Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women

Journal of the American College of Nutrition

Volumn 15, Issue 4, 1996, Pages 364-376

  Koehler, Kathleen M ^a,b   Romero, Linda J ^a,b   Stauber, Patricia M ^a,b   Pareo Tubbeh, Shirley L ^a,b   Liang, Hwa Chi ^a,b   Baumgartner, Richard N ^a,b   Garry, Philip J ^a,b   Allen, Robert H ^a,b   Stabler, Sally P ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Creatinine; Elderly; Folate; Homocysteine; Methylmalonic acid; Vitamin B 12; Vitamin supplements

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID;

AGED; ARTICLE; BODY MASS; CYANOCOBALAMIN DEFICIENCY; DIET SUPPLEMENTATION; DIETARY INTAKE; FEMALE; FOLIC ACID DEFICIENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; VASCULAR DISEASE; VITAMIN METABOLISM;

AGED; AGED, 80 AND OVER; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; FOOD, FORTIFIED; HOMOCYSTEINE; HUMANS; LINEAR MODELS; MALE; METHYLMALONIC ACID; PATIENT SELECTION; PROSPECTIVE STUDIES; VITAMIN B 12 DEFICIENCY;

EID: 0029836310     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1996.10718611     Document Type: Article

References (49)

1. Green R, Jacobsen DW: Clinical implications of hyperhomocysteinernia, In Bailey LB (ed): "Folate in Health and Disease." New York: Marcel Dekker, pp 75-122, 1995.
2. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH: Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 39:1764-1779, 1993.
3. Ueland PM, Refsum H, Brattstrom L: Plasma homocysteine and cardiovascular disease. In Francis RB Jr (ed): "Atherosclerotic Cardiovascular Disease, Hemostasis and Endothelial Function." New York: Marcel Dekker, pp 183-236, 1992.
4. Kang SS, Wong PWK, Malinow MR: Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 12: 279-98, 1992.
5. Lindenbaum J, Allen RH: Clinical spectrum and diagnosis of folate deficiency. In Bailey LB (ed): "Folate in Health and Disease." New York: Marcel Dekker, pp 43-73, 1995.
6. Savage DG, Lindenbaum J: Folate-cobalamin interactions. In Bailey LB (ed): "Folate in Health and Disease." New York: Marcel Dekker, pp 237-285, 1995.
7. Allen RH, Stabler SP, Savage DG, Lindenbaum J: Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB 17:1344-1353, 1993.
8. Savage DG, Lindenbaum JL, Stabler SP, Allen RH: Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 96: 239-246, 1994.
9. Brattstrom L, Israelsson B, Norrving B, Berqvist D, Thome J, Hultberg B, Hamfelt A: Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 81: 51-60, 1990.
10. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, Tishler PV, Hennekens CH: A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 268:877-881, 1992.
11. Pancharuniti N, Lewis CA, Sauberlich HE, Perkins LL, Go RCP, Alvarez JO, Macaluso M, Acton RT, Copeland RB, Cousins AL, Gore TB, Cornwell PE, Roseman JM: Plasma homocyst(e)ine, folate, and vitamin B12 concentrations and risk for early-onset coronary artery disease. Am J Clin Nutr 59:940--948, 1994.
12. Selhub J, lacques PF, Bostom AG, D' Agostino RB, Wilson PWF, Belanger AJ, O'Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH: Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 332:286-291, 1995.
13. Ubbink M, Vermaak WlH, van der Nerwe A, Becker PJ: Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 57:47-53, 1993.
14. Lacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Otto JM, Taylor LM: Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: Sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem 40:873-881, 1994.
15. Brattstrom L, Lindgren A, Israelsson B, Andersson A, Hultberg B: Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Int Med 236:633-641, 1994.
16. Brattstrom LE, Israelsson B, leppsson JO, Hultberg BL: Folic acid-an innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest 48:215-221, 1988.
17. Koehler KM, Garry PJ: Nutrition and aging. Clin Lab Med 13: 433-453, 1993.
18. White JV, Ham RJ, Lipschitz DA, Dwyer IT, Wellman NS: Consensus of the Nutrition Screening Initiative: Risk factors and indicators of poor nutritional status in older Americans. J Am Diet Assoc 91:783-787, 1991.
19. Russell RM, Suter PM: Vitamin requirements of elderly people: an update. Am J Clin Nutr 58:4-14, 1993.
20. National Research Council: "Recommended Dietary Allowances," 10th ed. Washington, DC: National Academy Press, 1989.
21. Loosten E, van den Berg A, Riezler R, Naurath HJ, Lindenbaum J, Stabler SP, Allen RH: Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 58:468-476, 1993.
22. Naurath JL, loosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum 1: Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 346:85-89, 1995.
23. Selhub J, lacques PF, Wilson PWF, Rush D, Rosenberg IH: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-2698, 1993.
24. Lindenbaum J, Rosenberg IH, Wilson PWF, Stabler SP, Allen RH: Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 60:2-11, 1994.
25. Garry PJ, Goodwin JS, Hunt WC, Hooper EM, Leonard AG: Nutritional status in a healthy elderly population: dietary and supplemental intakes. Am J Clin Nutr 36:319-331, 1982.
26. Allen RH, Stabler SP, Savage D, Lindenbaum J: Diagnosis of cobalamin deficiency. 1. Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 34:90--98, 1990.
27. Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41, 1976.
28. Yao Y, Yao Sol, Yao S-S, Yao G, Lou W: Prevalance of vitamin B12 deficiency among geriatric outpatients. J Farm Practice 35: 524-528, 1992.
29. Pennypacker LC, Allen RH, Kelly JP, Matthews LM, Grigsby J, Kaye K, Lindenbaum J, Stabler SP: High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 40:1197-1204, 1992.
30. Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, Gardner L: A data-based approach to diet questionnaire design and testing. Am J Epidem 124:453-469, 1986.
31. Block G, Woods M, Potosky A, Clifford C: Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidem 43:1327-1335, 1990.
32. National Cancer Institute: "Health Habits and History Questionnaire: Diet History and Other Risk Factors." Personal computer system packet. Version 2.2. Bethesda, MD: National Cancer Institute, 1989.
33. Smucker R, Block G, Coyle L, Harvin A, Kessler L: A dietary and risk factor questionnaire and analysis system for personal computers. Am J Epidem 129:445-449, 1989.
34. SAS Institute, Inc: "SAS/STAT User's Guide," version 6, 4th ed. Cary, NC: SAS Institute, Inc., 1989.
35. Stabler SP: Screening the older population for cobalamin (Vitamin B12) deficiency. J Am Geriatr Soc 43:1290-1297, 1995.
36. Lewis CA, Pancharuniti N, Sauberlich HE: Plasma folate adequacy as determined by homocysteine level. Ann NY Acad Sci 669:360-362, 1992.
37. Garry PJ, Goodwin JS, Hunt WC: Folate and vitamin B-12 status in a healthy elderly population. J Am Geriatr Soc 32:719-726, 1984.
38. Lacques PF, Sulsky SI, Sadowski JA, Phillips JCC, Rush D, Willett WC: Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient status. Am J Clin Nutr 57:182-189, 1993.
39. Brattstrom L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, Hamfelt A: Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 22:214-221, 1992.
40. Berg K, Malinow MR, Kierulf K, Upson B: Population variation and genetics of plasma homocyst(e)ine level. Clin Genet 41:315-321, 1992.
41. Andersson A, Brattstrom L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B: Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest 22:79-87, 1992.
42. Bostom A, Brosnan IT, Hall B, Nadeau MR, Selhub 1: Net uptake of plasma homocysteine by the rat kidney in vivo. Athersclerosis 116:59-62, 1995.
43. Stabler SP, Marcell PD, Podell ER, Allen RH: Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gaschromatography-mass spectrometry. Anal Biochem 162:185-196, 1987.
44. Guttonnsen AB, Schneede J, Ueland PM, Refsum H: Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency. AmJ Clin Nutr 63:194-202, 1996.
45. Bostom AG, Shemin D, Lapane KL, Miller JW, Sutherland P, Nadeau M, Seyoum E, Hartman W, Prior R, Wilson PWF, Selhub J: Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: a casecontrol study. Atherosclerosis 114:93-103, 1995.
46. Hultberg B, Andersson A, Sterner G: Plasma homocysteine in renal failure. Clin Nephrology 40:230-234, 1993.
47. Selhub J, Miller JW: The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55:131-138, 1992.
48. Miller JW, Ribaya-Mercado JD, Russell RM, Shepard DC, Morrow FD, Cochary EF, Sadowski JA, Gershoff SN, Selhub J: Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations. Am J Clin Nutr 55:1154-1160, 1992.
49. Subar AF, Block G, lames LD: Folate intake and food sources in the US population. Am J Clin Nutr 50:508-516, 1989.