Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16466-16471

  Mingueneau, Michael ^a,e   Krishnaswamy, Smita ^b   Spitzer, Matthew H ^c   Bendall, Sean C ^c   Stone, Erica L ^d   Hedrick, Stephen M ^d   Pe'er, Dana ^b   Mathis, Diane ^a   Nolan, Garry P ^c   Benoist, Christophe ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BIOGEN   (United States)

Author keywords

CyTOF; Diabetes; NOD; Signaling; Single cell

Indexed keywords

CD3 ANTIGEN; CD45 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; I KAPPA B KINASE ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; T LYMPHOCYTE RECEPTOR; I KAPPA B; LYMPHOCYTE ANTIGEN RECEPTOR; MAPK1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELLS; CYTOMETRY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MASS CYTOMETRY; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CELLULAR IMMUNITY; CYTOLOGY; DEFICIENCY; DISEASE MODEL; GENETIC VARIABILITY; GENETICS; IMMUNE DEFICIENCY; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; LYMPH NODE; LYMPHOPOIESIS; MALE; MASS SPECTROMETRY; METABOLISM; NONOBESE DIABETIC MOUSE; PHOSPHORYLATION; PHYSIOLOGY; PROCEDURES; PROTEIN PROCESSING; SINGLE CELL ANALYSIS; THYMUS;

MUS;

ANIMALS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENETIC VARIATION; I-KAPPA B PROTEINS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOLOGIC MEMORY; LYMPH NODES; LYMPHOPOIESIS; MALE; MAP KINASE SIGNALING SYSTEM; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; SINGLE-CELL ANALYSIS; THYMUS GLAND;

EID: 84914106706     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419337111     Document Type: Article

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