Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway

Mechanisms of Ageing and Development

Volumn 149, Issue , 2015, Pages 8-18

  Na, Hyun Jin ^a   Park, Joung Sun ^a   Pyo, Jung Hoon ^a   Jeon, Ho Jun ^a   Kim, Young Shin ^a   Arking, Robert ^b   Yoo, Mi Ae ^a  

^a Pusan National University   (South Korea)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

AKT TOR pathway; Centrosome amplification; DNA damage; Drosophila intestinal stem cells (ISCs); Metformin

Indexed keywords

METFORMIN; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; GREEN FLUORESCENT PROTEIN; PARAQUAT;

ADULT; AGE; ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOACCUMULATION; BIOLOGICAL MODEL; CELL PROLIFERATION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CENTROSOME AMPLIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DROSOPHILA; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; INTESTINAL STEM CELL; INTRACELLULAR SIGNALING; MIDGUT; MITOSIS; MOLECULAR DYNAMICS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; CELL AGING; CENTROSOME; CHEMISTRY; DRUG EFFECTS; FEMALE; INTESTINE; MALE; METABOLISM; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL AGING; CENTROSOME; DNA DAMAGE; DOWN-REGULATION; DROSOPHILA; FEMALE; GREEN FLUORESCENT PROTEINS; HYPOGLYCEMIC AGENTS; INTESTINES; MALE; METFORMIN; OXIDATIVE STRESS; PARAQUAT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84934964122     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2015.05.004     Document Type: Article

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