Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women

American Journal of Clinical Nutrition

Volumn 70, Issue 5, 1999, Pages 911-919

  Stabler, Sally P ^a   Allen, Robert H ^b   Fried, Linda P ^b   Pahor, Marco ^b   Kittner, Steven J ^b   Penninx, Brenda W J H ^b   Guralnik, Jack M ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b NONE

Author keywords

Cobalamin; Elderly; Folate; Homocysteine; Methylmalonic acid; Multivitamin use; Race; Women

Indexed keywords

COBALAMIN; CREATININE; FOLIC ACID; METHYLMALONIC ACID; MULTIVITAMIN;

AGED; ARTICLE; CAUCASIAN; DISABILITY; FEMALE; FOLIC ACID DEFICIENCY; GERIATRIC PATIENT; HUMAN; MAJOR CLINICAL STUDY; NEGRO; PREVALENCE; RACE DIFFERENCE; STATISTICAL ANALYSIS; VITAMIN DEFICIENCY;

PIERINAE;

EID: 0032692869     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/70.5.911     Document Type: Article

References (44)

1. Savage DG, Lindenbaum J, Stabler SP, et al. Sensitivity of serum MMA and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994;96:239-46.
2. Stabler SP, Allen RH, Savage DG, et al. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990;76:871-81.
3. Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatrie disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720-8.
4. 12 deficiency. Ann Intern Med 1987; 106:707-10.
5. Moelby L, Rasmussen K, Jensen MK, et al. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Intern Med 1990;228:373-8.
6. 12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiency. Metabolism 1988;37:175-8.
7. Lindenbaum J, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency II. Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990; 34:99-107.
8. Kang SS, Wong PWK, Norusis M. Homocysteinemia due to folate deficiency. Metabolism 1987;36:458-62.
9. Pennypacker LC, Allen, RH, Kelly JP, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992; 40:1197-204.
10. Lindenbaum J, Rosenberg I, Wilson P, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
11. Joosten E, van den Berg A, Reizler R, et al. Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 1993;58:468-76.
12. 12) deficiency using the urinary MMA assay by gas chromatography/mass spectrometry. Am J Med 1993;94:589-94.
13. Koehler KM, Romero LJ, Stauber PM, et al. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Nutr 1996;4:364-76.
14. 12 concentration in older people: a case control study. J Am Geriatr Soc 1996;44:1355-61.
15. 6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995;346:85-9.
16. Carmel R, Johnson CS. Racial patterns in pernicious anemia: early age at onset and increased frequency of intrinsic-factor antibody in black women. N Engl J Med 1978;298:647-50.
17. Solanki, DL, Jacobson, RJ, Green R, et al. Pernicious anemia in blacks. A study of 64 patients from Washington, DC and Johannesburg, SA. Am J Clin Pathol 1981;75:96-9.
18. Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996;156:1097-100.
19. 12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. Br J Haematol 1994;86:844-50.
20. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Fed Regist 1996; 61:8781-97.
21. 12 pantothenic acid, biotin and choline. Washington, DC: National Academy Press, (in press).
22. Boushey CJ, Beresford SAA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995; 274:1049-57.
23. Brattstrom L, Lindgren A, Israelsson B, et al. Homocysteine and cysteine: determinants of plasma level in middle-aged and elderly subjects. J Intern Med 1994;236:633-41.
24. 12 deficiency. J Nutr 1996;126:1266S-72S.
25. Guralnik JM, Fried LP, Simonsick EM, et al, eds. The Women's Health and Aging Study: health and social characteristics of older women with disability. Bethesda, MD: National Insitutes on Aging, 1995. (NIH publication no. 95-4009.)
26. Stabler SP, Marcell PD, Podell ER, et al. Assay of MMA in the serum of patients with cobalamin deficiency using capillary gas chromatography/mass spectrometry. J Clin Invest 1986;77: 1606-12.
27. Stabler SP, Marcell PD, Podell ER, Allen RH, Savage G, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988;81:466-74.
28. Stabler SP, Lindenbaum J, Savage DG, et al. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 1993;81:3104-13.
29. Allen RH, Stabler SP, Savage DG, et al. Elevation of 2-methylcitric acid I and II levels in serum, urine and cerebrospinal fluid of patients with cobalamin deficiency. Metabolism 1993;42:978-88.
30. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
31. Stabler SP, Sampson DA, Wang LP, et al. Elevations of serum cystathionine and total homocysteine in pyridoxine-, folate-, and cobalamin-deficient rats. J Nutr Biochem 1997;8:279-89.
32. 12-binding proteins of serum and saliva of healthy Nigerians and Europeans. Am J Clin Nutr 1978;31:1732-8.
33. Fernandes-Costa F, Metz J. A comparison of serum transcobalamin levels in white and black subjects. Am J Clin Nutr 1982;35:83-6.
34. 12 levels. J Nucl Med 1985;26:790-2.
35. 12 levels in the United States. Am J Clin Pathol 1987;88:95-7.
36. Stevenson RE, Schwartz CE, Du YZ, et al. Differences in methylenetetrahydrofolate reductase genotype frequencies, between White and Blacks. Am J Hum Genet 1997;60:229-30.
37. Franco RF, Araujo AG, Guerreiro JF, et al. Analysis of the 677 C→T mutation of the methylenetetrahydrofolate reductase gene in different ethnic groups. Thromb Haemost 1998;79:119-21.
38. DeLoughery TG, Gerhard GT, Evans A, et al. Elevated homocyst(e)ine (Hcy) levels in premenopausal black women are due to nutritional and not genetic factors. Blood 1996;88:471 (abstr).
39. Bradley SJ, Sacco RL, Roberts JK, et al. Race-ethnicity and other environmental determinants of serum homocysteine in northern Manhattan. Stroke 1998;29:277 (abstr).
40. Giles WH, Kittner SJ, Croft JB, Anda RF, Casper ML, Ford ES. Serum folate and risk for coronary heart disease: results from a cohort of US adults. Ann Epidemiol 1998;8:490-6.
41. Ubbink JB, Delport R, Vermaak WJH. Plasma homocysteine concentrations in a population with a low coronary heart disease prevalence. J Nutr 1996;126:1254S-7S.
42. McMartin KE, Phifer TJ, Alexander JS, et al. Homocysteine and iron interactions in endothelial cells: role in atherosclerosis. Ir J Med Sci 1995;164(suppl):14 (abstr).
43. Jacques PF, Rosenberg IH, Rogers G, et al. Serum total homocysteine concentrations in adolescent and adult American: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 1999;69:482-9.
44. Nygard O, Nordrehaug JE, Rufsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.