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Volumn 188, Issue 8, 2012, Pages 3716-3723

Complement component C1q regulates macrophage expression of mer tyrosine kinase to promote clearance of apoptotic cells

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COMPLEMENT COMPONENT C1Q; CYCLOHEXIMIDE; HYBRID PROTEIN; LIGAND; MANNOSE BINDING LECTIN; MER TYROSINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

EID: 84860341450     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102920     Document Type: Article
Times cited : (65)

References (44)
  • 3
    • 0034041159 scopus 로고    scopus 로고
    • Lupus, DNase and defective disposal of cellular debris
    • DOI 10.1038/75963
    • Walport, M. J. 2000. Lupus, DNase and defective disposal of cellular debris. Nat. Genet. 25: 135-136. (Pubitemid 30394978)
    • (2000) Nature Genetics , vol.25 , Issue.2 , pp. 135-136
    • Walport, M.J.1
  • 4
    • 77954396042 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: Implications in health and disease
    • Elliott, M. R., and K. S. Ravichandran. 2010. Clearance of apoptotic cells: implications in health and disease. J. Cell Biol. 189: 1059-1070.
    • (2010) J. Cell Biol. , vol.189 , pp. 1059-1070
    • Elliott, M.R.1    Ravichandran, K.S.2
  • 5
    • 78649848107 scopus 로고    scopus 로고
    • TAM receptor signaling and autoimmune disease
    • Rothlin, C. V., and G. Lemke. 2010. TAM receptor signaling and autoimmune disease. Curr. Opin. Immunol. 22: 740-746.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 740-746
    • Rothlin, C.V.1    Lemke, G.2
  • 6
    • 0023111156 scopus 로고
    • Modulation of FcR function by complement: Subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages
    • Bobak, D. A., T. A. Gaither, M. M. Frank, and A. J. Tenner. 1987. Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. J. Immunol. 138: 1150-1156. (Pubitemid 17017899)
    • (1987) Journal of Immunology , vol.138 , Issue.4 , pp. 1150-1156
    • Bobak, D.A.1    Gaither, T.A.2    Frank, M.M.3    Tenner, A.J.4
  • 7
    • 0024273027 scopus 로고
    • C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes
    • DOI 10.1002/eji.1830181220
    • Bobak, D. A., M. M. Frank, and A. J. Tenner. 1988. C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes. Eur. J. Immunol. 18: 2001-2007. (Pubitemid 19046217)
    • (1988) European Journal of Immunology , vol.18 , Issue.12 , pp. 2001-2007
    • Bobak, D.A.1    Frank, M.M.2    Tenner, A.J.3
  • 8
    • 0024380059 scopus 로고
    • Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis
    • Tenner, A. J., S. L. Robinson, J. Borchelt, and J. R. Wright. 1989. Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis. J. Biol. Chem. 264: 13923-13928. (Pubitemid 19198488)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.23 , pp. 13923-13928
    • Tenner, A.J.1    Robinson, S.L.2    Borchelt, J.3    Wright, J.R.4
  • 9
    • 0028880756 scopus 로고
    • Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor
    • Tenner, A. J., S. L. Robinson, and R. A. Ezekowitz. 1995. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor. Immunity 3: 485-493.
    • (1995) Immunity , vol.3 , pp. 485-493
    • Tenner, A.J.1    Robinson, S.L.2    Ezekowitz, R.A.3
  • 10
    • 0031569975 scopus 로고    scopus 로고
    • C1q Binds Directly and Specifically to Surface Blebs of Apoptotic Human Keratinocytes: Complement Deficiency and Systemic Lupus Erythematosus Revisited
    • Korb, L. C., and J. M. Ahearn. 1997. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J. Immunol. 158: 4525-4528. (Pubitemid 127483768)
    • (1997) Journal of Immunology , vol.158 , Issue.10 , pp. 4525-4528
    • Korb, L.C.1    Ahearn, J.M.2
  • 11
    • 33750491279 scopus 로고    scopus 로고
    • Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions
    • DOI 10.1016/j.molimm.2006.06.021, PII S0161589006002276
    • Bohlson, S. S., D. A. Fraser, and A. J. Tenner. 2007. Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol. Immunol. 44: 33-43. (Pubitemid 44647109)
    • (2007) Molecular Immunology , vol.44 , Issue.1-3 , pp. 33-43
    • Bohlson, S.S.1    Fraser, D.A.2    Tenner, A.J.3
  • 12
    • 14844363449 scopus 로고    scopus 로고
    • Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    • Stuart, L. M., K. Takahashi, L. Shi, J. Savill, and R. A. Ezekowitz. 2005. Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J. Immunol. 174: 3220-3226. (Pubitemid 40354024)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3220-3226
    • Stuart, L.M.1    Takahashi, K.2    Shi, L.3    Savill, J.4    Ezekowitz, R.A.B.5
  • 13
    • 40449099734 scopus 로고    scopus 로고
    • Directing an appropriate immune response: The role of defense collagens and other soluble pattern recognition molecules
    • DOI 10.2174/138945008783502476
    • Fraser, D. A., and A. J. Tenner. 2008. Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules. Curr. Drug Targets 9: 113-122. (Pubitemid 351461009)
    • (2008) Current Drug Targets , vol.9 , Issue.2 , pp. 113-122
    • Fraser, D.A.1    Tenner, A.J.2
  • 15
    • 73949145491 scopus 로고    scopus 로고
    • C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells
    • Fraser, D. A., A. K. Laust, E. L. Nelson, and A. J. Tenner. 2009. C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J. Immunol. 183: 6175-6185.
    • (2009) J. Immunol. , vol.183 , pp. 6175-6185
    • Fraser, D.A.1    Laust, A.K.2    Nelson, E.L.3    Tenner, A.J.4
  • 18
    • 0019472804 scopus 로고
    • Purification and radiolabeling of human C1q
    • Tenner, A. J., P. H. Lesavre, and N. R. Cooper. 1981. Purification and radiolabeling of human C1q. J. Immunol. 127: 648-653. (Pubitemid 11054682)
    • (1981) Journal of Immunology , vol.127 , Issue.2 , pp. 648-653
    • Tenner, A.J.1    Lesavre, P.H.2    Cooper, N.R.3
  • 19
    • 0025858875 scopus 로고
    • Complement subcomponent C1q stimulates Ig production by human B lymphocytes
    • Young, K. R., Jr., J. L. Ambrus, Jr., A. Malbran, A. S. Fauci, and A. J. Tenner. 1991. Complement subcomponent C1q stimulates Ig production by human B lymphocytes. J. Immunol. 146: 3356-3364.
    • (1991) J. Immunol. , vol.146 , pp. 3356-3364
    • Young Jr., K.R.1    Ambrus Jr., J.L.2    Malbran, A.3    Fauci, A.S.4    Tenner, A.J.5
  • 20
    • 0033559140 scopus 로고    scopus 로고
    • A novel receptor tyrosine kinase, mer, inhibits TNF-α production and lipopolysaccharide-induced endotoxic shock
    • Camenisch, T. D., B. H. Koller, H. S. Earp, and G. K. Matsushima. 1999. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162: 3498-3503. (Pubitemid 29313601)
    • (1999) Journal of Immunology , vol.162 , Issue.6 , pp. 3498-3503
    • Camenisch, T.D.1    Koller, B.H.2    Earp, H.S.3    Matsushima, G.K.4
  • 21
    • 0035183110 scopus 로고    scopus 로고
    • Role of complement in Mycobacterium avium pathogenesis: In vivo and in vitro analyses of the host response to infection in the absence of complement component C3
    • DOI 10.1128/IAI.69.12.7729-7735.2001
    • Bohlson, S. S., J. A. Strasser, J. J. Bower, and J. S. Schorey. 2001. Role of complement in Mycobacterium avium pathogenesis: in vivo and in vitro analyses of the host response to infection in the absence of complement component C3. Infect. Immun. 69: 7729-7735. (Pubitemid 33086603)
    • (2001) Infection and Immunity , vol.69 , Issue.12 , pp. 7729-7735
    • Bohlson, S.S.1    Strasser, J.A.2    Bower, J.J.3    Schorey, J.S.4
  • 22
    • 47949114495 scopus 로고    scopus 로고
    • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis
    • Lillis, A. P., M. C. Greenlee, I. Mikhailenko, S. V. Pizzo, A. J. Tenner, D. K. Strickland, and S. S. Bohlson. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J. Immunol. 181: 364-373.
    • (2008) J. Immunol. , vol.181 , pp. 364-373
    • Lillis, A.P.1    Greenlee, M.C.2    Mikhailenko, I.3    Pizzo, S.V.4    Tenner, A.J.5    Strickland, D.K.6    Bohlson, S.S.7
  • 23
    • 0031172246 scopus 로고    scopus 로고
    • CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion
    • Roach, T., S. Slater, M. Koval, L. White, E. D. Cahir McFarland, M. Okumura, M. Thomas, and E. Brown. 1997. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr. Biol. 7: 408-417. (Pubitemid 27274794)
    • (1997) Current Biology , vol.7 , Issue.6 , pp. 408-417
    • Roach, T.1    Slater, S.2    Koval, M.3    White, L.4    McFarland, E.C.5    Okumura, M.6    Thomas, M.7    Brown, E.8
  • 24
    • 0021813635 scopus 로고
    • Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages
    • DOI 10.1084/jem.161.5.912
    • Bohnsack, J. F., H. K. Kleinman, T. Takahashi, J. J. O'Shea, and E. J. Brown. 1985. Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages. J. Exp. Med. 161: 912-923. (Pubitemid 15011315)
    • (1985) Journal of Experimental Medicine , vol.161 , Issue.5 , pp. 912-923
    • Bohnsack, J.F.1    Kleinman, H.K.2    Takahashi, T.3
  • 25
    • 0041474715 scopus 로고    scopus 로고
    • The mer receptor tyrosine kinase: Expression and function suggest a role in innate immunity
    • DOI 10.1002/eji.200324076
    • Behrens, E. M., P. Gadue, S. Y. Gong, S. Garrett, P. L. Stein, and P. L. Cohen. 2003. The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur. J. Immunol. 33: 2160-2167. (Pubitemid 37010033)
    • (2003) European Journal of Immunology , vol.33 , Issue.8 , pp. 2160-2167
    • Behrens, E.M.1    Gadue, P.2    Gong, S.-Y.3    Garrett, S.4    Stein, P.L.5    Cohen, P.L.6
  • 26
    • 47249136911 scopus 로고    scopus 로고
    • The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus
    • Shao, W. H., R. A. Eisenberg, and P. L. Cohen. 2008. The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J. Immunol. 180: 7728-7735.
    • (2008) J. Immunol. , vol.180 , pp. 7728-7735
    • Shao, W.H.1    Eisenberg, R.A.2    Cohen, P.L.3
  • 27
    • 69949158152 scopus 로고    scopus 로고
    • The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells
    • Shao, W. H., Y. Zhen, R. A. Eisenberg, and P. L. Cohen. 2009. The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clin. Immunol. 133: 138-144.
    • (2009) Clin. Immunol. , vol.133 , pp. 138-144
    • Shao, W.H.1    Zhen, Y.2    Eisenberg, R.A.3    Cohen, P.L.4
  • 30
    • 0027365359 scopus 로고
    • Murine macrophages lack expression of the Cr2-145 (CR2) and Cr2-190 (CR1) gene products
    • DOI 10.1002/eji.1830231146
    • Martin, B. K., and J. H. Weis. 1993. Murine macrophages lack expression of the Cr2-145 (CR2) and Cr2-190 (CR1) gene products. Eur. J. Immunol. 23: 3037-3042. (Pubitemid 23323586)
    • (1993) European Journal of Immunology , vol.23 , Issue.11 , pp. 3037-3042
    • Martin, B.K.1    Weis, J.H.2
  • 31
    • 0035900697 scopus 로고    scopus 로고
    • Identification of a site on mannanbinding lectin critical for enhancement of phagocytosis
    • Arora, M., E. Munoz, and A. J. Tenner. 2001. Identification of a site on mannanbinding lectin critical for enhancement of phagocytosis. J. Biol. Chem. 276: 43087-43094.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43087-43094
    • Arora, M.1    Munoz, E.2    Tenner, A.J.3
  • 32
    • 33846872571 scopus 로고    scopus 로고
    • A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    • DOI 10.1182/blood-2006-05-021634
    • Sather, S., K. D. Kenyon, J. B. Lefkowitz, X. Liang, B. C. Varnum, P. M. Henson, and D. K. Graham. 2007. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood 109: 1026-1033. (Pubitemid 46220648)
    • (2007) Blood , vol.109 , Issue.3 , pp. 1026-1033
    • Sather, S.1    Kenyon, K.D.2    Lefkowitz, J.B.3    Liang, X.4    Varnum, B.C.5    Henson, P.M.6    Graham, D.K.7
  • 33
    • 0030944415 scopus 로고    scopus 로고
    • CDNA cloning and primary structure analysis of C1qR(p), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro
    • DOI 10.1016/S1074-7613(00)80419-7
    • Nepomuceno, R. R., A. H. Henschen-Edman, W. H. Burgess, and A. J. Tenner. 1997. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/ MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity 6: 119-129. (Pubitemid 27145557)
    • (1997) Immunity , vol.6 , Issue.2 , pp. 119-129
    • Nepomuceno, R.R.1    Henschen-Edman, A.H.2    Burgess, W.H.3    Tenner, A.J.4
  • 34
    • 0035903289 scopus 로고    scopus 로고
    • C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    • DOI 10.1084/jem.194.6.781
    • Ogden, C. A., A. deCathelineau, P. R. Hoffmann, D. Bratton, B. Ghebrehiwet, V. A. Fadok, and P. M. Henson. 2001. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 194: 781-795. (Pubitemid 32983014)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.6 , pp. 781-795
    • Ogden, C.A.1    DeCathelineau, A.2    Hoffmann, P.R.3    Bratton, D.4    Fadok, B.5    Ghebrehiwet, V.A.6    Henson, P.M.7
  • 37
    • 18144382667 scopus 로고    scopus 로고
    • Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation
    • Fan, R., and A. J. Tenner. 2005. Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation. J. Neuroinflammation 2: 1.
    • (2005) J. Neuroinflammation , vol.2 , pp. 1
    • Fan, R.1    Tenner, A.J.2
  • 39
    • 48649103571 scopus 로고    scopus 로고
    • The scavenger receptor SR - A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages
    • Todt, J. C., B. Hu, and J. L. Curtis. 2008. The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J. Leukoc. Biol. 84: 510-518.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 510-518
    • Todt, J.C.1    Hu, B.2    Curtis, J.L.3
  • 40
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • DOI 10.1126/science.1061663
    • Lu, Q., and G. Lemke. 2001. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-311. (Pubitemid 32694748)
    • (2001) Science , vol.293 , Issue.5528 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 42
    • 0033757463 scopus 로고    scopus 로고
    • Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
    • Gal, A., Y. Li, D. A. Thompson, J. Weir, U. Orth, S. G. Jacobson, E. ApfelstedtSylla, and D. Vollrath. 2000. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat. Genet. 26: 270-271.
    • (2000) Nat. Genet. , vol.26 , pp. 270-271
    • Gal, A.1    Li, Y.2    Thompson, D.A.3    Weir, J.4    Orth, U.5    Jacobson, S.G.6    ApfelstedtSylla, E.7    Vollrath, D.8


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