The PAX8/PPARγ fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARγ inhibition

Oncogene

Volumn 23, Issue 20, 2004, Pages 3634-3641

  Powell, J Gregory ^a   Wang, Xiying ^a   Allard, Brandon L ^a   Sahin, Mustafa ^b   Wang, Xiao Li ^a   Hay, Ian D ^a   Hiddinga, Henry J ^a   Deshpande, Seema S ^c   Kroll, Todd G ^c   Grebe, Stefan K G ^a   Eberhardt, Norman L ^a,d   McIver, Bryan ^a  

^a MAYO CLINIC   (United States)

^b ANKARA UNIVERSITY   (Turkey)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

Adenoma to carcinoma progression; Follicular thyroid carcinoma; Fusion oncogene; Inhibition; PAX8 PPAR ; PPAR

Indexed keywords

HYBRID PROTEIN; ONCOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECEPTOR BLOCKING AGENT; TRANSCRIPTION FACTOR PAX8; CELL RECEPTOR; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; PAX8 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

AGAR MEDIUM; ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL INTERACTION; CELL STRAIN 3T3; CONTACT INHIBITION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYROID CELL; THYROID FOLLICULAR CARCINOMA; TRANSACTIVATION; CELL CYCLE; CELL TRANSFORMATION; CYTOLOGY; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY; THYROID GLAND;

ANIMALIA; TRIXIS;

APOPTOSIS; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; HUMANS; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; THYROID GLAND; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 2442697906     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207399     Document Type: Article

References (38)

1. Aldred MA, Morrison C, Gimm O, Hoang-Vu C, Krause U, Dralle H, Jhiang S and Eng C. (2003). Oncogene, 22, 3412-3416.
2. Allen TD, Zhu YX, Hawley TS and Hawley RG. (2000). Leukemia Lymphoma, 39, 241-256.
3. Bongarzone I, Pierotti MA, Monzini N, Mondellini P, Manenti R, Donghi R, Pilotti S, Grieco M, Santoro M, Fusco A, Vecchio G and Della Porta G. (1989). Oncogene, 4, 1457-1462.
4. Burns JS, Lemoine L, Lemoine NR, Williams ED and Wynford-Thomas D. (1989). Br. J. Cancer, 59, 755-760.
5. Cimini A, Cristiano L, Bernardo A, Farioli-Vecchioli S, Stefanini S and Ceru MP. (2000). Biochem. Biophys. Acta, 1474, 397-409.
6. Espinoza CR, Schmitt TL and Loos U. (2001). J. Mol. Endocrinol., 27, 59-67.
7. Fagin JA. (2002). Mol. Endocrinol., 16, 903-911.
8. Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang SH and Koeffler HP. (1993). J. Clin. Invest., 91, 179-184.
9. French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore Jr F, Fletcher JA, Larsen PR and Kroll TG. (2003). Am. J. Pathol., 162, 1053-1060.
10. Hanahan D and Weinberg RA. (2000). Cell, 100, 57-70.
11. Hiddinga HJ and Eberhardt NL. (1999). Am. J. Pathol., 154, 1077-1088.
12. Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D and Glass CK. (1999). Nature, 400, 378-382.
13. IJpenberg A, Jeannin E, Wahli W and Desvergne B. (1997). J. Biol. Chem., 272, 20108-20117.
14. Jhiang SM, Cho JY, Furminger TL, Sagartz JE, Tong Q, Capen CC and Mazzaferri EL. (1998). Recent Results Cancer Res., 154, 265-270.
15. Jiang SW, Dong M, Trujillo MA, Miller LJ and Eberhardt NL. (2001). J. Biol. Chem., 276, 23464-23470.
16. Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D and Bond JA. (2000). Mol. Cell. Biol., 20, 5690-5699.
17. Knudson AG. (2001). Nat. Rev. Cancer, 1, 157-162.
18. Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM and Fletcher JA. (2000). Science, 289, 1357-1360.
19. Kubota T, Koshizuka K, Williamson EA, Asou H, Said JW, Holden S, Miyoshi I and Koeffler HP. (1998). Cancer Res., 58, 3344-3352.
20. Lemoine NR, Mayall ES, Jones T, Sheer D, McDermid S, Kendall-Taylor P and Wynford-Thomas D. (1989). Br. J. Cancer, 60, 897-903.
21. Marques AR, Espadinha C, Catarino AL, Moniz S, Pereira T, Sobrinho LG and Leite V. (2002). J. Clin. Endocrinol. Metab., 87, 3947-3952.
22. Martelli ML, Iuliano R, Le Pera I, Sama I, Monaco C, Cammarota S, Kroll T, Chiariotti L, Santoro M and Fusco A. (2002). J. Clin. Endocrinol. Metab., 87, 4728-4735.
23. Mascia A, Nitsch L, Di Lauro R and Zannini M. (2002). J. Endocrinol., 172, 163-176.
24. Meriane M, Charrasse S, Comunale F, Mery A, Fort P, Roux P and Gauthier-Rouviere C. (2002). Oncogene, 21, 2901-2907.
25. Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S and Spiegelman BM. (1998). Mol. Cell, 1, 465-470.
26. Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, Oh W, Demetri G, Figg WD, Zhou XP, Eng C, Spiegelman BM and Kantoff PW. (2000). Proc. Natl. Acad. Sci. USA, 97, 10990-10995.
27. Nikiforova MN, Biddinger PW, Caudill CM, Kroll TG and Nikiforov YE. (2002). Am J. Surg. Pathol., 26, 1016-1023.
28. Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW, Tallini G, Kroll TG and Nikiforov YE. (2003). J. Clin. Endocrinol. Metab., 88, 2318-2326.
29. Ohno M, Zannini M, Levy O, Carrasco N and di Lauro R. (1999). Mol. Cell. Biol., 19, 2051-2060.
30. Ohta T, Elnemr A, Yamamoto M, Ninomiya I, Fushida S, Nishimura G, Fujimura T, Kitagawa H, Kayahara M, Shimizu K, Yi S and Miwa K. (2002). Int. J. Oncol., 21, 37-42.
31. Poleev A, Wendler F, Fickenscher H, Zannini MS, Yaginuma K, Abbott C and Plachov D. (1995). Eur. J. Biochem., 228, 899-911.
32. Santelli G, de Franciscis V, Portella G, Chiappetta G, D'Alessio A, Califano D, Rosati R, Mineo A, Monaco C and Manzo G. (1993). Cancer Res., 53, 5523-5527.
33. Santoro M, Grieco M, Melillo RM, Fusco A and Vecchio G. (1995). Eur. J. Endocrinol., 133, 513-522.
34. Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, Holden SA, Chen LB, Singer S, Fletcher C and Spiegelman BM. (1998). Nat. Med., 4, 1046-1052.
35. Sarraf P, Mueller E, Smith WM, Wright HM, Kum JB, Aaltonen LA, de la Chapelle A, Spiegelman BM and Eng C. (1999). Mol. Cell, 3, 799-804.
36. Satoh T, Toyoda M, Hoshino H, Monden T, Yamada M, Shimizu H, Miyamoto K and Mori M. (2002). Oncogene, 21, 2171-2180.
37. Takashima T, Fujiwara Y, Higuchi K, Arakawa T, Yano Y, Hasuma T and Otani S. (2001). Int. J. Oncol., 19, 465-471.
38. Vilain C, Rydlewski C, Duprez L, Heinrichs C, Abramowicz M, Malvaux P, Renneboog B, Parma J, Costagliola S and Vassart G. (2001). J. Clin. Endocrinol. Metab., 86, 234-238.