-
1
-
-
0027197671
-
Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
-
Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192:553-60.
-
(1993)
Biochem Biophys Res Commun
, vol.192
, pp. 553-560
-
-
Kitamura, K.1
Kangawa, K.2
Kawamoto, M.3
Ichiki, Y.4
Nakamura, S.5
Matsuo, H.6
-
2
-
-
0034453838
-
Adrenomedullin, a multifunctional regulatory peptide
-
Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 2000;21:138-67.
-
(2000)
Endocr Rev
, vol.21
, pp. 138-167
-
-
Hinson, J.P.1
Kapas, S.2
Smith, D.M.3
-
4
-
-
30644461078
-
Adrenomedullin and tumour angiogenesis
-
Nikitenko LL, Fox SB, Kehoe S, Rees MC, Bicknell R. Adrenomedullin and tumour angiogenesis. Br J Cancer 2006;94:1-7.
-
(2006)
Br J Cancer
, vol.94
, pp. 1-7
-
-
Nikitenko, L.L.1
Fox, S.B.2
Kehoe, S.3
Rees, M.C.4
Bicknell, R.5
-
5
-
-
0036359548
-
Hypoxia a key regulatory factor in tumour growth
-
Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
6
-
-
0032574982
-
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
-
McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor- like receptor. Nature 1998;393: 333-9.
-
(1998)
Nature
, vol.393
, pp. 333-339
-
-
McLatchie, L.M.1
Fraser, N.J.2
Main, M.J.3
Wise, A.4
Brown, J.5
Thompson, N.6
-
7
-
-
0036266044
-
International union of pharmacology. XXXII. Themammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
-
Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, et al. International Union of Pharmacology. XXXII. Themammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002;54:233-46.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 233-246
-
-
Poyner, D.R.1
Sexton, P.M.2
Marshall, I.3
Smith, D.M.4
Quirion, R.5
Born, W.6
-
10
-
-
79952488185
-
Therapeutic potential of betaarrestin-and G protein-biased agonists
-
Whalen EJ, Rajagopal S, Lefkowitz RJ. Therapeutic potential of betaarrestin-and G protein-biased agonists. Trends Mol Med 2011;17: 126-39.
-
(2011)
Trends Mol Med
, vol.17
, pp. 126-139
-
-
Whalen, E.J.1
Rajagopal, S.2
Lefkowitz, R.J.3
-
11
-
-
78650845707
-
G protein-coupled receptors: Novel targets for drug discovery in cancer
-
Lappano R, Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 2011;10:47-60.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 47-60
-
-
Lappano, R.1
Maggiolini, M.2
-
12
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007;7:79-94.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
15
-
-
33744468281
-
A molecular map of mesenchymal tumors
-
Henderson SR, Guiliano D, Presneau N, McLean S, Frow R, Vujovic S, et al. A molecular map of mesenchymal tumors. Genome Biol 2005;6: R76.
-
(2005)
Genome Biol
, vol.6
-
-
Henderson, S.R.1
Guiliano, D.2
Presneau, N.3
McLean, S.4
Frow, R.5
Vujovic, S.6
-
16
-
-
3042738138
-
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
-
Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Makinen T, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 2004;36:687-93.
-
(2004)
Nat Genet
, vol.36
, pp. 687-693
-
-
Wang, H.W.1
Trotter, M.W.2
Lagos, D.3
Bourboulia, D.4
Henderson, S.5
Makinen, T.6
-
17
-
-
0034945441
-
Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus
-
Nikitenko LL, Brown NS, Smith DM, MacKenzie IZ, Bicknell R, Rees MC. Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus. Mol Hum Reprod 2001;7:655-64.
-
(2001)
Mol Hum Reprod
, vol.7
, pp. 655-664
-
-
Nikitenko, L.L.1
Brown, N.S.2
Smith, D.M.3
Mackenzie, I.Z.4
Bicknell, R.5
Rees, M.C.6
-
18
-
-
77952815349
-
Automated uro-oncology data collection: The Cancer Research Uro-Oncology Database
-
Charlesworth PJ, Kilbey N, Taylor M, Leek R, Cranston D, Turner G, et al. Automated uro-oncology data collection: the Cancer Research Uro-Oncology Database. BJU Int 2010;105:1663-6.
-
(2010)
BJU Int
, vol.105
, pp. 1663-1666
-
-
Charlesworth, P.J.1
Kilbey, N.2
Taylor, M.3
Leek, R.4
Cranston, D.5
Turner, G.6
-
20
-
-
0020376310
-
Prognostic significance of morphologic parameters in renal cell carcinoma
-
Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6: 655-63.
-
(1982)
Am J Surg Pathol
, vol.6
, pp. 655-663
-
-
Fuhrman, S.A.1
Lasky, L.C.2
Limas, C.3
-
22
-
-
33645223704
-
Adrenomedullin and CGRP interact with endogenous calcitoninreceptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms
-
Nikitenko LL, Blucher N, Fox SB, Bicknell R, Smith DM, Rees MC. Adrenomedullin and CGRP interact with endogenous calcitoninreceptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms. J Cell Sci 2006;119:910-22.
-
(2006)
J Cell Sci
, vol.119
, pp. 910-922
-
-
Nikitenko, L.L.1
Blucher, N.2
Fox, S.B.3
Bicknell, R.4
Smith, D.M.5
Rees, M.C.6
-
23
-
-
58749090733
-
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy
-
Tan EY, Yan M, Campo L, Han C, Takano E, Turley H, et al. The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. Br J Cancer 2009;100:405-11.
-
(2009)
Br J Cancer
, vol.100
, pp. 405-411
-
-
Tan, E.Y.1
Yan, M.2
Campo, L.3
Han, C.4
Takano, E.5
Turley, H.6
-
24
-
-
25444506836
-
Upregulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
-
Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL. Upregulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005;65:8690-7.
-
(2005)
Cancer Res
, vol.65
, pp. 8690-8697
-
-
Patel, N.S.1
Li, J.L.2
Generali, D.3
Poulsom, R.4
Cranston, D.W.5
Harris, A.L.6
-
25
-
-
17344392308
-
A new mathematical model for relative quantification in realtime RT-PCR
-
Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:e45.
-
(2001)
Nucleic Acids Res
, vol.29
-
-
Pfaffl, M.W.1
-
26
-
-
77950560825
-
Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer
-
Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, et al. Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am J Pathol 2010;176:2019-28.
-
(2010)
Am J Pathol
, vol.176
, pp. 2019-2028
-
-
Jubb, A.M.1
Soilleux, E.J.2
Turley, H.3
Steers, G.4
Parker, A.5
Low, I.6
-
27
-
-
0033067163
-
Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
-
Leek RD, Landers RJ, Harris AL, Lewis CE. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer 1999;79:991-5.
-
(1999)
Br J Cancer
, vol.79
, pp. 991-995
-
-
Leek, R.D.1
Landers, R.J.2
Harris, A.L.3
Lewis, C.E.4
-
28
-
-
0035800877
-
Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins
-
Hilairet S, Foord SM, Marshall FH, Bouvier M. Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins. J Biol Chem 2001;276:29575-81.
-
(2001)
J Biol Chem
, vol.276
, pp. 29575-29581
-
-
Hilairet, S.1
Foord, S.M.2
Marshall, F.H.3
Bouvier, M.4
-
29
-
-
33750379765
-
Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density
-
Nikitenko LL, Cross T, Campo L, Turley H, Leek R, Manek S, et al. Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: endothelial phenotype and association with microvascular density. Clin Cancer Res 2006;12:5648-58.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5648-5658
-
-
Nikitenko, L.L.1
Cross, T.2
Campo, L.3
Turley, H.4
Leek, R.5
Manek, S.6
-
30
-
-
0030568539
-
ABC of urology-urological malignancy. 3. Renal and testicular carcinoma
-
Dawson C, Whitfield H. ABC of urology-urological malignancy .3. Renal and testicular carcinoma. Br Med J 1996;312:1146-8.
-
(1996)
Br Med J
, vol.312
, pp. 1146-1148
-
-
Dawson, C.1
Whitfield, H.2
-
32
-
-
33846866256
-
Innovations and challenges in renal cell carcinoma: Summary statement from the Second Cambridge Conference
-
Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG Jr, et al. Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference. Clin Cancer Res 2007;13:667s-70s.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Atkins, M.B.1
Ernstoff, M.S.2
Figlin, R.A.3
Flaherty, K.T.4
George, D.J.5
Kaelin Jr., W.G.6
-
33
-
-
41149138113
-
Lessons from multidisciplinary translational trials on antiangiogenic therapy of cancer
-
Jain RK. Lessons from multidisciplinary translational trials on antiangiogenic therapy of cancer. Nat Rev Cancer 2008;8:309-16.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 309-316
-
-
Jain, R.K.1
-
34
-
-
67650380136
-
Biomarkers of response and resistance to antiangiogenic therapy
-
Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 2009;6:327-38.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 327-338
-
-
Jain, R.K.1
Duda, D.G.2
Willett, C.G.3
Sahani, D.V.4
Zhu, A.X.5
Loeffler, J.S.6
-
37
-
-
84864052669
-
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
-
Wilkinson RN, Koudijs MJ, Patient RK, Ingham PW, Schulte-Merker S, van Eeden FJ. Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood 2012;120:477-88.
-
(2012)
Blood
, vol.120
, pp. 477-488
-
-
Wilkinson, R.N.1
Koudijs, M.J.2
Patient, R.K.3
Ingham, P.W.4
Schulte-Merker, S.5
Van Eeden, F.J.6
-
38
-
-
70349859781
-
Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma
-
Deville JL, Bartoli C, Berenguer C, Fernandez-Sauze S, Kaafarani I, Delfino C, et al. Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma. Int J Cancer 2009;125:2307-15.
-
(2009)
Int J Cancer
, vol.125
, pp. 2307-2315
-
-
Deville, J.L.1
Bartoli, C.2
Berenguer, C.3
Fernandez-Sauze, S.4
Kaafarani, I.5
Delfino, C.6
-
39
-
-
0035996529
-
Involvement of adrenomedullin induced by hypoxia in angiogenesis in human renal cell carcinoma
-
Fujita Y, Mimata H, Nasu N, Nomura T, Nomura Y, Nakagawa M. Involvement of adrenomedullin induced by hypoxia in angiogenesis in human renal cell carcinoma. Int J Urol 2002;9:285-95.
-
(2002)
Int J Urol
, vol.9
, pp. 285-295
-
-
Fujita, Y.1
Mimata, H.2
Nasu, N.3
Nomura, T.4
Nomura, Y.5
Nakagawa, M.6
-
40
-
-
33745778687
-
Tissue expression and plasma levels of adrenomedullin in renal cancer patients
-
Michelsen J, Thiesson H, Walter S, Ottosen PD, Skott O, Jensen BL. Tissue expression and plasma levels of adrenomedullin in renal cancer patients. Clin Sci 2006;111:61-70.
-
(2006)
Clin Sci
, vol.111
, pp. 61-70
-
-
Michelsen, J.1
Thiesson, H.2
Walter, S.3
Ottosen, P.D.4
Skott, O.5
Jensen, B.L.6
-
41
-
-
84886425407
-
Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo
-
Nouguerede E, Berenguer C, Garcia S, Bennani B, Delfino C, Nanni I, et al. Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo. Cancer Med 2013;2:196-207.
-
(2013)
Cancer Med
, vol.2
, pp. 196-207
-
-
Nouguerede, E.1
Berenguer, C.2
Garcia, S.3
Bennani, B.4
Delfino, C.5
Nanni, I.6
-
42
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
43
-
-
38149064606
-
Adrenomedullin signaling is necessary for murine lymphatic vascular development
-
Fritz-Six KL, Dunworth WP, Li M, Caron KM. Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest 2008;118:40-50.
-
(2008)
J Clin Invest
, vol.118
, pp. 40-50
-
-
Fritz-Six, K.L.1
Dunworth, W.P.2
Li, M.3
Caron, K.M.4
-
44
-
-
56549093824
-
Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
-
Jin D, Harada K, Ohnishi S, Yamahara K, Kangawa K, Nagaya N. Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema. Cardiovasc Res 2008;80:339-45.
-
(2008)
Cardiovasc Res
, vol.80
, pp. 339-345
-
-
Jin, D.1
Harada, K.2
Ohnishi, S.3
Yamahara, K.4
Kangawa, K.5
Nagaya, N.6
-
45
-
-
79959469433
-
The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair
-
Maybin JA, Battersby S, Hirani N, Nikitenko LL, Critchley HO, Jabbour HN. The expression and regulation of adrenomedullin in the human endometrium: a candidate for endometrial repair. Endocrinology 2011;152:2845-56.
-
(2011)
Endocrinology
, vol.152
, pp. 2845-2856
-
-
Maybin, J.A.1
Battersby, S.2
Hirani, N.3
Nikitenko, L.L.4
Critchley, H.O.5
Jabbour, H.N.6
-
46
-
-
84879420155
-
Adrenomedullin haploinsufficiency predisposes to secondary lymphedema
-
Nikitenko LL, Shimosawa T, Henderson S, Makinen T, Shimosawa H, Qureshi U, et al. Adrenomedullin haploinsufficiency predisposes to secondary lymphedema. J Invest Dermatol 2013;133:1768-76.
-
(2013)
J Invest Dermatol
, vol.133
, pp. 1768-1776
-
-
Nikitenko, L.L.1
Shimosawa, T.2
Henderson, S.3
Makinen, T.4
Shimosawa, H.5
Qureshi, U.6
-
47
-
-
77957364747
-
Translating cancer research into targeted therapeutics
-
de Bono JS, Ashworth A. Translating cancer research into targeted therapeutics. Nature 2010;467:543-9.
-
(2010)
Nature
, vol.467
, pp. 543-549
-
-
De Bono, J.S.1
Ashworth, A.2
-
48
-
-
70349659021
-
Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice
-
Kaafarani I, Fernandez-Sauze S, Berenguer C, Chinot O, Delfino C, Dussert C, et al. Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice. FASEB J 2009;23:3424-35.
-
(2009)
FASEB J
, vol.23
, pp. 3424-3435
-
-
Kaafarani, I.1
Fernandez-Sauze, S.2
Berenguer, C.3
Chinot, O.4
Delfino, C.5
Dussert, C.6
-
49
-
-
80053374553
-
Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development
-
Archbold JK, Flanagan JU, Watkins HA, Gingell JJ, Hay DL. Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development. Trends Pharmacol Sci 2011;32:591-600.
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 591-600
-
-
Archbold, J.K.1
Flanagan, J.U.2
Watkins, H.A.3
Gingell, J.J.4
Hay, D.L.5
|