Monoallelic expression of the interleukin-2 locus

Science

Volumn 279, Issue 5359, 1998, Pages 2118-2121

  Holländer, Georg A ^a,b   Zuklys, Saulius ^a   Morel, Corinne ^c   Mizoguchi, Emiko ^d   Mobisson, Kathrine ^b   Simpson, Stephen ^e,g   Terhorst, Cox ^e   Wishart, William ^c   Golan, David E ^b,f   Bhan, Atul K ^d   Burakoff, Steven J ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Preclinical Research   (Switzerland)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CONTROL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; THYMOCYTE;

ALLELES; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CONCANAVALIN A; DNA REPLICATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HETEROZYGOTE; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MURIDAE; MUTATION; POLYMERASE CHAIN REACTION; S PHASE; TRANSCRIPTION, GENETIC;

EID: 7144256245     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5359.2118     Document Type: Article

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61. We thank I. Horak for the IL-2 knockout mice and the genomic IL-2 clone; R. Skoda for the c-mpl clone; A. Surani for the (C57BL6/6 × M. spretus) mice; P. Yacono and E. Ten Boekel for excellent technical assistance; and G. Balciunaite, J. Bluestone, W. Gehring, J. Seidman, C. Steinberg, and R. Zeller for helpful discussions. Supported by a grant from the Swiss National Science Foundation (31-43′600.95 to G.A.H.) and grants from the NIH (PO1 CA39542-09 and R01 Al17258-18 to S.J.B, RO1 DK47677 to A.K.B., P30 DK43351 to A.K.B and C.T., and HL32854 and HL15157 to D.E.G.).