Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin

Journal of Neurology Neurosurgery and Psychiatry

Volumn 74, Issue 7, 2003, Pages 959-961

  Refsum, H ^a   Smith, A David ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; COBALAMIN; CYANOCOBALAMIN; HOLOTRANSCOBALAMIN; HOMOCYSTEINE; METHYLMALONIC ACID; UNCLASSIFIED DRUG;

AGE; AGED; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; COGNITIVE DEFECT; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SEX DIFFERENCE; VITAMIN BLOOD LEVEL;

EID: 0038480240     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.74.7.959     Document Type: Article

References (18)

1. Carmel R. Cobalamin deficiency. In: Carmel R, Jacobsen DW, eds. Homocysteine in health and disease. Cambridge: Cambridge University Press, 2001:289-305.
2. Smith AD. Homocysteine, B vitamins, and cognitive deficit in the elderly. Am J Clin Nutr 2002;75:785-6.
3. Clarke R, Smith AD, Jobst KA, et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-55.
4. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
5. Herbert V. Staging vitamin B-12 (cobalamin) status in vegetarians. Am J Clin Nutr 1994;59:1213-22S.
6. Ulleland M, Eilertsen I, Quadros EV, et al. Direct assay for cobalamin bound to transcobalamin (holo-transcobalamin] in serum. Clin Chem 2002;48:526-32.
7. Fiskerstrand T, Refsum H, Kvalheim G, et al. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem 1993;39:263-71.
8. Husek P. Simultaneous profile analysis of plasma amino and organic acids by capillary gas chromatography. J Chromatogr B Biomed Appl 1995;669:352-7.
9. Renvall MJ, Spindler AA, Ramsdell JW, et al. Nutritional status of free-living Alzheimer's patients. Am J Med Sci 1989;298:20-7.
10. Kristensen MO, Gulmann NC, Christensen JEJ, et al. Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand 1993;87:475-81.
11. Joosten E, Lesaffre E, Riezler R, et al. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontal Ser A Biol Sci Med 1997;52:M76-9.
12. McCaddon A, Davies G, Hudson P, et al. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13:235-9.
13. Wang HX, Wahlin A, Basun H, et al. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurology 2001;56:1188-94.
14. Basun H, Fratiglioni L, Winblad B. Cobalamin levels are not reduced in Alzheimer's disease: results from a population-based study. J Am Geriatr Soc 1994;42:132-6.
15. McCaddon A, Regland B, Hudson P, et al. Functional vitamin B12 deficiency and Alzheimer disease. Neurology 2002;58:1395-9.
16. Namour F, Olivier J, Abdelmouttaleb I, et al. Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood. Bload 2001;97:1092-8.
17. Lievers KJ, Afman LA, Kluijtmans LA, et al. Polymarphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem 2002;48:1383-9.
18. Bjorksten KS, Dige N, Nexo E. Long-term memory correlates negatively with plasma transcobalamin in healthy elderly with normal plasma cobalamin levels. Int J Geriatr Psychiatry 2001;16:439-41.