Age- and oxidative stress-induced DNA damage in Drosophila intestinal stem cells as marked by Gamma-H2AX

Experimental Gerontology

Volumn 47, Issue 5, 2012, Pages 401-405

  Park, Joung Sun ^a   Lee, Shin Hae ^a   Na, Hyun Jin ^a   Pyo, Jung Hoon ^a   Kim, Young Shin ^a   Yoo, Mi Ae ^a  

^a Pusan National University   (South Korea)

Author keywords

H2AvD; H2AX; Aging; DNA damage; Drosophila; Intestinal stem cell

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; GAMMA HISTONE H2AVD; GAMMA HISTONE H2AX; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GAMMA IRRADIATION; IMAGO; INTESTINAL STEM CELL; MIDGUT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; STEM CELL;

AGING; ANIMALS; BIOLOGICAL MARKERS; DNA DAMAGE; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GAMMA RAYS; HISTONES; INTESTINES; MALE; OXIDATIVE STRESS; STEM CELLS;

MAMMALIA;

EID: 84862832405     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.02.007     Document Type: Article

References (26)

1. Amcheslavsky A., Jiang J., Ip Y.T. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 2009, 4:49-61.
2. Apidianakis Y., Rahme L.G. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis. Model. Mech. 2011, 4:21-30.
3. Ayoub N., Jeyasekharan A.D., Bernal J.A., Venkitaraman A.R. Paving the way for H2AX phosphorylation: Chromatin changes in the DNA damage response. Cell Cycle 2009, 8:1494-1500.
4. Biteau B., Hochmuth C.E., Jasper H. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging drosophila gut. Cell Stem Cell 2008, 3:442-455.
5. Biteau B., Karpac J., Supoyo S., Degennaro M., Lehmann R., Jasper H. Lifespan extension by preserving proliferative homeostasis in drosophila. PLoS Genet. 2010, 6:e1001159.
6. Choi N.H., Kim J.G., Yang D.J., Kim Y.S., Yoo M.A. Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell 2008, 7:318-334.
7. Jaskelioff M., Muller F.L., Paik J.H., Thomas E., Jiang S., Adams A.C., Sahin E., Kost-Alimova M., Protopopov A., Cadinanos J., Horner J.W., Maratos-Flier E., Depinho R.A. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011, 469:102-106.
8. Keogh M.C., Kim J.A., Downey M., Fillingham J., Chowdhury D., Harrison J.C., Onishi M., Datta N., Galicia S., Emili A., Lieberman J., Shen X., Buratowski S., Haber J.E., Durocher D., Greenblatt J.F., Krogan N.J. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 2006, 439:497-501.
9. Lee W.C., Beebe K., Sudmeier L., Micchelli C.A. Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development 2009, 136:2255-2264.
10. Madigan J.P., Chotkowski H.L., Glaser R.L. DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis. Nucleic Acids Res. 2002, 30:3698-3705.
11. Mah L.J., Vasireddy R.S., Tang M.M., Georgiadis G.T., El-Osta A., Karagiannis T.C. Quantification of gammaH2AX foci in response to ionising radiation. J. Vis. Exp. 2010, (38). pii: 1957. 10.3791/1957.
12. Mah L.J., El-Osta A., Karagiannis T.C. gammaH2AX: A sensitive molecular marker of DNA damage and repair. Leukemia 2010, 24:679-686.
13. Mah L.J., El-Osta A., Karagiannis T.C. GammaH2AX as a molecular marker of aging and disease. Epigenetics 2010, 5:129-136.
14. Micchelli C.A., Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 2006, 439:475-479.
15. Munoz-Najar U., Sedivy J.M. Epigenetic control of aging. Antioxid. Redox Signal. 2011, 14:241-259.
16. Ohlstein B., Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 2006, 439:470-474.
17. Ohlstein B., Spradling A. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 2007, 315:988-992.
18. Park J.S., Kim Y.S., Yoo M.A. The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila. Aging 2009, 1:637-651.
19. Rera M., Bahadorani S., Cho J., Koehler C.L., Ulgherait M., Hur J.H., Ansari W.S., Lo T., Jones D.L., Walker D.W. Modulation of longevity and tissue homeostasis by the drosophila PGC-1 homolog. Cell Metab. 2011, 14:623-634.
20. Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
21. Shin D.M., Kucia M., Ratajczak M.Z. Nuclear and chromatin reorganization during cell senescence and aging - a mini-review. Gerontology 2011, 57:76-84.
22. Simm A., Johnson T.E. Biomarkers of ageing: A challenge for the future. Exp. Gerontol. 2010, 45:731-732.
23. Srivastava N., Gochhait S., de Boer P., Bamezai R.N. Role of H2AX in DNA damage response and human cancers. Mutat. Res. 2009, 681:180-188.
24. Wang L., Jones D.L. The effects of aging on stem cell behavior in Drosophila. Exp. Gerontol. 2011, 46:340-344.
25. Xu Y., Price B.D. Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle 2011, 10:261-267.
26. Zhang J., Ju Z. Telomere, DNA damage, and oxidative stress in stem cell aging. Birth Defects Res. C Embryo Today 2010, 90:297-307.