-
1
-
-
0037393323
-
IL-13 receptors and signaling pathways: An evolving web
-
DOI 10.1067/mai.2003.1333
-
G.K. Hershey IL-13 receptors and signaling pathways: an evolving web J Allergy Clin Immunol 111 2003 677 690 (Pubitemid 36470232)
-
(2003)
Journal of Allergy and Clinical Immunology
, vol.111
, Issue.4
, pp. 677-690
-
-
Khurana Hershey, G.K.1
-
2
-
-
0032545213
-
Interleukin-13: Central mediator of allergic asthma
-
DOI 10.1126/science.282.5397.2258
-
M. Wills-Karp, J. Luyimbazi, X. Xu, B. Schofield, T.Y. Neben, and C.L. Karp Interleukin-13: central mediator of allergic asthma Science 282 1998 2258 2261 (Pubitemid 29004074)
-
(1998)
Science
, vol.282
, Issue.5397
, pp. 2258-2261
-
-
Wills-Karp, M.1
Luyimbazi, J.2
Xu, X.3
Schofield, B.4
Neben, T.Y.5
Karp, C.L.6
Donaldson, D.D.7
-
3
-
-
34247522910
-
IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
-
DOI 10.1016/j.jaci.2007.02.009, PII S0091674907003752
-
A. Bree, F.J. Schlerman, M. Wadanoli, L. Tchistiakova, K. Marquette, and X.Y. Tan IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys J Allergy Clin Immunol 119 2007 1251 1257 (Pubitemid 46654187)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.119
, Issue.5
, pp. 1251-1257
-
-
Bree, A.1
Schlerman, F.J.2
Wadanoli, M.3
Tchistiakova, L.4
Marquette, K.5
Tan, X.-Y.6
Jacobson, B.A.7
Widom, A.8
Cook, T.A.9
Wood, N.10
Vunnum, S.11
Krykbaev, R.12
Xu, X.13
Donaldson, D.D.14
Goldman, S.J.15
Sypek, J.16
Kasaian, M.T.17
-
4
-
-
8444245228
-
Effects of anticytokine therapy in a mouse model of chronic asthma
-
DOI 10.1164/rccm.200405-681OC
-
R.K. Kumar, C. Herbert, D.C. Webb, L. Li, and P.S. Foster Effects of anticytokine therapy in a mouse model of chronic asthma Am J Respir Crit Care Med 170 2004 1043 1048 (Pubitemid 39488615)
-
(2004)
American Journal of Respiratory and Critical Care Medicine
, vol.170
, Issue.10
, pp. 1043-1048
-
-
Kumar, R.K.1
Herbert, C.2
Webb, D.C.3
Li, L.4
Foster, P.S.5
-
5
-
-
9644276704
-
Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling
-
DOI 10.1016/j.cyto.2004.08.007, PII S1043466604002649
-
G. Yang, A. Volk, T. Petley, E. Emmell, J. Giles-Komar, and X. Shang Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling Cytokine 28 2004 224 232 (Pubitemid 39573497)
-
(2004)
Cytokine
, vol.28
, Issue.6
, pp. 224-232
-
-
Yang, G.1
Volk, A.2
Petley, T.3
Emmell, E.4
Giles-Komar, J.5
Shang, X.6
Li, J.7
Das, A.M.8
Shealy, D.9
Griswold, D.E.10
Li, L.11
-
6
-
-
58149143039
-
Tuning sensitivity to IL-4 and IL-13: Differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity
-
I.S. Junttila, K. Mizukami, H. Dickensheets, M. Meier-Schellersheim, H. Yamane, and R.P. Donnelly Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity J Exp Med 205 2008 2595 2608
-
(2008)
J Exp Med
, vol.205
, pp. 2595-2608
-
-
Junttila, I.S.1
Mizukami, K.2
Dickensheets, H.3
Meier-Schellersheim, M.4
Yamane, H.5
Donnelly, R.P.6
-
7
-
-
38649137731
-
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
-
DOI 10.1016/j.cell.2007.12.030, PII S0092867408000470
-
S.L. LaPorte, Z.S. Juo, J. Vaclavikova, L.A. Colf, X. Qi, and N.M. Heller Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system Cell 132 2008 259 272 (Pubitemid 351172435)
-
(2008)
Cell
, vol.132
, Issue.2
, pp. 259-272
-
-
LaPorte, S.L.1
Juo, Z.S.2
Vaclavikova, J.3
Colf, L.A.4
Qi, X.5
Heller, N.M.6
Keegan, A.D.7
Garcia, K.C.8
-
8
-
-
66949123901
-
A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
-
D.C. Newcomb, W. Zhou, M.L. Moore, K. Goleniewska, G.K. Hershey, and J.K. Kolls A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production J Immunol 182 2009 5317 5321
-
(2009)
J Immunol
, vol.182
, pp. 5317-5321
-
-
Newcomb, D.C.1
Zhou, W.2
Moore, M.L.3
Goleniewska, K.4
Hershey, G.K.5
Kolls, J.K.6
-
9
-
-
41549135632
-
The biological functions of T helper 17 cell effector cytokines in inflammation
-
DOI 10.1016/j.immuni.2008.03.004, PII S1074761308001192
-
W. Ouyang, J.K. Kolls, and Y. Zheng The biological functions of T helper 17 cell effector cytokines in inflammation Immunity 28 2008 454 467 (Pubitemid 351471762)
-
(2008)
Immunity
, vol.28
, Issue.4
, pp. 454-467
-
-
Ouyang, W.1
Kolls, J.K.2
Zheng, Y.3
-
10
-
-
27544490377
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
DOI 10.1038/ni1254, PII N1254
-
L.E. Harrington, R.D. Hatton, P.R. Mangan, H. Turner, T.L. Murphy, and K.M. Murphy Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat Immunol 6 2005 1123 1132 (Pubitemid 41541790)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
Weaver, C.T.7
-
11
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
DOI 10.1038/ni1261, PII N1261
-
H. Park, Z. Li, X.O. Yang, S.H. Chang, R. Nurieva, and Y.H. Wang A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat Immunol 6 2005 1133 1141 (Pubitemid 41541791)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
Chang, S.H.4
Nurieva, R.5
Wang, Y.-H.6
Wang, Y.7
Hood, L.8
Zhu, Z.9
Tian, Q.10
Dong, C.11
-
12
-
-
70349571184
-
Do studies in humans better depict Th17 cells?
-
F. Annunziato, and S. Romagnani Do studies in humans better depict Th17 cells? Blood 114 2009 2213 2219
-
(2009)
Blood
, vol.114
, pp. 2213-2219
-
-
Annunziato, F.1
Romagnani, S.2
-
14
-
-
70350376860
-
Properties and origin of human Th17 cells
-
S. Romagnani, E. Maggi, F. Liotta, L. Cosmi, and F. Annunziato Properties and origin of human Th17 cells Mol Immunol 47 2009 3 7
-
(2009)
Mol Immunol
, vol.47
, pp. 3-7
-
-
Romagnani, S.1
Maggi, E.2
Liotta, F.3
Cosmi, L.4
Annunziato, F.5
-
15
-
-
33947162110
-
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
-
DOI 10.1016/j.immuni.2007.02.009, PII S1074761307001768
-
A. Laurence, C.M. Tato, T.S. Davidson, Y. Kanno, Z. Chen, and Z. Yao Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation Immunity 26 2007 371 381 (Pubitemid 46413906)
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, RebeccaB.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
Shevach, E.M.11
O'Shea, JohnJ.12
-
16
-
-
44049104564
-
H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
-
DOI 10.1038/ni.1610, PII NI.1610
-
N. Manel, D. Unutmaz, and D.R. Littman The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat Nat Immunol 9 2008 641 649 (Pubitemid 351714729)
-
(2008)
Nature Immunology
, vol.9
, Issue.6
, pp. 641-649
-
-
Manel, N.1
Unutmaz, D.2
Littman, D.R.3
-
17
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
DOI 10.1074/jbc.C600321200
-
X.O. Yang, A.D. Panopoulos, R. Nurieva, S.H. Chang, D. Wang, and S.S. Watowich STAT3 regulates cytokine-mediated generation of inflammatory helper T cells J Biol Chem 282 2007 9358 9363 (Pubitemid 47104613)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.13
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
Seon, H.C.4
Wang, D.5
Watowich, S.S.6
Dong, C.7
-
18
-
-
69349093225
-
Interleukin-17 and type 17 helper T cells
-
P. Miossec, T. Korn, and V.K. Kuchroo Interleukin-17 and type 17 helper T cells N Engl J Med 361 2009 888 898
-
(2009)
N Engl J Med
, vol.361
, pp. 888-898
-
-
Miossec, P.1
Korn, T.2
Kuchroo, V.K.3
-
19
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
E. Bettelli, Y. Carrier, W. Gao, T. Korn, T.B. Strom, and M. Oukka Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 2006 235 238
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
-
20
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
DOI 10.1038/nature05969, PII NATURE05969
-
R. Nurieva, X.O. Yang, G. Martinez, Y. Zhang, A.D. Panopoulos, and L. Ma Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448 2007 480 483 (Pubitemid 47123514)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
Schluns, K.7
Tian, Q.8
Watowich, S.S.9
Jetten, A.M.10
Dong, C.11
-
21
-
-
34547188748
-
H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
DOI 10.1038/ni1488, PII NI1488
-
L. Zhou, Ivanov II, R. Spolski, R. Min, K. Shenderov, and T. Egawa IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 2007 967 974 (Pubitemid 47300011)
-
(2007)
Nature Immunology
, vol.8
, Issue.9
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
22
-
-
65349172388
-
Transcriptional regulatory networks in Th17 cell differentiation
-
L. Zhou, and D.R. Littman Transcriptional regulatory networks in Th17 cell differentiation Curr Opin Immunol 21 2009 146 152
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 146-152
-
-
Zhou, L.1
Littman, D.R.2
-
23
-
-
15644383836
-
The distribution of IL-13 receptor α1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4
-
P. Graber, D. Gretener, S. Herren, J.P. Aubry, G. Elson, and J. Poudrier The distribution of IL-13 receptor alpha1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4 Eur J Immunol 28 1998 4286 4298 (Pubitemid 28558660)
-
(1998)
European Journal of Immunology
, vol.28
, Issue.12
, pp. 4286-4298
-
-
Graber, P.1
Gretener, D.2
Herren, S.3
Aubry, J.-P.4
Elson, G.5
Poudrier, J.6
Lecoanet-Henchoz, S.7
Alouani, S.8
Losberger, C.9
Bonnefoy, J.-Y.10
Kosco-Vilbois, M.H.11
Gauchat, J.-F.12
-
24
-
-
35649017659
-
Regulation of IL-13 receptor α1 expression and signaling on human tonsillar B-lymphocyte subsets
-
DOI 10.1016/j.jaci.2007.07.011, PII S0091674907013838
-
O. Hajoui, H. Zheng, J. Guay, S. Letuve, L.M. Fawaz, and B.D. Mazer Regulation of IL-13 receptor alpha 1 expression and signaling on human tonsillar B-lymphocyte subsets J Allergy Clin Immunol 120 2007 1425 1432 (Pubitemid 350216583)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.120
, Issue.6
, pp. 1425-1432
-
-
Hajoui, O.1
Zheng, H.2
Guay, J.3
Letuve, S.4
Fawaz, L.M.5
Mazer, B.D.6
-
25
-
-
1642370744
-
Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-β1, TGF-β2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on α-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts
-
DOI 10.1111/j.1365-2222.2004.01885.x
-
V. Batra, A.I. Musani, A.T. Hastie, S. Khurana, K.A. Carpenter, and J.G. Zangrilli Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts Clin Exp Allergy 34 2004 437 444 (Pubitemid 38373007)
-
(2004)
Clinical and Experimental Allergy
, vol.34
, Issue.3
, pp. 437-444
-
-
Batra, V.1
Musani, A.I.2
Hastie, A.T.3
Khurana, S.4
Carpenter, K.A.5
Zangrilli, J.G.6
Peters, S.P.7
-
26
-
-
17844400081
-
Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: Effect on the Smad signaling pathway
-
S.J. McMillan, G. Xanthou, and C.M. Lloyd Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway J Immunol 174 2005 5774 5780 (Pubitemid 40593221)
-
(2005)
Journal of Immunology
, vol.174
, Issue.9
, pp. 5774-5780
-
-
McMillan, S.J.1
Xanthou, G.2
Lloyd, C.M.3
-
27
-
-
0008249094
-
Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus
-
I. Tillie-Leblond, J. Pugin, C.H. Marquette, C. Lamblin, F. Saulnier, and A. Brichet Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus Am J Respir Crit Care Med 159 1999 487 494 (Pubitemid 29084870)
-
(1999)
American Journal of Respiratory and Critical Care Medicine
, vol.159
, Issue.2
, pp. 487-494
-
-
Tillie-Leblond, I.1
Pugin, J.2
Marquette, C.-H.3
Lamblin, C.4
Saulnier, F.5
Brichet, A.6
Wallaert, B.7
Tonnel, A.-B.8
Gosset, P.9
-
28
-
-
73849098292
-
IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation
-
J. Peng, X.O. Yang, S.H. Chang, J. Yang, and C. Dong IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation Cell Res 20 2010 62 71
-
(2010)
Cell Res
, vol.20
, pp. 62-71
-
-
Peng, J.1
Yang, X.O.2
Chang, S.H.3
Yang, J.4
Dong, C.5
-
29
-
-
33744479688
-
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
-
DOI 10.1073/pnas.0600666103
-
Z. Chen, A. Laurence, Y. Kanno, M. Pacher-Zavisin, B.M. Zhu, and C. Tato Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells Proc Natl Acad Sci U S A 103 2006 8137 8142 (Pubitemid 43801065)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.21
, pp. 8137-8142
-
-
Chen, Z.1
Laurence, A.2
Kanno, Y.3
Pacher-Zavisin, M.4
Zhu, B.-M.5
Tato, C.6
Yoshimura, A.7
Hennighausen, L.8
O'Shea, J.J.9
-
30
-
-
40049098958
-
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
-
DOI 10.1038/nm1710, PII NM1710
-
S.J. Aujla, Y.R. Chan, M. Zheng, M. Fei, D.J. Askew, and D.A. Pociask IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia Nat Med 14 2008 275 281 (Pubitemid 351347908)
-
(2008)
Nature Medicine
, vol.14
, Issue.3
, pp. 275-281
-
-
Aujla, S.J.1
Chan, Y.R.2
Zheng, M.3
Fei, M.4
Askew, D.J.5
Pociask, D.A.6
Reinhart, T.A.7
McAllister, F.8
Edeal, J.9
Gaus, K.10
Husain, S.11
Kreindler, J.L.12
Dubin, P.J.13
Pilewski, J.M.14
Myerburg, M.M.15
Mason, C.A.16
Iwakura, Y.17
Kolls, J.K.18
-
31
-
-
40049099397
-
Increased sputum and bronchial biopsy IL-13 expression in severe asthma
-
DOI 10.1016/j.jaci.2008.01.005, PII S0091674908001267
-
S.K. Saha, M.A. Berry, D. Parker, S. Siddiqui, A. Morgan, and R. May Increased sputum and bronchial biopsy IL-13 expression in severe asthma J Allergy Clin Immunol 121 2008 685 691 (Pubitemid 351323866)
-
(2008)
Journal of Allergy and Clinical Immunology
, vol.121
, Issue.3
, pp. 685-691
-
-
Saha, S.K.1
Berry, M.A.2
Parker, D.3
Siddiqui, S.4
Morgan, A.5
May, R.6
Monk, P.7
Bradding, P.8
Wardlaw, A.J.9
Pavord, I.D.10
Brightling, C.E.11
-
33
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
-
J. Corren, W. Busse, E.O. Meltzer, L. Mansfield, G. Bensch, and J. Fahrenholz A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma Am J Respir Crit Care Med 181 2010 788 796
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
Mansfield, L.4
Bensch, G.5
Fahrenholz, J.6
-
34
-
-
79953652415
-
-
AccessedSeptember15,2010
-
IMA-026 clinical trial results. 2010. Available at: http:// clinicaltrials.gov/ct2/show/NCT00725582?term=ima-026&rank=1. Accessed September 15, 2010.
-
(2010)
IMA-026 Clinical Trial Results
-
-
-
35
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
-
DOI 10.1016/S0140-6736(07)61600-6, PII S0140673607616006
-
S. Wenzel, D. Wilbraham, R. Fuller, E.B. Getz, and M. Longphre Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies Lancet 370 2007 1422 1431 (Pubitemid 47576168)
-
(2007)
Lancet
, vol.370
, Issue.9596
, pp. 1422-1431
-
-
Wenzel, S.1
Wilbraham, D.2
Fuller, R.3
Getz, E.B.4
Longphre, M.5
|