메뉴 건너뛰기




Volumn 6, Issue 6, 2014, Pages 780-792

Complement protein C1q and adiponectin stimulate mer tyrosine kinase-dependent engulfment of apoptotic cells through a shared pathway

Author keywords

C1q; Complement; Efferocytosis; Lupus; Macrophages; Mer tyrosine kinase; Phagocytosis

Indexed keywords

ADENOSINE PHOSPHATE; ADIPONECTIN; CELL NUCLEUS RECEPTOR; COMPLEMENT COMPONENT C1Q; MER TYROSINE KINASE; RETINOID X RECEPTOR; TRANSCRIPTOME; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; ADIPOQ PROTEIN, MOUSE; MERTK PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN TYROSINE KINASE;

EID: 84908609269     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000363295     Document Type: Article
Times cited : (26)

References (54)
  • 1
    • 33750491279 scopus 로고    scopus 로고
    • Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions
    • Bohlson SS, Fraser DA, Tenner AJ: Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol Immunol 2007; 44:33-43.
    • (2007) Mol Immunol , vol.44 , pp. 33-43
    • Bohlson, S.S.1    Fraser, D.A.2    Tenner, A.J.3
  • 2
    • 40449099734 scopus 로고    scopus 로고
    • Directing an appropriate immune response: The role of defense col-lagens and other soluble pattern recognition molecules
    • Fraser DA, Tenner AJ: Directing an appropriate immune response: the role of defense col-lagens and other soluble pattern recognition molecules. Curr Drug Targets 2008; 9: 113-122.
    • (2008) Curr Drug Targets , vol.9 , pp. 113-122
    • Fraser, D.A.1    Tenner, A.J.2
  • 3
    • 84865517779 scopus 로고    scopus 로고
    • C1q and phagocytosis: The perfect complement to a good meal
    • Galvan MD, Greenlee-Wacker MC, Bohlson SS: C1q and phagocytosis: the perfect complement to a good meal. J Leukoc Biol 2012; 92: 489-497.
    • (2012) J Leukoc Biol , vol.92 , pp. 489-497
    • Galvan, M.D.1    Greenlee-Wacker, M.C.2    Bohlson, S.S.3
  • 4
    • 34547656330 scopus 로고    scopus 로고
    • Immunological consequences of apoptotic cell phagocytosis
    • Erwig LP, Henson PM: Immunological consequences of apoptotic cell phagocytosis. Am J Pathol 2007; 171:2-8.
    • (2007) Am J Pathol , vol.171 , pp. 2-8
    • Erwig, L.P.1    Henson, P.M.2
  • 5
    • 77949914141 scopus 로고    scopus 로고
    • Scent of dying cells: The role of attraction signals in the clearance of apop-totic cells and its immunological consequences
    • Munoz LE, Peter C, Herrmann M., Wessel-borg S, Lauber K: Scent of dying cells: the role of attraction signals in the clearance of apop-totic cells and its immunological consequences. Autoimmun Rev 2010; 9:425-430.
    • (2010) Autoimmun Rev , vol.9 , pp. 425-430
    • Munoz, L.E.1    Peter, C.2    Herrmann, M.3    Wessel-Borg, S.4    Lauber, K.5
  • 8
    • 0031569975 scopus 로고    scopus 로고
    • C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: Complement deficiency and systemic lupus erythematosus revisited
    • Korb LC, Ahearn JM: C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J Immunol 1997; 158:4525-4528.
    • (1997) J Immunol , vol.158 , pp. 4525-4528
    • Korb, L.C.1    Ahearn, J.M.2
  • 10
    • 84860341450 scopus 로고    scopus 로고
    • Complement component C1q regulates macrophage expression of mer ty-rosine kinase to promote clearance of apop-totic cells
    • Galvan MD, Foreman DB, Zeng E, Tan J.C., Bohlson SS: Complement component C1q regulates macrophage expression of Mer ty-rosine kinase to promote clearance of apop-totic cells. J Immunol 2012; 188:3716-3723.
    • (2012) J Immunol , vol.188 , pp. 3716-3723
    • Galvan, M.D.1    Foreman, D.B.2    Zeng, E.3    Tan, J.C.4    Bohlson, S.S.5
  • 11
    • 0032510463 scopus 로고    scopus 로고
    • The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
    • Shapiro L, Scherer PE: The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998; 8:335-338.
    • (1998) Curr Biol , vol.8 , pp. 335-338
    • Shapiro, L.1    Scherer, P.E.2
  • 12
    • 84858749562 scopus 로고    scopus 로고
    • CTRP family: Linking immunity to metabolism
    • Schaffler A, Buechler C: CTRP family: linking immunity to metabolism. Trends Endocrinol Metab 2012; 23:194-204.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 194-204
    • Schaffler, A.1    Buechler, C.2
  • 13
    • 79959762501 scopus 로고    scopus 로고
    • Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models
    • Parker J, Menn-Josephy H, Laskow B., Take-mura Y, Aprahamian T: Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models. J Clin Immunol 2011; 31:167-173.
    • (2011) J Clin Immunol , vol.31 , pp. 167-173
    • Parker, J.1    Menn-Josephy, H.2    Laskow, B.3    Take-Mura, Y.4    Aprahamian, T.5
  • 14
    • 59849087383 scopus 로고    scopus 로고
    • The peroxi-some proliferator-activated receptor γ agonist rosiglitazone ameliorates murine lupus by induction of adiponectin
    • Aprahamian T, Bonegio RG, Richez C, Yasu-da K, Chiang L.K., Sato K., et al.: The peroxi-some proliferator-activated receptor γ agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 2009; 182:340-346.
    • (2009) J Immunol , vol.182 , pp. 340-346
    • Aprahamian, T.1    Bonegio, R.G.2    Richez, C.3    Yasu-Da, K.4    Chiang, L.K.5    Sato, K.6
  • 15
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev 2005; 26: 439-451.
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 16
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi T, Kamon J, Ito Y., Tsuchida A, Yokomizo T, Kita S., et al.: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423:762-769.
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1    Kamon, J.2    Ito, Y.3    Tsuchida, A.4    Yokomizo, T.5    Kita, S.6
  • 17
    • 79953765855 scopus 로고    scopus 로고
    • Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway
    • Awazawa M, Ueki K, Inabe K., Yamauchi T, Kubota N, Kaneko K., et al.: Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab 2011; 13:401-412.
    • (2011) Cell Metab , vol.13 , pp. 401-412
    • Awazawa, M.1    Ueki, K.2    Inabe, K.3    Yamauchi, T.4    Kubota, N.5    Kaneko, K.6
  • 18
    • 77957579585 scopus 로고    scopus 로고
    • Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors
    • Heiker JT, Kosel D, Beck-Sickinger AG: Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors. Biol Chem 2010; 391:1005-1018.
    • (2010) Biol Chem , vol.391 , pp. 1005-1018
    • Heiker, J.T.1    Kosel, D.2    Beck-Sickinger, A.G.3
  • 19
    • 84862493914 scopus 로고    scopus 로고
    • AMP-activated protein kinase: New regulation, new roles?
    • Carling D, Thornton C, Woods A., Sanders MJ: AMP-activated protein kinase: new regulation, new roles? Biochem J 2012; 445:11-27.
    • (2012) Biochem J , vol.445 , pp. 11-27
    • Carling, D.1    Thornton, C.2    Woods, A.3    Sanders, M.J.4
  • 20
    • 58849115949 scopus 로고    scopus 로고
    • Adenos-ine 5'-monophosphate-activated protein ki-nase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D, Carling D, Stout R.D., Suttles J: Adenos-ine 5'-monophosphate-activated protein ki-nase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 2008; 181:8633-8641.
    • (2008) J Immunol , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 21
    • 84881356321 scopus 로고    scopus 로고
    • AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
    • Mounier R, Theret M, Arnold L., Cuvellier S, Bultot L, Goransson O., et al.: AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab 2013; 18:251-264.
    • (2013) Cell Metab , vol.18 , pp. 251-264
    • Mounier, R.1    Theret, M.2    Arnold, L.3    Cuvellier, S.4    Bultot, L.5    Goransson, O.6
  • 22
    • 84883738441 scopus 로고    scopus 로고
    • Mitochondria and AMP-activated protein kinase-depen-dent mechanism of efferocytosis
    • Jiang S, Park DW, Stigler W.S., Creighton J., Ravi S, Darley-Usmar V, et al.: Mitochondria and AMP-activated protein kinase-depen-dent mechanism of efferocytosis. J Biol Chem 2013; 288:26013-26026.
    • (2013) J Biol Chem , vol.288 , pp. 26013-26026
    • Jiang, S.1    Park, D.W.2    Stigler, W.S.3    Creighton, J.4    Ravi, S.5    Darley-Usmar, V.6
  • 23
    • 0019472804 scopus 로고
    • Purification and radiolabeling of human C1q
    • Tenner AJ, Lesavre PH, Cooper NR: Purification and radiolabeling of human C1q. J Immunol 1981; 127:648-653.
    • (1981) J Immunol , vol.127 , pp. 648-653
    • Tenner, A.J.1    Lesavre, P.H.2    Cooper, N.R.3
  • 24
    • 0025858875 scopus 로고
    • Complement subcomponent C1q stimulates ig production by human B lymphocytes
    • Young KR Jr, Ambrus JL Jr, Malbran A, Fauci AS, Tenner AJ: Complement subcomponent C1q stimulates Ig production by human B lymphocytes. J Immunol 1991; 146:3356-3364.
    • (1991) J Immunol , vol.146 , pp. 3356-3364
    • Young, K.R.1    Ambrus, J.L.2    Malbran, A.3    Fauci, A.S.4    Tenner, A.J.5
  • 25
    • 0031172246 scopus 로고    scopus 로고
    • CD45 regulates src family member kinase activity associated with macrophage integrin-mediated adhesion
    • Roach T, Slater S, Koval M., White L, Cahir McFarland ED, Okumura M, et al.: CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol 1997; 7:408-417.
    • (1997) Curr Biol , vol.7 , pp. 408-417
    • Roach, T.1    Slater, S.2    Koval, M.3    White, L.4    Cahir McFarland, E.D.5    Okumura, M.6
  • 26
    • 0021813635 scopus 로고
    • Connective tissue proteins and phagocytic cell function: Laminin enhances complement and fcmediated phagocytosis by cultured human macrophages
    • Bohnsack JF, Kleinman HK, Takahashi T, O'Shea JJ, Brown EJ: Connective tissue proteins and phagocytic cell function: laminin enhances complement and Fcmediated phagocytosis by cultured human macrophages. J Exp Med 1985; 161:912-923.
    • (1985) J Exp Med , vol.161 , pp. 912-923
    • Bohnsack, J.F.1    Kleinman, H.K.2    Takahashi, T.3    O'Shea, J.J.4    Brown, E.J.5
  • 27
    • 47949114495 scopus 로고    scopus 로고
    • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis
    • Lillis AP, Greenlee MC, Mikhailenko I, Pizzo S.V., Tenner AJ, Strickland DK, et al.: Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 2008; 181:364-373.
    • (2008) J Immunol , vol.181 , pp. 364-373
    • Lillis, A.P.1    Greenlee, M.C.2    Mikhailenko, I.3    Pizzo, S.V.4    Tenner, A.J.5    Strickland, D.K.6
  • 28
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of Normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003; 19:185-193.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 29
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003; 100:9440-9445.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 30
    • 0023111156 scopus 로고
    • Modulation of FcR function by complement: Subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages
    • Bobak DA, Gaither TA, Frank M.M., Tenner AJ: Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. J Immunol 1987; 138:1150-1156.
    • (1987) J Immunol , vol.138 , pp. 1150-1156
    • Bobak, D.A.1    Gaither, T.A.2    Frank, M.M.3    Tenner, A.J.4
  • 31
    • 0035900697 scopus 로고    scopus 로고
    • Identification of a site on mannan-binding lectin critical for enhancement of phagocytosis
    • Arora M, Munoz E, Tenner AJ: Identification of a site on mannan-binding lectin critical for enhancement of phagocytosis. J Biol Chem 2001; 276:43087-43094.
    • (2001) J Biol Chem , vol.276 , pp. 43087-43094
    • Arora, M.1    Munoz, E.2    Tenner, A.J.3
  • 32
    • 33846784058 scopus 로고    scopus 로고
    • Adipo-nectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
    • Takemura Y, Ouchi N, Shibata R., Aprahami-an T, Kirber MT, Summer R.S., et al.: Adipo-nectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 2007; 117: 375-386.
    • (2007) J Clin Invest , vol.117 , pp. 375-386
    • Takemura, Y.1    Ouchi, N.2    Shibata, R.3    Aprahami-An, T.4    Kirber, M.T.5    Summer, R.S.6
  • 33
    • 77949881805 scopus 로고    scopus 로고
    • Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    • Ohashi K, Parker JL, Ouchi N, Higuchi A., Vita JA, Gokce N, et al.: Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 2010; 285:6153-6160.
    • (2010) J Biol Chem , vol.285 , pp. 6153-6160
    • Ohashi, K.1    Parker, J.L.2    Ouchi, N.3    Higuchi, A.4    Vita, J.A.5    Gokce, N.6
  • 34
    • 84873404989 scopus 로고    scopus 로고
    • Adiponectin receptor as a key player in healthy longevity and obesity-related diseases
    • Yamauchi T, Kadowaki T: Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell Metab 2013; 17: 185-196.
    • (2013) Cell Metab , vol.17 , pp. 185-196
    • Yamauchi, T.1    Kadowaki, T.2
  • 35
    • 34250351211 scopus 로고    scopus 로고
    • PPARγ-dependent regulation of human macrophages in phagocytosis of apop-totic cells
    • Majai G, Sarang Z, Csomos K., Zahuczky G, Fesus L: PPARγ-dependent regulation of human macrophages in phagocytosis of apop-totic cells. Eur J Immunol 2007; 37:1343-1354.
    • (2007) Eur J Immunol , vol.37 , pp. 1343-1354
    • Majai, G.1    Sarang, Z.2    Csomos, K.3    Zahuczky, G.4    Fesus, L.5
  • 36
    • 79251561239 scopus 로고    scopus 로고
    • Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome prolif-erator-activated receptor γ or retinoid X receptor α deficiency
    • Roszer T, Menendez-Gutierrez MP, Lefter-ova MI, Alameda D, Nunez V., Lazar MA, et al.: Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome prolif-erator-activated receptor γ or retinoid X receptor α deficiency. J Immunol 2011; 186: 621-631.
    • (2011) J Immunol , vol.186 , pp. 621-631
    • Roszer, T.1    Menendez-Gutierrez, M.P.2    Lefter-Ova, M.I.3    Alameda, D.4    Nunez, V.5    Lazar, M.A.6
  • 37
    • 68949145931 scopus 로고    scopus 로고
    • Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    • A-Gonzalez N, Bensinger S.J., Hong C., Beceiro S, Bradley MN, Zelcer N, et al.: Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 2009; 31:245-258.
    • (2009) Immunity , vol.31 , pp. 245-258
    • A-Gonzalez, N.1    Bensinger, S.J.2    Hong, C.3    Beceiro, S.4    Bradley, M.N.5    Zelcer, N.6
  • 39
    • 0031778836 scopus 로고    scopus 로고
    • Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    • Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, et al.: Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 1998; 19:56-59.
    • (1998) Nat Genet , vol.19 , pp. 56-59
    • Botto, M.1    Dell'Agnola, C.2    Bygrave, A.E.3    Thompson, E.M.4    Cook, H.T.5    Petry, F.6
  • 41
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T, Oritani K, Takahashi I., Ishikawa J, Matsuyama A, Ouchi N., et al.: Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000; 96:1723-1732.
    • (2000) Blood , vol.96 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5    Ouchi, N.6
  • 42
    • 0035903289 scopus 로고    scopus 로고
    • C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    • Ogden CA, deCathelineau A, Hoffmann P.R., Bratton D., Ghebrehiwet B, Fadok VA, et al.: C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001; 194:781-795.
    • (2001) J Exp Med , vol.194 , pp. 781-795
    • Ogden, C.A.1    DeCathelineau, A.2    Hoffmann, P.R.3    Bratton, D.4    Ghebrehiwet, B.5    Fadok, V.A.6
  • 43
    • 0036785571 scopus 로고    scopus 로고
    • Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: Calreticulin and CD91 as a common collectin receptor complex
    • Vandivier RW, Ogden CA, Fadok V.A., Hoffmann PR, Brown KK, Botto M, et al.: Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol 2002; 169:3978-3986.
    • (2002) J Immunol , vol.169 , pp. 3978-3986
    • Vandivier, R.W.1    Ogden, C.A.2    Fadok, V.A.3    Hoffmann, P.R.4    Brown, K.K.5    Botto, M.6
  • 44
    • 4344643316 scopus 로고    scopus 로고
    • Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells
    • Nauta AJ, Castellano G, Xu W., Woltman AM, Borrias MC, Daha MR, et al.: Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol 2004; 173:3044-3050.
    • (2004) J Immunol , vol.173 , pp. 3044-3050
    • Nauta, A.J.1    Castellano, G.2    Xu, W.3    Woltman, A.M.4    Borrias, M.C.5    Daha, M.R.6
  • 45
    • 0141791335 scopus 로고    scopus 로고
    • Surfactant protein A enhances apoptotic cell uptake and TGF-β1 release by inflammatory alveolar macrophages
    • Reidy MF, Wright JR: Surfactant protein A enhances apoptotic cell uptake and TGF-β1 release by inflammatory alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 2003; 285:L854-L861.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , pp. L854-L861
    • Reidy, M.F.1    Wright, J.R.2
  • 46
    • 14244266540 scopus 로고    scopus 로고
    • Specific binding of L-ficolin and H-fi-colin to apoptotic cells leads to complement activation
    • Kuraya M, Ming Z, Liu X., Matsushita M, Fujita T: Specific binding of L-ficolin and H-fi-colin to apoptotic cells leads to complement activation. Immunobiology 2005; 209:689-697.
    • (2005) Immunobiology , vol.209 , pp. 689-697
    • Kuraya, M.1    Ming, Z.2    Liu, X.3    Matsushita, M.4    Fujita, T.5
  • 48
    • 34248592214 scopus 로고    scopus 로고
    • The innate immune component ficolin 3 (hakata antigen) mediates the clearance of late apoptotic cells
    • Honore C, Hummelshoj T, Hansen B.E., Mad-sen HO, Eggleton P, Garred P: The innate immune component ficolin 3 (hakata antigen) mediates the clearance of late apoptotic cells. Arthritis Rheum 2007; 56:1598-1607.
    • (2007) Arthritis Rheum , vol.56 , pp. 1598-1607
    • Honore, C.1    Hummelshoj, T.2    Hansen, B.E.3    Mad-Sen, H.O.4    Eggleton, P.5    Garred, P.6
  • 50
    • 82655173730 scopus 로고    scopus 로고
    • AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils
    • Bae HB, Zmijewski JW, Deshane J.S., Tadie JM, Chaplin DD, Takashima S, et al.: AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J 2011; 25:4358-4368.
    • (2011) FASEB J , vol.25 , pp. 4358-4368
    • Bae, H.B.1    Zmijewski, J.W.2    Deshane, J.S.3    Tadie, J.M.4    Chaplin, D.D.5    Takashima, S.6
  • 51
    • 84455200568 scopus 로고    scopus 로고
    • Metabolic connections during apoptotic cell engulfment
    • Han CZ, Ravichandran KS: Metabolic connections during apoptotic cell engulfment. Cell 2011; 147:1442-1445.
    • (2011) Cell , vol.147 , pp. 1442-1445
    • Han, C.Z.1    Ravichandran, K.S.2
  • 52
    • 80052597312 scopus 로고    scopus 로고
    • Continued clearance of apoptotic cells critically depends on the phagocyte ucp2 protein
    • Park D, Han CZ, Elliott M.R., Kinchen JM, Trampont PC, Das S, et al.: Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature 2011; 477:220-224.
    • (2011) Nature , vol.477 , pp. 220-224
    • Park, D.1    Han, C.Z.2    Elliott, M.R.3    Kinchen, J.M.4    Trampont, P.C.5    Das, S.6
  • 53
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autoph-agy and metabolism
    • Mihaylova MM, Shaw RJ: The AMPK signalling pathway coordinates cell growth, autoph-agy and metabolism. Nat Cell Biol 2011; 13: 1016-1023.
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 54
    • 84860116506 scopus 로고    scopus 로고
    • Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response
    • Nagy L, Szanto A, Szatmari I., Szeles L: Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response. Physiol Rev 2012; 92:739-789.
    • (2012) Physiol Rev , vol.92 , pp. 739-789
    • Nagy, L.1    Szanto, A.2    Szatmari, I.3    Szeles, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.