메뉴 건너뛰기




Volumn 2015, Issue , 2015, Pages

Harnessing the Therapeutic Potential of Th17 Cells

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR; GAMMA INTERFERON;

EID: 84935839982     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/205156     Document Type: Review
Times cited : (34)

References (102)
  • 1
    • 84886092484 scopus 로고    scopus 로고
    • T cell subsets and T cell mediated immunity
    • F. P. Nijkamp and M. J. Parnham, Eds. Birkhauser, Basel, Switzerland
    • F. Broere, S. G. Apasov, M. V. Sitkovsky, and W. van Eden, "T cell subsets and T cell mediated immunity, " in Principles of Immunopharmacology, F. P. Nijkamp and M. J. Parnham, Eds., Birkhauser, Basel, Switzerland, 2011.
    • (2011) Principles of Immunopharmacology
    • Broere, F.1    Apasov, S.G.2    Sitkovsky, M.V.3    Van Eden, W.4
  • 2
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • C. Sutton, C. Brereton, B. Keogh, K. H. G. Mills, and E. C. Lavelle, "A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis, " The Journal of Experimental Medicine, vol. 203, no. 7, pp. 1685-1691, 2006.
    • (2006) The Journal of Experimental Medicine , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.G.4    Lavelle, E.C.5
  • 3
    • 67349128569 scopus 로고    scopus 로고
    • Dual nature of the adaptive immune system in lampreys
    • P. Guo, M. Hirano, B. R. Herrin, et al., "Dual nature of the adaptive immune system in lampreys, " Nature, vol. 459, no. 7248, pp. 796-801, 2009.
    • (2009) Nature , vol.459 , Issue.7248 , pp. 796-801
    • Guo, P.1    Hirano, M.2    Herrin, B.R.3
  • 4
    • 84863151799 scopus 로고    scopus 로고
    • Microbiotainduced IL-1β, but not IL-6, is critical for the development of steady-state Tβ17 cells in the intestine
    • M. H. Shaw, N. Kamada, Y.-G. Kim, and G. Nunez, "Microbiotainduced IL-1β, but not IL-6, is critical for the development of steady-state Tβ17 cells in the intestine, " Journal of Experimental Medicine, vol. 209, no. 2, pp. 251-258, 2012.
    • (2012) Journal of Experimental Medicine , vol.209 , Issue.2 , pp. 251-258
    • Shaw, M.H.1    Kamada, N.2    Kim, Y.-G.3    Nunez, G.4
  • 5
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • W. Ouyang, J. K. Kolls, and Y. Zheng, "The biological functions of T helper 17 cell effector cytokines in inflammation, " Immunity, vol. 28, no. 4, pp. 454-467, 2008.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 6
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin mediates early host defense against attaching and effacing bacterial pathogens
    • Y. Zheng, P. A. Valdez, D. M. Danilenko, et al., "Interleukin mediates early host defense against attaching and effacing bacterial pathogens, " Nature Medicine, vol. 14, no. 3, pp. 282-289, 2008.
    • (2008) Nature Medicine , vol.14 , Issue.3 , pp. 282-289
    • Zheng, Y.1    Valdez, P.A.2    Danilenko, D.M.3
  • 8
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • S. L. Gaffen, "Structure and signalling in the IL-17 receptor family, " Nature Reviews Immunology, vol. 9, no. 8, pp. 556-567, 2009.
    • (2009) Nature Reviews Immunology , vol.9 , Issue.8 , pp. 556-567
    • Gaffen, S.L.1
  • 9
    • 4344688669 scopus 로고    scopus 로고
    • IL-17 markedly up-regulates β-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways
    • C. Y. Kao, Y. Chen, P. Thai, et al., "IL-17 markedly up-regulates β-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways, " Journal of Immunology, vol. 173, no. 5, pp. 3482-3491, 2004.
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3482-3491
    • Kao, C.Y.1    Chen, Y.2    Thai, P.3
  • 10
    • 10044236725 scopus 로고    scopus 로고
    • A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis
    • C. A. Hitchon, P. Alex, L. B. Erdile, et al., "A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis, "The Journal of Rheumatology, vol. 31, no. 12, pp. 2336-2346, 2004.
    • (2004) The Journal of Rheumatology , vol.31 , Issue.12 , pp. 2336-2346
    • Hitchon, C.A.1    Alex, P.2    Erdile, L.B.3
  • 11
    • 34248562792 scopus 로고    scopus 로고
    • IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    • S. A. Khader, G. K. Bell, J. E. Pearl, et al., "IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge, " Nature Immunology, vol. 8, no. 4, pp. 369-377, 2007.
    • (2007) Nature Immunology , vol.8 , Issue.4 , pp. 369-377
    • Khader, S.A.1    Bell, G.K.2    Pearl, J.E.3
  • 12
    • 70350510860 scopus 로고    scopus 로고
    • IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: A novel mechanism of osteoclastogenesis by IL-17
    • T. Yago, Y. Nanke, N. Ichikawa, et al., "IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17, " Journal of Cellular Biochemistry, vol. 108, no. 4, pp. 947-955, 2009.
    • (2009) Journal of Cellular Biochemistry , vol.108 , Issue.4 , pp. 947-955
    • Yago, T.1    Nanke, Y.2    Ichikawa, N.3
  • 13
    • 84863795747 scopus 로고    scopus 로고
    • A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells
    • H. Fujie, K. Niu, M. Ohba, et al., "A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells, " Inflammation, vol. 35, no. 3, pp. 1119-1131, 2012.
    • (2012) Inflammation , vol.35 , Issue.3 , pp. 1119-1131
    • Fujie, H.1    Niu, K.2    Ohba, M.3
  • 14
    • 80054033683 scopus 로고    scopus 로고
    • Human TH17 cells are longlived effector memory cells
    • Article ID 104ra100
    • I. Kryczek, E. Zhao, Y. Liu, et al., "Human TH17 cells are longlived effector memory cells, " Science TranslationalMedicine, vol. 3, no. 104, Article ID 104ra100, 2011.
    • (2011) Science TranslationalMedicine , vol.3 , Issue.104
    • Kryczek, I.1    Zhao, E.2    Liu, Y.3
  • 15
    • 84860241847 scopus 로고    scopus 로고
    • Pathogeninduced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
    • C. E. Zielinski, F. Mele, D. Aschenbrenner, et al., "Pathogeninduced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta, " Nature, vol. 484, no. 7395, pp. 514-518, 2012.
    • (2012) Nature , vol.484 , Issue.7395 , pp. 514-518
    • Zielinski, C.E.1    Mele, F.2    Aschenbrenner, D.3
  • 16
    • 49249135394 scopus 로고    scopus 로고
    • Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    • L. Cosmi, R. De Palma, V. Santarlasci, et al., "Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor, " The Journal of Experimental Medicine, vol. 205, no. 8, pp. 1903-1916, 2008.
    • (2008) The Journal of Experimental Medicine , vol.205 , Issue.8 , pp. 1903-1916
    • Cosmi, L.1    De Palma, R.2    Santarlasci, V.3
  • 17
    • 84892536761 scopus 로고    scopus 로고
    • Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
    • R. Ramesh, L. Kozhaya, K. McKevitt, et al., "Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids, " The Journal of Experimental Medicine, vol. 211, no. 1, pp. 89-104, 2014.
    • (2014) The Journal of Experimental Medicine , vol.211 , Issue.1 , pp. 89-104
    • Ramesh, R.1    Kozhaya, L.2    McKevitt, K.3
  • 18
    • 84255215452 scopus 로고    scopus 로고
    • Th17 cells are long lived and retain a stemcell-like molecular signature
    • P. Muranski, Z. A. Borman, S. P. Kerkar, et al., "Th17 cells are long lived and retain a stemcell-like molecular signature, " Immunity, vol. 35, no. 6, pp. 972-985, 2011.
    • (2011) Immunity , vol.35 , Issue.6 , pp. 972-985
    • Muranski, P.1    Borman, Z.A.2    Kerkar, S.P.3
  • 19
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin monoclonal antibody ixekizumab in chronic plaque psoriasis
    • C. Leonardi, R. Matheson, C. Zachariae, et al., "Anti-interleukin monoclonal antibody ixekizumab in chronic plaque psoriasis, " The New England Journal of Medicine, vol. 366, no. 13, pp. 1190-1191, 2012.
    • (2012) The New England Journal of Medicine , vol.366 , Issue.13 , pp. 1190-1191
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3
  • 20
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • K. A. Papp, C. Leonardi, A. Menter, et al., "Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis, " The New England Journal ofMedicine, vol. 366, no. 13, pp. 1181-1189, 2012.
    • (2012) The New England Journal OfMedicine , vol.366 , Issue.13 , pp. 1181-1189
    • Papp, K.A.1    Leonardi, C.2    Menter, A.3
  • 21
    • 84891740105 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: A 24-week, rand omised, double-blind, placebo-controlled, phase II proof-of-concept trial
    • I. B. McInnes, J. Sieper, J. Braun, et al., "Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, rand omised, double-blind, placebo-controlled, phase II proof-of-concept trial, " Annals of the Rheumatic Diseases, vol. 73, no. 2, pp. 349-356, 2014.
    • (2014) Annals of the Rheumatic Diseases , vol.73 , Issue.2 , pp. 349-356
    • McInnes, I.B.1    Sieper, J.2    Braun, J.3
  • 22
    • 84903478179 scopus 로고    scopus 로고
    • A phase II rand omized study of subcutaneous ixekizumab, an antiinterleukin monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors
    • M. C. Genovese, M. Greenwald, C. Cho, et al., "A phase II rand omized study of subcutaneous ixekizumab, an antiinterleukin monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors, " Arthritis & Rheumatology, vol. 66, no. 7, pp. 1693-1704, 2014.
    • (2014) Arthritis & Rheumatology , vol.66 , Issue.7 , pp. 1693-1704
    • Genovese, M.C.1    Greenwald, M.2    Cho, C.3
  • 23
    • 84887992906 scopus 로고    scopus 로고
    • Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A rand omised, double-blind, placebo-controlled trial
    • D. Baeten, X. Baraliakos, J. Braun, et al., "Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a rand omised, double-blind, placebo-controlled trial, " The Lancet, vol. 382, no. 9906, pp. 1705-1713, 2013.
    • (2013) The Lancet , vol.382 , Issue.9906 , pp. 1705-1713
    • Baeten, D.1    Baraliakos, X.2    Braun, J.3
  • 24
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohns disease: Unexpected results of a rand omised, double-blindplacebo-controlled trial
    • W. Hueber, B. E. Sands, S. Lewitzky, et al., "Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohns disease: unexpected results of a rand omised, double-blindplacebo-controlled trial, " Gut, vol. 61, no. 12, pp. 1693-1700, 2012.
    • (2012) Gut , vol.61 , Issue.12 , pp. 1693-1700
    • Hueber, W.1    Sands, E.B.2    Lewitzky, S.3
  • 25
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • K. Hirota, J. H. Duarte, M. Veldhoen, et al., "Fate mapping of IL-17-producing T cells in inflammatory responses, " Nature Immunology, vol. 12, no. 3, pp. 255-263, 2011.
    • (2011) Nature Immunology , vol.12 , Issue.3 , pp. 255-263
    • Hirota, K.1    Duarte, J.H.2    Veldhoen, M.3
  • 26
    • 84866532132 scopus 로고    scopus 로고
    • Induction and molecular signature of pathogenic TH17 cells
    • Y. Lee, A. Awasthi, N. Yosef, et al., "Induction and molecular signature of pathogenic TH17 cells, " Nature Immunology, vol. 13, no. 10, pp. 991-999, 2012.
    • (2012) Nature Immunology , vol.13 , Issue.10 , pp. 991-999
    • Lee, Y.1    Awasthi, A.2    Yosef, N.3
  • 27
    • 84928779693 scopus 로고    scopus 로고
    • Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to driveTh17-mediated tumorigenesis
    • article 6956
    • Z. Deng, J. Mu, M. Tseng, et al., "Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to driveTh17-mediated tumorigenesis, " Nature Communications, vol. 6, article 6956, 2015.
    • (2015) Nature Communications , vol.6
    • Deng, Z.1    Mu, J.2    Tseng, M.3
  • 28
    • 84867581744 scopus 로고    scopus 로고
    • A validated regulatory network for Th17 cell specification
    • M. Ciofani, A. Madar, C. Galan, et al., "A validated regulatory network for Th17 cell specification, " Cell, vol. 151, no. 2, pp. 289-303, 2012.
    • (2012) Cell , vol.151 , Issue.2 , pp. 289-303
    • Ciofani, M.1    Madar, A.2    Galan, C.3
  • 29
    • 67651001561 scopus 로고    scopus 로고
    • The AP-1 transcription factor Batf controls TH17 differentiation
    • B. U. Schraml, K. Hildner, W. Ise, et al., "The AP-1 transcription factor Batf controls TH17 differentiation, " Nature, vol. 460, no. 7253, pp. 405-409, 2009.
    • (2009) Nature , vol.460 , Issue.7253 , pp. 405-409
    • Schraml, B.U.1    Hildner, K.2    Ise, W.3
  • 30
    • 78649693010 scopus 로고    scopus 로고
    • Low-strength T-cell activation promotes Th17 responses
    • H. A. Purvis, J. N. Stoop, J. Mann, et al., "Low-strength T-cell activation promotes Th17 responses, " Blood, vol. 116, no. 23, pp. 4829-4837, 2010.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4829-4837
    • Purvis, H.A.1    Stoop, J.N.2    Mann, J.3
  • 31
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Y. Chung, S. H. Chang, G. J. Martinez, et al., "Critical regulation of early Th17 cell differentiation by interleukin-1 signaling, " Immunity, vol. 30, no. 4, pp. 576-587, 2009.
    • (2009) Immunity , vol.30 , Issue.4 , pp. 576-587
    • Chung, Y.1    Chang, S.H.2    Martinez, G.J.3
  • 32
    • 84896402211 scopus 로고    scopus 로고
    • The transcriptionfactors T-bet and runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells
    • Y. Wang, J. Godec, K. Ben-Aissa, et al., "The transcriptionfactors T-bet and runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells, " Immunity, vol. 40, no. 3, pp. 355-366, 2014.
    • (2014) Immunity , vol.40 , Issue.3 , pp. 355-366
    • Wang, Y.1    Godec, J.2    Ben-Aissa, K.3
  • 33
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORt and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • F. Zhang, G. Meng, and W. Strober, "Interactions among the transcription factors Runx1, RORt and Foxp3 regulate the differentiation of interleukin 17-producing T cells, " Nature Immunology, vol. 9, no. 11, pp. 1297-1306, 2008.
    • (2008) Nature Immunology , vol.9 , Issue.11 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 34
    • 58149251898 scopus 로고    scopus 로고
    • Late developmental plasticity in the T helper 17 lineage
    • Y. K. Lee, H. Turner, C. L. Maynard, et al., "Late developmental plasticity in the T helper 17 lineage, " Immunity, vol. 30, no. 1, pp. 92-107, 2009.
    • (2009) Immunity , vol.30 , Issue.1 , pp. 92-107
    • Lee, Y.K.1    Turner, H.2    Maynard, C.L.3
  • 35
    • 77953238901 scopus 로고    scopus 로고
    • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage
    • R. Mukasa, A. Balasubramani, Y. K. Lee, et al., "Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage, " Immunity, vol. 32, no. 5, pp. 616-627, 2010.
    • (2010) Immunity , vol.32 , Issue.5 , pp. 616-627
    • Mukasa, R.1    Balasubramani, A.2    Lee, Y.K.3
  • 36
    • 78650306567 scopus 로고    scopus 로고
    • T-bet represses TH 17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat
    • V. Lazarevic, X. Chen, J.-H. Shim, et al., "T-bet represses TH 17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat, " Nature Immunology, vol. 12, no. 1, pp. 96-104, 2011.
    • (2011) Nature Immunology , vol.12 , Issue.1 , pp. 96-104
    • Lazarevic, V.1    Chen, X.2    Shim, J.-H.3
  • 37
    • 84893850913 scopus 로고    scopus 로고
    • TNF-κ blockade induces IL-10 expression in human CD4+ T cells
    • article 3199
    • H. G. Evans, U. Roostalu, G. J. Walter, et al., "TNF-κ blockade induces IL-10 expression in human CD4+ T cells, " Nature Communications, vol. 5, article 3199, 2014.
    • (2014) Nature Communications , vol.5
    • Evans, H.G.1    Roostalu, U.2    Walter, G.J.3
  • 38
    • 73249149628 scopus 로고    scopus 로고
    • C-Maf regulates IL-10 expression during Th17 polarization
    • J. Xu, Y. Yang, G. Qiu, et al., "c-Maf regulates IL-10 expression during Th17 polarization, " Journal of Immunology, vol. 182, no. 10, pp. 6226-6236, 2009.
    • (2009) Journal of Immunology , vol.182 , Issue.10 , pp. 6226-6236
    • Xu, J.1    Yang, Y.2    Qiu, G.3
  • 39
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL) and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • S. C. Liang, X.-Y. Tan, D. P. Luxenberg, et al., "Interleukin (IL) and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides, " The Journal of Experimental Medicine, vol. 203, no. 10, pp. 2271-2279, 2006.
    • (2006) The Journal of Experimental Medicine , vol.203 , Issue.10 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.-Y.2    Luxenberg, D.P.3
  • 40
    • 73149118287 scopus 로고    scopus 로고
    • Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4
    • L. Cosmi, L. Maggi, V. Santarlasci, et al., "Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4, " The Journal of Allergy and Clinical Immunology, vol. 125, no. 1-3, pp. 222-230. e4, 2010.
    • (2010) The Journal of Allergy and Clinical Immunology , vol.125 , Issue.1-3 , pp. 222-222e4
    • Cosmi, L.1    Maggi, L.2    Santarlasci, V.3
  • 42
    • 33947134834 scopus 로고    scopus 로고
    • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • A. P. Bracken, D. Kleine-Kohlbrecher, N. Dietrich, et al., "The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells, " Genes and Development, vol. 21, no. 5, pp. 525-530, 2007.
    • (2007) Genes and Development , vol.21 , Issue.5 , pp. 525-530
    • Bracken, A.P.1    Kleine-Kohlbrecher, D.2    Dietrich, N.3
  • 43
    • 84896347048 scopus 로고    scopus 로고
    • β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells
    • Article ID 225ra28
    • S. Keerthivasan, K. Aghajani, M. Dose, et al., "β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells, " Science Translational Medicine, vol. 6, no. 225, Article ID 225ra28, 2014.
    • (2014) Science Translational Medicine , vol.6 , Issue.225
    • Keerthivasan, S.1    Aghajani, K.2    Dose, M.3
  • 44
    • 41449110468 scopus 로고    scopus 로고
    • Impaired Tβ17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • J. D. Milner, J. M. Brenchley, A. Laurence, et al., "Impaired Tβ17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome, " Nature, vol. 452, no. 7188, pp. 773-776, 2008.
    • (2008) Nature , vol.452 , Issue.7188 , pp. 773-776
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3
  • 45
    • 84255162082 scopus 로고    scopus 로고
    • Th17 cells mediate cladespecific, serotype-independent mucosal immunity
    • K. Chen, J. P. McAleer, Y. Lin, et al., "Th17 cells mediate cladespecific, serotype-independent mucosal immunity, " Immunity, vol. 35, no. 6, pp. 997-1009, 2011.
    • (2011) Immunity , vol.35 , Issue.6 , pp. 997-1009
    • Chen, K.1    McAleer, J.P.2    Lin, Y.3
  • 46
    • 15744392526 scopus 로고    scopus 로고
    • Are anticapsular antibodies the primarymechanism of protection against invasive pneumococcal disease?
    • article e15
    • M. Lipsitch, C. G. Whitney, E. Zell, T. Kaijalainen, R. Dagan, and R. Malley, "Are anticapsular antibodies the primarymechanism of protection against invasive pneumococcal disease?" PLoS Medicine, vol. 2, no. 1, article e15, 2005.
    • (2005) PLoS Medicine , vol.2 , Issue.1
    • Lipsitch, M.1    Whitney, C.G.2    Zell, E.3    Kaijalainen, T.4    Dagan, R.5    Malley, R.6
  • 47
    • 35348948374 scopus 로고    scopus 로고
    • Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
    • A. J. van Beelen, Z. Zelinkova, E. W. Taanman-Kueter, et al., "Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells, " Immunity, vol. 27, no. 4, pp. 660-669, 2007.
    • (2007) Immunity , vol.27 , Issue.4 , pp. 660-669
    • Van Beelen, A.J.1    Zelinkova, Z.2    Taanman-Kueter, E.W.3
  • 48
    • 84918502868 scopus 로고    scopus 로고
    • Ag-presenting CpGactivated pDCs prime Th17 cells that induce tumor regression
    • L. Guery, J. Dubrot, C. Lippens, et al., "Ag-presenting CpGactivated pDCs prime Th17 cells that induce tumor regression, " Cancer Research, vol. 74, no. 22, pp. 6430-6440, 2014.
    • (2014) Cancer Research , vol.74 , Issue.22 , pp. 6430-6440
    • Guery, L.1    Dubrot, J.2    Lippens, C.3
  • 49
    • 79961169153 scopus 로고    scopus 로고
    • IL-17 signaling in host defense against Candida albicans
    • S. L. Gaffen, N. Hernand ez-Santos, and A. C. Peterson, "IL-17 signaling in host defense against Candida albicans, " Immunologic Research, vol. 50, no. 2-3, pp. 181-187, 2011.
    • (2011) Immunologic Research , vol.50 , Issue.2-3 , pp. 181-187
    • Gaffen, S.L.1    Hernandez-Santos, N.2    Peterson, A.C.3
  • 50
    • 77953188589 scopus 로고    scopus 로고
    • Host responses to Candida albicans: Th17 cells and mucosal cand idiasis
    • H. R. Conti and S. L. Gaffen, "Host responses to Candida albicans: Th17 cells and mucosal cand idiasis, " Microbes and Infection, vol. 12, no. 7, pp. 518-527, 2010.
    • (2010) Microbes and Infection , vol.12 , Issue.7 , pp. 518-527
    • Conti, H.R.1    Gaffen, S.L.2
  • 51
    • 74549186432 scopus 로고    scopus 로고
    • Th1-Th17 cells mediate protective adaptiveimmunity against Staphylococcus aureus and Candida albicans infection in mice
    • Article ID e1000703
    • L. Lin, A. S. Ibrahim, X. Xu, et al., "Th1-Th17 cells mediate protective adaptiveimmunity against Staphylococcus aureus and Candida albicans infection in mice, " PLoS Pathogens, vol. 5, no. 12, Article ID e1000703, 2009.
    • (2009) PLoS Pathogens , vol.5 , Issue.12
    • Lin, L.1    Ibrahim, A.S.2    Xu, X.3
  • 52
    • 14244265144 scopus 로고    scopus 로고
    • Septic arthritis in the adult caused by Streptococcus pneumoniae: A report of 4 cases and review of the literature
    • J. Raad and J. E. Peacock Jr., "Septic arthritis in the adult caused by Streptococcus pneumoniae: a report of 4 cases and review of the literature, " Seminars in Arthritis and Rheumatism, vol. 34, no. 2, pp. 559-569, 2004.
    • (2004) Seminars in Arthritis and Rheumatism , vol.34 , Issue.2 , pp. 559-569
    • Raad, J.1    Peacock, J.E.2
  • 53
    • 0034619061 scopus 로고    scopus 로고
    • Prevention of pneumococcal disease by vaccination: Does serotype replacement matter?
    • B. G. Spratt and B. M. Greenwood, "Prevention of pneumococcal disease by vaccination: does serotype replacement matter?" The Lancet, vol. 356, no. 9237, pp. 1210-1211, 2000.
    • (2000) The Lancet , vol.356 , Issue.9237 , pp. 1210-1211
    • Spratt, B.G.1    Greenwood, B.M.2
  • 54
    • 79951617103 scopus 로고    scopus 로고
    • Tβ17-based vaccine design for prevention of Streptococcus pneumoniae colonization
    • K. L. Moffitt, T. M. Gierahn, Y.-J. Lu, et al., "Tβ17-based vaccine design for prevention of Streptococcus pneumoniae colonization, " Cell Host and Microbe, vol. 9, no. 2, pp. 158-165, 2011.
    • (2011) Cell Host and Microbe , vol.9 , Issue.2 , pp. 158-165
    • Moffitt, K.L.1    Gierahn, T.M.2    Lu, Y.-J.3
  • 55
    • 68449085481 scopus 로고    scopus 로고
    • Cellular effectorsmediatingTh17-dependent clearance of pneumococcal colonization in mice
    • Z. Zhang, T. B. Clarke, and J. N. Weiser, "Cellular effectorsmediatingTh17-dependent clearance of pneumococcal colonization in mice, "The Journal of Clinical Investigation, vol. 119, no. 7, pp. 1899-1909, 2009.
    • (2009) The Journal of Clinical Investigation , vol.119 , Issue.7 , pp. 1899-1909
    • Zhang, Z.1    Clarke, T.B.2    Weiser, J.N.3
  • 56
    • 53049107872 scopus 로고    scopus 로고
    • Interleukin-17A mediates acquired immunity to pneumococcal colonization
    • Article ID e1000159
    • Y.-J. Lu, J. Gross, D. Bogaert, et al., "Interleukin-17A mediates acquired immunity to pneumococcal colonization, " PLoS Pathogens, vol. 4, no. 9, Article ID e1000159, 2008.
    • (2008) PLoS Pathogens , vol.4 , Issue.9
    • Lu, Y.-J.1    Gross, J.2    Bogaert, D.3
  • 57
    • 33645521806 scopus 로고    scopus 로고
    • Antibodyindependent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide
    • R. Malley, A. Srivastava, M. Lipsitch, et al., "Antibodyindependent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide, " Infection and Immunity, vol. 74, no. 4, pp. 2187-2195, 2006.
    • (2006) Infection and Immunity , vol.74 , Issue.4 , pp. 2187-2195
    • Malley, R.1    Srivastava, A.2    Lipsitch, M.3
  • 58
    • 84861190678 scopus 로고    scopus 로고
    • Characterization of Th17 responses to Streptococcus pneumoniae in humans: Comparisons between adults and children in a developed and a developing country
    • A. Lundgren, T. R. Bhuiyan, D. Novak, et al., "Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country, " Vaccine, vol. 30, no. 26, pp. 3897-3907, 2012.
    • (2012) Vaccine , vol.30 , Issue.26 , pp. 3897-3907
    • Lundgren, A.1    Bhuiyan, T.R.2    Novak, D.3
  • 59
    • 58149314577 scopus 로고    scopus 로고
    • IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa
    • G. P. Priebe, R. L. Walsh, T. A. Cederroth, et al., "IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa, " Journal of Immunology, vol. 181, no. 7, pp. 4965-4975, 2008.
    • (2008) Journal of Immunology , vol.181 , Issue.7 , pp. 4965-4975
    • Priebe, G.P.1    Walsh, R.L.2    Cederroth, T.A.3
  • 60
    • 84865810704 scopus 로고    scopus 로고
    • Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia
    • W. Wu, J. Huang, B. Duan, et al., "Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia, " American Journal of Respiratory and Critical Care Medicine, vol. 186, no. 5, pp. 420-427, 2012.
    • (2012) American Journal of Respiratory and Critical Care Medicine , vol.186 , Issue.5 , pp. 420-427
    • Wu, W.1    Huang, J.2    Duan, B.3
  • 61
    • 33751579426 scopus 로고    scopus 로고
    • TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: Role of IL-17-producing T cells
    • S. C. Higgins, A. G. Jarnicki, E. C. Lavelle, and K. H. G. Mills, "TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells, " Journal of Immunology, vol. 177, no. 11, pp. 7980-7989, 2006.
    • (2006) Journal of Immunology , vol.177 , Issue.11 , pp. 7980-7989
    • Higgins, S.C.1    Jarnicki, A.G.2    Lavelle, E.C.3    Mills, K.H.G.4
  • 62
    • 79953664725 scopus 로고    scopus 로고
    • Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
    • D. C. Newcomb, M. G. Boswell, W. Zhou, et al., "Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production, " The Journal of Allergy and Clinical Immunology, vol. 127, no. 4, pp. 1006-1013, 2011.
    • (2011) The Journal of Allergy and Clinical Immunology , vol.127 , Issue.4 , pp. 1006-1013
    • Newcomb, D.C.1    Boswell, M.G.2    Zhou, W.3
  • 63
    • 84860997738 scopus 로고    scopus 로고
    • Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis
    • T. E. Faber, H. Groen, M. Welfing, K. J. G. Jansen, and L. J. Bont, "Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis, " Journal of Medical Virology, vol. 84, no. 7, pp. 1084-1088, 2012.
    • (2012) Journal of Medical Virology , vol.84 , Issue.7 , pp. 1084-1088
    • Faber, T.E.1    Groen, H.2    Welfing, M.3    Jansen, K.J.G.4    Bont, L.J.5
  • 64
    • 84892640386 scopus 로고    scopus 로고
    • Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism
    • C. Schnoeller, X. Roux, D. Sawant, et al., "Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism, " American Journal of Respiratory and Critical CareMedicine, vol. 189, no. 2, pp. 194-202, 2014.
    • (2014) American Journal of Respiratory and Critical CareMedicine , vol.189 , Issue.2 , pp. 194-202
    • Schnoeller, C.1    Roux, X.2    Sawant, D.3
  • 65
    • 0037849915 scopus 로고    scopus 로고
    • Interleukin-17 promotes angiogenesis and tumor growth
    • M. Numasaki, J. I. Fukushi, M. Ono, et al., "Interleukin-17 promotes angiogenesis and tumor growth, " Blood, vol. 101, no. 7, pp. 2620-2627, 2003.
    • (2003) Blood , vol.101 , Issue.7 , pp. 2620-2627
    • Numasaki, M.1    Fukushi, J.I.2    Ono, M.3
  • 66
    • 69849107597 scopus 로고    scopus 로고
    • Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    • I. Kryczek, M. Banerjee, P. Cheng, et al., "Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments, " Blood, vol. 114, no. 6, pp. 1141-1149, 2009.
    • (2009) Blood , vol.114 , Issue.6 , pp. 1141-1149
    • Kryczek, I.1    Banerjee, M.2    Cheng, P.3
  • 67
    • 64549108462 scopus 로고    scopus 로고
    • Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    • J.-P. Zhang, J. Yan, J. Xu, et al., "Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients, " Journal of Hepatology, vol. 50, no. 5, pp. 980-989, 2009.
    • (2009) Journal of Hepatology , vol.50 , Issue.5 , pp. 980-989
    • Zhang, J.-P.1    Yan, J.2    Xu, J.3
  • 68
    • 84868613705 scopus 로고    scopus 로고
    • Adenomalinked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    • S. I. Grivennikov, K. Wang, D. Mucida, et al., "Adenomalinked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth, " Nature, vol. 491, no. 7423, pp. 254-258, 2012.
    • (2012) Nature , vol.491 , Issue.7423 , pp. 254-258
    • Grivennikov, S.I.1    Wang, K.2    Mucida, D.3
  • 69
    • 84973897588 scopus 로고    scopus 로고
    • Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer
    • E. Punkenburg, T. Vogler, M. Buttner, et al., "Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer, " Gut, 2015.
    • (2015) Gut
    • Punkenburg, E.1    Vogler, T.2    Buttner, M.3
  • 70
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • S. Wu, K.-J. Rhee, E. Albesiano, et al., "A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses, " Nature Medicine, vol. 15, no. 9, pp. 1016-1022, 2009.
    • (2009) Nature Medicine , vol.15 , Issue.9 , pp. 1016-1022
    • Wu, S.1    Rhee, K.-J.2    Albesiano, E.3
  • 71
    • 84918535539 scopus 로고    scopus 로고
    • Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis
    • K. Wang, M. Kim, G. Di Caro, et al., "Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis, " Immunity, vol. 41, no. 6, pp. 1052-1063, 2014.
    • (2014) Immunity , vol.41 , Issue.6 , pp. 1052-1063
    • Wang, K.1    Kim, M.2    Di Caro, G.3
  • 72
    • 84863136709 scopus 로고    scopus 로고
    • IL-17 mediated inflammation promotes tumor growth and progression in the skin
    • Article ID e32126
    • D. He, H. Li, N. Yusuf, et al., "IL-17 mediated inflammation promotes tumor growth and progression in the skin, " PLoS ONE, vol. 7, no. 2, Article ID e32126, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.2
    • He, D.1    Li, H.2    Yusuf, N.3
  • 73
    • 77949329050 scopus 로고    scopus 로고
    • Tumor microenvironments direct the recruitment and expansion of humanTh17 cells
    • X. Su, J. Ye, E. C. Hsueh, Y. Zhang, D. F. Hoft, and G. Peng, "Tumor microenvironments direct the recruitment and expansion of humanTh17 cells, " Journal of Immunology, vol. 184, no. 3, pp. 1630-1641, 2010.
    • (2010) Journal of Immunology , vol.184 , Issue.3 , pp. 1630-1641
    • Su, X.1    Ye, J.2    Hsueh, E.C.3    Zhang, Y.4    Hoft, D.F.5    Peng, G.6
  • 74
    • 67650684023 scopus 로고    scopus 로고
    • The IL-17/IL-23 axis of inflammation in cancer: Friend or foe?
    • N. Martin-Orozco and C. Dong, "The IL-17/IL-23 axis of inflammation in cancer: friend or foe?" Current Opinion in Investigational Drugs, vol. 10, no. 6, pp. 543-549, 2009.
    • (2009) Current Opinion in Investigational Drugs , vol.10 , Issue.6 , pp. 543-549
    • Martin-Orozco, N.1    Dong, C.2
  • 75
    • 84858795377 scopus 로고    scopus 로고
    • Stat3 and Gfi transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression
    • F. Chalmin, G. Mignot, M. Bruchard, et al., "Stat3 and Gfi transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression, " Immunity, vol. 36, no. 3, pp. 362-373, 2012.
    • (2012) Immunity , vol.36 , Issue.3 , pp. 362-373
    • Chalmin, F.1    Mignot, G.2    Bruchard, M.3
  • 76
    • 77549083441 scopus 로고    scopus 로고
    • Transforming growth factor beta (TGF-β) and inflammation in cancer
    • B. Bierie and H. L. Moses, "Transforming growth factor beta (TGF-β) and inflammation in cancer, " Cytokine & Growth Factor Reviews, vol. 21, no. 1, pp. 49-59, 2010.
    • (2010) Cytokine & Growth Factor Reviews , vol.21 , Issue.1 , pp. 49-59
    • Bierie, B.1    Moses, H.L.2
  • 77
    • 79953681584 scopus 로고    scopus 로고
    • IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma
    • J. Liu, Y. Duan, X. Cheng, et al., "IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma, " Biochemical and Biophysical Research Communications, vol. 407, no. 2, pp. 348-354, 2011.
    • (2011) Biochemical and Biophysical Research Communications , vol.407 , Issue.2 , pp. 348-354
    • Liu, J.1    Duan, Y.2    Cheng, X.3
  • 79
    • 78049518331 scopus 로고    scopus 로고
    • The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells
    • Article ID 55ra78
    • C. M. Paulos, C. Carpenito, G. Plesa, et al., "The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells, " Science Translational Medicine, vol. 2, no. 55, Article ID 55ra78, 2010.
    • (2010) Science Translational Medicine , vol.2 , Issue.55
    • Paulos, C.M.1    Carpenito, C.2    Plesa, G.3
  • 80
    • 79955538365 scopus 로고    scopus 로고
    • Digoxin and its derivatives suppress T H17 cell differentiation by antagonizing ROR3t activity
    • J. R. Huh, M. W. L. Leung, P. Huang, et al., "Digoxin and its derivatives suppress T H17 cell differentiation by antagonizing ROR3t activity, " Nature, vol. 472, no. 7344, pp. 486-490, 2011.
    • (2011) Nature , vol.472 , Issue.7344 , pp. 486-490
    • Huh, J.R.1    Leung, M.W.L.2    Huang, P.3
  • 81
    • 84898688169 scopus 로고    scopus 로고
    • Small-molecule RORgammat antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms
    • S. Xiao, N. Yosef, J. Yang, et al., "Small-molecule RORgammat antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, " Immunity, vol. 40, no. 4, pp. 477-489, 2014.
    • (2014) Immunity , vol.40 , Issue.4 , pp. 477-489
    • Xiao, S.1    Yosef, N.2    Yang, J.3
  • 82
    • 79955526989 scopus 로고    scopus 로고
    • Suppression of T17 differentiation and autoimmunity by a synthetic ROR ligand
    • L. A. Solt, N. Kumar, P. Nuhant, et al., "Suppression of T17 differentiation and autoimmunity by a synthetic ROR ligand, " Nature, vol. 472, no. 7344, pp. 491-494, 2011.
    • (2011) Nature , vol.472 , Issue.7344 , pp. 491-494
    • Solt, L.A.1    Kumar, N.2    Nuhant, P.3
  • 83
    • 79959538387 scopus 로고    scopus 로고
    • Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORt protein
    • T. Xu, X. Wang, B. Zhong, R. I. Nurieva, S. Ding, and C. Dong, "Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORt protein, " The Journal of Biological Chemistry, vol. 286, no. 26, pp. 22707-22710, 2011.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.26 , pp. 22707-22710
    • Xu, T.1    Wang, X.2    Zhong, B.3    Nurieva, R.I.4    Ding, S.5    Dong, C.6
  • 84
    • 77955458613 scopus 로고    scopus 로고
    • Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis
    • O. Frey, J. Meisel, A. Hutloff, et al., "Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis, " Annals of the Rheumatic Diseases, vol. 69, no. 8, pp. 1495-1501, 2010.
    • (2010) Annals of the Rheumatic Diseases , vol.69 , Issue.8 , pp. 1495-1501
    • Frey, O.1    Meisel, J.2    Hutloff, A.3
  • 85
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • H. Kebir, K. Kreymborg, I. Ifergan, et al., "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation, " Nature Medicine, vol. 13, no. 10, pp. 1173-1175, 2007.
    • (2007) Nature Medicine , vol.13 , Issue.10 , pp. 1173-1175
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3
  • 86
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin drives intestinal inflammation through direct activity on T cells
    • P. P. Ahern, C. Schiering, S. Buonocore, et al., "Interleukin drives intestinal inflammation through direct activity on T cells, " Immunity, vol. 33, no. 2, pp. 279-288, 2010.
    • (2010) Immunity , vol.33 , Issue.2 , pp. 279-288
    • Ahern, P.P.1    Schiering, C.2    Buonocore, S.3
  • 87
  • 89
    • 67650650890 scopus 로고    scopus 로고
    • Highly purified Th17 cells from BDC2. 5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
    • D. Bending, H. de la Pena, M. Veldhoen, et al., "Highly purified Th17 cells from BDC2. 5NOD mice convert into Th1-like cells in NOD/SCID recipient mice, "The Journal of Clinical Investigation, vol. 119, no. 3, pp. 565-572, 2009.
    • (2009) The Journal of Clinical Investigation , vol.119 , Issue.3 , pp. 565-572
    • Bending, D.1    De La Pena, H.2    Veldhoen, M.3
  • 90
    • 70350052626 scopus 로고    scopus 로고
    • Preferential recruitment of interferon-β-expressing TH17 cells in multiple sclerosis
    • H. Kebir, I. Ifergan, J. I. Alvarez, et al., "Preferential recruitment of interferon-β-expressing TH17 cells in multiple sclerosis, " Annals of Neurology, vol. 66, no. 3, pp. 390-402, 2009.
    • (2009) Annals of Neurology , vol.66 , Issue.3 , pp. 390-402
    • Kebir, H.1    Ifergan, I.2    Alvarez, J.I.3
  • 91
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • C.-Q. Chu, S. Wittmer, and D. K. Dalton, "Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis, " The Journal of Experimental Medicine, vol. 192, no. 1, pp. 123-128, 2000.
    • (2000) The Journal of Experimental Medicine , vol.192 , Issue.1 , pp. 123-128
    • Chu, C.-Q.1    Wittmer, S.2    Dalton, D.K.3
  • 92
    • 61749093508 scopus 로고    scopus 로고
    • IL-17Aand IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    • S. Haak, A. L. Croxford, K. Kreymborg, et al., "IL-17Aand IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice, "The Journal of Clinical Investigation, vol. 119, no. 1, pp. 61-69, 2009.
    • (2009) The Journal of Clinical Investigation , vol.119 , Issue.1 , pp. 61-69
    • Haak, S.1    Croxford, A.L.2    Kreymborg, K.3
  • 93
    • 79956116032 scopus 로고    scopus 로고
    • ROR3t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • L. Codarri, G. Gyulveszii, V. Tosevski, et al., "ROR3t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation, " Nature Immunology, vol. 12, no. 6, pp. 560-567, 2011.
    • (2011) Nature Immunology , vol.12 , Issue.6 , pp. 560-567
    • Codarri, L.1    Gyulveszii, G.2    Tosevski, V.3
  • 94
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF
    • M. El-Behi, B. Ciric, H. Dai, et al., "The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF, " Nature Immunology, vol. 12, no. 6, pp. 568-575, 2011.
    • (2011) Nature Immunology , vol.12 , Issue.6 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3
  • 95
    • 84927580933 scopus 로고    scopus 로고
    • STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
    • W. Sheng, F. Yang, Y. Zhou, et al., "STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation, " Cell Research, vol. 24, no. 12, pp. 1387-1402, 2014.
    • (2014) Cell Research , vol.24 , Issue.12 , pp. 1387-1402
    • Sheng, W.1    Yang, F.2    Zhou, Y.3
  • 96
    • 84903783415 scopus 로고    scopus 로고
    • IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells
    • Article ID 241ra80
    • R. Noster, R. Riedel, M. Mashreghi, et al., "IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells, " Science Translational Medicine, vol. 6, no. 241, Article ID 241ra80, 2014.
    • (2014) Science Translational Medicine , vol.6 , Issue.241
    • Noster, R.1    Riedel, R.2    Mashreghi, M.3
  • 97
    • 84855272789 scopus 로고    scopus 로고
    • Overexpression of T-bet gene regulates murine autoimmune arthritis
    • Y. Kondo, M. Iizuka, E. Wakamatsu, et al., "Overexpression of T-bet gene regulates murine autoimmune arthritis, " Arthritis & Rheumatism, vol. 64, no. 1, pp. 162-172, 2012.
    • (2012) Arthritis & Rheumatism , vol.64 , Issue.1 , pp. 162-172
    • Kondo, Y.1    Iizuka, M.2    Wakamatsu, E.3
  • 98
    • 84866074216 scopus 로고    scopus 로고
    • Incomplete response of inflammatory arthritis to TNFalpha blockade is associated with the Th17 pathway
    • S. Alzabin, S. M. Abraham, T. E. Taher, et al., "Incomplete response of inflammatory arthritis to TNFalpha blockade is associated with the Th17 pathway, " Annals of the Rheumatic Diseases, vol. 71, no. 10, pp. 1741-1748, 2012.
    • (2012) Annals of the Rheumatic Diseases , vol.71 , Issue.10 , pp. 1741-1748
    • Alzabin, S.1    Abraham, S.M.2    Taher, T.E.3
  • 99
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-β
    • H. Takayanagi, K. Ogasawara, S. Hida, et al., "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-β, " Nature, vol. 408, no. 6812, pp. 600-605, 2000.
    • (2000) Nature , vol.408 , Issue.6812 , pp. 600-605
    • Takayanagi, H.1    Ogasawara, K.2    Hida, S.3
  • 100
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Y. Okada, D. Wu, G. Trynka, et al., "Genetics of rheumatoid arthritis contributes to biology and drug discovery, " Nature, vol. 506, no. 7488, pp. 376-381, 2014.
    • (2014) Nature , vol.506 , Issue.7488 , pp. 376-381
    • Okada, Y.1    Wu, D.2    Trynka, G.3
  • 101
    • 77949457699 scopus 로고    scopus 로고
    • Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    • article R26
    • T. S. Plantinga, J. Fransen, N. Takahashi, et al., "Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis, " Arthritis Research & Therapy, vol. 12, no. 1, article R26, 2010.
    • (2010) Arthritis Research & Therapy , vol.12 , Issue.1
    • Plantinga, T.S.1    Fransen, J.2    Takahashi, N.3
  • 102
    • 84896839730 scopus 로고    scopus 로고
    • Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses
    • article R50
    • S. Bishu, E. W. Su, E. R. Wilkerson, et al., "Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses, " Arthritis Research and Therapy, vol. 16, article R50, 2014.
    • (2014) Arthritis Research and Therapy , vol.16
    • Bishu, S.1    Su, E.W.2    Wilkerson, E.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.