Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 1, 2015, Pages L27-L36

  Sussan, Thomas E ^a   Gajghate, Sachin ^a   Chatterjee, Samit ^a   Mandke, Pooja ^b   McCormick, Sarah ^a   Sudini, Kuladeep ^a   Kumar, Sarvesh ^a   Breysse, Patrick N ^a   Diette, Gregory B ^b   Sidhaye, Venkataramana K ^b   Biswal, Shyam ^a  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Airway hyperresponsiveness; Inflammation; Ovalbumin; Oxidative stress; Th2

Indexed keywords

2 TRIFLUOROMETHYL 2' METHOXYCHALONE; AGENTS AFFECTING METABOLISM; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN ZO1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UVOMORULIN; 2-TRIFLUOROMETHYL-2'-METHOXYCHALONE; CADHERIN; CHALCONE DERIVATIVE; CYTOKINE; CYTOSKELETON PROTEIN; KEAP1 PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; OVALBUMIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE DELETION; GENE EXPRESSION; INFLAMMATION; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MALE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT ALLERGY; TH2 CELL; ANIMAL; ASTHMA; BRONCHUS HYPERREACTIVITY; C57BL MOUSE; CHEMICALLY INDUCED; CYTOLOGY; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; MOUSE; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SECRETION (PROCESS); TIGHT JUNCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CADHERINS; CHALCONES; CYTOKINES; CYTOPROTECTION; CYTOSKELETAL PROTEINS; EPITHELIAL CELLS; INFLAMMATION; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OVALBUMIN; OXIDATIVE STRESS; RESPIRATORY MUCOSA; TH2 CELLS; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84936146421     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00398.2014     Document Type: Article

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