A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment

Journal of Virology

Volumn 89, Issue 2, 2015, Pages 1428-1438

  Lee, Hyunwook ^a   Brendle, Sarah A ^a   Bywaters, Stephanie M ^a   Guan, Jian ^a   Ashley, Robert E ^a   Yoder, Joshua D ^b   Makhov, Alexander M ^b   Conway, James F ^b   Christensen, Neil D ^a   Hafenstein, Susan ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY H16.V5; UNCLASSIFIED DRUG; VIRUS CAPSID ANTIGEN; EPITOPE; PROTEIN BINDING; VIRUS ANTIBODY; VIRUS ANTIGEN;

ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; EPITOPE MAPPING; FOOTPRINT TEST; HUMAN PAPILLOMAVIRUS TYPE 16; IMAGE RECONSTRUCTION; INCUBATION TIME; MOLECULAR MODEL; NONHUMAN; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; VIRUS CAPSID; VIRUS NEUTRALIZATION; VIRUS PARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; IMAGE PROCESSING; IMMUNOLOGY; METABOLISM; PROTEIN CONFORMATION;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS - 16; HUMAN PAPILLOMAVIRUS TYPE 16; MIRIDAE;

ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CAPSID; CRYOELECTRON MICROSCOPY; EPITOPES; HUMAN PAPILLOMAVIRUS 16; IMAGE PROCESSING, COMPUTER-ASSISTED; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84920771777     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02898-14     Document Type: Article

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