Cis -restricted 3-aminopyrazole analogues of combretastatins: Synthesis from plant polyalkoxybenzenes and biological evaluation in the cytotoxicity and phenotypic sea urchin embryo assays

Journal of Natural Products

Volumn 76, Issue 8, 2013, Pages 1485-1491

  Tsyganov, Dmitry V ^a   Konyushkin, Leonid D ^a   Karmanova, Irina B ^a   Firgang, Sergei I ^a   Strelenko, Yuri A ^a   Semenova, Marina N ^b,c   Kiselyov, Alex S ^d   Semenov, Victor V ^a  

^a N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

^c Chemical Block Ltd   (Cyprus)

^d CHEMDIV INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPYRAZOLE DERIVATIVE; 4 (4 METHOXYPHENYL) 5 (2,3 DIMETHOXY 4,5 METHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (4 METHOXYPHENYL) 5 (2,5 DIMETHOXY 3,4 METHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (4 METHOXYPHENYL) 5 (3 METHOXY 4,5 ETHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (4 METHOXYPHENYL) 5 (3 METHOXY 4,5 METHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 4 (4 METHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; 5 (4 METHOXYPHENYL) 4 (2,3 DIMETHOXY 4,5 METHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 5 (4 METHOXYPHENYL) 4 (2,5 DIMETHOXY 3,4 METHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 5 (4 METHOXYPHENYL) 4 (3 METHOXY 4,5 METHYLENEDIOXYPHENYL) 1H PYRAZOL 3 AMINE; 5 (4 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; ALKOXYBENZENE DERIVATIVE; ANTIMITOTIC AGENT; COMBRETASTATIN; POLYALKOXYBENZENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; CELL DIVISION; CONTROLLED STUDY; CYTOTOXICITY; DILL; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PARSLEY; PLANT SEED; PROTON NUCLEAR MAGNETIC RESONANCE; SEA URCHIN;

ANETHUM GRAVEOLENS; ANIMALS; ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; BIBENZYLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; EMBRYO, NONMAMMALIAN; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PETROSELINUM; PYRAZOLES; SEA URCHINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 84883138617     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np400310m     Document Type: Article

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