A germacranolide sesquiterpene lactone suppressed inducible nitric oxide synthase by downregulating NF-κB activity

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 3, 2011, Pages 232-237

  Lee, Hwa Jin ^a   Jung, Hyeyoun ^a   Kwon, Junhye ^a   Li, Hua ^a   Lee, Da Yeon ^a   Lim, Hyo Jin ^a   Kim, Mi Ran ^b   Moon, Dong Cheul ^b   Ryu, Jae Ha ^a  

^a Sookmyung Women's University   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Carpesium triste var. manshuricum; Germacranolide sesquiterpene lactone; Inducible nitric oxide synthase; Inflammation; Macrophage; Nitric oxide; Nuclear factor B

Indexed keywords

2ALPHA,5 EPOXY 5,10 DIHYDROXY 6ALPHA ANGELOYLOXY 9BETA (3 METHYLBUTYLOXY)GERMACRAN 8ALPHA,12 OLIDE; GERMACRANOLIDE DERIVATIVE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE EXPRESSION; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; ASTERACEAE; CELL LINE; DOWN-REGULATION; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; SESQUITERPENES, GERMACRANE;

EID: 79952940937     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y11-004     Document Type: Article

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