메뉴 건너뛰기




Volumn 70, Issue 5, 1999, Pages 904-910

Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: Ethnic and sex differences in cobalamin and metabolite abnormalities

Author keywords

Asians; Blacks; Cobalamin; Cobalamin deficiency; Elderly; Ethnicity; Folate; Homocysteine; Latin Americans; Men; Methylmalonic acid; Women

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID;

EID: 0032740452     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/70.5.904     Document Type: Article
Times cited : (163)

References (38)
  • 3
    • 0030771355 scopus 로고    scopus 로고
    • Cobalamin, the stomach, and aging
    • Carmel R. Cobalamin, the stomach, and aging. Am J Clin Nutr 1997;66:750-9.
    • (1997) Am J Clin Nutr , vol.66 , pp. 750-759
    • Carmel, R.1
  • 4
    • 0023223851 scopus 로고
    • Atypical cobalamin deficiency: Subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption
    • Carmel R, Sinow RM, Karnaze DS. Atypical cobalamin deficiency: subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption. J Lab Clin Med 1987; 109:454-63.
    • (1987) J Lab Clin Med , vol.109 , pp. 454-463
    • Carmel, R.1    Sinow, R.M.2    Karnaze, D.S.3
  • 5
    • 0026475025 scopus 로고
    • High prevalence of cobalamin deficiency in elderly outpatients
    • Pennypacker LC, Allen RH, Kelly JP, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992; 40:1197-204.
    • (1992) J Am Geriatr Soc , vol.40 , pp. 1197-1204
    • Pennypacker, L.C.1    Allen, R.H.2    Kelly, J.P.3
  • 6
    • 0029054411 scopus 로고
    • The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities
    • Carmel R, Gott PS, Waters CH, et al. The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol 1995;54:245-53.
    • (1995) Eur J Haematol , vol.54 , pp. 245-253
    • Carmel, R.1    Gott, P.S.2    Waters, C.H.3
  • 7
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111-28.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 8
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease; probable benefits of increasing folate intakes
    • Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease; probable benefits of increasing folate intakes. JAMA 1995;274:1049-57.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 9
    • 0029132161 scopus 로고
    • Metabolite assays in cobalamin and folate deficiency
    • Green R. Metabolite assays in cobalamin and folate deficiency. Bailliere Clin Haematol 1995;8:533-66.
    • (1995) Bailliere Clin Haematol , vol.8 , pp. 533-566
    • Green, R.1
  • 10
    • 0024342063 scopus 로고
    • Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy
    • Ueland PM, Refsum H. Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy. J Lab Clin Med 1989;114:473-501.
    • (1989) J Lab Clin Med , vol.114 , pp. 473-501
    • Ueland, P.M.1    Refsum, H.2
  • 11
    • 0032963914 scopus 로고    scopus 로고
    • Ethnic and racial factors in cobalamin metabolism and its disorders
    • Carmel R. Ethnic and racial factors in cobalamin metabolism and its disorders. Semin Hematol 1999;36:88-100.
    • (1999) Semin Hematol , vol.36 , pp. 88-100
    • Carmel, R.1
  • 13
    • 0029978383 scopus 로고    scopus 로고
    • Plasma homocysteine concentrations in a population with low coronary disease prevalence
    • Ubbink JB, Delport R, Vermaak WJH. Plasma homocysteine concentrations in a population with low coronary disease prevalence. J Nutr 1996;126:12543-78.
    • (1996) J Nutr , vol.126 , pp. 12543-12578
    • Ubbink, J.B.1    Delport, R.2    Vermaak, W.J.H.3
  • 14
    • 0023849379 scopus 로고
    • Neurologic abnormalities in cobalamin deficiency are associated with higher cobalamin "analogue" values than are hematologic abnormalities
    • Carmel R, Karnaze DS, Weiner JM. Neurologic abnormalities in cobalamin deficiency are associated with higher cobalamin "analogue" values than are hematologic abnormalities. J Lab Clin Med 1988;111:57-62.
    • (1988) J Lab Clin Med , vol.111 , pp. 57-62
    • Carmel, R.1    Karnaze, D.S.2    Weiner, J.M.3
  • 15
    • 0028284362 scopus 로고
    • Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: Sex differences and correlation with cobalamin and folate concentrations in healthy subjects
    • Jacobsen DW, Gatautis VJ, Green R, et al. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem 1994;40:873-81.
    • (1994) Clin Chem , vol.40 , pp. 873-881
    • Jacobsen, D.W.1    Gatautis, V.J.2    Green, R.3
  • 16
    • 0030010213 scopus 로고    scopus 로고
    • Comparison of deoxyuridine suppression test with serum levels of methylmalonic acid and homocysteine in mild cobalamin deficiency
    • Carmel R, Rasmussen K, Jacobsen DW, Green R. Comparison of deoxyuridine suppression test with serum levels of methylmalonic acid and homocysteine in mild cobalamin deficiency. Br J Haematol 1996;93:311-8.
    • (1996) Br J Haematol , vol.93 , pp. 311-318
    • Carmel, R.1    Rasmussen, K.2    Jacobsen, D.W.3    Green, R.4
  • 17
    • 0024507370 scopus 로고
    • Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope- Dilution method
    • Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989;35:260-4.
    • (1989) Clin Chem , vol.35 , pp. 260-264
    • Rasmussen, K.1
  • 18
    • 0025063373 scopus 로고
    • Methylmalonic acid concentrations in serum of normal subjects: Biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin
    • Rasmussen K, Möller J, Östergaard K, Kristensen MÖ, Jensen J. Methylmalonic acid concentrations in serum of normal subjects: biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin. Clin Chem 1990;36:1295-9.
    • (1990) Clin Chem , vol.36 , pp. 1295-1299
    • Rasmussen, K.1    Möller, J.2    Östergaard, K.3    Kristensen, M.Ö.4    Jensen, J.5
  • 19
    • 0025041062 scopus 로고
    • Methymalonic acid in renal insufficiency: Evidence of accumulation and implications for diagnosis of cobalamin deficiency
    • Rasmussen K, Vyberg B, Pedersen KO, Bröchner-Mortensen J. Methymalonic acid in renal insufficiency: evidence of accumulation and implications for diagnosis of cobalamin deficiency. Clin Chem 1990;36:1523-4.
    • (1990) Clin Chem , vol.36 , pp. 1523-1524
    • Rasmussen, K.1    Vyberg, B.2    Pedersen, K.O.3    Bröchner-Mortensen, J.4
  • 20
    • 0023949170 scopus 로고
    • Folic acid lowers plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease
    • Wilcken DEL, Dudman NPD, Tyrrell PA, Robertson MR. Folic acid lowers plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease. Metabolism 1988; 37:697-701.
    • (1988) Metabolism , vol.37 , pp. 697-701
    • Wilcken, D.E.L.1    Npd, D.2    Tyrrell, P.A.3    Robertson, M.R.4
  • 21
    • 0025616163 scopus 로고
    • Concentrations of total homocysteine in plasma in chronic renal failure
    • Soria C, Chadefaux B, Coudé M, Gaillard O, Kamoun P. Concentrations of total homocysteine in plasma in chronic renal failure. Clin Chem 1990;36:2137-8.
    • (1990) Clin Chem , vol.36 , pp. 2137-2138
    • Soria, C.1    Chadefaux, B.2    Coudé, M.3    Gaillard, O.4    Kamoun, P.5
  • 22
    • 0028788020 scopus 로고
    • Total plasma homocysteine and cardiovascular risk profile. the Hordaland homocysteine study
    • Nygard O, Vollset SE, Refsum H, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland homocysteine study. JAMA 1995;274:1526-33.
    • (1995) JAMA , vol.274 , pp. 1526-1533
    • Nygard, O.1    Vollset, S.E.2    Refsum, H.3
  • 23
    • 0029891583 scopus 로고    scopus 로고
    • Prevalence of undiagnosed pernicious anemia in the elderly
    • Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996;156:1097-100.
    • (1996) Arch Intern Med , vol.156 , pp. 1097-1100
    • Carmel, R.1
  • 24
    • 0031824229 scopus 로고    scopus 로고
    • Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels
    • Howard JM, Azen C, Jacobsen DW, Green R, Carmel R. Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels. Eur J Clin Nutr 1998;52:582-7.
    • (1998) Eur J Clin Nutr , vol.52 , pp. 582-587
    • Howard, J.M.1    Azen, C.2    Jacobsen, D.W.3    Green, R.4    Carmel, R.5
  • 27
    • 0027430257 scopus 로고
    • Metabolic evidence that deficiencies of vitamin B-12, folate, and vitamin B-6 occur commonly in elderly people
    • Joosten E, van den Berg A, Riezler R, et al. Metabolic evidence that deficiencies of vitamin B-12, folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 1993;58:468-76.
    • (1993) Am J Clin Nutr , vol.58 , pp. 468-476
    • Joosten, E.1    Van Den Berg, A.2    Riezler, R.3
  • 28
    • 0031982698 scopus 로고    scopus 로고
    • Variability and determinants of total homocysteine concentrations in plasma in an elderly population
    • Clarke R, Woodhouse P, Ulvik A, et al. Variability and determinants of total homocysteine concentrations in plasma in an elderly population. Clin Chem 1998;44:102-7.
    • (1998) Clin Chem , vol.44 , pp. 102-107
    • Clarke, R.1    Woodhouse, P.2    Ulvik, A.3
  • 29
    • 0033004216 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations in adolescent and adult Americans: Results from the third National Health and Nutrition Examination Survey
    • Jacques PF, Rosenberg IH, Rogers G, et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 1999;69:482-9.
    • (1999) Am J Clin Nutr , vol.69 , pp. 482-489
    • Jacques, P.F.1    Rosenberg, I.H.2    Rogers, G.3
  • 30
    • 0031871314 scopus 로고    scopus 로고
    • Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects
    • van Asselt DZB, de Groot LCPGM, van Staveren WA, et al. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 1998;68:328-34.
    • (1998) Am J Clin Nutr , vol.68 , pp. 328-334
    • Van Asselt, D.Z.B.1    De Groot, L.C.P.G.M.2    Van Staveren, W.A.3
  • 31
    • 0027382008 scopus 로고
    • Vitamin status and input as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and input as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270:2693-8.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.F.3    Rush, D.4    Rosenberg, I.H.5
  • 32
    • 0028600627 scopus 로고
    • Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects
    • Brattstrom L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994;236:633-41.
    • (1994) J Intern Med , vol.236 , pp. 633-641
    • Brattstrom, L.1    Lindgren, A.2    Israelsson, B.3    Andersson, A.4    Hultberg, B.5
  • 33
    • 0029836310 scopus 로고    scopus 로고
    • Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women
    • Koehler KN, Romero LJ, Stauber PN, et al. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Nutr 1996; 15:364-76.
    • (1996) J Am Coll Nutr , vol.15 , pp. 364-376
    • Koehler, K.N.1    Romero, L.J.2    Stauber, P.N.3
  • 35
    • 0026664205 scopus 로고
    • Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations
    • Miller JW, Ribaya-Mercado JD, Russell RM, et al. Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations. Am J Clin Nutr 1992;55:1154-60.
    • (1992) Am J Clin Nutr , vol.55 , pp. 1154-1160
    • Miller, J.W.1    Ribaya-Mercado, J.D.2    Russell, R.M.3
  • 37
    • 0005775025 scopus 로고    scopus 로고
    • The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans
    • McAndrew PE, Brandt JT, Pearl DK, Prior TW. The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans. Thromb Res 1996;83:195-8.
    • (1996) Thromb Res , vol.83 , pp. 195-198
    • McAndrew, P.E.1    Brandt, J.T.2    Pearl, D.K.3    Prior, T.W.4
  • 38
    • 0029881286 scopus 로고    scopus 로고
    • Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation
    • Rasmussen K, Möller J, Lyngbak M, Holm Pedersen AM, Dybkjaer L. Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem 1996;42:630-6.
    • (1996) Clin Chem , vol.42 , pp. 630-636
    • Rasmussen, K.1    Möller, J.2    Lyngbak, M.3    Holm Pedersen, A.M.4    Dybkjaer, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.