B-Vitamin dependent methionine metabolism and alcoholic liver disease

Clinical Chemistry and Laboratory Medicine

Volumn 51, Issue 3, 2013, Pages 457-465

  Halsted, Charles H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol; Folate; S adenosylmethionine; Vitamin B12; Vitamin B6

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALCOHOL; BETAINE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CYANOCOBALAMIN; DEOXYURIDINE PHOSPHATE; FOLIC ACID; GLUTATHIONE; HOMOCYSTEINE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; METHYLENETETRAHYDROFOLIC ACID; PYRIDOXINE; S ADENOSYLMETHIONINE; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

ALCOHOL LIVER DISEASE; ALCOHOLISM; AMINO ACID METABOLISM; APOPTOSIS; CARCINOGENESIS; CLINICAL TRIAL (TOPIC); CONFERENCE PAPER; DISEASE ASSOCIATION; DNA STRAND BREAKAGE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FOLATE METABOLISM; FOLIC ACID DEFICIENCY; GENE EXPRESSION; HISTONE METHYLATION; HISTOPATHOLOGY; HUMAN; IMMUNOPRECIPITATION; INTESTINE BRUSH BORDER MEMBRANE; LIVER BIOPSY; LIVER CELL; LIVER INJURY; LIVER PRESERVATION; MALABSORPTION; MALIGNANT TRANSFORMATION; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PYRIDOXINE DEFICIENCY; STEATOSIS; URINARY EXCRETION; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY;

EPIGENESIS, GENETIC; ETHANOL; FOLIC ACID; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; LIVER; LIVER DISEASES, ALCOHOLIC; METHIONINE; S-ADENOSYLMETHIONINE; VITAMIN B COMPLEX; VITAMIN B DEFICIENCY;

EID: 84882292256     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0308     Document Type: Conference Paper

References (69)

1. Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011;141:1572-85.
2. Lieber CS, Jones DP, Decarli LM. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 1965;44:1009-21.
3. Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med 2009;360:2758-69.
4. Halsted CH. Nutrition and alcoholic liver disease. Semin Liver Dis 2004;24:289-304.
5. Kharbanda KK. Alcoholic liver disease and methionine metabolism. Semin Liver Dis 2009;29:155-65.
6. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, et al. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology 1996;23:497-505.
7. Halsted CH, Villanueva JA, Devlin AM, Niemela O, Parkkila S, Garrow TA, et al. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci USA 2002;99:10072-7.
8. Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol 2000;279:G178-85.
9. Trimble KC, Molloy AM, Scott JM, Weir DG. The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage. Hepatology 1993;18:984-9.
10. Kharbanda KK, Todero SL, King AL, Osna NA, McVicker BL, Tuma DJ, et al. Betaine treatment attenuates chronic ethanolinduced hepatic steatosis and alterations to the mitochondrial respiratory chain proteome. Int J Hepatol 2012;2012:962183.
11. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 2001;98:5560-5.
12. Ruiz F, Corrales FJ, Miqueo C, Mato JM. Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation. Hepatology 1998;28:1051-7.
13. Clarke S, Banfield K. S-adenosylmethionine-dependent methyltransferases. In: Carmel R, Jacobsen D, editors. Homocysteine in health and disease Cambridge: Cambridge University Press, 2001:63-78.
14. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R. S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci USA 2006;103:6489-94.
15. Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, et al. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 2004;28:173-81.
16. Villanueva JA, Halsted CH. Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology 2004;39:1303-10.
17. Lieber CS, Casini A, De Carli LM, Kim CI, Lowe N, Sasaki R, et al. S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 1990;11:165-72.
18. Zhuge J, Cederbaum AI. Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. Arch Biochem Biophys 2007;466:177-85.
19. Leevy CM, Cardi L, Frank O, Gellene R, Baker H. Incidence and significance of hypovitaminemia in a randomly selected municipal hospital population. Am J Clin Nutr 1965;17:259-71.
20. Herbert V, Zalusky R, Davidson CS. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia, and liver disease. Ann Intern Med 1963;58:977-88.
21. Cravo ML, Camilo ME. Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins B (6) and B (12) status. Nutrition 2000;16:296-302.
22. Pfeiffer CM, Hughes JP, Lacher DA, Bailey RL, Berry RJ, Zhang M, et al. Estimation of trends in serum and RBC folate in the U. S. population from pre-to postfortification using assay-adjusted data from the NHANES 1988-2010. J Nutr 2012;142:886-93.
23. Li SF, Jacob J, Feng J, Kulkarni M. Vitamin deficiencies in acutely intoxicated patients in the ED. Am J Emerg Med 2008;26:792-5.
24. Medici V, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, Virata MC, et al. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol 2010;53:551-7.
25. Shane B. Folate metabolism. In: Picciano M, Stokstad ELR, Gregory JF, editors. Folic acid metabolism in health and disease. New York, NY: Wiley, Liss, 1990:65-8.
26. Halsted CH, Ling EH, Luthi-Carter R, Villanueva JA, Gardner JM, Coyle JT. Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II. J Biol Chem 1998;273:20417-24.
27. Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006;127:917-28.
28. Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 2011;437:357-72.
29. Horne DW, Reed KA, Hoefs J, Said HM. 5-Methyltetrahydrofolate transport in basolateral membrane vesicles from human liver. Am J Clin Nutr 1993;58:80-4.
30. Van Hoozen CM, Ling EH, Halsted CH. Folate binding protein: molecular characterization and transcript distribution in pig liver, kidney and jejunum. Biochem J 1996;319:725-9.
31. Steinberg SE, Campbell CL, Hillman RS. The role of the enterohepatic cycle in folate supply to tumour in rats. Br J Haematol 1982;50:309-16.
32. Sikka PK, McMartin KE. Determination of folate transport pathways in cultured rat proximal tubule cells. Chem Biol Interact 1998;114:15-31.
33. Subramanian VS, Marchant JS, Said HM. Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia. Am J Physiol Cell Physiol 2008;294:C233-40.
34. Halsted CH, Griggs RC, Harris JW. The effect of alcoholism on the absorption of folic acid (H3-PGA) evaluated by plasma levels and urine excretion. J Lab Clin Med 1967;69:116-31.
35. Halsted CH, Robles EA, Mezey E. Decreased jejunal uptake of labeled folic acid (3 H-PGA) in alcoholic patients: roles of alcohol and nutrition. N Engl J Med 1971;285:701-6.
36. Romero JJ, Tamura T, Halsted CH. Intestinal absorption of [3H] folic acid in the chronic alcoholic monkey. Gastroenterology 1981;80:99-102.
37. Naughton CA, Chandler CJ, Duplantier RB, Halsted CH. Folate absorption in alcoholic pigs: in vitro hydrolysis and transport at the intestinal brush border membrane. Am J Clin Nutr 1989;50:1436-41.
38. Villanueva JA, Devlin AM, Halsted CH. Reduced folate carrier: tissue distribution and effects of chronic ethanol intake in the micropig. Alcohol Clin Exp Res 2001;25:415-20.
39. Herbert V. Predicting nutrient deficiency by formula. N Engl J Med 1971;284:976-7.
40. Eichner ER, Hillman RS. The evolution of anemia in alcoholic patients. Am J Med 1971;50:218-32.
41. Herbert V. Experimental nutritional folate deficiency in man. Trans Assoc Am Physicians 1962;75:307-20.
42. Tamura T, Romero JJ, Watson JE, Gong EJ, Halsted CH. Hepatic folate metabolism in the chronic alcoholic monkey. J Lab Clin Med 1981;97:654-61.
43. Russell RM, Rosenberg IH, Wilson PD, Iber FL, Oaks EB, Giovetti AC, et al. Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion. Am J Clin Nutr 1983;38:64-70.
44. McMartin KE, Collins TD, Eisenga BH, Fortney T, Bates WR, Bairnsfather L. Effects of chronic ethanol and diet treatment on urinary folate excretion and development of folate deficiency in the rat. J Nutr 1989;119:1490-7.
45. Tamura T, Halsted CH. Folate turnover in chronically alcoholic monkeys. J Lab Clin Med 1983;101:623-8.
46. Romanoff RL, Ross DM, McMartin KE. Acute ethanol exposure inhibits renal folate transport, but repeated exposure upregulates folate transport proteins in rats and human cells. J Nutr 2007;137:1260-5.
47. Leevy CM, Baker H, Tenhove W, Frank O, Cherrick GR. B-Complex vitamins in liver disease of the alcoholic. Am J Clin Nutr 1965;16:339-46.
48. Savage D, Lindenbaum J. Anemia in alcoholics. Medicine 1986;65:322-38.
49. Lumeng L. The role of acetaldehyde in mediating the deleterious effect of ethanol on pyridoxal 5'-phosphate metabolism. J Clin Invest 1978;62:286-93.
50. Labadarios D, Rossouw JE, McConnell JB, Davis M, Williams R. Vitamin B6 deficiency in chronic liver disease - evidence for increased degradation of pyridoxal-5'-phosphate. Gut 1977;18:23-7.
51. Lindenbaum J, Lieber CS. Alcohol-induced malabsorption of vitamin B12 in man. Nature 1969;224:806.
52. Kanazawa S, Herbert V. Total corrinoid, cobalamin (vitamin B12), and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest 1985;53:108-10.
53. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003;124:1488-99.
54. Song Z, Zhou Z, Uriarte S, Wang L, Kang YJ, Chen T, et al. S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 2004;40:989-97.
55. Esfandiari F, Villanueva JA, Wong DH, French SW, Halsted CH. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol 2005;289:G54-63.
56. Esfandiari F, You M, Villanueva JA, Wong DH, French SW, Halsted CH. S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin Exp Res 2007;31:1231-9.
57. Villanueva JA, Esfandiari F, White ME, Devaraj S, French SW, Halsted CH. S-Adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin Exp Res 2007;31:1934-43.
58. Mandrekar P. Epigenetic regulation in alcoholic liver disease. World J Gastroenterol 2011;17:2456-64.
59. Shukla SD, Velazquez J, French SW, Lu SC, Ticku MK, Zakhari S. Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res 2008;32:1525-34.
60. Pal-Bhadra M, Bhadra U, Jackson DE, Mamatha L, Park PH, Shukla SD. Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up-& down-regulation of genes by ethanol in hepatocytes. Life Sci 2007;81:979-87.
61. Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, et al. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthasedeficient mouse. Hepatology 2010;51:932-41.
62. Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2.
63. Barak AJ, Beckenhauer HC, Tuma DJ. S-adenosylmethionine generation and prevention of alcoholic fatty liver by betaine. Alcohol 1994;11:501-3.
64. Kharbanda KK, Mailliard ME, Baldwin CR, Beckenhauer HC, Sorrell MF, Tuma DJ. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J Hepatol 2007;46:314-21.
65. Kharbanda KK, Rogers DD 2nd, Mailliard ME, Siford GL, Barak AJ, Beckenhauer HC, et al. A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes. J Nutr 2005;135:519-24.
66. Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 1989;24:407-15.
67. Mato JM, Camara J, Fernandez De Paz J, Caballeria L, Coll S, Caballero A, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9.
68. Rambaldi A, Gluud C. S-adenosyl-L-methionine for alcoholic liver diseases. Cochrane Database Syst Rev 2006:CD002235.
69. Medici V, Virata MC, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, et al. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcohol Clin Exp Res 2011;35:1960-5.