Plant polyphenols as inhibitors of nf-Кb induced cytokine production—A potential anti-inflammatory treatment for alzheimer’s disease?

Frontiers in Molecular Neuroscience

Volumn 8, Issue June, 2015, Pages

  Karunaweera, Niloo ^a   Raju, Ritesh ^a   Gyengesi, Erika ^a   Munch, Gerald ^a  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Alzheimer s disease; Cytokine; Disease modifying drug; Inflammation; Neutraceuticals; Treatment

Indexed keywords

ANDALUSOL; APIGENIN; CINNAMALDEHYDE; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAMEBANIN; MYELOID DIFFERENTIATION FACTOR 88; POLYPHENOL DERIVATIVE; QUERCETIN; RESVERATROL; SILYMARIN; UNCLASSIFIED DRUG;

AGE RELATED MACULAR DEGENERATION; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; GENE EXPRESSION; INFLAMMATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84935901708     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2015.00024     Document Type: Article

References (56)

1. Abe, Y., Hashimoto, S. and Horie, T. (1999). Curcumin inhibition ofinflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol. Res. 39,41-47. doi: 10.1006/phrs.1998.0404
2. Ambegaokar, S. S., Wu, L., Alamshahi, K., Lau, J., Jazayeri, L., Chan, S., et al. (2003). Curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. Neuro Endocrinol. Lett. 24, 469-473.
3. Barnes, P. J. (1997). Nuclear factor-kappa B. Int. J. Biochem. Cell Biol. 29, 867-870. doi: 10.1016/S1357-2725(96)00159-8
4. Bellik, Y., Boukraa, L., Alzahrani, H. A., Bakhotmah, B. A., Abdellah, F., Hammoudi, S. M., et al. (2012a). Molecular mechanism underlying anti¬inflammatory and anti-allergic activities of phytochemicals: an update. Molecules 18, 322-353. doi: 10.3390/molecules18010322
5. Bellik, Y., Hammoudi, S. M., Abdellah, F., Iguer-Ouada, M., and Boukraa, L. (2012b). Phytochemicals to prevent inflammation and allergy. Recent Pat. Inflamm. Allergy DrugDiscov. 6, 147-158. doi: 10.2174/187221312800166886
6. Brasier, A. R. (2006). The NF-kappaB regulatory network. Cardiovasc. Toxicol. 6, 111-130. doi: 10.1385/CT:6:2:111
7. Bremner, P., and Heinrich, M. (2002). Natural products as targeted modulators of the nuclear factor-kappaB pathway. J. Pharm. Pharmacol. 54, 453-472. doi: 10.1211/0022357021778637
8. Calabrese, V., Scapagnini, G., Colombrita, C., Ravagna, A., Pennisi, G., Giuffrida Stella, A. M., et al. (2003). Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach. Amino Acids 25, 437-444. doi: 10.1007/s00726-003-0048-2
9. Carlsen, M. H., Halvorsen, B. L., Holte, K., Bohn, S. K., Dragland, S., Sampson, L., et al. (2010). The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr. J. 9:3. doi: 10.1186/1475-2891-9-3
10. Castello, M. A., Jeppson, J. D., and Soriano, S. (2014). Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease. BMC Neurol. 14:169. doi: 10.1186/s12883-014-0169-0
11. Chainani-Wu, N. (2003). Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J. Altern. Comp. Med. 9, 161-168. doi: 10.1089/107555303321223035
12. Chun, J. K., Seo, D. W., Ahn, S. H., Park, J. H., You, J. S., Lee, C. H., et al. (2007). Suppression of the NF-kappaB signalling pathway by ergolide, sesquiterpene lactone, in HeLa cells. J. Pharm. Pharmacol. 59, 561-566. doi: 10.1211/jpp.59.4.0011
13. Ebrahimi, A., and Schluesener, H. (2012). Natural polyphenols against neurodegenerative disorders: potentials and pitfalls. Ageing Res. Rev. 11, 329-345. doi: 10.1016/j.arr.2012.01.006
14. Endale, M., Park, S. C., Kim, S., Kim, S. H., Yang, Y., Cho, J. Y., et al. (2013). Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-kappaB-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology 218, 1452-1467. doi: 10.1016/j.imbio.2013.04.019
15. Figuera-Losada, M., Rojas, C., and Slusher, B. S. (2014). Inhibition of microglia activation as a phenotypic assay in early drug discovery. J. Biomol. Screen. 19, 17-31. doi: 10.1177/1087057113499406
16. Gautam, R., and Jachak, S. M. (2009). Recent developments in anti-inflammatory natural products. Med. Res. Rev. 29, 767-820. doi: 10.1002/med.20156
17. Ghosh, S., and Karin, M. (2002). Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl.), S81-S96. doi: 10.1016/S0092-8674(02)00703-1
18. Gil-Bea, F. J., Gerenu, G., Aisa, B., Kirazov, L. P., Schliebs, R., and Ramirez, M. J. (2012). Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice. Neurobiol. Dis. 48,439-446. doi: 10.1016/j.nbd.2012.06.020
19. Gilmore, T. D. (2006). Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25, 6680-6684. doi: 10.1038/sj.onc.1209954
20. Gotsis, E., Anagnostis, P., Mariolis, A., Vlachou, A., Katsiki, N., and Karagiannis, A. (2015). Health benefits of the mediterranean diet: an update of research over the last 5 years. Angiology 66, 304-318. doi: 10.1177/0003319714532169
21. Gunawardena, D., Shanmugam, K., Low, M., Bennett, L., Govindaraghavan, S., Head, R., et al. (2014). Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods. Eur. J. Nutr. 53, 335-343. doi: 10.1007/s00394-013-0531-9
22. Haridas, V., Arntzen, C. J., and Gutterman, J. U. (2001). Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA. Proc. Natl. Acad. Sci. U.S.A. 98, 11557-11562. doi: 10.1073/pnas.191363498
23. Heras, B. N. A., Jose, M., Guerra, D., Bermejo, P., Castrillo, A., Bosca, L., et al. (1999). Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kB by andalusol. Br. J. Pharmacol. 128, 605-612. doi: 10.1038/sj.bjp.0702844
24. Hoffmann, A., Natoli, G., and Ghosh, G. (2006). Transcriptional regulation via the NF-kappaB signaling module. Oncogene 25, 6706-6716. doi: 10.1038/sj.onc.1209933
25. Hwang, B. Y., Lee, J. H., Koo, T. H., Kim, H. S., Hong, Y. S., Ro, J. S., et al. (2001). Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells. Planta Med. 67, 406-410. doi: 10.1055/s-2001-15808
26. Jobin, C., Bradham, C. A., Russo, M. P., Juma, B., Narula, A. S., Brenner, D. A., et al. (1999). Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J. Immunol. 163, 3474-3483.
27. Kim, J., Lee, H. J., and Lee, K. W. (2010). Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J. Neurochem. 112, 1415-1430. doi: 10.1111/j.1471-4159.2009.06562.x
28. Kundu, J. K., Shin, Y. K., Kim, S. H., and Surh, Y. J. (2006). Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 27, 1465-1474. doi: 10.1093/carcin/bgi349
29. Latta, C. H., Brothers, H. M., and Wilcock, D. M. (2014). Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy. Neuroscience. doi: 10.1016/j.neuroscience.2014.09.061. [Epub ahead of print].
30. Lawrence, T. (2009). The nuclear factor NF-kappaB pathwayin inflammation. Cold SpringHarb. Perspect. Biol. 1:a001651. doi: 10.1101/cshperspect.a001651
31. Lee, H. J., Jung, H., Kwon, J., Li, H., Lee da, Y., Lim, H. J., et al. (2011). A germacranolide sesquiterpene lactone suppressed inducible nitric oxide synthase by downregulating NF-kappaB activity. Can. J. Physiol. Pharmacol. 89, 232-237. doi: 10.1139/Y11-004
32. Liu, R. H. (2004). Potential synergy of phytochemicals in cancer prevention: mechanism of action. J. Nutr. 134(12 Suppl.), 3479S-3485S.
33. Lyss, G., Schmidt, T. J., Merfort, I., and Pahl, H. L. (1997). Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. Biol. Chem. 378, 951-961. doi: 10.1515/bchm.1997.378.9.951
34. Millington, C., Sonego, S., Karunaweera, N., Rangel, A., Aldrich-Wright, J. R., Campbell, I. L., et al. (2014). Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs. BiomedRes. Int. 2014:309129. doi: 10.1155/2014/309129
35. Mogensen, T. H. (2009). Pathogen recognition and inflammatory signaling in innate immune defenses. Clin. Microbiol. Rev. 22, 240-273. doi: 10.1128/CMR.00046-08
36. Ojo-Amaize, E. A., Kapahi, P., Kakkanaiah, V. N., Takahashi, T., Shalom-Barak, T., Cottam, H. B., et al. (2001). Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell. Immunol. 209, 149-157. doi: 10.1006/cimm.2001.1798
37. Pan, M. H., Lai, C. S., and Ho, C. T. (2010). Anti-inflammatory activity of natural dietary flavonoids. Food Funct. 1, 15-31. doi: 10.1039/c0fo00103a
38. Perkins, N. D. (2007). Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat. Rev. Mol. Cell Biol. 8, 49-62. doi: 10.1038/nrm2083
39. Reddy, A. M., Seo, J. H., Ryu, S. Y., Kim, Y. S., Kim, Y. S., Min, K. R., et al. (2004). Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med. 70, 823-827. doi: 10.1055/s-2004-827230
40. Robinson, S. R., Bishop, G. M., Lee, H. G., and Munch, G. (2004). Lessons from the AN 1792 Alzheimer vaccine: lest we forget. Neurobiol. Aging 25, 609-615. doi: 10.1016/j.neurobiolaging.2003.12.020
41. Rosenblum, W. I. (2014). Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult. Neurobiol. Aging 35, 969-974. doi: 10.1016/j.neurobiolaging.2013.10.085
42. Ruiz, P. A., and Haller, D. (2006). Functional diversity of flavonoids in the inhibition of the proinflammatoryNF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells. J. Nutr. 136, 664-671.
43. Saadane, A., Masters, S., DiDonato, J., Li, J., and Berger, M. (2007). Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice. Am. J. Respir. Cell Mol. Biol. 36, 728-736. doi: 10.1165/rcmb.2006-0323OC
44. Saliou, C., Rihn, B., Cillard, J., Okamoto, T., and Packer, L. (1998). Selective inhibition ofNF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways. FEBS Lett. 440,8-12. doi: 10.1016/S0014-5793(98)01409-4
45. Shakibaei, M., John, T., Schulze-Tanzil, G., Lehmann, I., and Mobasheri, A. (2007). Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem. Pharmacol. 73, 1434-1445. doi: 10.1016/j.bcp.2007.01.005
46. Shi, S., Wang, Z., and Qiao, Z. (2013). The multifunctional anti-inflammatory drugs used in the therapy of Alzheimer's disease. Curr. Med. Chem. 20, 2583-2588. doi: 10.2174/0929867311320200006
47. Singh, S., and Aggarwal, B. B. (1995).Activation oftranscriptionfactorNF-kappaB is suppressed by curcumin (diferuloylmethane) [corrected]. J. Biol. Chem. 270, 24995-25000. doi: 10.1074/jbc.270.42.24995
48. Singh, S., Natarajan, K., and Aggarwal, B. B. (1996). Capsaicin (8-methyl-N- vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor- kappa B activation by diverse agents. J. Immunol. 157, 4412-4420.
49. Sofi, F., Macchi, C., Abbate, R., Gensini, G. F., and Casini, A. (2010). Effectiveness of the Mediterranean diet: can it help delay or prevent Alzheimer's disease? J. Alzheimers. Dis. 20, 795-801.
50. Sreenivasan, Y., Sarkar, A., and Manna, S. K. (2003). Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide. Biochem. Pharmacol. 66, 2223-2239. doi: 10.1016/j.bcp.2003.07.010
51. Tiedemann, R. E., Schmidt, J., Keats, J. J., Shi, C. X., Zhu, Y. X., Palmer, S. E., et al. (2009). Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood 113,4027-4037. doi: 10.1182/blood-2008-09179796
52. Tsao, R. (2010). Chemistry and biochemistry of dietary polyphenols. Nutrients 2, 1231-1246. doi: 10.3390/nu2121231
53. Vetrani, C., Costabile, G., Di Marino, L., and Rivellese, A. A. (2013). Nutrition and oxidative stress: a systematic review of human studies. Int. J. Food Sci. Nutr. 64, 312-326. doi: 10.3109/09637486.2012.738651
54. Wang, J., Liu, Y. T., Xiao, L., Zhu, L., Wang, Q., and Yan, T. (2014). Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation 37, 2085-2090. doi: 10.1007/s10753-014-9942-x
55. Wu, K., Liu, Y., Lv, Y., Cui, L., Li, W., Chen, J., et al. (2013). Ent- 11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis and cell cycle arrest in CNE-2Z nasopharyngeal carcinoma cells. Oncol. Rep. 29, 2101-2108.
56. Yoon, J. H., and Baek, S. J. (2005). Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med. J. 46, 585-596. doi: 10.3349/ymj.2005.46.5.585