New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6690-6698

  Sokolova, Anastasiya S ^a,b   Yarovaya, Olga I ^a,b   Shernyukov, Andrey V ^a   Pokrovsky, Michail A ^b   Pokrovsky, Andrey G ^b   Lavrinenko, Valentina A ^b   Zarubaev, Vladimir V ^c   Tretiak, Tatiana S ^c   Anfimov, Pavel M ^c   Kiselev, Oleg I ^c   Beklemishev, Anatoly B ^d   Salakhutdinov, Nariman F ^a  

^a N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c Influenza Research Institute   (Russian Federation)

^d INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

Antivirals; Camphor; Cytotoxicity; Genotoxicity; Imine derivatives; Influenza

Indexed keywords

ALIPHATIC COMPOUND; AMANTADINE; CAMPHOR DERIVATIVE; CARBON; DEITIPHORIN; GREEN FLUORESCENT PROTEIN; N,N DIETHYL N METHYL 2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)AMINO]ETHANAMINIUM IODIDE; N,N' [1,4 PHENYLENEBIS(METHYLENE)]BIS[N,N DIETHYL 2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2YLIDENE)AMINO]ETHANAMINIUM]BROMIDE; N,N,N TRIETHYL 2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)AMINO]ETHANAMINIUM BROMIDE; N1,N1,N10,N10 TETRAETHYL N1,N10 BIS[2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2YLIDENE)AMINO]ETHYL]DECANE 1,10 DIAMINIUM BROMIDE; N1,N1,N12,N12 TETRAETHYL N1,N10 BIS[2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2YLIDENE)AMINO]ETHYL]DODECANE 1,12 DIAMINIUM BROMIDE; N1,N1,N5,N5 TETRAETHYL N1,N5 BIS[2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2YLIDENE)AMINO]ETHYL]PENTANE 1,5 DIAMINIUM BROMIDE; N1,N1,N6,N6 TETRAETHYL N1,N6 BIS[2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2YLIDENE)AMINO]ETHYL]HEXANE 1,6 DIAMINIUM BROMIDE; N1,N1,N9,N9 TETRAETHYL N1,N9 BIS[2 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2YLIDENE)AMINO]ETHYL]NONANE 1,9 DIAMINIUM BROMIDE; NALIDIXIC ACID; NITROGEN; QUATERNARY AMMONIUM DERIVATIVE; RIMANTADINE; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOSENSOR; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER MODEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FOURIER TRANSFORMATION; GENOTOXICITY; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H1N1; MOLECULAR DOCKING; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; VIRUS INHIBITION;

DRYOBALANOPS; INFLUENZAVIRUS A;

ANTIVIRALS; CAMPHOR; CYTOTOXICITY; GENOTOXICITY; IMINE DERIVATIVES; INFLUENZA;

ANIMALS; ANTIVIRAL AGENTS; BICYCLO COMPOUNDS; BINDING SITES; CAMPHOR; CELL LINE, TUMOR; CELL SURVIVAL; DOGS; ESCHERICHIA COLI; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MOLECULAR DOCKING SIMULATION; MUTAGENICITY TESTS; PROTEIN STRUCTURE, TERTIARY; QUATERNARY AMMONIUM COMPOUNDS; VIRAL MATRIX PROTEINS;

EID: 84885172779     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.014     Document Type: Article

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