Oligodendrocyte-Specific Expression of Human Immunodeficiency Virus Type 1 Nef in Transgenic Mice Leads to Vacuolar Myelopathy and Alters Oligodendrocyte Phenotype In Vitro

Journal of Virology

Volumn 77, Issue 21, 2003, Pages 11745-11753

  Radia, Fatiha ^a   Kay, Denis G ^a   Albrecht, Steffen ^b   Jolicoeur, Paul ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; GALACTOSYLCERAMIDE; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; NEF PROTEIN; RNA; SULFATIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD DISEASE; TRANSGENIC MOUSE; VACUOLAR MYELOPATHY;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE PRODUCTS, NEF; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; MYELIN-ASSOCIATED GLYCOPROTEIN; OLIGODENDROGLIA; PHENOTYPE; SPINAL CORD; SPINAL CORD DISEASES; TRANSGENES; VACUOLES;

EID: 0142028840     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.21.11745-11753.2003     Document Type: Article

References (54)

1. Albright, A. V., J. Strizki, J. M. Harouse, E. Lavi, M. O'Connor, and F. Gonzalez-Scarano 1996. HIV-1 infection of cultured human adult oligodendrocytes. Virology 217:211-219.
2. An, S. F., M. Groves, B. Giometto, A. A. Beckett, and F. Scaravilli. 1999. Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/in situ hybridisation technique. Acta Neuropathol. 98:481-487.
3. Arendt, C. W., and D. R. Littman. 2001. HIV: master of the host cell. Genome Biol. 2:1030.
4. Bagasra, O., E. Lavi, L. Bobroski, K. Khalili, J. P. Pestaner, R. Tawadros, and R. J. Pomerantz. 1996. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 10:573-585.
5. Bansal, R., A. E. Warrington, A. L. Gard, B. Ranscht, and S. E. Pfeiffer. 1989. Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development. J. Neurosci. Res. 24:548-557.
6. Bansal, R., S. Winkler, and S. Bheddah. 1999. Negative regulation of oligodendrocyte differentiation by galactosphingolipids. J. Neurosci. 19:7913-7924.
7. Brack-Werner, R., A. Kleinschmidt, A. Ludvigsen, W. Mellert, M. Neumann, R. Herrmann, M. C. Khim, A. Burny, N. Muller-Lantzsch, and D. Stavrou. 1992. Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. AIDS 6:273-285.
8. Budka, H., and H. Lassmann. 1988. Human immunodeficiency virus in glial cells? J. Infect. Dis. 157:203-205.
9. Campagnoni, A. T. 1988. Molecular biology of myelin proteins from the central nervous system. J. Neurochem. 51:1-14.
10. Coȩtzee, T., N. Fujita, J. Dupree, R. Shi, A. Blight, K. Suzuki, and B. Popko. 1996. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 86:209-219.
11. Coetzee, T., K. Suzuki, and B. Popko. 1998. New perspectives on the function of myelin galactolipids. Trends Neurosci. 21:126-130.
12. Dal Pan, G. J., J. D. Glass, and J. C. McArthur. 1994. Clinicopathologic correlations of HIV-1-associated vacuolar myelopathy: an autopsy-based case-control study. Neurology 44:2159-2164.
13. Davies, K. 1993. The cause of Canavan's disease. Nature 365:590.
14. Eilbott, D. J., N. Peress, H. Burger, D. LaNeve, J. Orenstein, H. E. S. R. Gendelman, and B. Weiser. 1989. Human immunodeficiency virus type 1 in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages. Proc. Natl. Acad. Sci. USA 86:3337-3341.
15. Esiri, M., C. S. Morris, and P. R. Millard. 1991. Fate of oligodendrocytes in HIV-1 infection. AIDS 5:1081-1088.
16. Gosztonyi, G., J. Artigas, L. Lamperth, and H. D. Webster. 1994. Human immunodeficiency virus (HIV) distribution in HIV encephalitis: study of 19 cases with combined use of in situ hybridization and immunocytochemistry. J. Neuropathol. Exp. Neurol. 53:521-534.
17. Goudreau, G., S. Carpenter, N. Beaulieu, and P. Jolicoeur. 1996. Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulation of the myelin basic protein gene promoter. Nat. Med. 2:655-661.
18. Gravel, M., D. DeAngelis, and P. E. Braun. 1994. Molecular cloning and characterization of rat brain 2′,3′-cyclic nucleotide 3′-phosphodiesterase isoform 2. J. Neurosci. Res. 38:243-247.
19. Gyorkey, F., J. L. Melnick, and P. Gyorkey. 1987. Human immunodeficiency virus in brain biopsies of patients with AIDS and progressive encephalopathy. J. Infect. Dis. 155:870-876.
20. Hanna, Z., D. G. Kay, N. Rebai, A. Guimond, S. Jothy, and P. Jolicoeur. 1998. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95:163-175.
21. Hanna, Z., X. Weng, D. G. Kay, J. Poudrier, C. Lowell, and P. Jolicoeur. 2001. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J. Virol. 75:9378-9392.
22. Katsuki, M., M. Sato, M. Kimura, M. Yokoyama, K. Kobayashi, and T. Nomura. 1988. Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice. Science 241:593-595.
23. Kay, D. G., P. Yue, Z. Hanna, S. Jothy, E. Tremblay, and P. Jolicoeur. 2002. Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 Nef in cells of the immune system. Am. J. Pathol. 161:321-335.
24. Kimura, M., M. Sato, A. Akatsuka, S. Nozawa-Kimura, R. Takahashi, M. Yokoyama, T. Nomura, and M. Katsuki. 1989. Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice. Proc. Natl. Acad. Sci. USA 86:5661-5665.
25. Koenig, S., H. E. Gendelman, J. M. Orenstein, M. C. Dal Canto, G. H. Y. M. Pezeshkpour, F. Janotta, A. Aksamit, M. A. Martin, and A. S. Fauci. 1986. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089-1093.
26. Korber, B. T., K. J. Kunstman, B. K. Patterson, M. Furtado, M. McEvilly, and R. Levy, and S. M. Wolinsky. 1994. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J. Virol. 68:7467-7481.
27. Lappe-Siefke, C., S. Goebbels, M. Gravel, E. Nicksch, J. Lee, P. E. Braun, I. R. Griffiths, and K. A. Nave. 2003. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat. Gen. 33:366-374.
28. Levine, J. M., R. Reynolds, and J. W. Fawcett. 2001. The oligodendrocyte precursor cell in health and disease. Trends Neurosci. 24:39-47.
29. Li, J., Y. Liu, I. W. Park, and J. J. He. 2002. Expression of exogenous Sam68, the 68-kilodalton SRC-associated protein in mitosis, is able to alleviate impaired Rev function in astrocytes. J. Virol. 76:4526-4535.
30. Mangasarian, A., and D. Trono. 1997. The multifaceted role of HIV Nef. Res. Virol. 148:30-33.
31. McCarthy, K. D., and J. de Vellis. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85:890-902.
32. Montag, D., K. P. Giese, U. Bartsch, R. Martini, Y. Lang, H. Bluthmann, J. Karthigasan, D. A. Kirschner, E. S. Wintergerst, and K. A. Nave. 1994. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron 13:229-246.
33. Morell, P., and N. S. Radin. 1969. Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid. Biochemistry 8:506-512.
34. Nuovo, G. J., F. Gallery, P. MacConnell, and A. Braun. 1994. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. Am. J. Pathol. 144:659-666.
35. Osterhout, D. J., A. Wolven, R. M. Wolf, M. D. Resh, and M. V. Chao. 1999. Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase. J. Cell Biol. 145:1209-1218.
36. Petito, C. K., B. A. Navia, E. S. Cho, B. D. Jordan, D. C. George, and R. W. Price. 1985. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 312:874-879.
37. Pfeiffer, S. E., A. E. Warrington, and R. Bansal. 1993. The oligodendrocyte and its many cellular processes. Trends Cell Biol. 3:193-197.
38. Popko, B. 2003. Myelin: not just a conduit for conduction. Nat. Gen. 33:327-328.
39. Poudrier, J., X. Weng, D. G. Kay, G. Paré, E. L. Calvo, Z. Hanna, M. H. Kosco-Vilbois, and P. Jolicoeur. 2001. The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-γ and IL-6. Immunity 15:173-185.
40. Pumarola-Sune, T., B. A. Navia, C. Cordon-Cardo, E. S. Cho, and R. W. Price. 1987. HIV antigen in the brains of patients with the AIDS dementia complex. Ann. Neurol. 21:490-496.
41. Ranki, A., M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Raininko, H. Haapasalo, and K. Krohn. 1995. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 9:1001-1008.
42. Renkema, G. H., and K. Saksela. 2000. Interactions of HIV-1 Nef with cellular signal transducing proteins. Front. Biosci. 5:D268-D283.
43. Saito, Y., L. R. Sharer, L. G. Epstein, J. Michaels, M. Mintz, M. G. K. Louder, T. A. Cvetkovich, and B. M. Blumberg. 1994. Overexpression of Nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44:474-481.
44. Sharer, L., and J. W. Prineas. 1988. Human immunodeficiency virus in glial cells? J. Infect. Dis. 157:204.
45. Sharer, L. R. 1992. Pathology of HIV-1 infection of the central nervous system. A review. J. Neuropathol. Exp. Neurol. 51:3-11.
46. Skowronski, J., M. E. Greenberg, M. Lock, R. Mariani, S. Salghetti, T. Swigut, and A. J. Iafrate. 1999. HIV and SIV Nef modulate signal transduction and protein sorting in T cells. Cold Spring Harbor Symp. Quant. Biol. 64:453-463.
47. Spassky, N., C. Goujet-Zalc, E. Parmantier, C. Olivier, S. Martinez, A. Ivanova, K. Ikenaka, W. Macklin, I. Cerruti, B. Zalc, and J. L. Thomas. 1998. Multiple restricted origin of oligodendrocytes. J. Neurosci. 18:8331-8343.
48. Spassky, N., C. Olivier, E. Perez-Villegas, C. Goujet-Zalc, S. Martinez, J. Thomas, and B. Zalc. 2000. Single or multiple oligodendroglial lineages: a controversy. Glia 29:143-148.
49. Sperber, B. R., E. A. Boyle-Walsh, M. J. Engleka, P. Gadue, A. C. Peterson, P. L. Stein, S. S. Scherer, and F. A. McMorris. 2001. A unique role for Fyn in CNS myelination. J. Neurosci. 21:2039-2047.
50. Stoler, M. H., T. A. Eskin, S. Benn, R. C. Angerer, and L. M. Angerer. 1986. Human T-cell lymphotropic virus type III infection of the central nervous system. A preliminary in situ analysis. JAMA 256:2360-2364.
51. Takahashi, N., A. Roach, D. B. Teplow, S. B. Prusiner, and L. Hood. 1985. Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell 42:139-148.
52. Tornatore, C., R. Chandra, J. R. Berger, and E. O. Major. 1994. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44:481-487.
53. Vazeux, R., N. Brousse, A. Jarry, D. Henin, C. Marche, C. Vedrenne, J. W. M. Mikol, C. Michon, W. Rozenbaum, et al. 1987. AIDS subacute encephalitis. Identification of HIV-infected cells. Am. J. Pathol. 126:403-410.
54. Wiley, C. A., R. D. Schrier, J. A. Nelson, P. W. Lampert, and M. B. Oldstone. 1986. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc. Natl. Acad. Sci. USA 83:7089-7093.