Exogenous nef induces proinflammatory signaling events in murine macrophages

Viral Immunology

Volumn 25, Issue 2, 2012, Pages 117-130

  Mangino, Giorgio ^a,b   Serra, Valeria ^a   Borghi, Paola ^c   Percario, Zulema A ^a   Horenkamp, Florian A ^d   Geyer, Matthias ^d   Affabris, Elisabetta ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CHEMOKINE; CYTOKINE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEF PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNTHESIS; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; CYTOKINES; HIV-1; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; SIGNAL TRANSDUCTION; VIRULENCE FACTORS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE; MUS; MUS MUSCULUS;

EID: 84859570010     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2011.0082     Document Type: Article

References (52)

1. Geyer M, Fackler OT, and Peterlin BM: Structure-function relationships in HIV-1 Nef. EMBO Rep 2001;2:580-585. (Pubitemid 32707703)
2. Kestler HW, Ringler DJ, Mori K, et al.: Importance of the nef gene for maintenance of high virus loads and for development of AIDS Cell 1991;65:651-662.
3. Hanna Z, Kay DG, Rebai N, et al.: Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 1998;95:163-175. (Pubitemid 28473778)
4. Hanna Z, Kay DG, Cool M, et al.: Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease. J Virol 1998;72:21-32.
5. Roeth JF, and Collins KL: Human immunodeficiency virus type 1 Nef: Adapting to intracellular trafficking pathways. Microbiol Mol Biol Rev 2006;70:548-563. (Pubitemid 43895037)
6. Chaudhry A, Das SR, Hussain A, et al.: The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol 2005;175:4566-4574. (Pubitemid 41361995)
7. Landi A, Iannucci V, Nuffel AV, et al.: One protein to rule them all: Modulation of cell surface receptors and molecules by HIV Nef. Curr HIV Res 2011;9:496-504.
8. Simmons A, Aluvihare V, and McMichael A: Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 2001;14:763-777. (Pubitemid 32592423)
9. Xu XN, Laffert B, Screaton GR, et al.: Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain. J Exp Med 1999;189:1489-1496. (Pubitemid 29227535)
10. Dutartre H, Harris M, Olive D, and Collette Y: The human immunodeficiency virus type 1 Nef protein binds the Srcrelated tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism. Virology 1998; 247:200-211. (Pubitemid 28384011)
11. Fackler OT, Luo W, Geyer M, et al.: Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 1999;3:729-739. (Pubitemid 29323051)
12. Swingler S, Mann A, Jacque J, et al.: HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat Med 1999;5:997-1003. (Pubitemid 29439569)
13. Olivetta E, Percario Z, Fiorucci G, et al.: HIV-1 Nef induces the release of inflammatory factors from human monocyte/ macrophages: Involvement of Nef endocytotic signals and NF-kappaB activation. J Immunol 2003;170:1716-1727. (Pubitemid 36197386)
14. Swingler S, Brichacek B, Jacque JM, et al.: HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection. Nature 2003;424:213-219. (Pubitemid 36858691)
15. Qiao X, He B, Chiu A, et al.: Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat Immunol 2006; 7:302-310.
16. Lenassi M, Cagney G, Liao M, et al.: HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4 + T cells. Traffic 2010;11:110-122.
17. Muratori C, Cavallin LE, Krätzel K, et al.: Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells. Cell Host Microbe 2009;6:218-230.
18. Xu W, Santini PA, Sullivan JS, et al. HIV-1 evades virusspecific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat Immunol 2009;10:1008-1017.
19. Baur AS: HIV-Nef and AIDS pathogenesis: Are we barking up the wrong tree? Trends Microbiol 2011.
20. Percario Z, Mangino G, Gallo G, et al.: HIV-1 Nef transfer and intracellular signalling in uninfected cells. In: HIV-Host Interactions. (Chang TL, ed.). InTech Open Access Publisher, Rijeka, Croatia, 2011, pp. 61-78.
21. Joag SV: Primate models of AIDS. Microbes Infect 2000;2: 223-229. (Pubitemid 30154711)
22. Locher CP, Witt SA, Herndier BG, et al.: Baboons as an animal model for human immunodeficiency virus pathogenesis and vaccine development. Immunol Rev 2001;183: 127-140. (Pubitemid 34015444)
23. Klotman PE, Rappaport J, Ray P, et al.: Transgenic models of HIV-1. AIDS 1995;9:313-324.
24. Leonard JM, Abramczuk JW, Pezen DS, et al.: Development of disease and virus recovery in transgenic mice containing HIV proviral DNA. Science 1988;242:1665-1670. (Pubitemid 19022171)
25. Mangino G, Percario Z, Fiorucci G, et al.: In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon. J Virol 2007;81:2777-2791. (Pubitemid 46447042)
26. Federico M, Percario Z, Olivetta E, et al.: HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors. Blood 2001;98:2752-2761.
27. Percario Z, Olivetta E, Fiorucci G, et al. Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary humanmonocyte/macrophages through the release of soluble factors: Involvement of Nef domains interacting with the cell endocytotic machinery. J Leukoc Biol 2003;74:821-832. (Pubitemid 38040359)
28. Raschke W, Baird S, Ralph P, and Nakoinz I: Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 1978;15:261-267. (Pubitemid 9027529)
29. Ralph P, Moore M, and Nilsson K: Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines. J Exp Med 1976;143:1528-1533.
30. Alessi D, Cuenda A, Cohen P, et al.: PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and i. J Biol Chem 1995;270:27489-27494.
31. Young P, McLaughlin M, Kumar S, et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem 1997;272:12116-12121. (Pubitemid 27202792)
32. Bennett B, Sasaki D, Murray B, et al.: SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 2001;98:13681-13686. (Pubitemid 33115958)
33. Burke JR, Pattoli MA, Gregor KR, et al.: BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003;278: 1450-1456. (Pubitemid 36801370)
34. Breuer S, Gerlach H, Kolaric B, et al.: Biochemical Indication for myristoylation-dependent conformational changes in HIV-1 Nef. Biochemistry 2006;45:2339-2349. (Pubitemid 43271334)
35. Mangino G, Percario ZA, Fiorucci G, et al.: HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: Involvement of TNF Alpha receptor associated factor 2. PLoS One 2011;6:e22982.
36. Gerlach H, Laumann V, Martens S, et al.: HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol 2010;6:46-53.
37. Scott ML, Fujita T, Liou HC, et al.: The p65 subunit of NFkappa B regulates I kappa B by two distinct mechanisms. Genes Dev 1993;7:1266-1276. (Pubitemid 23207416)
38. Fujita T, Sakakibara J, Sudo Y, et al.: Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements. EMBO J 1988;7:3397-3405.
39. Miyamoto M, Fujita T, Kimura Y, et al.: Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 1988;54:903-913.
40. Arold ST, and Baur AS: Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein. Trends Biochem Sci 2001;26:356-363. (Pubitemid 32530653)
41. Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, et al.: HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3Kregulated ARF6 endocytic pathway. Cell 2002;111:853-866. (Pubitemid 36106406)
42. Horenkamp FA, Breuer S, Schulte A, et al.: Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly. Traffic 2011.
43. Geleziunas R, Xu W, Takeda K, et al.: HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 2001;410:834-838. (Pubitemid 32303784)
44. De SK, Venkateshan CN, Seth P, et al.: Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines. Blood 1998;91:2108-2117. (Pubitemid 28185515)
45. Quaranta MG, Tritarelli E, Giordani L, and Viora M: HIV-1 Nef induces dendritic cell differentiation: A possible mechanism of uninfected CD4( + ) T cell activation. Exp Cell Res 2002;275:243-254. (Pubitemid 34948365)
46. Messmer D, Jacqué JM, Santisteban C, et al.: Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells. J Immunol 2002;169:4172-4182. (Pubitemid 35178187)
47. Quaranta MG, Mattioli B, Spadaro F, et al.: HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells. FASEB J 2003;17:2025-2036. (Pubitemid 37392447)
48. Djordjevic JT, Schibeci SD, Stewart GJ, and Williamson P: HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion. AIDS Res Hum Retroviruses 2004;20:547-555. (Pubitemid 38720969)
49. James CO, Huang MB, Khan M, et al.: Extracellular Nef protein targets CD4 + T cells for apoptosis by interacting with CXCR4 surface receptors. J Virol 2004;78:3099-3109. (Pubitemid 38314368)
50. Huang MB, Jin LL, James CO, et al.: Characterization of Nef- CXCR4 interactions important for apoptosis induction. J Virol 2004;78:11084-11096. (Pubitemid 39299649)
51. Jolicoeur P: The CD4C/HIVNef transgenic model of AIDS. Curr HIV Res 2011;9:524-530.
52. Lülf S, Horenkamp FA, Breuer S, and Geyer M: Nef surfaces: Where to interfere with function. Curr HIV Res 2011;9: 543-551.