Triphenylphosphonium Cations of the Diterpenoid Isosteviol: Synthesis and Antimitotic Activity in a Sea Urchin Embryo Model

Journal of Natural Products

Volumn 78, Issue 6, 2015, Pages 1300-1308

  Strobykina, Irina Yu ^a   Belenok, Mayya G ^a   Semenova, Marina N ^b,c   Semenov, Victor V ^d   Babaev, Vasiliy M ^a   Rizvanov, Ildar Kh ^a   Mironov, Vladimir F ^a   Kataev, Vladimir E ^a  

^a A E ARBUZOV INSTITUTE OF ORGANIC AND PHYSICAL CHEMISTRY   (Russian Federation)

^b KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

^c Chemical Block Ltd   (Cyprus)

^d N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

11' BROMO 3',6',9' TRIOXAUNDECAN 1' YL 16 OXO ENT BEYERAN 19 OATE; 11' P TOLUENESULFONYLOXY 3',6',9' TRIOXAUNDECAN 1' YL 16 OXOENT BEYERAN 19 OATE; 14' BROMO 3',6',9',12 TETRAOXATETRADECAN 1' YL 16 OXO ENT BEYERAN 19 OATE; 14' P TOLUENESULFONYLOXY 3',6',9',12' TETRAOXATETRADECAN 1' YL 16 OXO ENT BEYERAN 19 OATE; 19 (12' TRIPHENYLPHOSPHONIUM 1',4',7',10' TETRAOXADODECYL) 16,19 DIOXO ENT BEYERANE BROMIDE; 19 (15' TRIPHENYLPHOSPHONIUM 1',4',7',10',13' PENTAOXAPENTADECACYL) 16,19 DIOXO ENT BEYERANE BROMIDE; 19 (3' TRIPHENYLPHOSPHONIUMPROPYLOXY) 16,19 DIOXO ENT BEYERANE BROMIDE; 19 (8' TRIPHENYLPHOSPHONIUMOCTYLOXY) 16,19 DIOXO ENT BEYERANE BROMIDE; 19 (9' TRIETHYLAMMONIUM 1',4',7' TRIOXANONYL) 16,19 DIOXO ENTBEYERANE BROMIDE; 19 (9' TRIPHENYLPHOSPHONIUM 1',4',7' TRIOXANONYL) 16,19 DIOXOENT BEYERANE BROMIDE; 3' BROMO N PROPYL 16 OXO ENT BEYERAN 19 OATE; 3',6' DIOXAOCTANE 1',8' DIYLBIS(16 OXO ENT BEYERAN 19 OATE); 3',6',9' TRIOXAUNDECANE 1',11' DIYLBIS(16 OXO ENT BEYERAN 19 OATE); 3',6',9',12' TETRAOXATETRADECANE 1',14' DIYLBIS(16 OXO ENT BEYERAN 19 OATE); 6' BROMO N HEXYL 16 OXO ENT BEYERAN 19 OATE; 8' BROMO N OCTYL 16 OXO ENT BEYERAN 19 OATE; 8' P TOLUENESULFONYLOXY 3',6' DIOXAOCTAN 1' YL 16 OXO ENT BEYERAN 19 OATE; ANTIMITOTIC AGENT; DITERPENOID; METHYLTRIPHENYLPHOSPHONIUM; MITOCHONDRIAL DNA; PHOSPHONIUM DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CATION; DITERPENE; ISOSTEVIC ACID; ISOSTEVIOL; KAURANE DERIVATIVE; ORGANOPHOSPHORUS COMPOUND;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMITOTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; EMBRYO; FEMALE; IN VIVO STUDY; MITOCHONDRION; MITOSIS INHIBITION; MITOSIS SPINDLE; NONHUMAN; SEA URCHIN; STRUCTURE ACTIVITY RELATION; ZYGOTE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HUMAN; MEDITERRANEAN SEA; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ECHINOIDEA;

ANIMALS; ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; CATIONS; DISEASE MODELS, ANIMAL; DITERPENES; DITERPENES, KAURANE; HUMANS; MEDITERRANEAN SEA; MITOCHONDRIA; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; SEA URCHINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84933059832     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.5b00124     Document Type: Article

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