메뉴 건너뛰기




Volumn 98, Issue 1, 2015, Pages 23-32

Emerging single-cell technologies in immunology

Author keywords

Infectious disease; Sepsis; Vaccines

Indexed keywords

CYTOMETRY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOLOGY; INFECTION; LYMPHOID CELL; MASS CYTOMETRY; MONOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SINGLE CELL ANALYSIS; MICROFLUIDICS;

EID: 84934760334     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.6RU0115-020R     Document Type: Review
Times cited : (11)

References (97)
  • 1
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway, Jr., C. A., (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 3
    • 84878232476 scopus 로고    scopus 로고
    • The history of Toll-like receptors-redefining innate immunity
    • O'Neill, L. A., Golenbock, D., Bowie, A. G. (2013) The history of Toll-like receptors-redefining innate immunity. Nat. Rev. Immunol. 13, 453-460.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 453-460
    • O'Neill, L.A.1    Golenbock, D.2    Bowie, A.G.3
  • 4
    • 84865411904 scopus 로고    scopus 로고
    • C-Type lectin receptors orchestrate antifungal immunity
    • Hardison, S. E., Brown, G. D. (2012) C-Type lectin receptors orchestrate antifungal immunity. Nat. Immunol. 13, 817-822.
    • (2012) Nat. Immunol. , vol.13 , pp. 817-822
    • Hardison, S.E.1    Brown, G.D.2
  • 6
    • 84901310586 scopus 로고    scopus 로고
    • Mechanisms and functions of inflammasomes
    • Lamkanfi, M., Dixit, V. M. (2014) Mechanisms and functions of inflammasomes. Cell 157, 1013-1022.
    • (2014) Cell , vol.157 , pp. 1013-1022
    • Lamkanfi, M.1    Dixit, V.M.2
  • 7
    • 79651473582 scopus 로고    scopus 로고
    • NF-κB in immunobiology
    • Hayden, M. S., Ghosh, S. (2011) NF-κB in immunobiology. Cell Res. 21, 223-244.
    • (2011) Cell Res. , vol.21 , pp. 223-244
    • Hayden, M.S.1    Ghosh, S.2
  • 8
    • 84883199752 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in innate immunity
    • Arthur, J. S., Ley, S. C. (2013) Mitogen-activated protein kinases in innate immunity. Nat. Rev. Immunol. 13, 679-692.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 679-692
    • Arthur, J.S.1    Ley, S.C.2
  • 9
    • 42649114059 scopus 로고    scopus 로고
    • The IRF family transcription factors in immunity and oncogenesis
    • Tamura, T., Yanai, H., Savitsky, D., Taniguchi, T. (2008) The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 26, 535-584.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 535-584
    • Tamura, T.1    Yanai, H.2    Savitsky, D.3    Taniguchi, T.4
  • 10
    • 84862883553 scopus 로고    scopus 로고
    • Information processing during phagocytosis
    • Underhill, D. M., Goodridge, H. S. (2012) Information processing during phagocytosis. Nat. Rev. Immunol. 12, 492-502.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 492-502
    • Underhill, D.M.1    Goodridge, H.S.2
  • 11
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki, A., Medzhitov, R. (2010) Regulation of adaptive immunity by the innate immune system. Science 327, 291-295.
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 12
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki, A., Medzhitov, R. (2004) Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5, 987-995.
    • (2004) Nat. Immunol. , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 13
    • 82255191977 scopus 로고    scopus 로고
    • TLR-dependent T cell activation in autoimmunity
    • Mills, K. H. (2011) TLR-dependent T cell activation in autoimmunity. Nat. Rev. Immunol. 11, 807-822.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 807-822
    • Mills, K.H.1
  • 15
    • 77950365906 scopus 로고    scopus 로고
    • Nonresolving inflammation
    • Nathan, C., Ding, A. (2010) Nonresolving inflammation. Cell 140, 871-882.
    • (2010) Cell , vol.140 , pp. 871-882
    • Nathan, C.1    Ding, A.2
  • 16
    • 79953061608 scopus 로고    scopus 로고
    • Human TLRs and IL- 1Rs in host defense: Natural insights from evolutionary, epidemiological, and clinical genetics
    • Casanova, J. L., Abel, L., Quintana-Murci, L. (2011) Human TLRs and IL- 1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu. Rev. Immunol. 29, 447-491.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 447-491
    • Casanova, J.L.1    Abel, L.2    Quintana-Murci, L.3
  • 17
    • 34447557009 scopus 로고    scopus 로고
    • Innate immunogenetics: A tool for exploring new frontiers of host defence
    • Bochud, P. Y., Bochud, M., Telenti, A., Calandra, T. (2007) Innate immunogenetics: a tool for exploring new frontiers of host defence. Lancet Infect. Dis. 7, 531-542.
    • (2007) Lancet Infect. Dis. , vol.7 , pp. 531-542
    • Bochud, P.Y.1    Bochud, M.2    Telenti, A.3    Calandra, T.4
  • 18
    • 84901014110 scopus 로고    scopus 로고
    • Natural selection and infectious disease in human populations
    • Karlsson, E. K., Kwiatkowski, D. P., Sabeti, P. C. (2014) Natural selection and infectious disease in human populations. Nat. Rev. Genet. 15, 379-393.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 379-393
    • Karlsson, E.K.1    Kwiatkowski, D.P.2    Sabeti, P.C.3
  • 19
    • 77952474987 scopus 로고    scopus 로고
    • Cellular heterogeneity: Do differences make a difference?
    • Altschuler, S. J., Wu, L. F. (2010) Cellular heterogeneity: do differences make a difference? Cell 141, 559-563.
    • (2010) Cell , vol.141 , pp. 559-563
    • Altschuler, S.J.1    Wu, L.F.2
  • 20
    • 77956651529 scopus 로고    scopus 로고
    • Bursts and pulses: Insights from single cell studies into transcriptional mechanisms
    • Chubb, J. R., Liverpool, T. B. (2010) Bursts and pulses: insights from single cell studies into transcriptional mechanisms. Curr. Opin. Genet. Dev. 20, 478-484.
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 478-484
    • Chubb, J.R.1    Liverpool, T.B.2
  • 23
    • 80755168360 scopus 로고    scopus 로고
    • Genomic analysis at the single-cell level
    • Kalisky, T., Blainey, P., Quake, S. R. (2011) Genomic analysis at the single-cell level. Annu. Rev. Genet. 45, 431-445.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 431-445
    • Kalisky, T.1    Blainey, P.2    Quake, S.R.3
  • 25
    • 77951912210 scopus 로고    scopus 로고
    • Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst
    • Guo, G., Huss, M., Tong, G. Q., Wang, C., Li Sun, L., Clarke, N. D., Robson, P. (2010) Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev. Cell 18, 675-685.
    • (2010) Dev. Cell , vol.18 , pp. 675-685
    • Guo, G.1    Huss, M.2    Tong, G.Q.3    Wang, C.4    Li Sun, L.5    Clarke, N.D.6    Robson, P.7
  • 30
    • 84904789189 scopus 로고    scopus 로고
    • Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus
    • Sen, N., Mukherjee, G., Sen, A., Bendall, S. C., Sung, P., Nolan, G. P., Arvin, A. M. (2014) Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus. Cell Reports 8, 633-645.
    • (2014) Cell Reports , vol.8 , pp. 633-645
    • Sen, N.1    Mukherjee, G.2    Sen, A.3    Bendall, S.C.4    Sung, P.5    Nolan, G.P.6    Arvin, A.M.7
  • 31
    • 33646591544 scopus 로고    scopus 로고
    • Transcriptional pulsing of a developmental gene
    • Chubb, J. R., Trcek, T., Shenoy, S. M., Singer, R. H. (2006) Transcriptional pulsing of a developmental gene. Curr. Biol. 16, 1018-1025.
    • (2006) Curr. Biol. , vol.16 , pp. 1018-1025
    • Chubb, J.R.1    Trcek, T.2    Shenoy, S.M.3    Singer, R.H.4
  • 32
    • 79955381895 scopus 로고    scopus 로고
    • Mammalian genes are transcribed with widely different bursting kinetics
    • Suter, D. M., Molina, N., Gatfield, D., Schneider, K., Schibler, U., Naef, F. (2011) Mammalian genes are transcribed with widely different bursting kinetics. Science 332, 472-474.
    • (2011) Science , vol.332 , pp. 472-474
    • Suter, D.M.1    Molina, N.2    Gatfield, D.3    Schneider, K.4    Schibler, U.5    Naef, F.6
  • 33
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz, M. B., Levine, A. J., Siggia, E. D., Swain, P. S. (2002) Stochastic gene expression in a single cell. Science 297, 1183-1186.
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 35
    • 0036790975 scopus 로고    scopus 로고
    • Intrinsic and extrinsic contributions to stochasticity in gene expression
    • Swain, P. S., Elowitz, M. B., Siggia, E. D. (2002) Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc. Natl. Acad. Sci. USA 99, 12795-12800.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12795-12800
    • Swain, P.S.1    Elowitz, M.B.2    Siggia, E.D.3
  • 36
    • 79960630264 scopus 로고    scopus 로고
    • Central dogma at the single-molecule level in living cells
    • Li, G. W., Xie, X. S. (2011) Central dogma at the single-molecule level in living cells. Nature 475, 308-315.
    • (2011) Nature , vol.475 , pp. 308-315
    • Li, G.W.1    Xie, X.S.2
  • 37
    • 84897059078 scopus 로고    scopus 로고
    • Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
    • Arsenio, J., Kakaradov, B., Metz, P. J., Kim, S. H., Yeo, G. W., Chang, J. T. (2014) Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Nat. Immunol. 15, 365-372.
    • (2014) Nat. Immunol. , vol.15 , pp. 365-372
    • Arsenio, J.1    Kakaradov, B.2    Metz, P.J.3    Kim, S.H.4    Yeo, G.W.5    Chang, J.T.6
  • 39
    • 84892179132 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells
    • Deng, Q., Ramsköld, D., Reinius, B., Sandberg, R. (2014) Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Science 343, 193-196.
    • (2014) Science , vol.343 , pp. 193-196
    • Deng, Q.1    Ramsköld, D.2    Reinius, B.3    Sandberg, R.4
  • 41
    • 25844433114 scopus 로고    scopus 로고
    • Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels
    • Bengtsson, M., Ståhlberg, A., Rorsman, P., Kubista, M. (2005) Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Res. 15, 1388-1392.
    • (2005) Genome Res. , vol.15 , pp. 1388-1392
    • Bengtsson, M.1    Ståhlberg, A.2    Rorsman, P.3    Kubista, M.4
  • 42
    • 84882582801 scopus 로고    scopus 로고
    • Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments
    • Wills, Q. F., Livak, K. J., Tipping, A. J., Enver, T., Goldson, A. J., Sexton, D. W., Holmes, C. (2013) Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nat. Biotechnol. 31, 748-752.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 748-752
    • Wills, Q.F.1    Livak, K.J.2    Tipping, A.J.3    Enver, T.4    Goldson, A.J.5    Sexton, D.W.6    Holmes, C.7
  • 45
    • 80051567423 scopus 로고    scopus 로고
    • Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets
    • Wong, K. L., Tai, J. J., Wong, W. C., Han, H., Sem, X., Yeap, W. H., Kourilsky, P., Wong, S. C. (2011) Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood 118, e16-e31.
    • (2011) Blood , vol.118 , pp. e16-e31
    • Wong, K.L.1    Tai, J.J.2    Wong, W.C.3    Han, H.4    Sem, X.5    Yeap, W.H.6    Kourilsky, P.7    Wong, S.C.8
  • 48
    • 34347256054 scopus 로고    scopus 로고
    • Microfluidic large-scale integration: The evolution of design rules for biological automation
    • Melin, J., Quake, S. R. (2007) Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu. Rev. Biophys. Biomol. Struct. 36, 213-231.
    • (2007) Annu. Rev. Biophys. Biomol. Struct. , vol.36 , pp. 213-231
    • Melin, J.1    Quake, S.R.2
  • 51
    • 68849103521 scopus 로고    scopus 로고
    • Mass cytometry: Technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry
    • Bandura, D. R., Baranov, V. I., Ornatsky, O. I., Antonov, A., Kinach, R., Lou, X., Pavlov, S., Vorobiev, S., Dick, J. E., Tanner, S. D. (2009) Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal. Chem. 81, 6813-6822.
    • (2009) Anal. Chem. , vol.81 , pp. 6813-6822
    • Bandura, D.R.1    Baranov, V.I.2    Ornatsky, O.I.3    Antonov, A.4    Kinach, R.5    Lou, X.6    Pavlov, S.7    Vorobiev, S.8    Dick, J.E.9    Tanner, S.D.10
  • 52
    • 84884138622 scopus 로고    scopus 로고
    • Single-cell mass cytometry for analysis of immune system functional states
    • Bjornson, Z. B., Nolan, G. P., Fantl, W. J. (2013) Single-cell mass cytometry for analysis of immune system functional states. Curr. Opin. Immunol. 25, 484-494.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 484-494
    • Bjornson, Z.B.1    Nolan, G.P.2    Fantl, W.J.3
  • 53
    • 77951174215 scopus 로고    scopus 로고
    • Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans
    • Autissier, P., Soulas, C., Burdo, T. H., Williams, K. C. (2010) Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans. Cytometry A 77, 410-419.
    • (2010) Cytometry A , vol.77 , pp. 410-419
    • Autissier, P.1    Soulas, C.2    Burdo, T.H.3    Williams, K.C.4
  • 60
    • 78651304279 scopus 로고    scopus 로고
    • Whole-genome molecular haplotyping of single cells
    • Fan, H. C., Wang, J., Potanina, A., Quake, S. R. (2011) Whole-genome molecular haplotyping of single cells. Nat. Biotechnol. 29, 51-57.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 51-57
    • Fan, H.C.1    Wang, J.2    Potanina, A.3    Quake, S.R.4
  • 62
    • 84896284039 scopus 로고    scopus 로고
    • The present and future role of microfluidics in biomedical research
    • Sackmann, E. K., Fulton, A. L., Beebe, D. J. (2014) The present and future role of microfluidics in biomedical research. Nature 507, 181-189.
    • (2014) Nature , vol.507 , pp. 181-189
    • Sackmann, E.K.1    Fulton, A.L.2    Beebe, D.J.3
  • 63
    • 84862231072 scopus 로고    scopus 로고
    • Commercialization of microfluidic point-of-care diagnostic devices
    • Chin, C. D., Linder, V., Sia, S. K. (2012) Commercialization of microfluidic point-of-care diagnostic devices. Lab Chip 12, 2118-2134.
    • (2012) Lab Chip , vol.12 , pp. 2118-2134
    • Chin, C.D.1    Linder, V.2    Sia, S.K.3
  • 64
  • 65
    • 84896503384 scopus 로고    scopus 로고
    • Antigen-dependent integration of opposing proximal TCR-signaling cascades determines the functional fate of T lymphocytes
    • Wolchinsky, R., Hod-Marco, M., Oved, K., Shen-Orr, S. S., Bendall, S. C., Nolan, G. P., Reiter, Y. (2014) Antigen-dependent integration of opposing proximal TCR-signaling cascades determines the functional fate of T lymphocytes. J. Immunol. 192, 2109-2119.
    • (2014) J. Immunol. , vol.192 , pp. 2109-2119
    • Wolchinsky, R.1    Hod-Marco, M.2    Oved, K.3    Shen-Orr, S.S.4    Bendall, S.C.5    Nolan, G.P.6    Reiter, Y.7
  • 66
    • 84856278095 scopus 로고    scopus 로고
    • Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
    • Newell, E. W., Sigal, N., Bendall, S. C., Nolan, G. P., Davis, M. M. (2012) Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity 36, 142-152.
    • (2012) Immunity , vol.36 , pp. 142-152
    • Newell, E.W.1    Sigal, N.2    Bendall, S.C.3    Nolan, G.P.4    Davis, M.M.5
  • 68
    • 84880289310 scopus 로고    scopus 로고
    • Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
    • Newell, E. W., Sigal, N., Nair, N., Kidd, B. A., Greenberg, H. B., Davis, M. M. (2013) Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization. Nat. Biotechnol. 31, 623-629.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 623-629
    • Newell, E.W.1    Sigal, N.2    Nair, N.3    Kidd, B.A.4    Greenberg, H.B.5    Davis, M.M.6
  • 73
    • 84910117189 scopus 로고    scopus 로고
    • Coordinated regulation of NK receptor expression in the maturing human immune system
    • Strauss-Albee, D. M., Horowitz, A., Parham, P., Blish, C. A. (2014) Coordinated regulation of NK receptor expression in the maturing human immune system. J. Immunol. 193, 4871-4879.
    • (2014) J. Immunol. , vol.193 , pp. 4871-4879
    • Strauss-Albee, D.M.1    Horowitz, A.2    Parham, P.3    Blish, C.A.4
  • 80
    • 84883076264 scopus 로고    scopus 로고
    • Severe sepsis and septic shock
    • Angus, D. C., van der Poll, T. (2013) Severe sepsis and septic shock. N. Engl. J. Med. 369, 840-851.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 840-851
    • Angus, D.C.1    van der Poll, T.2
  • 82
    • 84255183707 scopus 로고    scopus 로고
    • The search for effective therapy for sepsis: Back to the drawing board?
    • Angus, D. C. (2011) The search for effective therapy for sepsis: back to the drawing board? JAMA 306, 2614-2615.
    • (2011) JAMA , vol.306 , pp. 2614-2615
    • Angus, D.C.1
  • 84
    • 84863693768 scopus 로고    scopus 로고
    • Trial failure prompts soul-searching for critical-care specialists
    • Dolgin, E. (2012) Trial failure prompts soul-searching for critical-care specialists. Nat. Med. 18, 1000.
    • (2012) Nat. Med. , vol.18 , pp. 1000
    • Dolgin, E.1
  • 85
    • 84865302435 scopus 로고    scopus 로고
    • The rise and fall of drotrecogin alfa (activated)
    • Vincent, J. L. (2012) The rise and fall of drotrecogin alfa (activated). Lancet Infect. Dis. 12, 649-651.
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 649-651
    • Vincent, J.L.1
  • 86
    • 84861706642 scopus 로고    scopus 로고
    • Septic shock-evaluating another failed treatment
    • Wenzel, R. P., Edmond, M. B. (2012) Septic shock-evaluating another failed treatment. N. Engl. J. Med. 366, 2122-2124.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2122-2124
    • Wenzel, R.P.1    Edmond, M.B.2
  • 87
    • 84863712115 scopus 로고    scopus 로고
    • After Xigris, researchers look to new targets to combat sepsis
    • Williams, S. C. (2012) After Xigris, researchers look to new targets to combat sepsis. Nat. Med. 18, 1001.
    • (2012) Nat. Med. , vol.18 , pp. 1001
    • Williams, S.C.1
  • 89
    • 84921727957 scopus 로고    scopus 로고
    • Genomic responses in mouse models greatly mimic human inflammatory diseases
    • Takao, K., Miyakawa, T. (2014) Genomic responses in mouse models greatly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 112, 1167-1172.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 1167-1172
    • Takao, K.1    Miyakawa, T.2
  • 90
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn, T. A., Chawla, A., Pollard, J. W. (2013) Macrophage biology in development, homeostasis and disease. Nature 496, 445-455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 91
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., Edwards, J. P. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 95
    • 84873506978 scopus 로고    scopus 로고
    • Designing tomorrow's vaccines
    • Nabel, G. J. (2013) Designing tomorrow's vaccines. N. Engl. J. Med. 368, 551-560.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 551-560
    • Nabel, G.J.1
  • 97
    • 84907417476 scopus 로고    scopus 로고
    • Ebola-underscoring the global disparities in health care resources
    • Fauci, A. S. (2014) Ebola-underscoring the global disparities in health care resources. N. Engl. J. Med. 371, 1084-1086.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1084-1086
    • Fauci, A.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.