Synthesis and evaluation of cytotoxic effects of novel α- methylenelactone tetracyclic diterpenoids

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1922-1925

  Zeng, Yao Fu ^a   Wu, Jia Qiang ^a   Shi, Lian Yong ^a   Wang, Ke ^a   Zhou, Bin ^a   Tang, Yong ^a   Zhang, Da Yong ^a   Wu, Yang Chang ^b   Hua, Wei Yi ^a   Wu, Xiao Ming ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Methylenelactone; Anti tumor activity; Isosteviol; Steviol; Tetracyclic diterpenoids

Indexed keywords

ALPHA METHYLENELACTONE TETRACYCLIC DITERPENOID DERIVATIVE; ANTINEOPLASTIC AGENT; DITERPENOID; DOXORUBICIN; LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HEPG2; COLORECTAL CARCINOMA; COMPETITIVE INHIBITION; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DEPROTECTION REACTION; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ESTERIFICATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; PROSTATE CARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION; WALKER CARCINOMA;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; HUMANS; LACTONES; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862786915     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.051     Document Type: Article

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