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Volumn 53, Issue 8, 2015, Pages 1149-1159

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Author keywords

cut offs; folate; homocysteine; methylmalonic acid; vitamin B12 deficiency

Indexed keywords

CREATININE; CYANOCOBALAMIN; FOLIC ACID; HOLOTRANSCOBALAMIN; HOMOCYSTEINE; METHYLMALONIC ACID; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

EID: 84934272419     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2014-0784     Document Type: Review
Times cited : (102)

References (79)
  • 2
    • 0142088607 scopus 로고    scopus 로고
    • B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women
    • Wolters M, Hermann S, Hahn A. B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women. Am J Clin Nutr 2003;78:765-72.
    • (2003) Am J Clin Nutr , vol.78 , pp. 765-772
    • Wolters, M.1    Hermann, S.2    Hahn, A.3
  • 4
    • 78651301901 scopus 로고    scopus 로고
    • Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: A multicentre pragmatic randomised controlled trial
    • Favrat B, Vaucher P, Herzig L, Burnand B, Ali G, Boulat O, et al. Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: a multicentre pragmatic randomised controlled trial. BMC Fam Pract 2011;12:2.
    • (2011) BMC Fam Pract , vol.12 , pp. 2
    • Favrat, B.1    Vaucher, P.2    Herzig, L.3    Burnand, B.4    Ali, G.5    Boulat, O.6
  • 6
    • 0344256728 scopus 로고    scopus 로고
    • Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    • Herrmann W, Obeid R, Schorr H, Geisel J. Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk. Clin Chem Lab Med 2003;41:1478-88.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1478-1488
    • Herrmann, W.1    Obeid, R.2    Schorr, H.3    Geisel, J.4
  • 7
    • 84902204059 scopus 로고    scopus 로고
    • Vitamin B12 deficiency in inflammatory bowel disease: Prevalence, risk factors, evaluation, and management
    • Battat R, Kopylov U, Szilagyi A, Saxena A, Rosenblatt DS, Warner M, et al. Vitamin B12 deficiency in inflammatory bowel disease: prevalence, risk factors, evaluation, and management. Inflamm Bowel Dis 2014;20:1120-8.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1120-1128
    • Battat, R.1    Kopylov, U.2    Szilagyi, A.3    Saxena, A.4    Rosenblatt, D.S.5    Warner, M.6
  • 8
    • 0347337782 scopus 로고    scopus 로고
    • Psychiatric manifestations of vitamin B12 deficiency: A case report
    • Durand C, Mary S, Brazo P, Dollfus S. [Psychiatric manifestations of vitamin B12 deficiency: a case report]. Encephale. 2003;29:560-5.
    • (2003) Encephale. , vol.29 , pp. 560-565
    • Durand, C.1    Mary, S.2    Brazo, P.3    Dollfus, S.4
  • 9
    • 84882292256 scopus 로고    scopus 로고
    • B-Vitamin dependent methionine metabolism and alcoholic liver disease
    • Halsted CH. B-Vitamin dependent methionine metabolism and alcoholic liver disease. Clin Chem Lab Med 2013;51:457-65.
    • (2013) Clin Chem Lab Med , vol.51 , pp. 457-465
    • Halsted, C.H.1
  • 11
    • 84934298277 scopus 로고    scopus 로고
    • Health impact of vitamin b12 and folate deficiency
    • Gonzalez-Gross M. Health impact of vitamin b12 and folate deficiency. Aktuel Ernaehr Med 2005;S1:26-9.
    • (2005) Aktuel Ernaehr Med , vol.S1 , pp. 26-29
    • Gonzalez-Gross, M.1
  • 12
    • 24044507638 scopus 로고    scopus 로고
    • Biochemical indicators of B vitamin status in the US population after folic acid fortification: Results from the National Health and Nutrition Examination Survey 1999-2000
    • Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82:442-50.
    • (2005) Am J Clin Nutr , vol.82 , pp. 442-450
    • Pfeiffer, C.M.1    Caudill, S.P.2    Gunter, E.W.3    Osterloh, J.4    Sampson, E.J.5
  • 13
    • 71749120426 scopus 로고    scopus 로고
    • Determinants of plasma methylmalonic acid in a large population: Implications for assessment of vitamin B12 status
    • Vogiatzoglou A, Oulhaj A, Smith AD, Nurk E, Drevon CA, Ueland PM, et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem 2009;55:2198-206.
    • (2009) Clin Chem , vol.55 , pp. 2198-2206
    • Vogiatzoglou, A.1    Oulhaj, A.2    Smith, A.D.3    Nurk, E.4    Drevon, C.A.5    Ueland, P.M.6
  • 14
    • 33645064021 scopus 로고    scopus 로고
    • Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency
    • Andres E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol 2006;28:50-6.
    • (2006) Clin Lab Haematol , vol.28 , pp. 50-56
    • Andres, E.1    Affenberger, S.2    Zimmer, J.3    Vinzio, S.4    Grosu, D.5    Pistol, G.6
  • 15
    • 0027430257 scopus 로고
    • Metabolic evidence that deficiencies of vitamin B12 (cobalamin), folate, and vitamin B6 occur commonly in elderly people
    • Joosten E, van den Berg A, Riezler R, Naurath H, Lindenbaum J, Stabler S, et al. Metabolic evidence that deficiencies of vitamin B12 (cobalamin), folate, and vitamin B6 occur commonly in elderly people. Am J Clin Nutr 1993;58:468-76.
    • (1993) Am J Clin Nutr , vol.58 , pp. 468-476
    • Joosten, E.1    Van Den Berg, A.2    Riezler, R.3    Naurath, H.4    Lindenbaum, J.5    Stabler, S.6
  • 16
    • 19344377753 scopus 로고    scopus 로고
    • Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: A dose-finding trial
    • Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH, et al. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med 2005;165:1167-72.
    • (2005) Arch Intern Med , vol.165 , pp. 1167-1172
    • Eussen, S.J.1    De Groot, L.C.2    Clarke, R.3    Schneede, J.4    Ueland, P.M.5    Hoefnagels, W.H.6
  • 17
    • 35148871233 scopus 로고    scopus 로고
    • The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people
    • Eussen SJ, Ueland PM, Clarke R, Blom HJ, Hoefnagels WH, van Staveren WA, et al. The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people. Br J Nutr 2007;98:960-8.
    • (2007) Br J Nutr , vol.98 , pp. 960-968
    • Eussen, S.J.1    Ueland, P.M.2    Clarke, R.3    Blom, H.J.4    Hoefnagels, W.H.5    Van Staveren, W.A.6
  • 20
    • 0036217326 scopus 로고    scopus 로고
    • Screening for cobalamin deficiency in geriatric outpatients: Prevalence and influence of synthetic cobalamin intake
    • Rajan S, Wallace JI, Beresford SA, Brodkin KI, Allen RA, Stabler SP. Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake. J Am Geriatr Soc 2002;50:624-30.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 624-630
    • Rajan, S.1    Wallace, J.I.2    Beresford, S.A.3    Brodkin, K.I.4    Allen, R.A.5    Stabler, S.P.6
  • 21
    • 3242744561 scopus 로고    scopus 로고
    • Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms
    • Nilsson K, Isaksson A, Gustafson L, Hultberg B. Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms. Clin Chem Lab Med 2004;42:637-43.
    • (2004) Clin Chem Lab Med , vol.42 , pp. 637-643
    • Nilsson, K.1    Isaksson, A.2    Gustafson, L.3    Hultberg, B.4
  • 22
    • 79957754169 scopus 로고    scopus 로고
    • Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B(1)(2) status in the elderly
    • Valente E, Scott JM, Ueland PM, Cunningham C, Casey M, Molloy AM. Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B(1)(2) status in the elderly. Clin Chem 2011;57:856-63.
    • (2011) Clin Chem , vol.57 , pp. 856-863
    • Valente, E.1    Scott, J.M.2    Ueland, P.M.3    Cunningham, C.4    Casey, M.5    Molloy, A.M.6
  • 23
    • 0345169173 scopus 로고    scopus 로고
    • Holotranscobalamin as a predictor of vitamin B12 status
    • Hvas A-M, Nexo E. Holotranscobalamin as a predictor of vitamin B12 status. Clin Chem Lab Med 2003;41:1489-92.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1489-1492
    • Hvas, A.-M.1    Nexo, E.2
  • 24
    • 33644857598 scopus 로고    scopus 로고
    • A daily intake of approximately 6 μg vitamin B12 appears to saturate all the vitamin B12-related variables in Danish postmenopausal women
    • Bor MV, Lydeking-Olsen E, Moller J, Nexo E. A daily intake of approximately 6 μg vitamin B12 appears to saturate all the vitamin B12-related variables in Danish postmenopausal women. Am J Clin Nutr 2006;83:52-8.
    • (2006) Am J Clin Nutr , vol.83 , pp. 52-58
    • Bor, M.V.1    Lydeking-Olsen, E.2    Moller, J.3    Nexo, E.4
  • 25
  • 27
    • 0032740452 scopus 로고    scopus 로고
    • Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: Ethnic and sex differences in cobalamin and metabolite abnormalities
    • Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr 1999;70:904-10.
    • (1999) Am J Clin Nutr , vol.70 , pp. 904-910
    • Carmel, R.1    Green, R.2    Jacobsen, D.W.3    Rasmussen, K.4    Florea, M.5    Azen, C.6
  • 30
    • 84883763121 scopus 로고    scopus 로고
    • Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin B12 status in older adults; Secondary outcome analysis from the CENEX Study (ISRCTN48153354)
    • Sanchez H, Albala C, Lera L, Dangour AD, Uauy R. Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin B12 status in older adults; secondary outcome analysis from the CENEX Study (ISRCTN48153354). Nutr J 2013;12:124.
    • (2013) Nutr J , vol.12 , pp. 124
    • Sanchez, H.1    Albala, C.2    Lera, L.3    Dangour, A.D.4    Uauy, R.5
  • 31
    • 0022385317 scopus 로고
    • Folic acid responsive postmenopausal homocysteinemia
    • Brattstrom LE, Hultberg BL, Hardebo JE. Folic acid responsive postmenopausal homocysteinemia. Metabolism 1985;34:1073-7.
    • (1985) Metabolism , vol.34 , pp. 1073-1077
    • Brattstrom, L.E.1    Hultberg, B.L.2    Hardebo, J.E.3
  • 32
    • 48249129119 scopus 로고    scopus 로고
    • Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies
    • de Benoist B. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008; 29(2 Suppl):S238-44.
    • (2008) Food Nutr Bull , vol.29 , Issue.2 , pp. S238-S244
    • De Benoist, B.1
  • 33
    • 84871290753 scopus 로고    scopus 로고
    • Central Registry: University of Ulster, Accessed on 08 October 2014
    • Folic Acid Mandatory Fortification. European Surveillance of congenital anomalies (EUROCAT) [Internet]. Central Registry: University of Ulster. Available from: http://www.eurocatnetwork. eu/preventionandriskfactors/folicacid/folicacidmandatoryfortification. Accessed on 08 October 2014
    • European Surveillance of Congenital Anomalies (EUROCAT) [Internet]
  • 34
    • 0041417599 scopus 로고    scopus 로고
    • Plasma vitamin B-12 concentrations in an elderly latino population are predicted by serum gastrin concentrations and crystalline vitamin B-12 intake
    • Campbell AK, Miller JW, Green R, Haan MN, Allen LH. Plasma vitamin B-12 concentrations in an elderly latino population are predicted by serum gastrin concentrations and crystalline vitamin B-12 intake. J Nutr 2003;133:2770-6.
    • (2003) J Nutr , vol.133 , pp. 2770-2776
    • Campbell, A.K.1    Miller, J.W.2    Green, R.3    Haan, M.N.4    Allen, L.H.5
  • 36
    • 9144225352 scopus 로고    scopus 로고
    • Facts and recommendations about total homocysteine determinations: An expert opinion
    • Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50:3-32.
    • (2004) Clin Chem , vol.50 , pp. 3-32
    • Refsum, H.1    Smith, A.D.2    Ueland, P.M.3    Nexo, E.4    Clarke, R.5    McPartlin, J.6
  • 37
    • 0029069203 scopus 로고
    • Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations
    • Naurath HJ, Joosten E, Riezler R, Stabler S, Allen RH, Lindenbaum J. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995;346:85-9.
    • (1995) Lancet , vol.346 , pp. 85-89
    • Naurath, H.J.1    Joosten, E.2    Riezler, R.3    Stabler, S.4    Allen, R.H.5    Lindenbaum, J.6
  • 38
    • 0035724608 scopus 로고    scopus 로고
    • Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes - A population-based study
    • Bjorkegren K, Svardsudd K. Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes - a population-based study. J Intern Med 2001;249:423-32.
    • (2001) J Intern Med , vol.249 , pp. 423-432
    • Bjorkegren, K.1    Svardsudd, K.2
  • 39
    • 0033778284 scopus 로고    scopus 로고
    • An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: Is a preventable public health issue on the rise?
    • Ray JG, Cole DE, Boss SC. An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise? Clin Biochem 2000;33:337-43.
    • (2000) Clin Biochem , vol.33 , pp. 337-343
    • Ray, J.G.1    Cole, D.E.2    Boss, S.C.3
  • 40
    • 33644537960 scopus 로고    scopus 로고
    • The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency
    • Goringe A, Ellis R, McDowell I, Vidal-Alaball J, Jenkins C, Butler C, et al. The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica 2006;91:231-4.
    • (2006) Haematologica , vol.91 , pp. 231-234
    • Goringe, A.1    Ellis, R.2    McDowell, I.3    Vidal-Alaball, J.4    Jenkins, C.5    Butler, C.6
  • 42
    • 0034513748 scopus 로고    scopus 로고
    • Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in highaged subjects
    • Herrmann W, Schorr H, Bodis M, Knapp JP, Muller A, Stein G, et al. Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in highaged subjects. Eur J Clin Invest 2000;30:1083-9.
    • (2000) Eur J Clin Invest , vol.30 , pp. 1083-1089
    • Herrmann, W.1    Schorr, H.2    Bodis, M.3    Knapp, J.P.4    Muller, A.5    Stein, G.6
  • 43
    • 84878009344 scopus 로고    scopus 로고
    • Association between vitamin b12 levels and melancholic depressive symptoms: A Finnish population-based study
    • Seppala J, Koponen H, Kautiainen H, Eriksson JG, Kampman O, Leiviska J, et al. Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study. BMC Psychiatry 2013;13:145.
    • (2013) BMC Psychiatry , vol.13 , pp. 145
    • Seppala, J.1    Koponen, H.2    Kautiainen, H.3    Eriksson, J.G.4    Kampman, O.5    Leiviska, J.6
  • 44
    • 33644861860 scopus 로고    scopus 로고
    • Efficacy of B vitamins in lowering homocysteine in older men: Maximal effects for those with B12 deficiency and hyperhomocysteinemia
    • Flicker L, Vasikaran SD, Thomas J, Acres JM, Norman P, Jamrozik K, et al. Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia. Stroke 2006;37:547-9.
    • (2006) Stroke , vol.37 , pp. 547-549
    • Flicker, L.1    Vasikaran, S.D.2    Thomas, J.3    Acres, J.M.4    Norman, P.5    Jamrozik, K.6
  • 45
    • 0344961124 scopus 로고    scopus 로고
    • High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel
    • Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N, et al. High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel. Br J Haematol 2003;123:696-701.
    • (2003) Br J Haematol , vol.123 , pp. 696-701
    • Figlin, E.1    Chetrit, A.2    Shahar, A.3    Shpilberg, O.4    Zivelin, A.5    Rosenberg, N.6
  • 47
    • 0242693157 scopus 로고    scopus 로고
    • Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: A randomised trial
    • Lewerin C, Nilsson-Ehle H, Matousek M, Lindstedt G, Steen B. Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial. Eur J Clin Nutr 2003;57:1426-36.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 1426-1436
    • Lewerin, C.1    Nilsson-Ehle, H.2    Matousek, M.3    Lindstedt, G.4    Steen, B.5
  • 48
    • 31844440194 scopus 로고    scopus 로고
    • Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency
    • Miller JW, Garrod MG, Rockwood AL, Kushnir MM, Allen LH, Haan MN, et al. Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency. Clin Chem 2006;52:278-85.
    • (2006) Clin Chem , vol.52 , pp. 278-285
    • Miller, J.W.1    Garrod, M.G.2    Rockwood, A.L.3    Kushnir, M.M.4    Allen, L.H.5    Haan, M.N.6
  • 49
    • 0036713436 scopus 로고    scopus 로고
    • Elevated serum methylmalonic acid concentrations are common among elderly Americans
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J. Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr 2002;132:2799-803.
    • (2002) J Nutr , vol.132 , pp. 2799-2803
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 50
    • 33846102164 scopus 로고    scopus 로고
    • Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200.
    • (2007) Am J Clin Nutr , vol.85 , pp. 193-200
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 51
    • 12844254924 scopus 로고    scopus 로고
    • Cobalamin-responsive disorders in the ambulatory care setting: Unreliability of cobalamin, methylmalonic acid, and homocysteine testing
    • Solomon LR. Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing. Blood 2005;105:978-85.
    • (2005) Blood , vol.105 , pp. 978-985
    • Solomon, L.R.1
  • 52
    • 30944451366 scopus 로고    scopus 로고
    • Vitamin status and cognitive function in a long-term care population
    • Paulionis L, Kane SL, Meckling KA. Vitamin status and cognitive function in a long-term care population. BMC Geriatr 2005;5:16.
    • (2005) BMC Geriatr , vol.5 , pp. 16
    • Paulionis, L.1    Kane, S.L.2    Meckling, K.A.3
  • 53
    • 0031410993 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men
    • Fenech M, Dreosti I, Rinaldi J. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 1997;18:1329-36.
    • (1997) Carcinogenesis , vol.18 , pp. 1329-1336
    • Fenech, M.1    Dreosti, I.2    Rinaldi, J.3
  • 54
    • 0037372649 scopus 로고    scopus 로고
    • RIA for serum holotranscobalamin: Method evaluation in the clinical laboratory and reference interval
    • Loikas S, Lopponen M, Suominen P, Moller J, Irjala K, Isoaho R, et al. RIA for serum holotranscobalamin: method evaluation in the clinical laboratory and reference interval. Clin Chem 2003;49:455-62.
    • (2003) Clin Chem , vol.49 , pp. 455-462
    • Loikas, S.1    Lopponen, M.2    Suominen, P.3    Moller, J.4    Irjala, K.5    Isoaho, R.6
  • 55
    • 0034934781 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    • Refsum H, Yajnik CS, Gadkari M, Schneede J, Vollset SE, Orning L, et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nutr 2001;74:233-41.
    • (2001) Am J Clin Nutr , vol.74 , pp. 233-241
    • Refsum, H.1    Yajnik, C.S.2    Gadkari, M.3    Schneede, J.4    Vollset, S.E.5    Orning, L.6
  • 56
    • 0029865065 scopus 로고    scopus 로고
    • Relations of vitamin B12, vitamin B6, folate, and homocysteine to cognitive performance in the Normative Aging Study
    • Riggs K, Spiro A, 3rd, Tucker K, Rush D. Relations of vitamin B12, vitamin B6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 1996;63:306-14.
    • (1996) Am J Clin Nutr , vol.63 , pp. 306-314
    • Riggs, K.1    Spiro, A.2    Tucker, K.3    Rush, D.4
  • 57
    • 33644916668 scopus 로고    scopus 로고
    • Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: A case for the methylfolate trap
    • Smulders YM, Smith DE, Kok RM, Teerlink T, Swinkels DW, Stehouwer CD, et al. Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap. Br J Haematol 2006;132:623-9.
    • (2006) Br J Haematol , vol.132 , pp. 623-629
    • Smulders, Y.M.1    Smith, D.E.2    Kok, R.M.3    Teerlink, T.4    Swinkels, D.W.5    Stehouwer, C.D.6
  • 58
    • 77954855822 scopus 로고    scopus 로고
    • Relationship between the levels of holotranscobalamin and vitamin B12
    • Woo KS, Kim KE, Park JS, Park JI, Han JY. Relationship between the levels of holotranscobalamin and vitamin B12. Korean J Lab Med 2010;30:185-9.
    • (2010) Korean J Lab Med , vol.30 , pp. 185-189
    • Woo, K.S.1    Kim, K.E.2    Park, J.S.3    Park, J.I.4    Han, J.Y.5
  • 61
    • 84891715861 scopus 로고    scopus 로고
    • The role of plasma melatonin and vitamins C and B12 in the development of idiopathic tinnitus in the elderly
    • Lasisi AO, Fehintola FA, Lasisi TJ. The role of plasma melatonin and vitamins C and B12 in the development of idiopathic tinnitus in the elderly. Ghana Med J 2012;46:152-7.
    • (2012) Ghana Med J , vol.46 , pp. 152-157
    • Lasisi, A.O.1    Fehintola, F.A.2    Lasisi, T.J.3
  • 62
    • 41149156810 scopus 로고    scopus 로고
    • Vitamin B12 deficiency neurological syndromes: Correlation of clinical, MRI and cognitive evoked potential
    • Kalita J, Misra UK. Vitamin B12 deficiency neurological syndromes: correlation of clinical, MRI and cognitive evoked potential. J Neurol 2008;255:353-9.
    • (2008) J Neurol , vol.255 , pp. 353-359
    • Kalita, J.1    Misra, U.K.2
  • 63
    • 0036170011 scopus 로고    scopus 로고
    • The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B12 deficiency in elderly people
    • Hirsch S, de la Maza P, Barrera G, Gattas V, Petermann M, Bunout D. The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B12 deficiency in elderly people. J Nutr 2002;132:289-91.
    • (2002) J Nutr , vol.132 , pp. 289-291
    • Hirsch, S.1    De La Maza, P.2    Barrera, G.3    Gattas, V.4    Petermann, M.5    Bunout, D.6
  • 64
    • 0037775351 scopus 로고    scopus 로고
    • Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies
    • Holleland G, Schneede J, Ueland PM, Lund PK, Refsum H, Sandberg S. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Clin Chem 1999;45:189-98.
    • (1999) Clin Chem , vol.45 , pp. 189-198
    • Holleland, G.1    Schneede, J.2    Ueland, P.M.3    Lund, P.K.4    Refsum, H.5    Sandberg, S.6
  • 65
    • 84894625194 scopus 로고    scopus 로고
    • Low serum vitamin B12 levels among psychiatric patients admitted in Butabika mental hospital in Uganda
    • Ssonko M, Ddungu H, Musisi S. Low serum vitamin B12 levels among psychiatric patients admitted in Butabika mental hospital in Uganda. BMC Res Notes 2014;7:90.
    • (2014) BMC Res Notes , vol.7 , pp. 90
    • Ssonko, M.1    Ddungu, H.2    Musisi, S.3
  • 66
    • 33644693101 scopus 로고    scopus 로고
    • Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    • Stott DJ, MacIntosh G, Lowe GD, Rumley A, McMahon AD, Langhorne P, et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr 2005;82:1320-6.
    • (2005) Am J Clin Nutr , vol.82 , pp. 1320-1326
    • Stott, D.J.1    Macintosh, G.2    Lowe, G.D.3    Rumley, A.4    McMahon, A.D.5    Langhorne, P.6
  • 67
    • 1342310863 scopus 로고    scopus 로고
    • Vitamin B12 status in the elderly as judged by available biochemical markers
    • Obeid R, Schorr H, Eckert R, Herrmann W. Vitamin B12 status in the elderly as judged by available biochemical markers. Clin Chem 2004;50:238-41.
    • (2004) Clin Chem , vol.50 , pp. 238-241
    • Obeid, R.1    Schorr, H.2    Eckert, R.3    Herrmann, W.4
  • 68
    • 14844317329 scopus 로고    scopus 로고
    • Holotranscobalamin - A first choice assay for diagnosing early vitamin B12 deficiency?
    • Hvas A-M, Nexo E. Holotranscobalamin - a first choice assay for diagnosing early vitamin B12 deficiency? J Intern Med 2005;257:289-98.
    • (2005) J Intern Med , vol.257 , pp. 289-298
    • Hvas, A.-M.1    Nexo, E.2
  • 69
    • 0032925193 scopus 로고    scopus 로고
    • Holotranscobalamin -a sensitive marker of cobalamin malabsorption
    • Lindgren A, Kilander A, Bagge E, Nexo E. Holotranscobalamin -a sensitive marker of cobalamin malabsorption. Eur J Clin Invest 1999;29:321-9.
    • (1999) Eur J Clin Invest , vol.29 , pp. 321-329
    • Lindgren, A.1    Kilander, A.2    Bagge, E.3    Nexo, E.4
  • 70
    • 18644368562 scopus 로고    scopus 로고
    • Holotranscobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study
    • Nexo E, Hvas AM, Bleie O, Refsum H, Fedosov SN, Vollset SE, et al. Holotranscobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study. Clin Chem 2002;48:1768-71.
    • (2002) Clin Chem , vol.48 , pp. 1768-1771
    • Nexo, E.1    Hvas, A.M.2    Bleie, O.3    Refsum, H.4    Fedosov, S.N.5    Vollset, S.E.6
  • 71
    • 0038480240 scopus 로고    scopus 로고
    • Low vitamin B12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin
    • Refsum H, Smith AD. Low vitamin B12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 2003;74:959-61.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 959-961
    • Refsum, H.1    Smith, A.D.2
  • 72
    • 34248376360 scopus 로고    scopus 로고
    • Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    • Clarke R, Sherliker P, Hin H, Nexo E, Hvas AM, Schneede J, et al. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clin Chem 2007;53:963-70.
    • (2007) Clin Chem , vol.53 , pp. 963-970
    • Clarke, R.1    Sherliker, P.2    Hin, H.3    Nexo, E.4    Hvas, A.M.5    Schneede, J.6
  • 73
    • 0029836310 scopus 로고    scopus 로고
    • Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women
    • Koehler KM, Romero LJ, Stauber PM, Pareo-Tubbeh SL, Liang HC, Baumgartner RN, et al. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Nutr 1996;15:364-76.
    • (1996) J Am Coll Nutr , vol.15 , pp. 364-376
    • Koehler, K.M.1    Romero, L.J.2    Stauber, P.M.3    Pareo-Tubbeh, S.L.4    Liang, H.C.5    Baumgartner, R.N.6
  • 74
    • 84880313383 scopus 로고    scopus 로고
    • Homocysteine, cobalamin and folate status and their relations to neurocognitive and psychological markers in elderly in Northeasten of Iran
    • Manavifar L, Nemati Karimooy H, Jamali J, Talebi Doluee M, Shirdel A, Nejat Shokohi A, et al. Homocysteine, cobalamin and folate status and their relations to neurocognitive and psychological markers in elderly in Northeasten of Iran. Iran J Basic Med Sci 2013;16:772-80.
    • (2013) Iran J Basic Med Sci , vol.16 , pp. 772-780
    • Manavifar, L.1    Nemati Karimooy, H.2    Jamali, J.3    Talebi Doluee, M.4    Shirdel, A.5    Nejat Shokohi, A.6
  • 77
    • 20544474458 scopus 로고    scopus 로고
    • Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products
    • Robertson J, Iemolo F, Stabler SP, Allen RH, Spence JD. Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products. CMAJ 2005;172:1569-73.
    • (2005) CMAJ , vol.172 , pp. 1569-1573
    • Robertson, J.1    Iemolo, F.2    Stabler, S.P.3    Allen, R.H.4    Spence, J.D.5
  • 78
    • 0032692869 scopus 로고    scopus 로고
    • Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
    • Stabler SP, Allen RH, Fried LP, Pahor M, Kittner SJ, Penninx BW, et al. Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. Am J Clin Nutr 1999;70:911-9.
    • (1999) Am J Clin Nutr , vol.70 , pp. 911-919
    • Stabler, S.P.1    Allen, R.H.2    Fried, L.P.3    Pahor, M.4    Kittner, S.J.5    Penninx, B.W.6
  • 79


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