Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 585-593

  Salomatina, Oksana V ^a   Markov, Andrey V ^b   Logashenko, Evgeniya B ^b   Korchagina, Dina V ^a   Zenkova, Marina A ^b   Salakhutdinov, Nariman F ^a   Vlassov, Valentin V ^b   Tolstikov, Genrikh A ^a  

^a N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

Author keywords

Biological activity; Cytotoxicity; Glycyrrhetinic acid derivatives; Nitric oxide; Selectivity index

Indexed keywords

GLYCYRRHETINIC ACID DERIVATIVE; METHYL 11 OXOISOXAZOLO[4,5 B] OLEAN 9(11),18(19) DIEN 30 OATE; METHYL 2 CYANO 3,11 DIOXO 18BETA OLEAN 1(2),12(13) DIEN 30 OATE; METHYL 2 CYANO 3,11 DIOXOOLEAN 1(2),9(11),18(19) TRIEN 30 OATE; METHYL 2 CYANO 3,12 DIOXO 18BETA OLEAN 30 OATE; METHYL 2 HYDROXYMETHYLENE 3 OXO 18BETA OLEAN 12(13) EN 30 OATE; METHYL 2 HYDROXYMETHYLENE 3,11 DIOXOOLEAN 12(13),18(19) DIEN 30 OATE; METHYL 3,11 DIOXOOLEAN 12(13),18(19) DIEN 30 OATE; METHYL 3,12 DIOXO 18BETA OLEAN 30 OATE; METHYL 3BETA ACETOXY 11 OXOOLEAN 12(13), 18(19) DIEN 30 OATE; METHYL 3BETA HYDROXY 12 OXO 18BETA OLEAN 30 OATE; METHYL 3BETA HYDROXY 18BETA OLEAN 12(13) EN 30 OATE; METHYL ISOXAZOLO[4,5 B] 18BETA OLEAN 12(13) EN 30 OATE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CANCER INHIBITION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

BIOLOGICAL ACTIVITY; CYTOTOXICITY; GLYCYRRHETINIC ACID DERIVATIVES; NITRIC OXIDE; SELECTIVITY INDEX;

CELL PROLIFERATION; GLYCYRRHETINIC ACID; HUMANS; LIPOPOLYSACCHARIDES; NEOPLASMS; NITRIC OXIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891402001     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.049     Document Type: Article

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