The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after Influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Tantawy, Mohamed A ^a,d   Hatesuer, Bastian ^a   Wilk, Esther ^a   Dengler, Leonie ^a   Kasnitz, Nadine ^b   Weiß, Siegfried ^b   Schughart, Klaus ^a,c  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR; PROTEIN IFI27L2A; UNCLASSIFIED DRUG; IFI27 PROTEIN, HUMAN; INTERFERON; ISG12B1 PROTEIN, MOUSE; MEMBRANE PROTEIN; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE SILENCING; HOST RESISTANCE; IFI27L2A GENE; IMMUNE RESPONSE; IN VITRO STUDY; INFECTION SENSITIVITY; INFLUENZA A; LUNG; LUNG ALVEOLUS MACROPHAGE; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NEUTROPHIL; NONHUMAN; POLYMERASE CHAIN REACTION; REPORTER GENE; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INFLUENZA; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H7N7; MACROPHAGE; METABOLISM; PATHOGENICITY; PATHOLOGY;

MUS;

ANIMALS; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H7N7 SUBTYPE; INFLUENZA, HUMAN; INTERFERONS; LUNG; LYMPHOCYTES; MACROPHAGES; MEMBRANE PROTEINS; MICE; PROTEINS; TRANSCRIPTIONAL ACTIVATION;

EID: 84906963961     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106392     Document Type: Article

References (58)

1. Fauci AS (2006) Seasonal and pandemic influenza preparedness: science and countermeasures. J Infect Dis 194 Suppl 2: S73-76.
2. Kilbourne ED (2006) Influenza pandemics of the 20th century. Emerg Infect Dis 12: 9-14.
3. Klenk HD, Garten W, Matrosovich M (2011) Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic. Bioessays 33: 180-188.
4. Russell CJ, Webster RG (2005) The genesis of a pandemic influenza virus. Cell 123: 368-371.
5. Johnson NP, Mueller J (2002) Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic. Bull Hist Med 76: 105-115.
6. Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, et al. (2009) Pandemic potential of a strain of influenza A (H1N1): early findings. Science 324: 1557-1561.
7. Neumann G, Noda T, Kawaoka Y (2009) Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459: 931-939.
8. Wang TT, Palese P (2009) Unraveling the mystery of swine influenza virus. Cell 137: 983-985.
9. Takeuchi O, Akira S (2009) Innate immunity to virus infection. Immunol Rev 227: 75-86.
10. Pichlmair A, Reis eSC (2007) Innate recognition of viruses. Immunity 27: 370-383.
11. Haller O, Weber F (2009) The interferon response circuit in antiviral host defense. Verh K Acad Geneeskd Belg 71: 73-86.
12. Kato A, Schleimer RP (2007) Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol 19: 711-720.
13. Kohlmeier JE, Woodland DL (2009) Immunity to respiratory viruses. Annu Rev Immunol 27: 61-82.
14. Julkunen I, Melen K, Nyqvist M, Pirhonen J, Sareneva T, et al. (2000) Inflammatory responses in influenza A virus infection. Vaccine 19 Suppl 1: S32-37.
15. Julkunen I, Sareneva T, Pirhonen J, Ronni T, Melen K, et al. (2001) Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12: 171-180.
16. Davidson S, Crotta S, McCabe TM, Wack A (2014) Pathogenic potential of interferon alphabeta in acute influenza infection. Nat Commun 5: 3864.
17. Liu SY, Sanchez DJ, Cheng G (2011) New developments in the induction and antiviral effectors of type I interferon. Curr Opin Immunol 23: 57-64.
18. Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, et al. (2007) Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 6: 975-990.
19. Pestka S, Krause CD, Walter MR (2004) Interferons, interferon-like cytokines, and their receptors. Immunol Rev 202: 8-32.
20. Platanias LC (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 5: 375-386.
21. Takaoka A, Yanai H (2006) Interferon signalling network in innate defence. Cell Microbiol 8: 907-922.
22. Taniguchi T, Ogasawara K, Takaoka A, Tanaka N (2001) IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19: 623-655.
23. de Veer MJ, Holko M, Frevel M, Walker E, Der S, et al. (2001) Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 69: 912-920.
24. MacMicking JD (2012) Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol 12: 367-382.
25. Diamond MS, Farzan M (2013) The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol 13: 46-57.
26. Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8: 559-568.
27. Zhou X, Michal JJ, Zhang L, Ding B, Lunney JK, et al. (2013) Interferon induced IFIT family genes in host antiviral defense. Int J Biol Sci 9: 200-208.
28. Haller O, Staeheli P, Kochs G (2009) Protective role of interferon-induced Mx GTPases against influenza viruses. Rev Sci Tech 28: 219-231.
29. Lim JK, Lisco A, McDermott DH, Huynh L, Ward JM, et al. (2009) Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. PLoS Pathog 5: e1000321.
30. Moritoh K, Yamauchi H, Asano A, Yoshii K, Kariwa H, et al. (2009) Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J. Jpn J Vet Res 57: 89-99.
31. Everitt AR, Clare S, Pertel T, John SP, Wash RS, et al. (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484(7395): 519-523.
32. Feeley EM, Sims JS, John SP, Chin CR, Pertel T, et al. (2011) IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog 7: e1002337.
33. Bergmann M, Garcia-Sastre A, Carnero E, Pehamberger H, Wolff K, et al. (2000) Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J Virol 74: 6203-6206.
34. Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schafer R, et al. (1995) Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 14: 6095-6106.
35. Lai C, Struckhoff JJ, Schneider J, Martinez-Sobrido L, Wolff T, et al. (2009) Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection. J Virol 83: 1147-1151.
36. Fitzgerald KA (2011) The interferon inducible gene: Viperin. J Interferon Cytokine Res 31: 131-135.
37. Bottomly D, Ferris MT, Aicher LD, Rosenzweig E, Whitmore A, et al. (2012) Expression quantitative trait Loci for extreme host response to influenza a in precollaborative cross mice. G3 (Bethesda) 2: 213-221.
38. Pommerenke C, Wilk E, Srivastava B, Schulze A, Novoselova N, et al. (2012) Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses. PLoS ONE 7: e41169.
39. Martensen PM, Sogaard TM, Gjermandsen IM, Buttenschon HN, Rossing AB, et al. (2001) The interferon alpha induced protein ISG12 is localized to the nuclear membrane. Eur J Biochem 268: 5947-5954.
40. Papac-Milicevic N, Breuss JM, Zaujec J, Ryban L, Plyushch T, et al. (2012) The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors. Circ Res 110: e50-63.
41. Cheriyath V, Leaman DW, Borden EC (2011) Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer. J Interferon Cytokine Res 31: 173-181.
42. Uhrin P, Perkmann T, Binder B, Schabbauer G (2013) ISG12 is a critical modulator of innate immune responses in murine models of sepsis. Immunobiology 218: 1207-1216.
43. Toapanta FR, Ross TM (2009) Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res 10: 112.
44. Weiss DJ, Liggitt D, Clark JG (1997) In situ histochemical detection of beta-galactosidase activity in lung: assessment of X-Gal reagent in distinguishing lacZ gene expression and endogenous beta-galactosidase activity. Hum Gene Ther 8: 1545-1554.
45. Wang J, Nikrad MP, Phang T, Gao B, Alford T, et al. (2011) Innate immune response to influenza A virus in differentiated human alveolar type II cells. Am J Respir Cell Mol Biol 45: 582-591.
46. Ioannidis I, McNally B, Willette M, Peeples ME, Chaussabel D, et al. (2012) Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection. J Virol 86: 5422-5436.
47. Haller O, Staeheli P, Kochs G (2007) Interferon-induced Mx proteins in antiviral host defense. Biochimie 89: 812-818.
48. Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, et al. (2010) Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. J Virol 84: 5670-5677.
49. Srivastava B, Blazejewska P, Hessmann M, Bruder D, Geffers R, et al. (2009) Host genetic background strongly influences the response to influenza a virus infections. PLoS ONE 4: e4857.
50. Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, et al. (2008) Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog 4: e1000151.
51. Murray PJ, Wynn TA (2011) Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 11: 723-737.
52. Rittirsch D, Flierl MA, Ward PA (2008) Harmful molecular mechanisms in sepsis. Nat Rev Immunol 8: 776-787.
53. Benoit M, Desnues B, Mege JL (2008) Macrophage polarization in bacterial infections. J Immunol 181: 3733-3739.
54. Blazejewska P, Koscinski L, Viegas N, Anhlan D, Ludwig S, et al. (2011) Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors. Virology 412: 36-45.
55. Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, et al. (2005) The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A 102: 18590-18595.
56. Wilk E, Schughart K (2012) The mouse as model system to study host-pathogen interactions in influenza A infections. Curr Protoc Mouse Biol 2: 177-205.
57. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, et al. (2011) A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474: 337-342.
58. Limberis M, Bell P, Wilson JM (2007) Detection of reporter gene expression in murine airways. Methods Mol Biol 411: 25-34.