Vitamin B12 deficiency in the aged: A population-based study

Age and Ageing

Volumn 36, Issue 2, 2007, Pages 177-183

  Loikas, Saila ^a,b   Koskinen, Pertti ^a,b   Irjala, Kerttu ^a,c   Löppönen, Minna ^a,d   Isoaho, Raimo ^a,e   Kivelä, Sirkka Liisa ^a,f,g   Pelliniemi, Tarja Terttu ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b HOSPITAL DISTRICT OF SOUTHWEST FINLAND   (Finland)

^c Mehilainen Oy   (Finland)

^d Harkatie Health Centre   (Finland)

^e Pori Health Centre   (Finland)

^f TURKU UNIVERSITY HOSPITAL   (Finland)

^g SATAKUNTA CENTRAL HOSPITAL   (Finland)

Author keywords

Aged; Cohort study; Holotranscobalamin; Screening; Vitamin B12; Vitamin B12 deficiency

Indexed keywords

ANTACID AGENT; ANTIBIOTIC AGENT; COBALAMIN DERIVATIVE; CYANOCOBALAMIN; ESTROGEN; HOLOTRANSCOBALAMIN; HOMOCYSTEINE; HYDROXOCOBALAMIN; METFORMIN; UNCLASSIFIED DRUG;

AGED; ANEMIA; ARTICLE; CYANOCOBALAMIN DEFICIENCY; DAIRY PRODUCT; DISEASE PREDISPOSITION; DISEASE SEVERITY; EARLY DIAGNOSIS; FEMALE; FINLAND; GENERAL PRACTITIONER; HIGH RISK POPULATION; HUMAN; LABORATORY DIAGNOSIS; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; MEGALOCYTOSIS; PHYSICAL EXAMINATION; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; PROBABILITY; RISK FACTOR; SEX RATIO; VITAMIN BLOOD LEVEL;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; FEMALE; FINLAND; HUMANS; LIFE STYLE; MALE; PREVALENCE; RISK FACTORS; VITAMIN B 12 DEFICIENCY;

EID: 33947400160     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afl150     Document Type: Article

References (24)

1. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr 1999; 19: 357-77.
2. Carmel R. Current concepts in cobalamin deficiency. Annu Rev Med 2000; 51: 357-75.
3. Bjorkegren K, Svardsudd K. Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes-a population-based study. J Intern Med 2001; 249: 423-32.
4. Clarke R, Grimley Evans J, Schneede J et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004; 33: 34-41.
5. Wolters M, Strohle A, Hahn A. Cobalamin: A critical vitamin in the elderly. Prev Med 2004; 39: 1256-66.
6. Bjorkegren K, Svardsudd K. Reported symptoms and clinical findings in relation to serum cobalamin, folate, methylmalonic acid and total homocysteine among elderly swedes: A population-based study. J Intern Med 2003; 254: 343-52.
7. Schneede J, Ueland PM. Novel and established markers of cobalamin deficiency: Complementary or exclusive diagnostic strategies. Semin Vasc Med 2005; 5: 140-55.
8. Herrmann W, Geisel J. Vegetarian lifestyle and monitoring of vitamin B-12 status. Clin Chim Acta 2002; 326: 47-59.
9. Gregg CR. Enteric bacterial flora and bacterial overgrowth syndrome. Semin Gastrointest Dis 2002; 13: 200-9.
10. Valuck RJ, Ruscin JM. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults. J Clin Epidemiol 2004; 57: 422-28.
11. Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000; 23: 1227-31.
12. Toh BH, van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med 1997; 337:1441-48.
13. The Lieto Study. http://www.utu.fi/med/yleislaak/lietostd.html. Institute of Clinical Medicine, Family Medicine, University of Turku. Accessed March 15, 2006.
14. Refsum H, Smith AD, Ueland PM et al. Facts and recommendations about total homocysteine determinations: An expert opinion. Clin Chem 2004; 50: 3-32.
15. Selhub J, Jacques PF, Rosenberg IH et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): Population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 1999; 131: 331-39.
16. Carmel R. Mild transcobalamin I (haptocorrin) deficiency and low serum cobalamin concentrations. Clin Chem 2003; 49: 1367-74.
17. Clarke R, Refsum H, Birks J et al. Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr 2003; 77: 1241-47.
18. Hvas AM, Ellegaard J, Nexo E. Increased plasma methylmalonic acid level does not predict clinical manifestations of vitamin B12 deficiency. Arch Intern Med 2001; 161: 1534-41.
19. Hvas AM, Nexo E. Holotranscobalamin-a first choice assay for diagnosing early vitamin B deficiency? J Intern Med 2005; 257: 289-98.
20. Calvaresi E, Bryan J. B vitamins, cognition, and aging: A review. J Gerontol B Psychol Sci Soc Sci 2001; 56: 327-39.
21. Hin H, Clarke R, Sherliker P et al. Clinical relevance of low serum vitamin B12 concentrations in older people: The Banbury B12 study. Age Ageing 2006; 35: 416-22.
22. Tiemeier H, van Tuijl HR, Hofman A et al Vitamin B12, folate, and homocysteine in depression: The Rotterdam Study. Am J Psychiatry 2002; 159: 2099-101.
23. Penninx BW, Guralnik JM, Ferrucci L et al. Vitamin B(12) deficiency and depression in physically disabled older women: Epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry 2000; 157: 715-21.
24. Bernard MA, Nakonezny PA, Kashner TM. The effect of vitamin B12 deficiency on older veterans and its relationship to health. J Am Geriatr Soc 1998; 46: 1199-206.