-
1
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
CrossRef PubMed
-
Valente, E.M., Abou-Sleiman, P.M., Caputo, V., Muqit, M.M.K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A.R., Healy, D.G. et al. (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160 CrossRef PubMed
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.K.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
-
2
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
CrossRef PubMed
-
Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166 CrossRef PubMed
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huh, J.R.5
Seol, J.H.6
Yoo, S.J.7
Hay, B.A.8
Guo, M.9
-
3
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
CrossRef PubMed
-
Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J-W, Yang, L., Beal, M.F., Vogel, H. and Lu, B. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl. Acad. Sci. U.S.A. 103, 10793-10798 CrossRef PubMed
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
Gehrke, S.2
Imai, Y.3
Huang, Z.4
Ouyang, Y.5
Wang, J.-W.6
Yang, L.7
Beal, M.F.8
Vogel, H.9
Lu, B.10
-
4
-
-
36049038504
-
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
-
CrossRef PubMed
-
Exner, N., Treske, B., Paquet, D., Holmström, K., Schiesling, C., Gispert, S., Carballo-Carbajal, I., Berg, D., Hoepken, H-H, Gasser, T. et al. (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27, 12413-12418 CrossRef PubMed
-
(2007)
J. Neurosci.
, vol.27
, pp. 12413-12418
-
-
Exner, N.1
Treske, B.2
Paquet, D.3
Holmström, K.4
Schiesling, C.5
Gispert, S.6
Carballo-Carbajal, I.7
Berg, D.8
Hoepken, H.-H.9
Gasser, T.10
-
5
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
CrossRef PubMed
-
Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D., Gautier, C.A., Shen, J., Cookson, M.R. and Youle, R.J. (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 8, e1000298 CrossRef PubMed
-
(2010)
PLoS Biol.
, vol.8
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.4
Gautier, C.A.5
Shen, J.6
Cookson, M.R.7
Youle, R.J.8
-
6
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
CrossRef PubMed
-
Kim, Y., Park, J., Kim, S., Song, S., Kwon, S.-K., Lee, S.-H., Kitada, T., Kim, J.-M. and Chung, J. (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377, 975-980 CrossRef PubMed
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 975-980
-
-
Kim, Y.1
Park, J.2
Kim, S.3
Song, S.4
Kwon, S.-K.5
Lee, S.-H.6
Kitada, T.7
Kim, J.-M.8
Chung, J.9
-
7
-
-
84864267876
-
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine 65
-
CrossRef PubMed
-
Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H.I., Campbell, D.G., Gourlay, R., Burchell, L., Walden, H., Macartney, T.J., Deak, M. et al. (2012) PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine 65. Open Biol. 2, 120080 CrossRef PubMed
-
(2012)
Open Biol.
, vol.2
-
-
Kondapalli, C.1
Kazlauskaite, A.2
Zhang, N.3
Woodroof, H.I.4
Campbell, D.G.5
Gourlay, R.6
Burchell, L.7
Walden, H.8
Macartney, T.J.9
Deak, M.10
-
8
-
-
84874322054
-
Characterization of phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) mutations associated with Parkinson's disease in mammalian cells and Drosophila
-
CrossRef PubMed
-
Song, S., Jang, S., Park, J., Bang, S., Choi, S., Kwon, K-Y, Zhuang, X., Kim, E. and Chung, J. (2013) Characterization of phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) mutations associated with Parkinson's disease in mammalian cells and Drosophila. J. Biol. Chem. 288, 5660-5672 CrossRef PubMed
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 5660-5672
-
-
Song, S.1
Jang, S.2
Park, J.3
Bang, S.4
Choi, S.5
Kwon, K.-Y.6
Zhuang, X.7
Kim, E.8
Chung, J.9
-
9
-
-
84881260124
-
Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation
-
CrossRef PubMed
-
Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K. and Matsuda, N. (2013) Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J. Biol. Chem. 288, 22019-22032 CrossRef PubMed
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 22019-22032
-
-
Iguchi, M.1
Kujuro, Y.2
Okatsu, K.3
Koyano, F.4
Kosako, H.5
Kimura, M.6
Suzuki, N.7
Uchiyama, S.8
Tanaka, K.9
Matsuda, N.10
-
10
-
-
84871891737
-
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
-
CrossRef
-
Shiba-Fukushima, K., Imai, Y., Yoshida, S., Ishihama, Y. and Kanao, T. (2012) PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci. Rep. 2, 1-8CrossRef
-
(2012)
Sci. Rep.
, vol.2
, pp. 1-8
-
-
Shiba-Fukushima, K.1
Imai, Y.2
Yoshida, S.3
Ishihama, Y.4
Kanao, T.5
-
11
-
-
78649463381
-
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1 / parkin-dependent manner upon induction of mitophagy
-
CrossRef PubMed
-
Gegg, M.E., Cooper, J.M., Chau, K., Rojo, M. and Schapira, A.H.V. (2010) Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1 / parkin-dependent manner upon induction of mitophagy. Hum. Mol. Genet. 19, 4861-4870 CrossRef PubMed
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 4861-4870
-
-
Gegg, M.E.1
Cooper, J.M.2
Chau, K.3
Rojo, M.4
Schapira, A.H.V.5
-
12
-
-
77955844260
-
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
-
CrossRef PubMed
-
Poole, A.C., Thomas, R.E., Yu, S., Vincow, E.S. and Pallanck, L. (2010) The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One 5, e10054 CrossRef PubMed
-
(2010)
PLoS One
, vol.5
-
-
Poole, A.C.1
Thomas, R.E.2
Yu, S.3
Vincow, E.S.4
Pallanck, L.5
-
13
-
-
77950384477
-
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
-
CrossRef PubMed
-
Ziviani, E., Tao, R.N. and Whitworth, A.J. (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl. Acad. Sci. U.S.A. 107, 5018-5023 CrossRef PubMed
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 5018-5023
-
-
Ziviani, E.1
Tao, R.N.2
Whitworth, A.J.3
-
14
-
-
84876531457
-
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
-
CrossRef PubMed
-
Chen, Y. and Dorn, G.W. (2013) PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340, 471-475 CrossRef PubMed
-
(2013)
Science
, vol.340
, pp. 471-475
-
-
Chen, Y.1
Dorn, G.W.2
-
15
-
-
84899539731
-
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
-
CrossRef PubMed
-
Kane, L.A., Lazarou, M., Fogel, A.I., Li, Y., Yamano, K., Sarraf, S.A., Banerjee, S. and Youle, R.J. (2014) PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J. Cell Biol. 205, 143-153 CrossRef PubMed
-
(2014)
J. Cell Biol.
, vol.205
, pp. 143-153
-
-
Kane, L.A.1
Lazarou, M.2
Fogel, A.I.3
Li, Y.4
Yamano, K.5
Sarraf, S.A.6
Banerjee, S.7
Youle, R.J.8
-
16
-
-
84899421556
-
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at serine65
-
CrossRef PubMed
-
Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D.G., Ritorto, M.S., Hofmann, K., Alessi, D.R., Knebel, A., Trost, M. and Muqit, M.M.K. (2014) Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at serine65. Biochem. J. 460, 127-139 CrossRef PubMed
-
(2014)
Biochem. J.
, vol.460
, pp. 127-139
-
-
Kazlauskaite, A.1
Kondapalli, C.2
Gourlay, R.3
Campbell, D.G.4
Ritorto, M.S.5
Hofmann, K.6
Alessi, D.R.7
Knebel, A.8
Trost, M.9
Muqit, M.M.K.10
-
17
-
-
84901751574
-
Ubiquitin is phosphorylated by PINK1 to activate parkin
-
PubMed
-
Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T. et al. (2014) Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510, 162-166 PubMed
-
(2014)
Nature
, vol.510
, pp. 162-166
-
-
Koyano, F.1
Okatsu, K.2
Kosako, H.3
Tamura, Y.4
Go, E.5
Kimura, M.6
Kimura, Y.7
Tsuchiya, H.8
Yoshihara, H.9
Hirokawa, T.10
-
18
-
-
84922434418
-
Article quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis
-
CrossRef PubMed
-
Ordureau, A., Sarraf, S.A., Duda, D.M., Heo, J., Jedrykowski, M.P., Sviderskiy, V.O., Olszewski, J.L., Koerber, J.T., Xie, T., Beausoleil, S.A. et al. (2014) Article quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol. Cell 56, 360-375 CrossRef PubMed
-
(2014)
Mol. Cell
, vol.56
, pp. 360-375
-
-
Ordureau, A.1
Sarraf, S.A.2
Duda, D.M.3
Heo, J.4
Jedrykowski, M.P.5
Sviderskiy, V.O.6
Olszewski, J.L.7
Koerber, J.T.8
Xie, T.9
Beausoleil, S.A.10
-
19
-
-
33646117742
-
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking
-
CrossRef PubMed
-
Fransson, S., Ruusala, A. and Aspenström, P. (2006) The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Biochem. Biophys. Res. Commun. 344, 500-510 CrossRef PubMed
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.344
, pp. 500-510
-
-
Fransson, S.1
Ruusala, A.2
Aspenström, P.3
-
20
-
-
81055140895
-
PINK1 and parkin target miro for phosphorylation and degradation to arrest mitochondrial motility
-
CrossRef PubMed
-
Wang, X., Winter, D., Ashrafi, G., Schlehe, J., Wong, Y.L., Selkoe, D., Rice, S., Steen, J., Lavoie, M.J. and Schwarz, T.L. (2011) PINK1 and parkin target miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147, 893-906 CrossRef PubMed
-
(2011)
Cell
, vol.147
, pp. 893-906
-
-
Wang, X.1
Winter, D.2
Ashrafi, G.3
Schlehe, J.4
Wong, Y.L.5
Selkoe, D.6
Rice, S.7
Steen, J.8
Lavoie, M.J.9
Schwarz, T.L.10
-
21
-
-
84859237566
-
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
-
CrossRef PubMed
-
Liu, S., Sawada, T., Lee, S., Yu, W., Silverio, G., Alapatt, P., Millan, I., Shen, A., Saxton, W., Kanao, T. et al. (2012) Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet. 8, e1002537 CrossRef PubMed
-
(2012)
PLoS Genet.
, vol.8
-
-
Liu, S.1
Sawada, T.2
Lee, S.3
Yu, W.4
Silverio, G.5
Alapatt, P.6
Millan, I.7
Shen, A.8
Saxton, W.9
Kanao, T.10
-
22
-
-
84882754147
-
A neo-substrate that amplifies catalytic activity of Parkinson's-disease-related kinase PINK1
-
CrossRef PubMed
-
Hertz, N.T., Berthet, A., Sos, M.L., Thorn, K.S., Burlingame, A.L., Nakamura, K. and Shokat, K.M. (2013) A neo-substrate that amplifies catalytic activity of Parkinson's-disease-related kinase PINK1. Cell 154, 737-747 CrossRef PubMed
-
(2013)
Cell
, vol.154
, pp. 737-747
-
-
Hertz, N.T.1
Berthet, A.2
Sos, M.L.3
Thorn, K.S.4
Burlingame, A.L.5
Nakamura, K.6
Shokat, K.M.7
-
23
-
-
84873843566
-
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: Study in human primary fibroblasts and induced pluripotent stem cell-derived neurons
-
CrossRef PubMed
-
Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D. and Klein, C. (2013) Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. J. Biol. Chem. 288, 2223-2237 CrossRef PubMed
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 2223-2237
-
-
Rakovic, A.1
Shurkewitsch, K.2
Seibler, P.3
Grünewald, A.4
Zanon, A.5
Hagenah, J.6
Krainc, D.7
Klein, C.8
-
24
-
-
84883492814
-
Parkin- and PINK1-dependent mitophagy in neurons: Will the real pathway please stand up?
-
CrossRef PubMed
-
Grenier, K., McLelland, G.-L. and Fon, E.A. (2013) Parkin- and PINK1-dependent mitophagy in neurons: will the real pathway please stand up? Front. Neurol. 4, 100 CrossRef PubMed
-
(2013)
Front. Neurol.
, vol.4
, pp. 100
-
-
Grenier, K.1
McLelland, G.-L.2
Fon, E.A.3
-
25
-
-
84895806924
-
Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: The pink-parkin pathway
-
CrossRef PubMed
-
Amadoro, G., Corsetti, V., Florenzano, F., Atlante, A., Bobba, A., Nicolin, V., Nori, S.L. and Calissano, P. (2014) Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway. Front. Aging Neurosci. 6, 18 CrossRef PubMed
-
(2014)
Front. Aging Neurosci.
, vol.6
, pp. 18
-
-
Amadoro, G.1
Corsetti, V.2
Florenzano, F.3
Atlante, A.4
Bobba, A.5
Nicolin, V.6
Nori, S.L.7
Calissano, P.8
-
26
-
-
34547127902
-
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
-
CrossRef PubMed
-
Pridgeon, J.W., Olzmann, J.A., Chin, L.-S. and Li, L. (2007) PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 5, e172 CrossRef PubMed
-
(2007)
PLoS Biol.
, vol.5
, pp. e172
-
-
Pridgeon, J.W.1
Olzmann, J.A.2
Chin, L.-S.3
Li, L.4
-
27
-
-
84878533362
-
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease
-
CrossRef PubMed
-
Costa, A.C., Loh, S.H.Y. and Martins, L.M. (2013) Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Cell Death Dis. 4, e467 CrossRef PubMed
-
(2013)
Cell Death Dis.
, vol.4
, pp. e467
-
-
Costa, A.C.1
Loh, S.H.Y.2
Martins, L.M.3
-
28
-
-
84878529485
-
TRAP1 rescues PINK1 loss-of-function phenotypes
-
CrossRef PubMed
-
Zhang, L., Karsten, P., Hamm, S., Pogson, J.H., Lutz, A.K., Exner, N., Haass, C., Whitworth, A., Winklhofer, K., Schulz, J.B. and Voigt, A. (2013) TRAP1 rescues PINK1 loss-of-function phenotypes. Hum. Mol. Genet. 22, 2829-2841 CrossRef PubMed
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 2829-2841
-
-
Zhang, L.1
Karsten, P.2
Hamm, S.3
Pogson, J.H.4
Lutz, A.K.5
Exner, N.6
Haass, C.7
Whitworth, A.8
Winklhofer, K.9
Schulz, J.B.10
Voigt, A.11
-
29
-
-
35748935851
-
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
-
CrossRef PubMed
-
Plun-Favreau, H., Klupsch, K., Moisoi, N., Gandhi, S., Kjaer, S., Frith, D., Harvey, K., Deas, E., Harvey, R.J., McDonald, N. et al. (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat. Cell Biol. 9, 1243-1252 CrossRef PubMed
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1243-1252
-
-
Plun-Favreau, H.1
Klupsch, K.2
Moisoi, N.3
Gandhi, S.4
Kjaer, S.5
Frith, D.6
Harvey, K.7
Deas, E.8
Harvey, R.J.9
McDonald, N.10
-
30
-
-
0142246441
-
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
-
CrossRef PubMed
-
Jones, J.M., Datta, P., Srinivasula, S.M., Ji, W., Gupta, S., Zhang, Z., Davies, E., Hajnóczky, G., Saunders, T.L., Van Keuren, M.L. et al. (2003) Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 425, 721-727 CrossRef PubMed
-
(2003)
Nature
, vol.425
, pp. 721-727
-
-
Jones, J.M.1
Datta, P.2
Srinivasula, S.M.3
Ji, W.4
Gupta, S.5
Zhang, Z.6
Davies, E.7
Hajnóczky, G.8
Saunders, T.L.9
Van Keuren, M.L.10
-
31
-
-
7644230386
-
Neuroprotective role of the reaper-related serine protease HtrA2 / Omi revealed by targeted deletion in mice
-
CrossRef PubMed
-
Martins, L.M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G.P. et al. (2004) Neuroprotective role of the reaper-related serine protease HtrA2 / Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 24, 9848-9862 CrossRef PubMed
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9848-9862
-
-
Martins, L.M.1
Morrison, A.2
Klupsch, K.3
Fedele, V.4
Moisoi, N.5
Teismann, P.6
Abuin, A.7
Grau, E.8
Geppert, M.9
Livi, G.P.10
-
32
-
-
25444498785
-
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
-
CrossRef PubMed
-
Strauss, K., Martins, L., Plun-Favreau, H., Marx, F., Kautzmann, S., Berg, D., Gasser, T., Wszolek, Z., Müller, T., Bornemann, A. et al. (2005) Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum. Mol. Genet. 14, 2099-2111 CrossRef PubMed
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2099-2111
-
-
Strauss, K.1
Martins, L.2
Plun-Favreau, H.3
Marx, F.4
Kautzmann, S.5
Berg, D.6
Gasser, T.7
Wszolek, Z.8
Müller, T.9
Bornemann, A.10
-
33
-
-
77953666757
-
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
-
CrossRef PubMed
-
Morais, V.A., Verstreken, P., Roethig, A., Smet, J., Snellinx, A., Vanbrabant, M., Haddad, D., Frezza, C., Mandemakers, W., Vogt-Weisenhorn, D. et al. (2009) Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol. Med. 1, 99-111 CrossRef PubMed
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 99-111
-
-
Morais, V.A.1
Verstreken, P.2
Roethig, A.3
Smet, J.4
Snellinx, A.5
Vanbrabant, M.6
Haddad, D.7
Frezza, C.8
Mandemakers, W.9
Vogt-Weisenhorn, D.10
-
34
-
-
49649097747
-
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
-
CrossRef PubMed
-
Gautier, C.A., Kitada, T. and Shen, J. (2008) Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 105, 11364-11369 CrossRef PubMed
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 11364-11369
-
-
Gautier, C.A.1
Kitada, T.2
Shen, J.3
-
35
-
-
0020680904
-
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
-
CrossRef
-
Langston, J., Ballard, P., Tetrud, J. and Irwin, I. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 25, 979-980 CrossRef
-
(1983)
Science
, vol.25
, pp. 979-980
-
-
Langston, J.1
Ballard, P.2
Tetrud, J.3
Irwin, I.4
-
36
-
-
0024390719
-
Mitochondrial complex I deficency in Parkinson's disase
-
CrossRef PubMed
-
Schapira, A.H., Cooper, J., Dexter, D., Jenner, P., Clark, J. and Marsden, C. (1989) Mitochondrial complex I deficency in Parkinson's disase. Lancet 1, 1269 CrossRef PubMed
-
(1989)
Lancet
, vol.1
, pp. 1269
-
-
Schapira, A.H.1
Cooper, J.2
Dexter, D.3
Jenner, P.4
Clark, J.5
Marsden, C.6
-
37
-
-
84898023373
-
PINK1 Loss of function mutations affect mitochondrial complex i activity via ndufa10 ubiquinone uncoupling
-
CrossRef PubMed
-
Morais, V.A., Haddad, D., Craessaerts, K., De Bock, P.-J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., Grünewald, A., Seibler, P. et al. (2014) PINK1 Loss of function mutations affect mitochondrial complex i activity via ndufa10 ubiquinone uncoupling. Science 344, 203-207 CrossRef PubMed
-
(2014)
Science
, vol.344
, pp. 203-207
-
-
Morais, V.A.1
Haddad, D.2
Craessaerts, K.3
De Bock, P.-J.4
Swerts, J.5
Vilain, S.6
Aerts, L.7
Overbergh, L.8
Grünewald, A.9
Seibler, P.10
-
38
-
-
84912124648
-
The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy
-
CrossRef PubMed
-
Pogson, J.H., Ivatt, R.M., Sanchez-Martinez, A., Tufi, R., Wilson, E., Mortiboys, H. and Whitworth, A.J. (2014) The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. PLoS Genet. 10, e1004815 CrossRef PubMed
-
(2014)
PLoS Genet.
, vol.10
-
-
Pogson, J.H.1
Ivatt, R.M.2
Sanchez-Martinez, A.3
Tufi, R.4
Wilson, E.5
Mortiboys, H.6
Whitworth, A.J.7
-
39
-
-
84890957474
-
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment
-
CrossRef PubMed
-
Okatsu, K., Uno, M., Koyano, F., Go, E., Kimura, M., Oka, T., Tanaka, K. and Matsuda, N. (2013) A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment. J. Biol. Chem. 288, 36372-36384 CrossRef PubMed
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 36372-36384
-
-
Okatsu, K.1
Uno, M.2
Koyano, F.3
Go, E.4
Kimura, M.5
Oka, T.6
Tanaka, K.7
Matsuda, N.8
-
40
-
-
84866072587
-
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
-
CrossRef
-
Okatsu, K., Oka, T., Iguchi, M., Imamura, K., Kosako, H., Tani, N., Kimura, M., Go, E., Koyano, F., Funayama, M. et al. (2012) PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat. Commun. 3, 1-10 CrossRef
-
(2012)
Nat. Commun.
, vol.3
, pp. 1-10
-
-
Okatsu, K.1
Oka, T.2
Iguchi, M.3
Imamura, K.4
Kosako, H.5
Tani, N.6
Kimura, M.7
Go, E.8
Koyano, F.9
Funayama, M.10
-
41
-
-
84858022944
-
MARK2 Turns on PINK1 at Thr-313, a mutation site in Parkinson Disease: Effects on mitochondrial transport
-
CrossRef PubMed
-
Matenia, D., Hempp, C., Timm, T., Eikhof, A. and Mandelkow, E-M. (2012) MARK2 Turns on PINK1 at Thr-313, a mutation site in Parkinson Disease: effects on mitochondrial transport. J. Biol. Chem. 287, 8174-8186 CrossRef PubMed
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 8174-8186
-
-
Matenia, D.1
Hempp, C.2
Timm, T.3
Eikhof, A.4
Mandelkow, E.-M.5
-
42
-
-
84921925390
-
PINK1 catalytic activity is regulated by phosphorylation on serines 228 and 402
-
Aerts, L., Craessaerts, K., De Strooper, B. and Morais, V.A. (2014) PINK1 catalytic activity is regulated by phosphorylation on serines 228 and 402. J. Biol. Chem., doi: 10.1074/jbc.M114.620906
-
(2014)
J. Biol. Chem.
-
-
Aerts, L.1
Craessaerts, K.2
De Strooper, B.3
Morais, V.A.4
-
43
-
-
84866283918
-
Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)
-
CrossRef PubMed
-
Sim, C.H., Gabriel, K., Mills, R.D., Culvenor, J.G. and Cheng, H.-C. (2012) Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1). Hum. Mutat. 33, 1408-1422 CrossRef PubMed
-
(2012)
Hum. Mutat.
, vol.33
, pp. 1408-1422
-
-
Sim, C.H.1
Gabriel, K.2
Mills, R.D.3
Culvenor, J.G.4
Cheng, H.-C.5
-
44
-
-
27944444154
-
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
-
CrossRef PubMed
-
Silvestri, L., Caputo, V., Bellacchio, E., Atorino, L., Dallapiccola, B., Valente, E.M. and Casari, G. (2005) Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum. Mol. Genet. 14, 3477-3492 CrossRef PubMed
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 3477-3492
-
-
Silvestri, L.1
Caputo, V.2
Bellacchio, E.3
Atorino, L.4
Dallapiccola, B.5
Valente, E.M.6
Casari, G.7
-
45
-
-
84859428688
-
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
-
CrossRef PubMed
-
Greene, A.W., Grenier, K., Aguileta, M.A., Muise, S., Farazifard, R., Haque, M.E., McBride, H.M., Park, D.S. and Fon, E.A. (2012) Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep. 13, 378-385 CrossRef PubMed
-
(2012)
EMBO Rep.
, vol.13
, pp. 378-385
-
-
Greene, A.W.1
Grenier, K.2
Aguileta, M.A.3
Muise, S.4
Farazifard, R.5
Haque, M.E.6
McBride, H.M.7
Park, D.S.8
Fon, E.A.9
-
46
-
-
79551574736
-
PINK1 cleavage at position A103 by the mitochondrial protease PARL
-
CrossRef PubMed
-
Deas, E., Plun-Favreau, H., Gandhi, S., Desmond, H., Kjaer, S., Loh, S.H.Y., Renton, A.E.M., Harvey, R.J., Whitworth, A.J., Martins, L.M. et al. (2010) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum. Mol. Genet. 20, 867-879 CrossRef PubMed
-
(2010)
Hum. Mol. Genet.
, vol.20
, pp. 867-879
-
-
Deas, E.1
Plun-Favreau, H.2
Gandhi, S.3
Desmond, H.4
Kjaer, S.5
Loh, S.H.Y.6
Renton, A.E.M.7
Harvey, R.J.8
Whitworth, A.J.9
Martins, L.M.10
-
47
-
-
79955667485
-
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
-
CrossRef PubMed
-
Meissner, C., Lorenz, H., Weihofen, A., Selkoe, D.J. and Lemberg, M.K. (2011) The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J. Neurochem. 117, 856-867 CrossRef PubMed
-
(2011)
J. Neurochem.
, vol.117
, pp. 856-867
-
-
Meissner, C.1
Lorenz, H.2
Weihofen, A.3
Selkoe, D.J.4
Lemberg, M.K.5
-
48
-
-
78649685455
-
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
-
CrossRef PubMed
-
Jin, S.M., Lazarou, M., Wang, C., Kane, L.A., Narendra, D.P. and Youle, R.J. (2010) Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J. Cell Biol. 191, 933-942 CrossRef PubMed
-
(2010)
J. Cell Biol.
, vol.191
, pp. 933-942
-
-
Jin, S.M.1
Lazarou, M.2
Wang, C.3
Kane, L.A.4
Narendra, D.P.5
Youle, R.J.6
-
49
-
-
84887453820
-
PINK1 is degraded through the N-end rule pathway
-
CrossRef PubMed
-
Yamano, K. and Youle, R.J. (2013) PINK1 is degraded through the N-end rule pathway. Autophagy 9, 1758-1769 CrossRef PubMed
-
(2013)
Autophagy
, vol.9
, pp. 1758-1769
-
-
Yamano, K.1
Youle, R.J.2
-
50
-
-
33745087689
-
PINK1 protein in normal human brain and Parkinson's disease
-
CrossRef PubMed
-
Gandhi, S., Muqit, M.M.K., Stanyer, L., Healy, D.G., Abou-Sleiman, P.M., Hargreaves, I., Heales, S., Ganguly, M., Parsons, L., Lees, A.J. et al. (2006) PINK1 protein in normal human brain and Parkinson's disease. Brain 129, 1720-1731 CrossRef PubMed
-
(2006)
Brain
, vol.129
, pp. 1720-1731
-
-
Gandhi, S.1
Muqit, M.M.K.2
Stanyer, L.3
Healy, D.G.4
Abou-Sleiman, P.M.5
Hargreaves, I.6
Heales, S.7
Ganguly, M.8
Parsons, L.9
Lees, A.J.10
-
51
-
-
84894599877
-
Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy
-
CrossRef PubMed
-
Fedorowicz, M.A., de Vries-Schneider, R.L.A., Rüb, C., Becker, D., Huang, Y., Zhou, C., Alessi Wolken, D.M., Voos, W., Liu, Y. and Przedborski, S. (2014) Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy. EMBO Rep. 15, 86-93 CrossRef PubMed
-
(2014)
EMBO Rep.
, vol.15
, pp. 86-93
-
-
Fedorowicz, M.A.1
De Vries-Schneider, R.L.A.2
Rüb, C.3
Becker, D.4
Huang, Y.5
Zhou, C.6
Alessi Wolken, D.M.7
Voos, W.8
Liu, Y.9
Przedborski, S.10
-
52
-
-
84864197915
-
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: Analysis of substrate specificity and impact of mutations
-
CrossRef PubMed
-
Woodroof, H.I., Pogson, J.H., Begley, M., Cantley, L.C., Deak, M., Campbell, D.G., van Aalten, D.M.F., Whitworth, A.J., Alessi, D.R. and Muqit, M.K. (2011) Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1 : analysis of substrate specificity and impact of mutations. Open Biol. 1, 110012 CrossRef PubMed
-
(2011)
Open Biol.
, vol.1
-
-
Woodroof, H.I.1
Pogson, J.H.2
Begley, M.3
Cantley, L.C.4
Deak, M.5
Campbell, D.G.6
Van Aalten, D.M.F.7
Whitworth, A.J.8
Alessi, D.R.9
Muqit, M.K.10
-
53
-
-
84861983560
-
Vitamin K2 Is a mitochondrial electron carrier that rescues Pink1 deficiency
-
CrossRef PubMed
-
Vos, M., Esposito, G., Edirisinghe, J.N., Vilain, S., Haddad, D.M., Slabbaert, J.R., Van Meensel, S., Schaap, O., De Strooper, B., Meganathan, R. et al. (2012) Vitamin K2 Is a mitochondrial electron carrier that rescues Pink1 deficiency. Science 336, 1306-1310 CrossRef PubMed
-
(2012)
Science
, vol.336
, pp. 1306-1310
-
-
Vos, M.1
Esposito, G.2
Edirisinghe, J.N.3
Vilain, S.4
Haddad, D.M.5
Slabbaert, J.R.6
Van Meensel, S.7
Schaap, O.8
De Strooper, B.9
Meganathan, R.10
|