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Volumn 378, Issue 9, 1997, Pages 951-961

Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB

Author keywords

Gene expression; NF B; NSAIDs; Sesquiterpene lactones; Transcription factors

Indexed keywords

ACETYLSALICYLIC ACID; HELENALIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN SUBUNIT; SESQUITERPENE LACTONE; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1;

EID: 0030823162     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm.1997.378.9.951     Document Type: Article
Times cited : (237)

References (48)
  • 1
    • 0024294357 scopus 로고
    • Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
    • Baeuerle, P.A., and Baltimore, D. (1988). Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor. Cell 53, 211-217.
    • (1988) Cell , vol.53 , pp. 211-217
    • Baeuerle, P.A.1    Baltimore, D.2
  • 2
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle, P.A., and Baltimore, D. (1996). NF-κB: Ten years after. Cell 87, 13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 3
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle, P.A., and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 4
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κB in preventing TNF-α-induced cell death
    • Beg, A.A., and Baltimore, D. (1996). An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 5
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB-α: A mechanism for NF-κB activation
    • Beg, A.A., Finco, T.S., Nantermet, P.V., and Baldwin, A.S. Jr., (1993). Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB-α: a mechanism for NF-κB activation. Mol. Cell. Biol. 13, 3301-3310.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3301-3310
    • Beg, A.A.1    Finco, T.S.2    Nantermet, P.V.3    Baldwin A.S., Jr.4
  • 6
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
    • Beg, A.A., Sha, W.C., Bronson, R.T., Gosh, S., and Baltimore, D. (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376, 167-170.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Gosh, S.4    Baltimore, D.5
  • 7
    • 0027462682 scopus 로고
    • Mutual regulation of the transcriptional activator NF-κB and its inhibitor IκB-α
    • Brown, K., Park, S., Kanno, T., Franzoso, G., and Siebenlist, U. (1993). Mutual regulation of the transcriptional activator NF-κB and its inhibitor IκB-α. Proc. Natl. Acad. Sci., USA 90, 2532-2536.
    • (1993) Proc. Natl. Acad. Sci., USA , vol.90 , pp. 2532-2536
    • Brown, K.1    Park, S.2    Kanno, T.3    Franzoso, G.4    Siebenlist, U.5
  • 8
    • 0000656939 scopus 로고
    • Sesquiterpenoid Lactones
    • Fischer, N.H. (1991). Sesquiterpenoid Lactones. Meth. Plant Biochem. 7, 187-211.
    • (1991) Meth. Plant Biochem. , vol.7 , pp. 187-211
    • Fischer, N.H.1
  • 9
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F.L., and van der Eb, A.J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 10
    • 0027536852 scopus 로고
    • The inducible transcription factor NF-kappa B: Structure-function relationship of its protein subunits
    • Grimm, S., and Baeuerle, P.A. (1993). The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits. Biochem. J. 290, 297-308.
    • (1993) Biochem. J. , vol.290 , pp. 297-308
    • Grimm, S.1    Baeuerle, P.A.2
  • 11
    • 0017334148 scopus 로고
    • Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones
    • Hall, I.H., Lee, K.H., Mar, E.C., Starnes, C.O, and Wadell, T.G. (1977). Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones. J. Med. Chem. 20, 333-337.
    • (1977) J. Med. Chem. , vol.20 , pp. 333-337
    • Hall, I.H.1    Lee, K.H.2    Mar, E.C.3    Starnes, C.O.4    Wadell, T.G.5
  • 12
    • 0018077292 scopus 로고
    • Antitumor agents. XXX. Evaluation of alpha-methylene-gamma-lactone-containing agents for inhibition of tumor growth, respiration and nucleic acid synthesis
    • Hall, I.H., Lee, K.H., Starnes, C.O., Eigebaly, S.A., Ihuka, T., Wu, Y.H., Kimura, T., and Haruna, M. (1978). Antitumor agents. XXX. Evaluation of alpha-methylene-gamma-lactone-containing agents for inhibition of tumor growth, respiration and nucleic acid synthesis. J. Pharm. Sci. 67, 1235-1240.
    • (1978) J. Pharm. Sci. , vol.67 , pp. 1235-1240
    • Hall, I.H.1    Lee, K.H.2    Starnes, C.O.3    Eigebaly, S.A.4    Ihuka, T.5    Wu, Y.H.6    Kimura, T.7    Haruna, M.8
  • 14
    • 0019307324 scopus 로고
    • Mode of action of sesquiterpene lactones as anti-inflammatory agents
    • Hall, I.H., Starnes, C.O., Lee, K.-H., and Waddell, T.G. (1980). Mode of action of sesquiterpene lactones as anti-inflammatory agents. J. Pharm. Sci. 69, 537-543.
    • (1980) J. Pharm. Sci. , vol.69 , pp. 537-543
    • Hall, I.H.1    Starnes, C.O.2    Lee, K.-H.3    Waddell, T.G.4
  • 15
    • 0027176524 scopus 로고
    • Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
    • Henkel, T., Machleidt, T., Alkalay, I., Ben-Neriah, Y.M.K., and Baeuerle, RA. (1993). Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365, 182-184.
    • (1993) Nature , vol.365 , pp. 182-184
    • Henkel, T.1    Machleidt, T.2    Alkalay, I.3    Ben-Neriah, Y.M.K.4    Baeuerle, R.A.5
  • 16
    • 0030600363 scopus 로고    scopus 로고
    • Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of map kinases
    • Hwang, D., Fischer, N.H., Jang, B.C., Tak, H., Kim, J.K., and Lee, W. (1996). Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of map kinases. Biochem. Biophys. Res. Comm. 226, 810-818.
    • (1996) Biochem. Biophys. Res. Comm. , vol.226 , pp. 810-818
    • Hwang, D.1    Fischer, N.H.2    Jang, B.C.3    Tak, H.4    Kim, J.K.5    Lee, W.6
  • 18
    • 0029150389 scopus 로고
    • Mice lacking the c-rel protooncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression
    • Köntgen, F., Grumont, R.J., Strasser, A., Metcalf, D., Li, R., Tarlinton, D., and Gerondakis, S. (1995). Mice lacking the c-rel protooncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression. Genes and Development 9, 1965-1977.
    • (1995) Genes and Development , vol.9 , pp. 1965-1977
    • Köntgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 19
    • 0028167846 scopus 로고
    • Inhibition of NF-κB by sodium salicylate and aspirin
    • Kopp, E., and Ghosh, S. (1994). Inhibition of NF-κB by sodium salicylate and aspirin. Science 265, 956-959.
    • (1994) Science , vol.265 , pp. 956-959
    • Kopp, E.1    Ghosh, S.2
  • 20
    • 0026652879 scopus 로고
    • The RxxRxRxxC motif conserved in all Rel/kB proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
    • Kumar, S., Rabson, A.B., and Gelinas, C. (1992). The RxxRxRxxC motif conserved in all Rel/kB proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein. Mol. Cell. Biol. 12, 3094-3106.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3094-3106
    • Kumar, S.1    Rabson, A.B.2    Gelinas, C.3
  • 22
    • 11844252150 scopus 로고
    • Cytokines, phagocytes and pentoxifylline
    • Mandell, G.L. (1995). Cytokines, phagocytes and pentoxifylline. J. Cardiovasc. Pharmacol. 25, S20-22.
    • (1995) J. Cardiovasc. Pharmacol. , vol.25
    • Mandell, G.L.1
  • 23
    • 0026715172 scopus 로고
    • Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond invoving cysteine 62
    • Matthews, J.R., Wakasugi, N., Virelizier, J.-L., Yodoi, J., and Hay, R.T. (1992). Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond invoving cysteine 62. Nucl. Acids Res. 30, 3821-3830.
    • (1992) Nucl. Acids Res. , vol.30 , pp. 3821-3830
    • Matthews, J.R.1    Wakasugi, N.2    Virelizier, J.-L.3    Yodoi, J.4    Hay, R.T.5
  • 24
    • 0014668947 scopus 로고
    • Effect of sulphhydryl binding compounds on the inflammatory process
    • Oronsky, A.L., Triner, L., Steinsland, O.S., and Nahas, G.G. (1969). Effect of sulphhydryl binding compounds on the inflammatory process. Nature 223, 619-621.
    • (1969) Nature , vol.223 , pp. 619-621
    • Oronsky, A.L.1    Triner, L.2    Steinsland, O.S.3    Nahas, G.G.4
  • 25
    • 0030603101 scopus 로고    scopus 로고
    • 2+ and reactive oxygen intermediates as messengers
    • 2+ and reactive oxygen intermediates as messengers. FEBS Lett. 392, 129-136.
    • (1996) FEBS Lett. , vol.392 , pp. 129-136
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 26
    • 0018698573 scopus 로고
    • Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione
    • Picman, A.K., Rodriguez, E., and Towers, C.H.N. (1979). Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione. Chem. Biol. Interact. 28, 83-89.
    • (1979) Chem. Biol. Interact. , vol.28 , pp. 83-89
    • Picman, A.K.1    Rodriguez, E.2    Towers, C.H.N.3
  • 27
    • 0029870463 scopus 로고    scopus 로고
    • Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leucocyte adhesion molecule expression and neutrophil transmigration
    • Pierce, J.W., Read, M.A., Ding, H., Luscinskas, F.W., and Collins, T. (1996). Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leucocyte adhesion molecule expression and neutrophil transmigration. J. Immunol. 156, 3961-3969.
    • (1996) J. Immunol. , vol.156 , pp. 3961-3969
    • Pierce, J.W.1    Read, M.A.2    Ding, H.3    Luscinskas, F.W.4    Collins, T.5
  • 29
    • 0030606137 scopus 로고    scopus 로고
    • Helenanolide type sesquiterpene lactones. Part 1. Conformations and molecular dynamics of helenalin, its esters and 11,13-dihydro derivatives
    • Schmidt, T.J. (1996). Helenanolide type sesquiterpene lactones. Part 1. Conformations and molecular dynamics of helenalin, its esters and 11,13-dihydro derivatives. J. Mol. Str. 385, 99-112.
    • (1996) J. Mol. Str. , vol.385 , pp. 99-112
    • Schmidt, T.J.1
  • 30
    • 0025820624 scopus 로고
    • A role of oxygen radicals as second messengers
    • Schreck, R., and Baeuerle, P.A. (1991). A role of oxygen radicals as second messengers. Trends Cell. Biol. 1, 39-42.
    • (1991) Trends Cell. Biol. , vol.1 , pp. 39-42
    • Schreck, R.1    Baeuerle, P.A.2
  • 31
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
    • Schreck, R., Rieber, P., and Baeuerle, P.A. (1991). Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 10, 2247-2258.
    • (1991) EMBO J. , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 32
    • 0026760583 scopus 로고
    • Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein
    • Schreck, R., Grassmann, R., Fleckenstein, B., and Baeuerle, P.A. (1992). Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein. J. Virol. 66, 6288-6293.
    • (1992) J. Virol. , vol.66 , pp. 6288-6293
    • Schreck, R.1    Grassmann, R.2    Fleckenstein, B.3    Baeuerle, P.A.4
  • 33
    • 0025304714 scopus 로고
    • Helenalin and 11α, 13-dihydrohelenalin, two constituents from Arnica montana I., inhibit human platelet function via thiol dependent pathways
    • Schröder, H., Lösche, W., Strobach, H., Leven, W., Willuhn, G., Till, U., and Schrör, K. (1990). Helenalin and 11α, 13-dihydrohelenalin, two constituents from Arnica montana I., inhibit human platelet function via thiol dependent pathways. Thromb. Res. 57, 839-845.
    • (1990) Thromb. Res. , vol.57 , pp. 839-845
    • Schröder, H.1    Lösche, W.2    Strobach, H.3    Leven, W.4    Willuhn, G.5    Till, U.6    Schrör, K.7
  • 34
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune reponses
    • Sha, W.C., Liou, H.-C., Tuomanen, E.I., and Baltimore, D. (1995). Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune reponses. Cell 80, 321-330.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.-C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 35
    • 0028181243 scopus 로고
    • Autoregulation of the NF-kappa B transactivator ReIA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs
    • Sun, S.-C., Ganchi, P.A., Béraud, C., Ballard, D.W., and Greene, W.C. (1994). Autoregulation of the NF-kappa B transactivator ReIA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc. Natl. Acad. Sci. USA 87, 1346-1350.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1346-1350
    • Sun, S.-C.1    Ganchi, P.A.2    Béraud, C.3    Ballard, D.W.4    Greene, W.C.5
  • 36
    • 0025852479 scopus 로고
    • Modulation of transcription factor NF-κB binding activity by oxidation-reductio in vitro
    • Toledano, M.B., and Leonhard, W.J. (1991). Modulation of transcription factor NF-κB binding activity by oxidation-reductio in vitro. Proc. Natl. Acad. Sci. 88, 4328-4332.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 4328-4332
    • Toledano, M.B.1    Leonhard, W.J.2
  • 37
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB
    • Traenckner, E.B.-M., Wilk, S., and Baeuerle, P.A. (1994). A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13, 5433-5441.
    • (1994) EMBO J. , vol.13 , pp. 5433-5441
    • Traenckner, E.B.-M.1    Wilk, S.2    Baeuerle, P.A.3
  • 38
    • 0028978032 scopus 로고
    • Phosphorylation of human IκB-α on serine 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
    • Traenckner, E.B.-M., Pahl, H.L., Henkel, T., Schmidt, K.N., Wilk, S., and Baeuerle, P.A. (1995). Phosphorylation of human IκB-α on serine 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14, 2876-2883.
    • (1995) EMBO J. , vol.14 , pp. 2876-2883
    • Traenckner, E.B.-M.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 39
    • 0025813098 scopus 로고
    • The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequences
    • Urban, M.B., and Baeuerle, P.A. (1991). The role of the p50 and p65 subunits of NF-kappa B in the recognition of cognate sequences. New Biol. 3, 279-288.
    • (1991) New Biol. , vol.3 , pp. 279-288
    • Urban, M.B.1    Baeuerle, P.A.2
  • 41
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
    • Wang, C.-Y., Mayo, M.W., and Baldwin, A.S. (1996). TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274, 784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.-Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 42
    • 0011287540 scopus 로고
    • Sesquiterpenelactone aus Arnica chamissonis less.: Röntgenstrukturanalyse von Chamissonolid
    • Wiebcke, M., Kresken, J., Mootz, D., and Willuhn, G. (1982). Sesquiterpenelactone aus Arnica chamissonis less.: Röntgenstrukturanalyse von Chamissonolid. Tetrahedron 38, 2709-2714.
    • (1982) Tetrahedron , vol.38 , pp. 2709-2714
    • Wiebcke, M.1    Kresken, J.2    Mootz, D.3    Willuhn, G.4
  • 43
    • 0026778831 scopus 로고
    • Human 55 kDa receptor for tumor necrosis factor coupled to signal transduction cascades
    • Wiegmann, K., Schütze, S., Kampen, E., Himmler, A., Machleidt, T., and Kröncke, M. (1992). Human 55 kDa receptor for tumor necrosis factor coupled to signal transduction cascades. J. Biol. Chem. 267, 17997-18001.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17997-18001
    • Wiegmann, K.1    Schütze, S.2    Kampen, E.3    Himmler, A.4    Machleidt, T.5    Kröncke, M.6
  • 44
    • 0000935295 scopus 로고
    • Sesquiterpenlactone, potentielle Leitsubstanzen für die Arzneistoffindung
    • Willuhn, G. (1987). Sesquiterpenlactone, potentielle Leitsubstanzen für die Arzneistoffindung. Dtsch. Apoth. Ztg. 127, 2511-2517.
    • (1987) Dtsch. Apoth. Ztg. , vol.127 , pp. 2511-2517
    • Willuhn, G.1
  • 45
    • 0025211845 scopus 로고
    • Weitere Helenanolide aus den Blüten von Arnica chamissonis subsp. foliosa
    • Willuhn, G., Kresken, J., and Leven, W. (1990). Weitere Helenanolide aus den Blüten von Arnica chamissonis subsp. foliosa. Planta Med. 56, 111-114.
    • (1990) Planta Med. , vol.56 , pp. 111-114
    • Willuhn, G.1    Kresken, J.2    Leven, W.3
  • 46
    • 0025905387 scopus 로고
    • On the Qualitative and Quantitative analysis of the Sesquiterpene Lactones of Arnicae flos DAB 9
    • Willuhn, G., and Leven, W. (1991). On the Qualitative and Quantitative analysis of the Sesquiterpene Lactones of Arnicae flos DAB 9. Pz. Wissenschaft 136, 32-39.
    • (1991) Pz. Wissenschaft , vol.136 , pp. 32-39
    • Willuhn, G.1    Leven, W.2
  • 48
    • 0029595394 scopus 로고
    • Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
    • Yamamoto, K., Arakawa, T., Ueda, N., and Yamamoto, S. (1995). Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270, 31315-31320.
    • (1995) J. Biol. Chem. , vol.270 , pp. 31315-31320
    • Yamamoto, K.1    Arakawa, T.2    Ueda, N.3    Yamamoto, S.4


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