B-vitamins and homocysteine in Spanish institutionalized elderly

International Journal for Vitamin and Nutrition Research

Volumn 77, Issue 1, 2007, Pages 22-33

  Gonzalez Gross, Marcela ^a,b   Sola, Ricardo ^a   Albers, Ulrike ^b   Barrios, Laura ^c   Alder, Monika ^b,d   Castillo, Manuel J ^a   Pietrzik, Klaus ^d  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^c CSIC   (Spain)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

Elderly; Folate; Holotranscobalamin II; Homocysteine; Vitamin B12

Indexed keywords

ANTACID AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID; PYRIDOXINE; TRANSCOBALAMIN II; VITAMIN B GROUP;

ADOLESCENT; AGED; ANAMNESIS; ARTICLE; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; ELDERLY CARE; ERYTHROCYTE; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PREVALENCE; VITAMIN SUPPLEMENTATION;

AGED; AGED, 80 AND OVER; AGING; ERYTHROCYTES; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INSTITUTIONALIZATION; MALE; MIDDLE AGED; REGRESSION ANALYSIS; SEX CHARACTERISTICS; SPAIN; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; VITAMIN B COMPLEX; VITAMIN B DEFICIENCY;

EID: 34248176430     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.77.1.22     Document Type: Article

References (88)

1. Boushey, C.J., Beresford, S.A.A., Omenn, G.S. and Motulsky, A.G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes. JAMA 274, 1049-1057.
2. Graham, I.M., Daly, L.E., Refsum, H.M., Robinson, K., Brattstrom, L.E., Ueland, P.M., Palma-Reis, R.J., Boers, G.H., Sheahan, R.G., Israelsson, B., Uiterwaal, C.S., Meleady, R., McMaster, D., Verhoef, P., Witteman, J., Rubba, P., Bellet, H., Wautrecht, J.C., de Valk, H.W., Sales Luis, A.C., Parrot-Rouland, F.M., Tan, K.S., Higgins, I., Garcon, D., Andria, G. et al. (1997) Plasma homocysteine as a risk factor for vascular disease. European Concerted Action Project. JAMA 277, 1775-1781.
3. Nygard, O., Nordrehaug, J.E., Refsum, H., Ueland, P.M., Farstad, M. and Vollset, S.E. (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N. Engl. J. Med. 337, 230-236.
4. Refsum, M.H., Ueland, M.P. M., Nygard, M.O. and Vollset, S.E. (1998) Homocysteine and cardiovascular disease. Annu. Rev. Med. 49, 31-62.
5. Wald, N.J., Watt, H.C., Law, M.R., Weir, D.G., McPartlin, J. and Scott, J.M. (1998) Homocysteine and ischemic heart disease: Results of a prospective study with implications regarding prevention Arch. Intern. Med. 158, 862-867.
6. 6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am. J. Clin. Nutr. 63, 306-314.
7. Miller, J.W. (1999) Homocysteine and Alzheimer's disease. Nutr. Rev. 57, 126-129.
8. Lehmann, M., Gottfries, C.G. and Regland, B. (1999) Identification of cognitive impairment in the elderly: homocysteine is an early marker. Dement. Geriatr. Cogn. Disord. 10, 12-20.
9. McCaddon, A., Davies, G., Hudson, P., Tandy, S. and Cattell, H. (1998) Total serum homocysteine in senile dementia of Alzheimer type. Int. J. Geriatr. Psychiatry 13, 235-239.
10. Bell, I.R., Edman, J.S., Morrow, F.D., Marby, D.W., Mirages, S., Perrone, G., Kayne, H.L. and Cole, J.O. (1991) B complex vitamin patterns in geriatric and young adult inpatients with major depression. J. Am. Geriatr. Soc. 39, 252-257.
11. Budge, M., Johnston, C., Hogervorst, E., de Jager, C., Milwain, E., Iversen, S.D., Barnetson, L., King, E. and Smith, A.D. (2000) Plasma total homocysteine and cognitive performance in a volunteer elderly population. Ann. N.Y. Acad. Sci. 903, 407-410.
12. Nilsson, K., Gustafson, L. and Hultberg, B. (2000) The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population. Clin. Chem. 46, 691-696.
13. Morris, M.S., Jacques, P.F., Rosenberg, I.H. and Selhub, J. (2001) Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am. J. Clin. Nutr. 73, 927-933.
14. Jensen, E., Dehlin, O., Erfurth, E.-M., Hagberg, B., Samuelsson, G., Svensson, T. and Hultberg, B. (1998) Plasma homocysteine in 80-year-olds: Relationships to medical, psychological and social variables. Arch. Gerontol. Geriat. 26, 215-226.
15. Gonzalez-Gross, M., Marcos, A. and Pietrzik, K. (2001) Nutrition and cognitive impairment in the elderly. Br. J. Nutr. 86, 313-321.
16. McLean, R.R., Jacques, P.F., Selhub, J., Tucker, K.L., Samelson, E.J., Broe, K.E., Hannan, M.T., Cupples, L.A. and Kiel, D.P. (2004) Homocysteine as a predictive factor for hip fracture in older persons. N. Engl. J. Med. 350, 2042-2049.
17. Herrmann, M., Widmann, T. and Herrmann, W. (2005) Homocysteine - a newly recognised risk factor for osteoporosis. Clin. Chem. Lab. Med. 43, 1111-1117.
18. 12 and folic acid levels in different types of glaucoma. B.M.C. Ophthalmol. 6, 6.
19. Selhub, J., Jacques, P.F., Wilson, P.W.F., Rush, D. and Rosenberg, I.H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270, 2693-2698.
20. Selhub, J., Jacques, P.F., Rosenberg, I.H., Rogers, G., Bowman, B.A., Gunter, E.W., Wright, J.D. and Johnson, C.L. (1999) Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann. Intern. Med. 131, 331-339.
21. Kalmijn, S., Launer, L.J., Lindemans, J., Bots, M.L., Hofman, A. and Breteler, M.M. (1999) Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am. J. Epidemiol. 150, 283-289.
22. Ravaglia, G., Forti, P., Maioli, F., Zanardi, V., Dalmonte, E., Grossi, G., Cucinotta, D., Macini, P. and Caldarera, M. (2000) Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects. J. Nutr. Health. Aging. 4, 218-222.
23. Vrentzos, G.E., Papadakis, J.A., Malliaraki, N., Bampalis, D.E., Repa, A., Lemonomichelaki, V., Petinellis, E.G. and Ganotakis, E.S. (2006) Serum homocysteine concentration as a marker of nutritional status of healthy subjects in Crete, Greece. J. Hum. Nutr. Diet. 19, 117-123.
24. Koehler, K.M., Baumgartner, R.N., Garry, P.J., Allen, R.H., Stabler, S.P. and Rimm, E.B. (2001) Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use. Am. J. Clin. Nutr. 73, 628-637.
25. Carmel, R., Green, R., Rosenblatt, D.S. and Watkins, D. (2003) Update on cobalamin, folate, and homocysteine. Hematol. (Am. Soc. Hematol. Educ. Program), 62-81.
26. Jacques, P.F., Selhub, J., Bostom, A.G., Wilson, P.W.F. and Rosenberg, I.H. (1999) The effect of folic acid fortification on plasma folate and total homocysteine concentrations N. Engl. J. Med. 340, 1449-1454.
27. Selhub, J. (2006) The many facets of hyperhomocysteinemia: studies from the Framingham cohorts. J. Nutr. 136, 1726S-1730S.
28. Gonzalez-Gross, M., Prinz-Langenohl, R. and Pietrzik, K. (2002) Folate status in Germany 1997-2000. Int. J. Vitam. Nutr. Res. 72, 351-359.
29. Morrison, H.I., Schaubel, D., Desmeules, M. and Wigle, D.T. (1996) Serum folate and risk of fatal coronary heart disease. JAMA 275, 1893-1896.
30. Snowdon, D.A., Tully, C.L., Smith, C.D., Riley, K.P. and Markesbery, W.R. (2000) Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study. Am. J. Clin. Nutr. 71, 993-998.
31. Seshadri, S., Beiser, A., Selhub, J., Jacques, P.F., Rosenberg, I.H., D'Agostino, R.B., Wilson, P.W.F. and Wolf, P.A. (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346, 476-483.
32. Ramos, M.I., Allen, L.H., Mungas, D.M., Jagust, W.J., Haan, M.N., Green, R. and Miller, J.W. (2005) Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. Am. J. Clin. Nutr. 82, 1346-1352.
33. Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E. and Licastro, F. (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am. J. Clin. Nutr. 82, 636-643.
34. 12 deficiency. Age Ageing 23, 334-337.
35. 12? Nutr. Hosp.
36. 6 status, deficiency and its consequences - an overview. Nutr. Hosp. 22, 7-24.
37. Folsom, A.R., Nieto, F.J., McGovern, P.G., Tsai, M.Y., Malinow, M.R., Eckfeldt, J.H., Hess, D.L. and Davis, C.E. (1998) Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 98, 204-210.
38. Robinson, K., Mayer, E.L., Miller, D.P., Green, R., van Lente, F., Gupta, A., Kottke-Marchant, K., Savon, S.R., Selhub, J., Nissen, S.E. et al. (1995) Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 92, 2825-2830.
39. 6 is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circula-tion 103, 2788-2791.
40. Paulionis, L., Kane, S.L. and Meckling, K.A. (2005) Vitamin status and cognitive function in a long-term care population. B.M.C. Geriatr. 5, 16.
41. Serra-Majem, L., Ribas Barba, L., Armas Navarro, A., Alvarez Leon, E. and Sierra, A. (2000) Ingesta de energía y nutrientes y riesgo de ingesta inadecuada en las Islas Canarias (1997-1998). Arch. Latinoam. Nutr. 50, 7-22.
42. Christodoulakos, G., Panoulis, C., Rizos, D., Moustakarias, T., Phocas, I. and Creatsas, G. (2001) Homocysteine and folate levels in postmenopausal women. Maturitas 39, 161-167.
43. van Wayenburg, C.A., van de Laar, F.A., de Waal, M.W., Okkes, I.M., van den Akker, M., van der Veen, W.J., Schellevis, F.G., van Staveren, W.A., van Binsbergen, J.J. and van Weel, C. (2005) Nutritional deficiency in Dutch primary care: Data from general practice research and registration networks. Eur. J. Clin. Nutr. 59 Suppl. 1, 187-194.
44. 12 in an older Australian population. Aust. N. Z. J. Public Health 30, 38-41.
45. Wolters, M., Hermann, S. and Hahn, A. (2003) B vitamin status and concentrations of homocysteine and methyl-malonic acid in elderly German women. Am. J. Clin. Nutr. 78, 765-772.
46. Bates, C.J., Pentieva, K.D., Prentice, A., Mansoor, M.A. and Finch, S. (1999) Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over. Brit. J. Nutr. 81, 191-201.
47. 6 status and requirements in older adults. Brit. J. Nutr. 81, 175-176.
48. 12. Am. J. Clin. Nutr. 67, 739-740.
49. Schumann, K. (1999) Interactions between drugs and vitamins at advanced age. Int. J. Vitam. Nutr. Res. 69, 173-178.
50. Arjona Mateos, C.R., Criado Velasco, J. and Sánchez Solís, L. (2002) Enfermedades crónicas y consumo de fármacos en mayores de 65 anos. Med. Gen. 47, 684-695.
51. 12 deficiency. Ann. Pharmacother. 33, 641-643.
52. 12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over. Eur. J. Clin. Nutr. 57, 349-357.
53. Refsum, H., Smith, A.D., Ueland, P.M., Nexo, E., Clarke, R., McPartlin, J., Johnston, C., Engbaek, F., Schneede, J., McPartlin, C. and Scott, J.M. (2004) Facts and recommendations about total homocysteine determinations: An expert opinion. Clin. Chem. 50, 3-32.
54. 6 compounds in plasma. Clin. Chem. 35, 241-245.
55. 6 vitamers and pyridoxic acid in plasma, tissues and urine using high performance liquid chromatography. Nutr. Res. 9, 259-263.
56. Roe, D.A. (1986) Nutritional assessment of the elderly. World. Rev. Nutr. Diet. 48, 85-113.
57. Keller, H.E. and Salkeld, R.M. (1988) Bereichswerte von Analysenparametern für den Vitaminstatus. G.C.R. B. 106, 334.
58. 12 and folate deficiency in older persons. Am. J. Clin. Nutr. 77, 1241-1247.
59. 12 (cobalamin) status in vegetarians. Am. J. Clin. Nutr. 59, 1213S-1222.
60. 12 in serum samples from healthy subjects and patients. J. Clin. Pathol. 46, 537-539.
61. Stanger, O., Herrmann, W., Pietrzik, K., Fowler, B., Geisel, J., Dierkes, J. and Weger, M. (2003) DACH-LIGA homocystein (German, Austrian, and Swiss Homocysteine Society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations. Clin. Chem. Lab. Med. 41, 1392-1403.
62. Stampfer, M.J., Malinow, M.R., Willett, W.C., Newcomer, L.M., Upson, B., Ullmann, D., Tishler, P.V. and Hennekens, C.H. (1992) A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 268, 877-881.
63. Saw, S.M., Yuan, J.M., Ong, C.N., Arakawa, K., Lee, H.P., Coetzee, G.A. and Yu, M.C. (2001) Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am. J. Clin. Nutr. 73, 232-239.
64. 12 and folic acid intakes. J. Nutr. Health Aging 6, 69-71.
65. 12 concentrations. Geront. 47, 30-35.
66. Jacques, P.F., Bostom, A.G., Wilson, P.W., Rich, S., Rosenberg, I.H. and Selhub, J. (2001) Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am. J. Clin. Nutr. 73, 613-621.
67. Chen, K.J., Pan, W.H., Yang, F.L., Wei, I.L., Shaw, N.S. and Lin, B.F. (2005) Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia. Pac. J. Clin. Nutr. 14, 250-255.
68. Lindenbaum, J., Rosenberg, I., Wilson, P., Stabler, S. and Allen, R. (1994) Prevalence of cobalamin deficiency in the Framingham elderly population. Am. J. Clin. Nutr. 60, 2-11.
69. 6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease. J. Cardio. Risk. 5, 249-255.
70. Arnesen, E., Refsum, H., Bonaa, K.H., Ueland, P.M., Forde, O.H. and Nordrehaug, J.E. (1995) Serum total homocysteine and coronary heart disease. Int. J. Epidemiol. 24, 704-709.
71. Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. JAMA 288, 2015-2022.
72. rd (2005) High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am. J. Clin. Nutr. 82, 627-635.
73. Guttormsen, A.B., Schneede, J., Ueland, P.M. and Refsum, H. (1996) Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency. Am. J. Clin. Nutr. 63, 194-202.
74. Pietrzik, K. and Bronstrup, A. (1997) Causes and consequences of hyperhomocyst(e)inemia. Int. J. Vitam. Nutr. Res. 67, 89-395.
75. 12 deficiency in the elderly. Ann. Rev. Nutr. 19, 357-377.
76. Tawakol, A., Omland, T., Gerhard, M., Wu, J.T. and Creager, M.A. (1997) Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 95, 1119-1121.
77. Selhub, J., Bagley, L.C., Miller, J. and Rosenberg, I.H. (2000) B vitamins, homocysteine, and neurocognitive function in the elderly. Am. J. Clin. Nutr. 71, 614S-620S.
78. 12 and folate tissue deficiency markers amongst elderly Swedes - a population-based study. J. Intern. Med. 249, 423-432.
79. Bronstrup, A., Hages, M. and Pietrzik, K. (1999) Lowering of homocysteine concentrations in elderly men and women. Int. J. Vitam. Nutr. Res. 69, 187-193.
80. 6 occur commonly in elderly people. Am. J. Clin. Nutr. 58, 468-476.
81. 12 (Banerjee, R., ed.) pp. 343-365, John Wiley and Sons, New York.
82. Carmel, R. (2000) Current concepts in cobalamin deficiency. Annu. Rev. Med. 51, 357-375.
83. Lindenbaum, J. and Allen, R.H. (1995) Clinical spectrum and diagnosis of folate deficiency. In: Folate in health and disease (Bailey, L.B., ed.) pp. 43-73, Marcel Dekker, New York.
84. 12 deficiency. Clin. Chem. 48, 561-562.
85. 12 balance. Lab. Invest. 58, 332-337.
86. Lindenbaum, J., Savage, D.G., Stabler, S.P. and Allen, R.H. (1990) Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am. J. Hematol. 34, 99-107.
87. van Asselt, D.Z., de Groot, L.C., van Staveren, W.A., Blom, H. J., Wevers, R. A., Biemond, I. and Hoefnagels, W.H. (1998) Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am. J. Clin. Nutr. 68, 328-334.
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