HIV-1 myristoylated nef treatment of murine microglial cells activates inducible nitric oxide synthase, NO2 production and neurotoxic activity

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Mangino, Giorgio ^a,b   Famiglietti, Marylinda ^a   Capone, Caterina ^a   Veroni, Caterina ^c   Percario, Zulema Antonia ^a   Leone, Stefano ^a   Fiorucci, Gianna ^d   Lülf, Sebastian ^e   Romeo, Giovanna ^b,d   Agresti, Cristina ^c   Persichini, Tiziana ^a   Geyer, Matthias ^e   Affabris, Elisabetta ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d CNR   (Italy)

^e CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; HOST FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; NEF PROTEIN; NITROGEN DIOXIDE; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; VIRUS PROTEIN; GAMMA INTERFERON; MESSENGER RNA; MYRISTIC ACID; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; NITRIC OXIDE; NOS2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME RELEASE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROGLIA; MOUSE; MYRISTYLATION; NEUROTOXICITY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SUPERNATANT; UPREGULATION; ANIMAL; CELL CULTURE; ENZYME IMMUNOASSAY; GENETICS; MACROPHAGE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE; MUS MUSCULUS;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; HUMANS; IMMUNOENZYME TECHNIQUES; INTERFERON-GAMMA; MACROPHAGES; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; MYRISTIC ACID; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84936102283     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130189     Document Type: Article

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