Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney

Drug Metabolism and Disposition

Volumn 37, Issue 4, 2009, Pages 834-840

  Buckley, David B ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; DNA; ESTRADIOL; GLUCURONOSYLTRANSFERASE; GROWTH HORMONE; MESSENGER RNA; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE EXPRESSION; HORMONAL REGULATION; HORMONE RELEASE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; FEMALE; GLUCURONOSYLTRANSFERASE; GONADAL STEROID HORMONES; GROWTH HORMONE; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS;

MUS; RATTUS; RODENTIA;

EID: 63849241530     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.024224     Document Type: Article

References (34)

1. Anderson GD (2002) Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferase. J Gend Specif Med 5:25-33.
2. Buckley DB and Klaassen CD (2007) Tissue- and gender-specific mRNA expression of UDP- glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos 35:121-127.
3. Buist SC, Cherrington NJ, and Klaassen CD (2003) Endocrine regulation of rat organic anion transporters. Drug Metab Dispos 31:559-564.
4. Buist SC and Klaassen CD (2004) Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab Dispos 32:620-625.
5. Burchell B, Brierley CH, and Rance D (1995) Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation. Life Sci 57:1819-1831.
6. Chen C, Staudinger JL, and Klaassen CD (2003) Nuclear receptor, pregnane X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metab Dispos 31:908-915.
7. Cheng X, Maher J, Lu H, and Klaassen CD (2006) Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Mol Pharmacol 70:1291-1297.
8. Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, and Waxman DJ (2006) Sex- dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol 20:1333-1351.
9. Court MH, Hao Q, Krishnaswamy S, Bekaii-Saab T, Al-Rohaimi A, von Moltke LL, and Greenblatt DJ (2004) UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. J Pharmacol Exp Ther 310:656-665.
10. Delesque-Touchard N, Park SH, and Waxman DJ (2000) Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver. J Biol Chem 275:34173-34182.
11. Endo M, Takahashi Y, Sasaki Y, Saito T, and Kamataki T (2005) Novel gender-related regulation of CYP2C12 gene expression in rats. Mol Endocrinol 19:1181-1190.
12. Greenblatt DJ, Divoll M, Harmatz JS, and Shader RI (1980) Oxazepam kinetics: effects of age and sex. J Pharmacol Exp Ther 215:86-91.
13. Gueraud F, Masmoudi T, Goudonnet H, and Paris A (1997) Differential effect of hypophysectomy and growth hormone treatment on hepatic glucuronosyltransferases in male rats: evidence for an action at a pretranslational level for isoforms glucuronidating bilirubin. Biochem Pharmacol 53:1637-1647.
14. Holloway MG, Cui Y, Laz EV, Hosui A, Helmighausen L, and Waxman DJ (2007) Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology 148:1977-1986.
15. Jaffe CA, Turgeon DK, Lown K, Demott-Friberg R, and Watkins PB (2002) Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans. Am J Physiol Endocrinol Metab 283:E1008-E1015.
16. Jansson JO, Edén S, and Isaksson O (1985) Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 6:128-150.
17. Liu HF, Vincent-Viry M, Galteau MM, Guéguen R, Magdalou J, Nicolas A, Leroy P, and Siest G (1991) Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic? Eur J Clin Pharmacol 41:153-159.
18. Ljubojevic M, Herak-Kramberger CM, Hagos Y, Bahn A, Endou H, Burckhardt G, and Sabolic I (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 287:F124-F138.
19. Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, and Nebert DW (2005) Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 15:677-685.
20. MacLeod JN, Pampori NA, and Shapiro BH (1991) Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice. J Endocrinol 131:395-399.
21. Maher JM, Cheng X, Tanaka Y, Scheffer GL, and Klaassen CD (2006) Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochem Pharmacol 71:1470-1478.
22. Muraca M and Fevery J (1984) Influence of sex and sex steroids on bilirubin uridine diphosphate-glucuronosyltransferase activity of rat liver. Gastroenterology 87:308 -313.
23. Radominska-Pandya A, Czernik PJ, Little JM, Battaglia E, and Mackenzie PI (1999) Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev 31:817-899.
24. Shelby MK, Cherrington NJ, Vansell NR, and Klaassen CD (2003) Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. Drug Metab Dispos 31:326-333.
25. Stern ST, Tallman MN, Miles KK, Ritter JK, Dupuis RE, and Smith PC (2007) Gender-related differences in mycophenolate mofetil-induced gastrointestinal toxicity in rats. Drug Metab Dispos 35:449-454.
26. Strasser SI, Smid SA, Mashford ML, and Desmond PV (1997) Sex hormones differentially regulate isoforms of UDP-glucuronosyltransferase. Pharm Res 14:1115-1121.
27. Takeuchi T, Tsutsumi O, Nakamura N, Ikezuki Y, Takai Y, Yano T, and Taketani Y (2004) Gender difference in serum bisphenol A levels may be caused by liver UDP-glucuronosyltransferase activity in rats. Biochem Biophys Res Commun 325:549-554.
28. Tephly TR, Green MD, Coffman BL, King C, Cheng Z, and Rios G (1998) Metabolism of endobiotics and xenobiotics by UDP-glucuronosyltransferase. Adv Pharmacol 42:343-346.
29. Veldhuis JD, Liem AY, South S, Weltman A, Weltman J, Clemmons DA, Abbott R, Mulligan T, Johnson ML, and Pincus S (1995) Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 80:3209-3222.
30. Waxman DJ and O'Connor C (2006) Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 20:2613-2629.
31. Waxman DJ, Pampori NA, Ram PA, Agrawal AK, and Shapiro BH (1991) Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Natl Acad Sci US A 88:6868-6872.
32. Waxman DJ, Ram PA, Park SH, and Choi HK (1995) Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription. J Biol Chem 270:13262-13270.
33. Wiwi CA and Waxman DJ (2005) Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2. J Biol Chem 280:3259-3268.
34. Zucker SD, Horn PS, and Sherman KE (2004) Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Hepatology 40:827-835. Curtis Klaassen Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7417 cklaasse@kumc.edu