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Volumn 133, Issue 1, 2012, Pages 108-115

Metformin and neoplasia: Implications and indications

Author keywords

AMPK; Cancer; Cancer stem cell; Chemoprevention; IGF; Keywords; Metastasis; Metformin; mTOR; Rapamycin

Indexed keywords

ADENYLATE KINASE; DOXORUBICIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; SOMATOMEDIN;

EID: 83555164657     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.09.004     Document Type: Review
Times cited : (114)

References (84)
  • 1
    • 0031682742 scopus 로고    scopus 로고
    • The IGF family and folliculogenesis
    • E.Y. Adashi The IGF family and folliculogenesis J Reprod Immunol 39 1998 13 19
    • (1998) J Reprod Immunol , vol.39 , pp. 13-19
    • Adashi, E.Y.1
  • 2
    • 53849118108 scopus 로고    scopus 로고
    • Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth
    • C. Algire, M. Zakikhani, M.J. Blouin, J.H. Shuai, and M. Pollak Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth Endocr Relat Cancer 15 2008 833 839
    • (2008) Endocr Relat Cancer , vol.15 , pp. 833-839
    • Algire, C.1    Zakikhani, M.2    Blouin, M.J.3    Shuai, J.H.4    Pollak, M.5
  • 3
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • I.N. Alimova, B. Liu, Z. Fan, S.M. Edgerton, T. Dillon, and S.E. Lind Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro Cell Cycle 8 2009 909 915
    • (2009) Cell Cycle , vol.8 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3    Edgerton, S.M.4    Dillon, T.5    Lind, S.E.6
  • 4
    • 24644475793 scopus 로고    scopus 로고
    • Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    • V.N. Anisimov, L.M. Berstein, P.A. Egormin, T.S. Piskunova, I.G. Popovich, and M.A. Zabezhinski Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice Exp Gerontol 40 2005 685 693
    • (2005) Exp Gerontol , vol.40 , pp. 685-693
    • Anisimov, V.N.1    Berstein, L.M.2    Egormin, P.A.3    Piskunova, T.S.4    Popovich, I.G.5    Zabezhinski, M.A.6
  • 6
    • 44849099894 scopus 로고    scopus 로고
    • The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
    • I. Ben Sahra, K. Laurent, A. Loubat, S. Giorgetti-Peraldi, P. Colosetti, and P. Auberger The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level Oncogene 27 2008 3576 3586
    • (2008) Oncogene , vol.27 , pp. 3576-3586
    • Ben Sahra, I.1    Laurent, K.2    Loubat, A.3    Giorgetti-Peraldi, S.4    Colosetti, P.5    Auberger, P.6
  • 7
    • 34247872895 scopus 로고    scopus 로고
    • Characterization of insulin/IGF hybrid receptors: Contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
    • S. Benyoucef, K.H. Surinya, D. Hadaschik, and K. Siddle Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation Biochem J 403 2007 603 613
    • (2007) Biochem J , vol.403 , pp. 603-613
    • Benyoucef, S.1    Surinya, K.H.2    Hadaschik, D.3    Siddle, K.4
  • 9
    • 33646073085 scopus 로고    scopus 로고
    • Genotoxic factors associated with the development of receptor-negative breast cancer: Potential role of the phenomenon of switching of estrogen effects
    • L.M. Berstein, E.V. Tsyrlina, T.E. Poroshina, V.V. Levina, D.A. Vasilyev, and I.G. Kovalenko Genotoxic factors associated with the development of receptor-negative breast cancer: potential role of the phenomenon of switching of estrogen effects Exp Oncol 28 2006 64 69
    • (2006) Exp Oncol , vol.28 , pp. 64-69
    • Berstein, L.M.1    Tsyrlina, E.V.2    Poroshina, T.E.3    Levina, V.V.4    Vasilyev, D.A.5    Kovalenko, I.G.6
  • 10
    • 77953539812 scopus 로고    scopus 로고
    • Long-term metformin use is associated with decreased risk of breast cancer
    • M. Bodmer, C. Meier, S. Krahenbuhl, S.S. Jick, and C.R. Meier Long-term metformin use is associated with decreased risk of breast cancer Diabetes Care 33 2010 1304 1308
    • (2010) Diabetes Care , vol.33 , pp. 1304-1308
    • Bodmer, M.1    Meier, C.2    Krahenbuhl, S.3    Jick, S.S.4    Meier, C.R.5
  • 11
    • 3142729250 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of prostate cancer: A meta-analysis
    • S. Bonovas, K. Filioussi, and A. Tsantes Diabetes mellitus and risk of prostate cancer: a meta-analysis Diabetologia 47 2004 1071 1078
    • (2004) Diabetologia , vol.47 , pp. 1071-1078
    • Bonovas, S.1    Filioussi, K.2    Tsantes, A.3
  • 12
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • S.L. Bowker, S.R. Majumdar, P. Veugelers, and J.A. Johnson Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin Diabetes Care 29 2006 254 258
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 13
    • 70749106139 scopus 로고    scopus 로고
    • Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy
    • L.A. Cantrell, C. Zhou, A. Mendivil, K.M. Malloy, P.A. Gehrig, and V.L. Bae-Jump Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy Gynecol Oncol 116 2010 92 98
    • (2010) Gynecol Oncol , vol.116 , pp. 92-98
    • Cantrell, L.A.1    Zhou, C.2    Mendivil, A.3    Malloy, K.M.4    Gehrig, P.A.5    Bae-Jump, V.L.6
  • 14
    • 0037083568 scopus 로고    scopus 로고
    • Weight loss in breast cancer patient management
    • R.T. Chlebowski, E. Aiello, and A. McTiernan Weight loss in breast cancer patient management J Clin Oncol 20 2002 1128 1143
    • (2002) J Clin Oncol , vol.20 , pp. 1128-1143
    • Chlebowski, R.T.1    Aiello, E.2    McTiernan, A.3
  • 15
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • C.J. Currie, C.D. Poole, and E.A. Gale The influence of glucose-lowering therapies on cancer risk in type 2 diabetes Diabetologia 52 2009 1766 1777
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 16
  • 18
    • 0028804071 scopus 로고
    • M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    • A.T. De Souza, G.R. Hankins, M.K. Washington, T.C. Orton, and R.L. Jirtle M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity Nat Genet 11 1995 447 449
    • (1995) Nat Genet , vol.11 , pp. 447-449
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Orton, T.C.4    Jirtle, R.L.5
  • 19
    • 75149162547 scopus 로고    scopus 로고
    • Metformin: An old medication of new fashion: Evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
    • E. Diamanti-Kandarakis, C.D. Christakou, E. Kandaraki, and F.N. Economou Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome Eur J Endocrinol 162 2010 193 212
    • (2010) Eur J Endocrinol , vol.162 , pp. 193-212
    • Diamanti-Kandarakis, E.1    Christakou, C.D.2    Kandaraki, E.3    Economou, F.N.4
  • 20
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • R.J. Dowling, M. Zakikhani, I.G. Fantus, M. Pollak, and N. Sonenberg Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells Cancer Res 67 2007 10804 10812
    • (2007) Cancer Res , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 22
    • 0029017953 scopus 로고
    • Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis
    • J. Everhart, and D. Wright Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis JAMA 273 1995 1605 1609
    • (1995) JAMA , vol.273 , pp. 1605-1609
    • Everhart, J.1    Wright, D.2
  • 23
    • 34249948987 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of endometrial cancer: A meta-analysis
    • E. Friberg, N. Orsini, C.S. Mantzoros, and A. Wolk Diabetes mellitus and risk of endometrial cancer: A meta-analysis Diabetologia 50 2007 1365 1374
    • (2007) Diabetologia , vol.50 , pp. 1365-1374
    • Friberg, E.1    Orsini, N.2    Mantzoros, C.S.3    Wolk, A.4
  • 24
    • 77949703788 scopus 로고    scopus 로고
    • Metformin: A therapeutic opportunity in breast cancer
    • A.M. Gonzalez-Angulo, and F. Meric-Bernstam Metformin: a therapeutic opportunity in breast cancer Clin Cancer Res 16 2010 1695 1700
    • (2010) Clin Cancer Res , vol.16 , pp. 1695-1700
    • Gonzalez-Angulo, A.M.1    Meric-Bernstam, F.2
  • 26
    • 34247520866 scopus 로고    scopus 로고
    • Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors
    • C.A. Granville, N. Warfel, J. Tsurutani, M.C. Hollander, M. Robertson, and S.D. Fox Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors Clin Cancer Res 13 2007 2281 2289
    • (2007) Clin Cancer Res , vol.13 , pp. 2281-2289
    • Granville, C.A.1    Warfel, N.2    Tsurutani, J.3    Hollander, M.C.4    Robertson, M.5    Fox, S.D.6
  • 27
    • 0036830256 scopus 로고    scopus 로고
    • Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells
    • V. Grunwald, L. DeGraffenried, D. Russel, W.E. Friedrichs, R.B. Ray, and M. Hidalgo Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells Cancer Res 62 2002 6141 6145
    • (2002) Cancer Res , vol.62 , pp. 6141-6145
    • Grunwald, V.1    Degraffenried, L.2    Russel, D.3    Friedrichs, W.E.4    Ray, R.B.5    Hidalgo, M.6
  • 29
    • 78149456040 scopus 로고    scopus 로고
    • Gene signature of metformin actions on primary breast cancer within a window of opportunity randomized clinical trial
    • S. Hadad, J. Dewar, E. Elseedawy, L. Jordan, C. Purdie, and S. Bray Gene signature of metformin actions on primary breast cancer within a window of opportunity randomized clinical trial J Clin Oncol Vol. 28 2010 560 (Suppl)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. , pp. 560
    • Hadad, S.1    Dewar, J.2    Elseedawy, E.3    Jordan, L.4    Purdie, C.5    Bray, S.6
  • 30
    • 33748118458 scopus 로고    scopus 로고
    • Neither LKB1 nor AMPK are the direct targets of metformin
    • author reply 974-975.
    • D.G. Hardie Neither LKB1 nor AMPK are the direct targets of metformin Gastroenterology 131 2006 973 author reply 974-975.
    • (2006) Gastroenterology , vol.131 , pp. 973
    • Hardie, D.G.1
  • 31
    • 0036324142 scopus 로고    scopus 로고
    • The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
    • S.A. Hawley, A.E. Gadalla, G.S. Olsen, and D.G. Hardie The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism Diabetes 51 2002 2420 2425
    • (2002) Diabetes , vol.51 , pp. 2420-2425
    • Hawley, S.A.1    Gadalla, A.E.2    Olsen, G.S.3    Hardie, D.G.4
  • 32
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev 18 2004 1926 1945
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 33
    • 77952098898 scopus 로고    scopus 로고
    • Diabetes therapy and cancer risk: Causal effects and other plausible explanations
    • S. Hernandez-Diaz, and H.O. Adami Diabetes therapy and cancer risk: causal effects and other plausible explanations Diabetologia 53 2010 802 808
    • (2010) Diabetologia , vol.53 , pp. 802-808
    • Hernandez-Diaz, S.1    Adami, H.O.2
  • 34
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • H.A. Hirsch, D. Iliopoulos, P.N. Tsichlis, and K. Struhl Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission Cancer Res 69 2009 7507 7511
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 36
    • 77954468475 scopus 로고    scopus 로고
    • Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase
    • K. Hosono, H. Endo, H. Takahashi, M. Sugiyama, T. Uchiyama, and K. Suzuki Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase Mol Carcinog 49 2010 662 671
    • (2010) Mol Carcinog , vol.49 , pp. 662-671
    • Hosono, K.1    Endo, H.2    Takahashi, H.3    Sugiyama, M.4    Uchiyama, T.5    Suzuki, K.6
  • 38
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • K. Inoki, M.N. Corradetti, and K.L. Guan Dysregulation of the TSC-mTOR pathway in human disease Nat Genet 37 2005 19 24
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 39
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • K. Inoki, T. Zhu, and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577 590
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 40
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • S. Jiralerspong, S.L. Palla, S.H. Giordano, F. Meric-Bernstam, C. Liedtke, and C.M. Barnett Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer J Clin Oncol 27 2009 3297 3302
    • (2009) J Clin Oncol , vol.27 , pp. 3297-3302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3    Meric-Bernstam, F.4    Liedtke, C.5    Barnett, C.M.6
  • 41
    • 33845328853 scopus 로고    scopus 로고
    • A meta-analysis of diabetes mellitus and the risk of prostate cancer
    • J.S. Kasper, and E. Giovannucci A meta-analysis of diabetes mellitus and the risk of prostate cancer Cancer Epidemiol Biomarkers Prev 15 2006 2056 2062
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 2056-2062
    • Kasper, J.S.1    Giovannucci, E.2
  • 42
    • 11144355692 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein (SREBP)-1: Gene regulatory target for insulin resistance?
    • J. Kotzka, and D. Muller-Wieland Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance? Expert Opin Ther Targets 8 2004 141 149
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 141-149
    • Kotzka, J.1    Muller-Wieland, D.2
  • 44
    • 66149147056 scopus 로고    scopus 로고
    • Glycemic load, glycemic index and breast cancer risk in a prospective cohort of Swedish women
    • S.C. Larsson, L. Bergkvist, and A. Wolk Glycemic load, glycemic index and breast cancer risk in a prospective cohort of Swedish women Int J Cancer 125 2009 153 157
    • (2009) Int J Cancer , vol.125 , pp. 153-157
    • Larsson, S.C.1    Bergkvist, L.2    Wolk, A.3
  • 45
    • 34547127614 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of breast cancer: A meta-analysis
    • S.C. Larsson, C.S. Mantzoros, and A. Wolk Diabetes mellitus and risk of breast cancer: a meta-analysis Int J Cancer 121 2007 856 862
    • (2007) Int J Cancer , vol.121 , pp. 856-862
    • Larsson, S.C.1    Mantzoros, C.S.2    Wolk, A.3
  • 46
    • 33750930105 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of bladder cancer: A meta-analysis
    • S.C. Larsson, N. Orsini, K. Brismar, and A. Wolk Diabetes mellitus and risk of bladder cancer: a meta-analysis Diabetologia 49 2006 2819 2823
    • (2006) Diabetologia , vol.49 , pp. 2819-2823
    • Larsson, S.C.1    Orsini, N.2    Brismar, K.3    Wolk, A.4
  • 47
    • 27944450832 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of colorectal cancer: A meta-analysis
    • S.C. Larsson, N. Orsini, and A. Wolk Diabetes mellitus and risk of colorectal cancer: a meta-analysis J Natl Cancer Inst 97 2005 1679 1687
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1679-1687
    • Larsson, S.C.1    Orsini, N.2    Wolk, A.3
  • 49
    • 79955673061 scopus 로고    scopus 로고
    • Effects of metformin and rosiglitazone on peripheral insulin resistance and beta-cell function in obesity: A double-blind, randomized, controlled study
    • X. Li, N. Zhang, Y. Li, Y. Shi, D. Li, and Y. Xie Effects of metformin and rosiglitazone on peripheral insulin resistance and beta-cell function in obesity: a double-blind, randomized, controlled study J Int Med Res 39 2011 358 365
    • (2011) J Int Med Res , vol.39 , pp. 358-365
    • Li, X.1    Zhang, N.2    Li, Y.3    Shi, Y.4    Li, D.5    Xie, Y.6
  • 50
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • G. Libby, L.A. Donnelly, P.T. Donnan, D.R. Alessi, A.D. Morris, and J.M. Evans New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes Diabetes Care 32 2009 1620 1625
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3    Alessi, D.R.4    Morris, A.D.5    Evans, J.M.6
  • 51
    • 67650514082 scopus 로고    scopus 로고
    • Metformin induces unique biological and molecular responses in triple negative breast cancer cells
    • B. Liu, Z. Fan, S.M. Edgerton, X.S. Deng, I.N. Alimova, and S.E. Lind Metformin induces unique biological and molecular responses in triple negative breast cancer cells Cell Cycle 8 2009 2031 2040
    • (2009) Cell Cycle , vol.8 , pp. 2031-2040
    • Liu, B.1    Fan, Z.2    Edgerton, S.M.3    Deng, X.S.4    Alimova, I.N.5    Lind, S.E.6
  • 52
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: Systematic review and meta-analysis
    • J.M. Lord, I.H. Flight, and R.J. Norman Metformin in polycystic ovary syndrome: systematic review and meta-analysis BMJ 327 2003 951 953
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 54
    • 77949323798 scopus 로고    scopus 로고
    • Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: An ongoing clinical-translational research experience at the Catalan Institute of Oncology
    • B. Martin-Castillo, J. Dorca, A. Vazquez-Martin, C. Oliveras-Ferraros, E. Lopez-Bonet, and M. Garcia Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology Ann Oncol 21 2010 187 189
    • (2010) Ann Oncol , vol.21 , pp. 187-189
    • Martin-Castillo, B.1    Dorca, J.2    Vazquez-Martin, A.3    Oliveras-Ferraros, C.4    Lopez-Bonet, E.5    Garcia, M.6
  • 57
    • 79954979578 scopus 로고    scopus 로고
    • Clinical and biologic effects of metformin in early stage breast cancer
    • Abstract # PD03-06
    • S. Niraula, V. Stambolic, R. Dowling, M. Ennis, M. Chang, and S. Done Clinical and biologic effects of metformin in early stage breast cancer Abstract # PD03-06 Cancer Res Vol. 70 2010 24,Suppl 104S
    • (2010) Cancer Res , vol.70 , Issue.SUPPL. 104S , pp. 24
    • Niraula, S.1    Stambolic, V.2    Dowling, R.3    Ennis, M.4    Chang, M.5    Done, S.6
  • 59
    • 78149357382 scopus 로고    scopus 로고
    • Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin
    • T. Patel, G. Hruby, K. Badani, C. Abate-Shen, and J.M. McKiernan Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin Urology 76 2010 1240 1244
    • (2010) Urology , vol.76 , pp. 1240-1244
    • Patel, T.1    Hruby, G.2    Badani, K.3    Abate-Shen, C.4    McKiernan, J.M.5
  • 61
    • 1842506719 scopus 로고    scopus 로고
    • Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
    • L. Pawelczyk, R.Z. Spaczynski, B. Banaszewska, and A.J. Duleba Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome Eur J Obstet Gynecol Reprod Biol 113 2004 209 213
    • (2004) Eur J Obstet Gynecol Reprod Biol , vol.113 , pp. 209-213
    • Pawelczyk, L.1    Spaczynski, R.Z.2    Banaszewska, B.3    Duleba, A.J.4
  • 62
    • 58149156184 scopus 로고    scopus 로고
    • Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model
    • K.N. Phoenix, F. Vumbaca, and K.P. Claffey Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model Breast Cancer Res Treat 113 2009 101 111
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 101-111
    • Phoenix, K.N.1    Vumbaca, F.2    Claffey, K.P.3
  • 63
    • 20044370885 scopus 로고    scopus 로고
    • Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
    • K. Sakamoto, A. McCarthy, D. Smith, K.A. Green, D. Grahame Hardie, and A. Ashworth Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction EMBO J 24 2005 1810 1820
    • (2005) EMBO J , vol.24 , pp. 1810-1820
    • Sakamoto, K.1    McCarthy, A.2    Smith, D.3    Green, K.A.4    Grahame Hardie, D.5    Ashworth, A.6
  • 64
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • R.J. Shaw, K.A. Lamia, D. Vasquez, S.H. Koo, N. Bardeesy, and R.A. Depinho The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 2005 1642 1646
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 65
    • 0036735346 scopus 로고    scopus 로고
    • Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
    • Y. Shi, J. Gera, L. Hu, J.H. Hsu, R. Bookstein, and W. Li Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779 Cancer Res 62 2002 5027 5034
    • (2002) Cancer Res , vol.62 , pp. 5027-5034
    • Shi, Y.1    Gera, J.2    Hu, L.3    Hsu, J.H.4    Bookstein, R.5    Li, W.6
  • 66
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • S.Y. Shieh, M. Ikeda, Y. Taya, and C. Prives DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 91 1997 325 334
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 68
    • 79952290187 scopus 로고    scopus 로고
    • Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells
    • B.K. Tan, R. Adya, J. Chen, H. Lehnert, L.J. Sant Cassia, and H.S. Randeva Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells J Clin Endocrinol Metab 96 2011 808 816
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 808-816
    • Tan, B.K.1    Adya, R.2    Chen, J.3    Lehnert, H.4    Sant Cassia, L.J.5    Randeva, H.S.6
  • 70
    • 78650754301 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells
    • A. Vazquez-Martin, C. Oliveras-Ferraros, S. Cufi, S. del Barco, B. Martin-Castillo, and E. Lopez-Bonet The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells Oncol Rep 25 2011 135 140
    • (2011) Oncol Rep , vol.25 , pp. 135-140
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Cufi, S.3    Del Barco, S.4    Martin-Castillo, B.5    Lopez-Bonet, E.6
  • 71
    • 77957005003 scopus 로고    scopus 로고
    • Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
    • A. Vazquez-Martin, C. Oliveras-Ferraros, S. Cufi, S. del Barco, B. Martin-Castillo, and J.A. Menendez Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status Cell Cycle 9 2010 3807 3814
    • (2010) Cell Cycle , vol.9 , pp. 3807-3814
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Cufi, S.3    Del Barco, S.4    Martin-Castillo, B.5    Menendez, J.A.6
  • 72
    • 61649095657 scopus 로고    scopus 로고
    • The antidiabetic drug metformin: A pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy
    • A. Vazquez-Martin, C. Oliveras-Ferraros, S. del Barco, B. Martin-Castillo, and J.A. Menendez The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy Ann Oncol 20 2009 592 595
    • (2009) Ann Oncol , vol.20 , pp. 592-595
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Del Barco, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 73
    • 70450021431 scopus 로고    scopus 로고
    • MTOR inhibitors and the anti-diabetic biguanide metformin: New insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb)
    • A. Vazquez-Martin, C. Oliveras-Ferraros, S. del Barco, B. Martin-Castillo, and J.A. Menendez mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb) Clin Transl Oncol 11 2009 455 459
    • (2009) Clin Transl Oncol , vol.11 , pp. 455-459
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Del Barco, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 74
    • 79954460690 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
    • A. Vazquez-Martin, C. Oliveras-Ferraros, S. del Barco, B. Martin-Castillo, and J.A. Menendez The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells Breast Cancer Res Treat 126 2011 355 364
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 355-364
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Del Barco, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 75
    • 60749108023 scopus 로고    scopus 로고
    • The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
    • A. Vazquez-Martin, C. Oliveras-Ferraros, and J.A. Menendez The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells Cell Cycle 8 2009 88 96
    • (2009) Cell Cycle , vol.8 , pp. 88-96
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 76
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • O. Warburg On the origin of cancer cells Science 123 1956 309 314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 77
    • 14644433735 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy
    • G.S. Warshamana-Greene, J. Litz, E. Buchdunger, C. Garcia-Echeverria, F. Hofmann, and G.W. Krystal The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy Clin Cancer Res 11 2005 1563 1571
    • (2005) Clin Cancer Res , vol.11 , pp. 1563-1571
    • Warshamana-Greene, G.S.1    Litz, J.2    Buchdunger, E.3    Garcia-Echeverria, C.4    Hofmann, F.5    Krystal, G.W.6
  • 79
    • 70350583054 scopus 로고    scopus 로고
    • Metformin use and prostate cancer in Caucasian men: Results from a population-based case-control study
    • J.L. Wright, and J.L. Stanford Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study Cancer Causes Control 20 2009 1617 1622
    • (2009) Cancer Causes Control , vol.20 , pp. 1617-1622
    • Wright, J.L.1    Stanford, J.L.2
  • 80
    • 33751509395 scopus 로고    scopus 로고
    • Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones
    • S. Yakar, N.P. Nunez, P. Pennisi, P. Brodt, H. Sun, and L. Fallavollita Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones Endocrinology 147 2006 5826 5834
    • (2006) Endocrinology , vol.147 , pp. 5826-5834
    • Yakar, S.1    Nunez, N.P.2    Pennisi, P.3    Brodt, P.4    Sun, H.5    Fallavollita, L.6
  • 81
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • M. Zakikhani, R. Dowling, I.G. Fantus, N. Sonenberg, and M. Pollak Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells Cancer Res 66 2006 10269 10273
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 82
    • 61449113987 scopus 로고    scopus 로고
    • The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase
    • M. Zakikhani, R.J. Dowling, N. Sonenberg, and M.N. Pollak The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase Cancer Prev Res (Phila) 1 2008 369 375
    • (2008) Cancer Prev Res (Phila) , vol.1 , pp. 369-375
    • Zakikhani, M.1    Dowling, R.J.2    Sonenberg, N.3    Pollak, M.N.4
  • 83
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, and J. Fenyk-Melody Role of AMP-activated protein kinase in mechanism of metformin action J Clin Investig 108 2001 1167 1174
    • (2001) J Clin Investig , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5    Fenyk-Melody, J.6
  • 84
    • 58149354390 scopus 로고    scopus 로고
    • Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
    • Y. Zhuang, and W.K. Miskimins Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1 J Mol Signal 3 2008 18
    • (2008) J Mol Signal , vol.3 , pp. 18
    • Zhuang, Y.1    Miskimins, W.K.2


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