. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer 1999;79:991-5.
    • (1999) Br J Cancer , vol.79 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 28
    • 0035800877 scopus 로고    scopus 로고
    • Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins
    • Hilairet S, Foord SM, Marshall FH, Bouvier M. Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins. J Biol Chem 2001;276:29575-81.
    • (2001) J Biol Chem , vol.276 , pp. 29575-29581
    • Hilairet, S.1    Foord, S.M.2    Marshall, F.H.3    Bouvier, M.4
  • 29
    • 33750379765 scopus 로고    scopus 로고
    • Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density
    • Nikitenko LL, Cross T, Campo L, Turley H, Leek R, Manek S, et al. Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: endothelial phenotype and association with microvascular density. Clin Cancer Res 2006;12:5648-58.
    • (2006) Clin Cancer Res , vol.12 , pp. 5648-5658
    • Nikitenko, L.L.1    Cross, T.2    Campo, L.3    Turley, H.4    Leek, R.5    Manek, S.6
  • 30
    • 0030568539 scopus 로고    scopus 로고
    • ABC of urology-urological malignancy. 3. Renal and testicular carcinoma
    • Dawson C, Whitfield H. ABC of urology-urological malignancy .3. Renal and testicular carcinoma. Br Med J 1996;312:1146-8.
    • (1996) Br Med J , vol.312 , pp. 1146-1148
    • Dawson, C.1    Whitfield, H.2
  • 33
    • 41149138113 scopus 로고    scopus 로고
    • Lessons from multidisciplinary translational trials on antiangiogenic therapy of cancer
    • Jain RK. Lessons from multidisciplinary translational trials on antiangiogenic therapy of cancer. Nat Rev Cancer 2008;8:309-16.
    • (2008) Nat Rev Cancer , vol.8 , pp. 309-316
    • Jain, R.K.1
  • 37
    • 84864052669 scopus 로고    scopus 로고
    • Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
    • Wilkinson RN, Koudijs MJ, Patient RK, Ingham PW, Schulte-Merker S, van Eeden FJ. Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood 2012;120:477-88.
    • (2012) Blood , vol.120 , pp. 477-488
    • Wilkinson, R.N.1    Koudijs, M.J.2    Patient, R.K.3    Ingham, P.W.4    Schulte-Merker, S.5    Van Eeden, F.J.6
  • 38
    • 70349859781 scopus 로고    scopus 로고
    • Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma
    • Deville JL, Bartoli C, Berenguer C, Fernandez-Sauze S, Kaafarani I, Delfino C, et al. Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma. Int J Cancer 2009;125:2307-15.
    • (2009) Int J Cancer , vol.125 , pp. 2307-2315
    • Deville, J.L.1    Bartoli, C.2    Berenguer, C.3    Fernandez-Sauze, S.4    Kaafarani, I.5    Delfino, C.6
  • 39
    • 0035996529 scopus 로고    scopus 로고
    • Involvement of adrenomedullin induced by hypoxia in angiogenesis in human renal cell carcinoma
    • Fujita Y, Mimata H, Nasu N, Nomura T, Nomura Y, Nakagawa M. Involvement of adrenomedullin induced by hypoxia in angiogenesis in human renal cell carcinoma. Int J Urol 2002;9:285-95.
    • (2002) Int J Urol , vol.9 , pp. 285-295
    • Fujita, Y.1    Mimata, H.2    Nasu, N.3    Nomura, T.4    Nomura, Y.5    Nakagawa, M.6
  • 41
    • 84886425407 scopus 로고    scopus 로고
    • Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo
    • Nouguerede E, Berenguer C, Garcia S, Bennani B, Delfino C, Nanni I, et al. Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo. Cancer Med 2013;2:196-207.
    • (2013) Cancer Med , vol.2 , pp. 196-207
    • Nouguerede, E.1    Berenguer, C.2    Garcia, S.3    Bennani, B.4    Delfino, C.5    Nanni, I.6
  • 42
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 43
    • 38149064606 scopus 로고    scopus 로고
    • Adrenomedullin signaling is necessary for murine lymphatic vascular development
    • Fritz-Six KL, Dunworth WP, Li M, Caron KM. Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest 2008;118:40-50.
    • (2008) J Clin Invest , vol.118 , pp. 40-50
    • Fritz-Six, K.L.1    Dunworth, W.P.2    Li, M.3    Caron, K.M.4
  • 44
  • 45
    • 79959469433 scopus 로고    scopus 로고
    • The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair
    • Maybin JA, Battersby S, Hirani N, Nikitenko LL, Critchley HO, Jabbour HN. The expression and regulation of adrenomedullin in the human endometrium: a candidate for endometrial repair. Endocrinology 2011;152:2845-56.
    • (2011) Endocrinology , vol.152 , pp. 2845-2856
    • Maybin, J.A.1    Battersby, S.2    Hirani, N.3    Nikitenko, L.L.4    Critchley, H.O.5    Jabbour, H.N.6
  • 47
    • 77957364747 scopus 로고    scopus 로고
    • Translating cancer research into targeted therapeutics
    • de Bono JS, Ashworth A. Translating cancer research into targeted therapeutics. Nature 2010;467:543-9.
    • (2010) Nature , vol.467 , pp. 543-549
    • De Bono, J.S.1    Ashworth, A.2
  • 48
    • 70349659021 scopus 로고    scopus 로고
    • Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice
    • Kaafarani I, Fernandez-Sauze S, Berenguer C, Chinot O, Delfino C, Dussert C, et al. Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice. FASEB J 2009;23:3424-35.
    • (2009) FASEB J , vol.23 , pp. 3424-3435
    • Kaafarani, I.1    Fernandez-Sauze, S.2    Berenguer, C.3    Chinot, O.4    Delfino, C.5    Dussert, C.6
  • 49
    • 80053374553 scopus 로고    scopus 로고
    • Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development
    • Archbold JK, Flanagan JU, Watkins HA, Gingell JJ, Hay DL. Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development. Trends Pharmacol Sci 2011;32:591-600.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 591-600
    • Archbold, J.K.1    Flanagan, J.U.2    Watkins, H.A.3    Gingell, J.J.4    Hay, D.L.5


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