Kinetic instability of the serpin Z α1-antitrypsin promotes aggregation

Journal of Molecular Biology

Volumn 396, Issue 2, 2010, Pages 375-383

  Knaupp, Anja S ^a   Levina, Vita ^a   Robertson, Amy L ^a   Pearce, Mary C ^a   Bottomley, Stephen P ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Aggregation; Metastability; Misfolding; Polymerization; Serpin

Indexed keywords

ALPHA 1 ANTITRYPSIN; GUANIDINE; SERINE PROTEINASE INHIBITOR; UREA; ISOPROTEIN;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; GEL ELECTROPHORESIS; KINETICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN POLYMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMODYNAMICS; ULTRAVIOLET RADIATION; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PRECIPITATION;

ALPHA 1-ANTITRYPSIN; CHEMICAL PRECIPITATION; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN ISOFORMS; PROTEIN STABILITY; SERPINS; THERMODYNAMICS;

EID: 77449144020     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.11.048     Document Type: Article

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